|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 284 out of 284 for Hcfc1

<< First    < Previous  |  Next >    Last >>
0.027s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Protein Domain
IPR037854 | HCF1
Type: Family
Description: Host cell factor 1 (HCFC1) is associated with the activation and repression of gene expression. It is brought to specific promoters by association with DNA-sequence-specific transcription factors such as Sp1, GABP, YY1, Ronin/THAP11, and E2F1 and E2F4 []. HCFC1 recruits and is a part of several different complexes, including the SET1 histone methyltransferase complex (transcription activation), the SIN3 histone deacetylase complex (transcription repression) [], the THAP1/THAP3-HCFC1-OGT complex (required for the regulation of the transcriptional activity of RRM1) [], and the NSL complex (acetylation of nucleosomal histone H4) []. This entry includes mammalian HCFC1 and the Drosophila homologue, dHCF. They undergo a process of proteolytic maturation to produce a heterodimeric complex of HCF-N and HCF-C subunits, by different enzymes, O-GlcNAc transferase and taspase1, respectively [, ]. They share a Kelch domain, regions biased for basic (Basic) or acidic (Acidic) amino acids, fibronectin type 3 repeats, and a nuclear localization signal [].During human herpes simplex virus infection, HCFC1 forms a multiprotein-DNA complex enabling transcription of the virus's early genes []. It is also a co-activator of EGR2/Krox20 []and the GA-binding protein GABP2 [], and represses ZBTB17/Miz-1 [].
•
•
•
•
•
Publication
22174740 | -
First Author: Rodriguez-Jato S
Year: 2011
Journal: PLoS One
Title: Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators.
Volume: 6
Issue: 12
Pages: e27479
•
•
•
•
•
Protein Domain
IPR037841 | SETD1A
Type: Family
Description: In animals, histone-lysine N-methyltransferase SETD1A () is a histone methyltransferase that produces mono-, di-, and trimethylated histone H3 at 'Lys-4. However, if 'Lys-9' residue is already methylated, 'Lys-4' will not be. The 'Lys-4' methylation is a tag for epigenetic transcriptional activation [, ]. The SET1 complex contains either SETD1A or SETD1B.The SET1 complex is a methyltransferase that that produces trimethylated histone H3 at Lys(4). It is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. In yeast there is only one SET1 complex, but in mammals there are additional H3K4 methylases [].
•
•
•
•
•
Protein Domain
IPR037842 | SETD1B
Type: Family
Description: Histone-lysine N-methyltransferase SETD1B () is a histone methyltransferase that produces trimethylated histone H3 at 'Lys-4'. However, if 'Lys-9' residue is already methylated, 'Lys-4' will not be. The 'Lys-4' methylation is a tag for epigenetic transcriptional activation []. The SET1 complex contains either SETD1A or SETD1B.The SET1 complex is a methyltransferase that that produces trimethylated histone H3 at Lys(4). It is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. In yeast there is only one SET1 complex, but in mammals there are additional H3K4 methylases [].
•
•
•
•
•
Publication
23395176 | J:198047
First Author: Li MD
Year: 2013
Journal: Cell Metab
Title: O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.
Volume: 17
Issue: 2
Pages: 303-10
•
•
•
•
•
Publication
15361863 | -
First Author: Jínek M
Year: 2004
Journal: Nat Struct Mol Biol
Title: The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.
Volume: 11
Issue: 10
Pages: 1001-7
•
•
•
•
•
Publication
20018868 | -
First Author: Whelan SA
Year: 2010
Journal: J Biol Chem
Title: Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes.
Volume: 285
Issue: 8
Pages: 5204-11
•
•
•
•
•
Publication
22923583 | -
First Author: Yi W
Year: 2012
Journal: Science
Title: Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Volume: 337
Issue: 6097
Pages: 975-80
•
•
•
•
•
Publication
22121020 | -
First Author: Fujiki R
Year: 2011
Journal: Nature
Title: GlcNAcylation of histone H2B facilitates its monoubiquitination.
