Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 317 out of 317 for Fgg

<< First < Previous | Next > Last >>

0.019s

Type

Details

Score

Publication

2404012 | -

First Author:	Lord ST
Year:	1990
Journal:	J Biol Chem
Title:	Analysis of fibrinogen A alpha-fusion proteins. Mutants which inhibit thrombin equivalently are not equally good substrates.
Volume:	265
Issue:	2
Pages:	838-43

•

Publication

2143188 | -

First Author:	Kirschbaum NE
Year:	1990
Journal:	J Biol Chem
Title:	A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.
Volume:	265
Issue:	23
Pages:	13669-76

•

Publication

33157038 | J:302472

First Author:	Ghosh S
Year:	2020
Journal:	Cell
Title:	β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.
Volume:	183
Issue:	6
Pages:	1520-1535.e14

•

Publication

16014971 | -

First Author:	Tan YJ
Year:	2005
Journal:	J Virol
Title:	The severe acute respiratory syndrome coronavirus 3a protein up-regulates expression of fibrinogen in lung epithelial cells.
Volume:	79
Issue:	15
Pages:	10083-7

•

Publication

16474139 | -

First Author:	Oostra M
Year:	2006
Journal:	J Virol
Title:	Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M.
Volume:	80
Issue:	5
Pages:	2326-36

•

Publication

16894145 | -

First Author:	Lu W
Year:	2006
Journal:	Proc Natl Acad Sci U S A
Title:	Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release.
Volume:	103
Issue:	33
Pages:	12540-5

•

Publication

15135062 | -

First Author:	Yu CJ
Year:	2004
Journal:	FEBS Lett
Title:	Identification of a novel protein 3a from severe acute respiratory syndrome coronavirus.
Volume:	565
Issue:	1-3
Pages:	111-6

•

Publication

15781262 | -

First Author:	Shen S
Year:	2005
Journal:	Biochem Biophys Res Commun
Title:	The severe acute respiratory syndrome coronavirus 3a is a novel structural protein.
Volume:	330
Issue:	1
Pages:	286-92

•

Publication

20020050 | -

First Author:	Minakshi R
Year:	2009
Journal:	PLoS One
Title:	The SARS Coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the type 1 interferon receptor.
Volume:	4
Issue:	12
Pages:	e8342

•

Publication

31034780 | -

First Author:	Siu KL
Year:	2019
Journal:	FASEB J
Title:	Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC.
Volume:	33
Issue:	8
Pages:	8865-8877

•

Publication

32156572 | -

First Author:	Farag NS
Year:	2020
Journal:	Int J Biochem Cell Biol
Title:	Viroporins and inflammasomes: A key to understand virus-induced inflammation.
Volume:	122

Pages:	105738

•

Publication

33422265 | -

First Author:	Miao G
Year:	2021
Journal:	Dev Cell
Title:	ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.
Volume:	56
Issue:	4
Pages:	427-442.e5

•

Publication

34158638 | -

First Author:	Kern DM
Year:	2021
Journal:	Nat Struct Mol Biol
Title:	Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Volume:	28
Issue:	7
Pages:	573-582

•

Protein Domain

IPR024407 | Protein_3a_bCoV

Type:

Family

Description:

Coronavirus encodes two viroporins, E protein and protein 3a, which act as ion-conductive pores in planar lipid bilayers and are required for maximal SARS-CoV replication and virulence []. In betacoronavirus, this protein plays a role in viral egress via lysosomal trafficking [, ]. Protein 3a from SARS-CoV-2 also blocks autolysosomes formation by binding and sequestering the host component VPS39 for homotypic fusion and protein sorting (HOPS) on late endosomes. This prevents fusion of autophagosomes with lysosomes, disrupting autophagy and facilitating virus egress [].This entry represents protein 3a encoded by Orf3/3a, also known as X1, which forms homotetrameric potassium, sodium or calcium sensitive ion channels (viroporin) and may modulate virus release. It has also been shown to up-regulate expression of fibrinogen subunits FGA, FGBand FGG in host lung epithelial cells [, , , ].3a protein is a pro-apoptosis-inducing protein. It localises to the endoplasmic reticulum (ER)-Golgi compartment. SARS-CoV causes apoptosis of infected cells through NLRP3 inflammasome activation, as ORF3a is a potent activator of the signals required for this activation, pro-IL-1beta gene transcription and protein maturation. This protein also promotes the ubiquitination of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) mediated by its interaction with TNF receptor-associated factor 3 (TRAF3). The expression of ORF3a induces NF-kappa B activation and up-regulates fibrinogen secretion with the consequent high cytokine production [, , , ]. Another apoptosis mechanism described for this protein is the activation of the PERK pathway of unfolded protein response (UPR), which causes phosphorylation of eIF2alpha and leads to reduced translation of cellular proteins as well as the activation of pro-apoptotic downstream effectors (i.e ATF4, CHOP) [].

•

Protein

Q8VCM7

Organism:	Mus musculus/domesticus
Length:	436
Fragment?:	false

•

Protein

Q3UEM7

Organism:	Mus musculus/domesticus
Length:	436
Fragment?:	false

•

Protein

Q3UER8

Organism:	Mus musculus/domesticus
Length:	443
Fragment?:	false

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do;jsessionid=8764D93AA8377B874E484C418842BF4A?searchOffset=300&searchTerm=Fgg

MouseMine

Search our database by keyword

Examples

Search results 301 to 317 out of 317 for Fgg

Categories

Hits by Pathway

Hits by Category

Hits by Strain