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Search results 1 to 100 out of 374 for Acan

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Category: Publication
Type Details Score
Publication
First Author: Schmidt S
Year: 2021
Journal: Eur J Neurosci
Title: Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L - Acan mouse model.
Volume: 53
Issue: 12
Pages: 3889-3904
Publication
First Author: Rowlands D
Year: 2018
Journal: J Neurosci
Title: Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity.
Volume: 38
Issue: 47
Pages: 10102-10113
Publication  
First Author: Rashid H
Year: 2017
Journal: Genesis
Title: Dwarfism in homozygous Agc1CreERT mice is associated with decreased expression of aggrecan.
Volume: 55
Issue: 10
Publication
First Author: Han Y
Year: 2008
Journal: Mol Cell Biol
Title: L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer.
Volume: 28
Issue: 16
Pages: 4999-5013
Publication
First Author: Yoshida CA
Year: 2014
Journal: J Biol Chem
Title: Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.
Volume: 289
Issue: 38
Pages: 26584-96
Publication
First Author: Dupuis LE
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Adamts5-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies.
Volume: 39
Issue: 10
Pages: 2067-2081
Publication
First Author: Lauing KL
Year: 2014
Journal: Dev Biol
Title: Aggrecan is required for growth plate cytoarchitecture and differentiation.
Volume: 396
Issue: 2
Pages: 224-36
Publication
First Author: Yoshida R
Year: 2016
Journal: Connect Tissue Res
Title: Murine supraspinatus tendon injury model to identify the cellular origins of rotator cuff healing.
Volume: 57
Issue: 6
Pages: 507-515
Publication    
First Author: Jing Y
Year: 2016
Journal: J Vis Exp
Title: Co-localization of Cell Lineage Markers and the Tomato Signal.
Issue: 118
Publication
First Author: Henry SP
Year: 2009
Journal: Genesis
Title: Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage.
Volume: 47
Issue: 12
Pages: 805-14
Publication  
First Author: Alberton P
Year: 2019
Journal: Int J Mol Sci
Title: Aggrecan Hypomorphism Compromises Articular Cartilage Biomechanical Properties and Is Associated with Increased Incidence of Spontaneous Osteoarthritis.
Volume: 20
Issue: 5
Publication  
First Author: O-Sullivan I
Year: 2022
Journal: Int J Mol Sci
Title: Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization.
Volume: 23
Issue: 20
Publication
First Author: Mailhiot SE
Year: 2015
Journal: PLoS One
Title: Non-Invasive Quantification of Cartilage Using a Novel In Vivo Bioluminescent Reporter Mouse.
Volume: 10
Issue: 7
Pages: e0130564
Publication  
First Author: Novak S
Year: 2023
Journal: Bone
Title: AcanCreER lacks specificity to chondrocytes and targets periosteal progenitors in the fractured callus.
Volume: 166
Pages: 116599
Publication
First Author: Bell L
Year: 1986
Journal: J Hered
Title: A new mutation at the cmd locus in the mouse.
Volume: 77
Issue: 3
Pages: 205-6
Publication  
First Author: Juriloff DM
Year: 1985
Journal: Mouse News Lett
Title: Agccmd-Bc - cartilage matrix deficiency-British Columbia
Volume: 72
Pages: 95
Publication
First Author: Krueger RC Jr
Year: 1999
Journal: Mamm Genome
Title: Completion of the mouse aggrecan gene structure and identification of the defect in the cmd-Bc mouse as a near complete deletion of the murine aggrecan gene.
Volume: 10
Issue: 12
Pages: 1119-25
Publication  
First Author: Rittenhouse E
Year: 1978
Journal: J Embryol Exp Morphol
Title: Cartilage matrix deficiency (cmd): a new autosomal recessive lethal mutation in the mouse.
Volume: 43
Pages: 71-84
Publication  
First Author: Yoo TJ
Year: 1991
Journal: Ann N Y Acad Sci
Title: Hearing impairment in mice with the cmd/cmd (cartilage matrix deficiency) mutant gene.