Volume: 480
Issue: 7378
Pages: 557-60
•
•
•
•
•
Protein Domain
IPR037919 | OGT
Type: Family
Description: The UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (OGT; ) is a heterotrimer of one 78kDa subunit and two 110kDa subunits. OGT catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in a protein. Substrate proteins include histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. The consequences of this form of glycosylation are diverse, including insulin resistance in muscle and adipocyte cells (brought about by inhibiting the 'Thr-308' phosphorylation of AKT1) []; regulation of glycolysis by inhibiting PFKL activity []; in the cell cycle O-glycosylation stabilizes ARNTL/BMAL1 and CLOCK, preventing their ubiquitination and subsequent degradation []; glycosylation of HCFC1 and interaction with TET proteins promotes binding of the SET1/COMPASS methyltransferase SETD1A to chromatin []; and H2B GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination []. It is a component of several complexes, including MLL5-L, NSL []and THAP1/THAP3-HCFC1-OGT [].This entry represents the 110kDa subunit which has thirteen tetratricopeptide (TPR) repeats that are required for substrate binding and oligomerization [].The NSL complex is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. The complex is composed of at least MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 [].
•
•
•
•
•
Publication
22072714 | J:228714
First Author: Badeaux AI
Year: 2012
Journal: J Biol Chem
Title: Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.
Volume: 287
Issue: 1
Pages: 429-37
•
•
•
•
•
Publication
12670868 | -
First Author: Wysocka J
Year: 2003
Journal: Genes Dev
Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.
Volume: 17
Issue: 7
Pages: 896-911
•
•
•
•
•
Publication
14992727 | J:88588
First Author: Hughes CM
Year: 2004
Journal: Mol Cell
Title: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Volume: 13
Issue: 4
Pages: 587-97
•
•
•
•
•
Publication
19651892 | -
First Author: Xu Z
Year: 2009
Journal: J Cell Biol
Title: A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking.
Volume: 186
Issue: 3
Pages: 343-53
•
•
•
•
•
Protein Domain
IPR037856 | Sdc1/DPY30
Type: Family
Description: This entry includes Sdc1 from yeasts, and its homologues, Dpy-30, from animals. Protein dpy-30 homologue (DPY30) is a component of the MLL1/MLL complex which trimethylates histone H3 at 'Lys-4' as a specific tag for epigenetic transcriptional activation []. DPY30 is also a component in MLL2/3 and MLL4/WBP7 methyltransferase-containing complexes [, ]and the SET1 complex []. DPY30 is found in the nucleus and the trans-Golgi network where it interacts with ARFGEF1 implying a role in endosomal trafficking []. This entry also includes C. elegans dpy-30, which is an essential component of the C. elegans dosage compensation machinery that reduces X chromosome transcript levels in hermaphrodites (XX) [].The SET1 complex is a methyltransferase that that produces trimethylated histone H3 at Lys(4). It is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. In yeast there is only one SET1 complex, but in mammals there are additional H3K4 methylases [].
•
•
•
•
•
Protein Coding Gene
MGI:1916746 | Dydc1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:2444804 | Bod1l
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
23353889 | J:194478
First Author: Deplus R
Year: 2013
Journal: EMBO J
Title: TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.
Volume: 32
Issue: 5
Pages: 645-55
•
•
•
•
•
Protein
D3YXL2
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
•
•
•
•
•
Publication
16253997 | -
First Author: Lee JH
Year: 2005
Journal: J Biol Chem
Title: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.
Volume: 280
Issue: 50
Pages: 41725-31
•
•
•
•
•
Publication
20200153 | -
First Author: Mazars R
Year: 2010
Journal: J Biol Chem
Title: The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.
Volume: 285
Issue: 18
Pages: 13364-71
•
•
•
•
•
Publication
20018852 | -
First Author: Cai Y
Year: 2010
Journal: J Biol Chem
Title: Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.
Volume: 285
Issue: 7
Pages: 4268-72
•
•
•
•
•
Protein Coding Gene
MGI:1921572 | Cxxc1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
17355966 | -
First Author: Lee JH
Year: 2007
Journal: J Biol Chem
Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.
Volume: 282
Issue: 18
Pages: 13419-28
•
•
•
•
•
Protein
Q3USQ6
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
•
•
•
•
•
Publication
18838538 | -
First Author: Wu M
Year: 2008
Journal: Mol Cell Biol
Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
Volume: 28
Issue: 24
Pages: 7337-44
•
•
•
•
•
Publication
17500065 | J:123598
First Author: Cho YW
Year: 2007
Journal: J Biol Chem
Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Volume: 282
Issue: 28
Pages: 20395-406
•
•
•
•
•
Publication
31049581 | -
First Author: Gudkova D
Year: 2019
Journal: Nucleic Acids Res
Title: HCF-2 inhibits cell proliferation and activates differentiation-gene expression programs.