Volume: 630
Pages: 265-7
Publication
First Author: Houghton MJ
Year: 1989
Journal: Pediatr Pathol
Title: Pulmonary hypoplasia in mice homozygous for the cartilage matrix deficiency (cmd) gene: a model for human congenital disorder.
Volume: 9
Issue: 5
Pages: 501-12
Publication
First Author: Kimata K
Year: 1981
Journal: J Biol Chem
Title: Absence of proteoglycan core protein in cartilage from the cmd/cmd (cartilage matrix deficiency) mouse.
Volume: 256
Issue: 13
Pages: 6961-8
Publication
First Author: Watanabe H
Year: 1998
Journal: J Biochem
Title: Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function.
Volume: 124
Issue: 4
Pages: 687-93
Publication
First Author: Katayama K
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis.
Volume: 499
Issue: 3
Pages: 459-465
Publication
First Author: Brown KS
Year: 1991
Journal: J Craniofac Genet Dev Biol
Title: New genetic approaches to craniofacial growth and malformation in the mouse.
Volume: 11
Issue: 4
Pages: 357-65
Publication
First Author: Brennan MJ
Year: 1983
Journal: Dev Biol
Title: Immunological evidence for two distinct chondroitin sulfate proteoglycan core proteins: differential expression in cartilage matrix deficient mice.
Volume: 98
Issue: 1
Pages: 139-47
Publication  
First Author: Tsukahara T
Year: 1991
Journal: J Cell Sci
Title: Enhanced expression of fibronectin by cmd/cmd chondrocytes and its modulation by exogenously added proteoglycan.
Volume: 100 ( Pt 2)
Pages: 387-95
Publication      
First Author: Kochhar DM
Year: 1985
Title: Cellular expression of a mutant gene (cmd/cmd) causing limb and other defects in mouse embryos
Pages: 131-44
Publication
First Author: Giamanco KA
Year: 2010
Journal: Neuroscience
Title: Perineuronal net formation and structure in aggrecan knockout mice.
Volume: 170
Issue: 4
Pages: 1314-27
Publication
First Author: Little CB
Year: 2005
Journal: Mol Cell Biol
Title: Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.
Volume: 25
Issue: 8
Pages: 3388-99
Publication
First Author: Little CB
Year: 2007
Journal: J Clin Invest
Title: Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair.
Volume: 117
Issue: 6
Pages: 1627-36
Publication
First Author: Liu Y
Year: 1997
Journal: J Biol Chem
Title: Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells.
Volume: 272
Issue: 47
Pages: 29880-5
Publication  
First Author: Dzyubenko E
Year: 2016
Journal: J Neurosci Methods
Title: Colocalization of synapse marker proteins evaluated by STED-microscopy reveals patterns of neuronal synapse distribution in vitro.
Volume: 273
Pages: 149-159
Publication  
First Author: Watanabe H
Year: 1995
Journal: Biochem J
Title: Mouse aggrecan, a large cartilage proteoglycan: protein sequence, gene structure and promoter sequence.
Volume: 308 ( Pt 2)
Pages: 433-40
Publication  
First Author: Hu Y
Year: 2017
Journal: Front Cell Neurosci
Title: Increased Susceptibility to Ischemic Brain Injury in Neuroplastin 65-Deficient Mice Likely via Glutamate Excitotoxicity.
Volume: 11
Pages: 110
Publication
First Author: Cornelis FMF
Year: 2019
Journal: Osteoarthritis Cartilage
Title: Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice.
Volume: 27
Issue: 3
Pages: 513-525
Publication
First Author: Kitami M
Year: 2019
Journal: Biochem Biophys Res Commun
Title: IFT20 is required for the maintenance of cartilaginous matrix in condylar cartilage.
Volume: 509
Issue: 1
Pages: 222-226
Publication  
First Author: Jo SY
Year: 2023
Journal: Bone
Title: In vivo intra-articular contrast enhanced μCT imaging of mouse knee cartilage.
Volume: 167
Pages: 116632
Publication
First Author: Jo SY
Year: 2020
Journal: JBMR Plus
Title: The Role of Dot1l in Prenatal and Postnatal Murine Chondrocytes and Trabecular Bone.
Volume: 4
Issue: 2
Pages: e10254
Publication
First Author: Fu W
Year: 2021
Journal: Ann Rheum Dis
Title: 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis.
Volume: 80
Issue: 12
Pages: 1615-1627
Publication  
First Author: Puertas-Frías G
Year: 2019
Journal: Neurochem Int
Title: Mitochondrial movement in Aralar/Slc25a12/AGC1 deficient cortical neurons.
Volume: 131
Pages: 104541
Publication
First Author: Juaristi I
Year: 2017
Journal: J Neurochem
Title: ARALAR/AGC1 deficiency, a neurodevelopmental disorder with severe impairment of neuronal mitochondrial respiration, does not produce a primary increase in brain lactate.
Volume: 142
Issue: 1
Pages: 132-139
Publication
First Author: Lai Y
Year: 2022
Journal: Int J Oral Sci
Title: Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice.
Volume: 14
Issue: 1
Pages: 33
Publication
First Author: Chen S
Year: 2022
Journal: Bone Res
Title: Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc.
Volume: 10
Issue: 1
Pages: 5
Publication
First Author: Weisz-Hubshman M
Year: 2022
Journal: Hum Mol Genet
Title: DDRGK1 is required for the proper development and maintenance of the growth plate cartilage.
Volume: 31
Issue: 16
Pages: 2820-2830
Publication  
First Author: Horner NR
Year: 2021
Journal: Development
Title: LAMA: automated image analysis for the developmental phenotyping of mouse embryos.
Volume: 148
Issue: 18
Publication
First Author: Matsumoto K
Year: 2006
Journal: J Biol Chem
Title: Identification and characterization of versican/PG-M aggregates in cartilage.
Volume: 281
Issue: 26
Pages: 18257-63
Publication
First Author: Hill A
Year: 2014
Journal: PLoS One
Title: Lubricin protects the temporomandibular joint surfaces from degeneration.
Volume: 9
Issue: 9
Pages: e106497
Publication
First Author: Glumoff V
Year: 1994
Journal: Biochim Biophys Acta
Title: Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes.
Volume: 1219
Issue: 3
Pages: 613-22
Publication
First Author: Jing J
Year: 2013
Journal: Int J Biol Sci
Title: BMP receptor 1A determines the cell fate of the postnatal growth plate.
Volume: 9
Issue: 9
Pages: 895-906
Publication
First Author: Jing Y
Year: 2017
Journal: Sci Rep
Title: Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process.
Volume: 7
Issue: 1
Pages: 10020
Publication
First Author: Sessions GA
Year: 2019
Journal: FASEB J
Title: Controlled induction and targeted elimination of p16INK4a-expressing chondrocytes in cartilage explant culture.
Volume: 33
Issue: 11
Pages: 12364-12373
Publication
First Author: Liao L
Year: 2019
Journal: J Cell Physiol
Title: Deletion of Runx2 in condylar chondrocytes disrupts TMJ tissue homeostasis.
Volume: 234
Issue: 4
Pages: 3436-3444
Publication
First Author: Liao L
Year: 2017
Journal: Sci Rep
Title: Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice.
Volume: 7
Issue: 1
Pages: 2371
Publication
First Author: Jing J
Year: 2014
Journal: J Dent Res
Title: Osterix couples chondrogenesis and osteogenesis in post-natal condylar growth.
Volume: 93
Issue: 10
Pages: 1014-21
Publication
First Author: Brooks JM
Year: 2013
Journal: Cell Rep
Title: A molecular mechanism regulating the timing of corticogeniculate innervation.
Volume: 5
Issue: 3
Pages: 573-81
Publication
First Author: Zhou Y
Year: 2019
Journal: J Cell Physiol
Title: Deletion of Axin1 in condylar chondrocytes leads to osteoarthritis-like phenotype in temporomandibular joint via activation of β-catenin and FGF signaling.
Volume: 234
Issue: 2
Pages: 1720-1729
Publication  
First Author: Schmidt S
Year: 2022
Journal: Biomolecules
Title: Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model.
Volume: 12
Issue: 4
Publication  
First Author: Novais EJ
Year: 2019
Journal: Matrix Biol
Title: p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence.
Volume: 82
Pages: 54-70
Publication
First Author: Zhou X
Year: 2014
Journal: PLoS Genet
Title: Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice.
Volume: 10
Issue: 12
Pages: e1004820
Publication  
First Author: Dai C
Year: 2020
Journal: Bone
Title: Selective inhibition of progesterone receptor in osteochondral progenitor cells, but not in mature chondrocytes, modulated subchondral bone structures.
Volume: 132
Pages: 115196
Publication
First Author: Catheline SE
Year: 2019
Journal: J Bone Miner Res
Title: Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice.
Volume: 34
Issue: 9
Pages: 1676-1689
Publication
First Author: Culley KL
Year: 2019
Journal: Sci Rep
Title: Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.
Volume: 9
Issue: 1
Pages: 8905
Publication  
First Author: Collins JA
Year: 2021
Journal: Free Radic Biol Med
Title: Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Volume: 166
Pages: 90-103
Publication
First Author: Sinha S
Year: 2017
Journal: PLoS Genet
Title: Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.
Volume: 13
Issue: 4
Pages: e1006742
Publication
First Author: Henry SP
Year: 2012
Journal: J Bone Miner Res
Title: The postnatal role of Sox9 in cartilage.
Volume: 27
Issue: 12
Pages: 2511-25
Publication  
First Author: Tsingas M
Year: 2020
Journal: Matrix Biol
Title: Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes.
Volume: 94
Pages: 110-133
Publication  
First Author: Yao Q
Year: 2023
Journal: J Orthop Translat
Title: Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4(CreERT2) versus Aggrecan(CreERT2) transgene in mice.
Volume: 41
Pages: 12-19
Publication  
First Author: Qin H
Year: 2023
Journal: Biomolecules
Title: Silencing miR-146a-5p Protects against Injury-Induced Osteoarthritis in Mice.
Volume: 13
Issue: 1
Publication  
First Author: Kurio N
Year: 2018
Journal: Matrix Biol
Title: Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage.
Volume: 67
Pages: 15-31
Publication
First Author: Wang C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis.
Volume: 117
Issue: 48
Pages: 30488-30497
Publication
First Author: Liu Z
Year: 2015
Journal: Sci Signal
Title: A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
Volume: 8
Issue: 386
Pages: ra71
Publication
First Author: Watanabe H
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Dwarfism and age-associated spinal degeneration of heterozygote cmd mice defective in aggrecan.
Volume: 94
Issue: 13
Pages: 6943-7
Publication
First Author: Furutera T
Year: 2017
Journal: Development
Title: Differing contributions of the first and second pharyngeal arches to tympanic membrane formation in the mouse and chick.
Volume: 144
Issue: 18
Pages: 3315-3324
Publication
First Author: Puttaparthi K
Year: 2003
Journal: J Neurochem
Title: Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes.
Volume: 87
Issue: 4
Pages: 851-60
Publication
First Author: Sardinha DF
Year: 1999
Journal: Immunogenetics
Title: Cis-acting regulation of splenic Art2 gene expression in inbred mouse strains.
Volume: 49
Issue: 7-8
Pages: 700-3
Publication
First Author: Fülöp C
Year: 1993
Journal: J Biol Chem
Title: Expression of alternatively spliced epidermal growth factor-like domains in aggrecans of different species. Evidence for a novel module.
Volume: 268
Issue: 23
Pages: 17377-83
Publication
First Author: Rhee DK
Year: 2005
Journal: J Clin Invest
Title: The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.
Volume: 115
Issue: 3
Pages: 622-31
Publication
First Author: Walcz E
Year: 1994
Journal: Genomics
Title: Complete coding sequence, deduced primary structure, chromosomal localization, and structural analysis of murine aggrecan.
Volume: 22
Issue: 2
Pages: 364-71
Publication
First Author: Jing Y
Year: 2018
Journal: Int J Biol Sci
Title: Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells.
Volume: 14
Issue: 1
Pages: 1-9
Publication
First Author: Boerboom D
Year: 2011
Journal: Dev Dyn
Title: Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla.
Volume: 240
Issue: 7
Pages: 1806-14
Publication
First Author: Ge X
Year: 2016
Journal: JCI Insight
Title: NFAT restricts osteochondroma formation from entheseal progenitors.
Volume: 1
Issue: 4
Pages: e86254
Publication
First Author: Chester N
Year: 1998
Journal: Genes Dev
Title: Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.
Volume: 12
Issue: 21
Pages: 3382-93
Publication
First Author: Liu W
Year: 2008
Journal: Growth Factors
Title: Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity.
Volume: 26
Issue: 6
Pages: 343-54
Publication  
First Author: Ma C
Year: 2021
Journal: Bone
Title: ScxLin cells directly form a subset of chondrocytes in temporomandibular joint that are sharply increased in Dmp1-null mice.
Volume: 142
Pages: 115687
Publication
First Author: Huang X
Year: 1999
Journal: Dev Dyn
Title: Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization.
Volume: 216
Issue: 4-5
Pages: 434-41
Publication  
First Author: Cikach FS
Year: 2018
Journal: JCI Insight
Title: Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.
Volume: 3
Issue: 5
Publication
First Author: Manning LB
Year: 2016
Journal: Am J Pathol
Title: Discoidin Domain Receptor 2 as a Potential Therapeutic Target for Development of Disease-Modifying Osteoarthritis Drugs.
Volume: 186
Issue: 11
Pages: 3000-3010
Publication
First Author: Li K
Year: 2022
Journal: FASEB J
Title: Impaired glucose metabolism underlies articular cartilage degeneration in osteoarthritis.
Volume: 36
Issue: 6
Pages: e22377
Publication  
First Author: Wu X
Year: 2023
Journal: Front Cell Dev Biol
Title: Brief research report: Effects of Pinch deficiency on cartilage homeostasis in adult mice.
Volume: 11
Pages: 1116128
Publication
First Author: Seegmiller RE
Year: 1988
Journal: Teratology
Title: Histochemical, immunofluorescence, and ultrastructural differences in fetal cartilage among three genetically distinct chondrodystrophic mice.
Volume: 38
Issue: 6
Pages: 579-92
Publication
First Author: Tran CM
Year: 2013
Journal: J Biol Chem
Title: Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity.
Volume: 288
Issue: 18
Pages: 12654-66
Publication
First Author: Wang L
Year: 2011
Journal: J Assoc Res Otolaryngol
Title: Scleraxis is required for differentiation of the stapedius and tensor tympani tendons of the middle ear.
Volume: 12
Issue: 4
Pages: 407-21
Publication
First Author: Inoue H
Year: 2008
Journal: Bone
Title: High levels of serum IL-18 promote cartilage loss through suppression of aggrecan synthesis.
Volume: 42
Issue: 6
Pages: 1102-10
Publication
First Author: Shibata S
Year: 2003
Journal: J Anat
Title: In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage.
Volume: 203
Issue: 4
Pages: 425-32
Publication
First Author: Yamaguchi Y
Year: 2000
Journal: Cell Mol Life Sci
Title: Lecticans: organizers of the brain extracellular matrix.
Volume: 57
Issue: 2
Pages: 276-89
Publication
First Author: Thompson H
Year: 2010
Journal: Dev Biol
Title: The retinal pigment epithelium of the eye regulates the development of scleral cartilage.
Volume: 347
Issue: 1
Pages: 40-52
Publication
First Author: Bekku Y
Year: 2003
Journal: Mol Cell Neurosci
Title: Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets.
Volume: 24
Issue: 1
Pages: 148-59
Publication
First Author: Fujikawa K
Year: 2015
Journal: Eur J Histochem
Title: An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.
Volume: 59
Issue: 3
Pages: 2553
Publication
First Author: Sakai K
Year: 2007
Journal: J Biol Chem
Title: Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.
Volume: 282
Issue: 6
Pages: 4152-61
Publication
First Author: Murphy JM
Year: 1999
Journal: Matrix Biol
Title: Distribution of cartilage molecules in the developing mouse joint.
Volume: 18
Issue: 5
Pages: 487-97