Volume: 47
Issue: 11
Pages: 5792-5808
•
•
•
•
•
Publication
12609738 | -
First Author: Izeta A
Year: 2003
Journal: Gene
Title: Primary structure and compartmentalization of Drosophila melanogaster host cell factor.
Volume: 305
Issue: 2
Pages: 175-83
•
•
•
•
•
Publication
2568582 | -
First Author: Sabina RL
Year: 1989
Journal: Mol Cell Biol
Title: Expression of three stage-specific transcripts of AMP deaminase during myogenesis.
Volume: 9
Issue: 5
Pages: 2244-6
•
•
•
•
•
Publication
19726574 | -
First Author: Berr A
Year: 2009
Journal: Plant Physiol
Title: SET DOMAIN GROUP25 encodes a histone methyltransferase and is involved in FLOWERING LOCUS C activation and repression of flowering.
Volume: 151
Issue: 3
Pages: 1476-85
•
•
•
•
•
Protein Domain
IPR043536 | HCF1/2
Type: Family
Description: This entry includes Host cell factor 1 (HCF1) and Host cell factor 2 (HCF2) from humans. They contain an N-terminal kelch domain and a C-terminal FnIII domain. However, HCF2 is smaller than HCF-1, lacking the complete central region including the HCF1 specific repeats and as a result is not subject to proteolytic processing []. This entry also includes their Drosophila melanogaster homologue, dHCF, which is involved in both activation and repression of transcription during fly development []. Host cell factor homologue hcf-1 from C. elegans controls the cell cycle through mitotic histone phosphorylation modulation and negatively regulates responses to environmental stresses [].HCF1 is associated with the activation and repression of gene expression. It is brought to specific promoters by association with DNA-sequence-specific transcription factors such as Sp1, GABP, YY1, Ronin/THAP11, and E2F1 and E2F4 []. HCFC1 recruits and is a part of several different complexes, including the SET1 histone methyltransferase complex (transcription activation), the SIN3 histone deacetylase complex (transcription repression) [], the THAP1/THAP3-HCFC1-OGT complex (required for the regulation of the transcriptional activity of RRM1) [], and the NSL complex (acetylation of nucleosomal histone H4) [].HCF2 is involved in activation of differentiation and morphogenesis gene expression programs, and in parallel in inhibition of cellular growth and metabolism [].
•
•
•
•
•
Protein Domain
IPR044570 | Set1-like
Type: Family
Description: The COMPASS complex (complex proteins associated with Set1) is conserved in yeasts and in other eukaryotes up to humans. This entry represents Set1 and its homologues. Set1 is a methyltransferase and the catalytic component of the COMPASS that produces trimethylated histone H3 at Lys(4). The yeast COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation [, , ]. In yeasts, the Set1C complex consists of Set1(2), Bre2(2), Spp1(2), Sdc1(1), Shg1(1), Swd1(1), Swd2(1), and Swd3(1) [, , , ].In animals, SETD1A/B are histone methyltransferases that produce mono-, di-, and trimethylated histone H3 at 'Lys-4. However, if 'Lys-9' residue is already methylated, 'Lys-4' will not be. The 'Lys-4' methylation is a tag for epigenetic transcriptional activation [, ]. The animal COMPASS complex is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. ATXR7, the Arabidopsis homologue to Set1, is required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family [, ]. ATXR7 is also involved in the control of seed dormancy and germination [].
•
•
•
•
•
Protein Coding Gene
MGI:1916806 | Bod1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1913560 | Dpy30
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:2652820 | Setd1b
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1344416 | Ash2l
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q9D9T0
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
•
•
•
•
•
Protein
Q99LT0
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
•
•
•
•
•
Protein
Q9D3X8
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: false
•
•
•
•
•
Protein
A2AV92
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
•
•
•
•
•
Protein
E0CXB0
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
•
•
•
•
•
Protein
Q7TQ15
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
•
•
•
•
•
Protein
F6SJS2
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: true
•
•
•
•
•
Publication
7588066 | -
First Author: Hsu DR
Year: 1995
Journal: Development
Title: DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation.
Volume: 121
Issue: 10
Pages: 3323-34
•
•
•
•
•
Protein Coding Gene
MGI:1918367 | Rbbp5
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1915183 | Hcfc2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1924555 | Wdr82
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q61191
Organism: Mus musculus/domesticus
Length: 2045  
Fragment?: false
•
•
•
•
•
Protein
B1AUX2
Organism: Mus musculus/domesticus
Length: 2090  
Fragment?: false
•
•
•
•
•
Publication
18849979 | -
First Author: Vitaliano-Prunier A
Year: 2008
Journal: Nat Cell Biol
Title: Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.
Volume: 10
Issue: 11
Pages: 1365-71
•
•
•
•
•
Publication
18083099 | -
First Author: Lee JS
Year: 2007
Journal: Cell
Title: Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS.
Volume: 131
Issue: 6
Pages: 1084-96
•
•
•
•
•
Publication
12488447 | -
First Author: Roguev A
Year: 2003
Journal: J Biol Chem
Title: High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts.
Volume: 278
Issue: 10
Pages: 8487-93
•
•
•
•
•
Publication
9988274 | -
First Author: Corda Y
Year: 1999
Journal: Nat Genet
Title: Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions.
Volume: 21
Issue: 2
Pages: 204-8
•
•
•
•
•
Publication
14617822 | -
First Author: Roguev A
Year: 2004
Journal: Mol Cell Proteomics
Title: A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Volume: 3
Issue: 2
Pages: 125-32
•
•
•
•
•
Publication
19556245 | -
First Author: Patel A
Year: 2009
Journal: J Biol Chem
Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Volume: 284
Issue: 36
Pages: 24242-56
•
•
•
•
•
Protein
Q3TQV0
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: false
•
•
•
•
•
Protein
Q3URP1
Organism: Mus musculus/domesticus
Length: 737  
Fragment?: true
•
•
•
•
•
Protein
D3YUD4
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
•
•
•
•
•
Protein
D3YX07
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
•
•
•
•
•
Protein
Q80XU6
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
•
•
•
•
•
Protein
Q8C676
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
•
•
•
•
•
Publication
21799800 | -
First Author: Liu Y
Year: 2011
Journal: PLoS One
Title: Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a role for the polymerase associated factor 1 complex in seed dormancy.
Volume: 6
Issue: 7
Pages: e22241
•
•
•
•
•
Publication
11687631 | -
First Author: Miller T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.
Volume: 98
Issue: 23
Pages: 12902-7
•
•
•
•
•
Publication
19855050 | -
First Author: Tamada Y
Year: 2009
Journal: Plant Cell
Title: ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.
Volume: 21
Issue: 10
Pages: 3257-69
•
•
•
•
•
Protein Coding Gene
MGI:1923089 | Daw1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:2155884 | Wdr5
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:2446244 | Setd1a
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q8CGY8
Organism: Mus musculus/domesticus
Length: 1046  
Fragment?: false
•
•
•
•
•
Protein
Q80V17
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
•
•
•
•
•
Protein
Q80V59
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
•
•
•
•
•
Protein
Q91Z33
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
•
•
•
•
•
Protein
A0A0U1RNP2
Organism: Mus musculus/domesticus
Length: 1173  
Fragment?: true
•
•
•
•
•
Protein
F6T088
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: true
•
•
•
•
•
Protein
G3UZ56
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
•
•
•
•
•
Protein
F6T0G2
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
•
•
•
•
•
Protein
A0A0U1RPA4
Organism: Mus musculus/domesticus
Length: 29  
Fragment?: true
•
•
•
•
•
Protein
A0AUN4
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: true
•
•
•
•
•
Protein
E9PYH6
Organism: Mus musculus/domesticus
Length: 1716  
Fragment?: false
•
•
•
•
•
Protein
Q8CFT2
Organism: Mus musculus/domesticus
Length: 1985  
Fragment?: false
•
•
•
•
•
Protein
Q9D968
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
•
•
•
•
•
Protein
Q8BLG0
Organism: Mus musculus/domesticus
Length: 1010  
Fragment?: false
•
•
•
•
•
Protein
Q6PAR7
Organism: Mus musculus/domesticus
Length: 1023  
Fragment?: false
•
•
•
•
•
Publication
15960975 | J:156231
First Author: Dou Y
Year: 2005
Journal: Cell
Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Volume: 121
Issue: 6
Pages: 873-85
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom