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Search results 1401 to 1500 out of 1521 for Rb1

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Type Details Score
Allele
Tg(Rb1)1Blg | MGI:3699596
Name: transgene insertion 1, Brenda L Gallie
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1 Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1<+> Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1<+> Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pten/Pten Rb1/Rb1 Tg(Pbsn-cre)4Prb/?
Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pten/Pten Rb1/Rb1<+> Tg(Pbsn-cre)4Prb/?
Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Rb1/Rb1 Tg(Pbsn-cre)4Prb/?
Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
3772065 | J:8451
First Author: Sánchez ER
Year: 1986
Journal: J Hered
Title: Wild-derived Robertsonian translocation in mice. Chromosome 17, Rb (16:17)7, shows novel interactions with t-alleles.
Volume: 77
Issue: 5
Pages: 290-4
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Publication
8119578 | J:18203
First Author: Safronova LD
Year: 1993
Journal: Genetika
Title: [Disturbance of the relationship of transmission in male mice carrying the translocation Rb(8,17)1 Iem in combination with t-haplotypes].
Volume: 29
Issue: 12
Pages: 1992-9
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Publication
11861365 | J:75025
First Author: Chen D
Year: 2002
Journal: Cancer Res
Title: Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN.
Volume: 62
Issue: 4
Pages: 967-71
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Publication
19934342 | J:309210
First Author: Wang Y
Year: 2009
Journal: Cancer Prev Res (Phila)
Title: Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer.
Volume: 2
Issue: 12
Pages: 1059-64
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1 Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Allele
Tg(tetO-Ctsb/RB1)14Smrs | MGI:5911114
Name: transgene insertion 14, Sonia M Rocha-Sanchez
Allele Type: Transgenic
Attribute String: Dominant negative, Epitope tag, Humanized sequence, Inserted expressed sequence
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Publication
30674894 | J:276500
First Author: Annunziato S
Year: 2019
Journal: Nat Commun
Title: Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.
Volume: 10
Issue: 1
Pages: 397
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Publication
36696903 | J:333345
First Author: Gong Y
Year: 2023
Journal: Dev Cell
Title: Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.
Volume: 58
Issue: 3
Pages: 192-210.e11
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Publication
28805815 | J:258019
First Author: Chow RD
Year: 2017
Journal: Nat Neurosci
Title: AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma.
Volume: 20
Issue: 10
Pages: 1329-1341
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Publication
37267950 | J:336652
First Author: Arora M
Year: 2023
Journal: Cell
Title: Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity.
Volume: 186
Issue: 12
Pages: 2628-2643.e21
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Publication
9931482 | J:52583
First Author: Brunelli JP
Year: 1999
Journal: Gene
Title: Sequence, expression and genetic mapping of a rainbow trout retinoblastoma cDNA.
Volume: 226
Issue: 2
Pages: 175-80
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Publication
20610631 | J:162247
First Author: Bremner R
Year: 2010
Journal: Cancer Res
Title: Cyclins, Cdks, E2f, Skp2, and more at the first international RB Tumor Suppressor Meeting.
Volume: 70
Issue: 15
Pages: 6114-8
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Publication
22941188 | J:190016
First Author: Peifer M
Year: 2012
Journal: Nat Genet
Title: Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
Volume: 44
Issue: 10
Pages: 1104-10
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Publication
23334668 | J:198063
First Author: Holmfeldt L
Year: 2013
Journal: Nat Genet
Title: The genomic landscape of hypodiploid acute lymphoblastic leukemia.
Volume: 45
Issue: 3
Pages: 242-52
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Publication
25002614 | J:217924
First Author: Hinds PW
Year: 2014
Journal: Cancer Discov
Title: A little pRB can lead to big problems.
Volume: 4
Issue: 7
Pages: 764-5
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Publication
25486431 | J:224251
First Author: Zhu L
Year: 2015
Journal: Oncogene
Title: Antitumor mechanisms when pRb and p53 are genetically inactivated.
Volume: 34
Issue: 35
Pages: 4547-57
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Publication
26235627 | J:232893
First Author: Akamatsu S
Year: 2015
Journal: Cell Rep
Title: The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer.
Volume: 12
Issue: 6
Pages: 922-36
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Publication
27557444 | J:236393
   
First Author: Papale A
Year: 2016
Journal: Elife
Title: Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors.
Volume: 5
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Publication
36230849 | J:330140
 
First Author: Hopkins J
Year: 2022
Journal: Cancers (Basel)
Title: PRELP Regulates Cell-Cell Adhesion and EMT and Inhibits Retinoblastoma Progression.
Volume: 14
Issue: 19
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Publication
37244438 | J:336409
 
First Author: Giaccone G
Year: 2023
Journal: Semin Cancer Biol
Title: Current knowledge of small cell lung cancer transformation from non-small cell lung cancer.
Volume: 94
Pages: 1-10
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Publication
35967587 | J:345785
First Author: Jin Y
Year: 2022
Journal: Natl Sci Rev
Title: Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis.
Volume: 9
Issue: 7
Pages: nwab232
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Strain
MGI:6160072 | B6;129-Tg(tetO-Ctsb/RB1)14Smrs/J
Attribute String: transgenic, mutant stock
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Publication
12391155 | -
First Author: Yochum GS
Year: 2002
Journal: Mol Cell Biol
Title: Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split.
Volume: 22
Issue: 22
Pages: 7868-76
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Publication
14506250 | -
First Author: Tominaga K
Year: 2003
Journal: J Biol Chem
Title: MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.
Volume: 278
Issue: 49
Pages: 49618-24
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Publication
20870719 | -
First Author: Saddic LA
Year: 2010
Journal: J Biol Chem
Title: Methylation of the retinoblastoma tumor suppressor by SMYD2.
Volume: 285
Issue: 48
Pages: 37733-40
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Publication
17108971 | J:245303
First Author: Huang J
Year: 2006
Journal: Nature
Title: Repression of p53 activity by Smyd2-mediated methylation.
Volume: 444
Issue: 7119
Pages: 629-32
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Publication
22241783 | J:179899
First Author: Donlin LT
Year: 2012
Journal: Genes Dev
Title: Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.
Volume: 26
Issue: 2
Pages: 114-9
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Publication
26826421 | -
 
First Author: Ohtomo-Oda R
Year: 2016
Journal: Hum Pathol
Title: SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas.
Volume: 49
Pages: 145-55
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Publication
27655694 | J:240508
First Author: Bagislar S
Year: 2016
Journal: Oncotarget
Title: Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
Volume: 7
Issue: 41
Pages: 66398-66415
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Protein Domain
IPR038012 | MRGX
Type: Family
Description: Mortality factor 4-like protein 2 (MORF4L2 or MRGX) is a component of the NuA4 histone acetyltransferase complex []and the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones []. MRGX interacts with MRFAP1 and RB1 and represses the B-myb promoter in EJ cells but activates it in HeLa cells []. MRGX contains an MRG domain.The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
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Protein Domain
IPR044419 | SMYD2_SET
Type: Domain
Description: This entry represents the SET domain of SET and MYND domain-containing protein 2 (SMYD2). SMYD2 functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1 [, ]. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organisation in both skeletal and cardiac muscles via Hsp90 methylation []. SMYD2 overexpression is associated with tumour cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas []. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML) [].The SMYD family consists of five members including SMYD1/2/3/4/5. They contain two highly conserved structural and functional domains, the SET and MYND domains. The SET domain is involved in lysine methylation, while the MYND domain is involved in protein-protein interaction. They are essential in several mammalian developmental pathways [, , , ].
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Publication
28134624 | J:242936
First Author: Kent LN
Year: 2017
Journal: J Clin Invest
Title: Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma.
Volume: 127
Issue: 3
Pages: 830-842
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Publication
30484104 | J:307676
First Author: Hollern DP
Year: 2019
Journal: Breast Cancer Res Treat
Title: A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.
Volume: 174
Issue: 1
Pages: 143-155
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Publication
21862643 | J:181594
First Author: Pajovic S
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: The TAg-RB murine retinoblastoma cell of origin has immunohistochemical features of differentiated Muller glia with progenitor properties.
Volume: 52
Issue: 10
Pages: 7618-24
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Publication
25676421 | J:221968
First Author: Yamamoto K
Year: 2015
Journal: Leukemia
Title: Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice.
Volume: 29
Issue: 6
Pages: 1414-24
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Publication
31930396 | J:298073
First Author: Shi M
Year: 2020
Journal: Biol Reprod
Title: Inactivation of TRP53, PTEN, RB1, and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis.
Volume: 102
Issue: 5
Pages: 1055-1064
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Publication
31010267 | J:289705
First Author: Veras MA
Year: 2019
Journal: J Cell Physiol
Title: Loss of ENT1 increases cell proliferation in the annulus fibrosus of the intervertebral disc.
Volume: 234
Issue: 8
Pages: 13705-13719
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Publication
28807937 | J:245677
First Author: Sun M
Year: 2017
Journal: Cancer Res
Title: HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas.
Volume: 77
Issue: 19
Pages: 5313-5326
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Publication
28847987 | J:317020
First Author: Akeno N
Year: 2017
Journal: Mol Cancer Ther
Title: TRP53 Mutants Drive Neuroendocrine Lung Cancer Through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response.
Volume: 16
Issue: 12
Pages: 2913-2926
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Publication
25500889 | J:219600
First Author: Hu Z
Year: 2015
Journal: J Clin Invest
Title: TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.
Volume: 125
Issue: 1
Pages: 425-36
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Publication
31345090 | J:307231
First Author: Xu X
Year: 2019
Journal: Autophagy
Title: Gene essentiality of Tubgcp4: dosage effect and autophagy regulation in retinal photoreceptors.
Volume: 15
Issue: 10
Pages: 1834-1837
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Publication
28099942 | J:274792
First Author: Allaman-Pillet N
Year: 2017
Journal: Oncotarget
Title: Bigh3 silencing increases retinoblastoma tumor growth in the murine SV40-TAg-Rb model.
Volume: 8
Issue: 9
Pages: 15490-15506
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Publication
22253802 | J:184317
First Author: Ihler F
Year: 2012
Journal: PLoS One
Title: Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen.
Volume: 7
Issue: 1
Pages: e29846
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Publication
12625510 | J:82324
First Author: Smith AP
Year: 2003
Journal: Comp Med
Title: Switching of melanocyte pigmentation associated with pituitary pars intermedia tumors in Rb+/- and p27-/- female mice with yellow pelage.
Volume: 53
Issue: 1
Pages: 75-80
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Publication
16827746 | J:114931
First Author: Tonks ID
Year: 2006
Journal: Pigment Cell Res
Title: Pocket protein function in melanocyte homeostasis and neoplasia.
Volume: 19
Issue: 4
Pages: 260-83
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Publication
18948947 | J:157601
First Author: Ding L
Year: 2008
Journal: Nature
Title: Somatic mutations affect key pathways in lung adenocarcinoma.
Volume: 455
Issue: 7216
Pages: 1069-75
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Publication
7753555 | J:209789
First Author: Ledent C
Year: 1995
Journal: Oncogene
Title: Differentiated carcinomas develop as a consequence of the thyroid specific expression of a thyroglobulin-human papillomavirus type 16 E7 transgene.
Volume: 10
Issue: 9
Pages: 1789-97
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Publication
25182511 | J:217915
 
First Author: Flowers S
Year: 2014
Journal: Bone
Title: p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation.
Volume: 69
Pages: 47-54
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Publication
30643022 | J:275340
First Author: Li Z
Year: 2019
Journal: J Biol Chem
Title: A novel thyroid hormone receptor isoform, TRβ2-46, promotes SKP2 expression and retinoblastoma cell proliferation.
Volume: 294
Issue: 8
Pages: 2961-2969
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Publication
31727771 | J:284196
First Author: Oser MG
Year: 2019
Journal: Genes Dev
Title: The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
Volume: 33
Issue: 23-24
Pages: 1718-1738
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Publication
30957234 | J:279295
First Author: Cemeli T
Year: 2019
Journal: J Pathol
Title: Cytoplasmic cyclin D1 regulates glioblastoma dissemination.
Volume: 248
Issue: 4
Pages: 501-513
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Publication
27181203 | J:318832
First Author: Zhao H
Year: 2017
Journal: Oncogene
Title: p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.
Volume: 36
Issue: 1
Pages: 60-70
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Publication
34675406 | J:317029
First Author: Chen J
Year: 2022
Journal: Oncogene
Title: Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium.
Volume: 41
Issue: 1
Pages: 138-145
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Publication
36092730 | J:329293
 
First Author: Zhang S
Year: 2022
Journal: Front Cell Dev Biol
Title: The cell cycle inhibitor RB is diluted in G1 and contributes to controlling cell size in the mouse liver.
Volume: 10
Pages: 965595
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Publication
38191672 | J:345581
First Author: Oser MG
Year: 2024
Journal: Oncogene
Title: Genetically-engineered mouse models of small cell lung cancer: the next generation.
Volume: 43
Issue: 7
Pages: 457-469
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Publication
26168399 | J:345783
First Author: George J
Year: 2015
Journal: Nature
Title: Comprehensive genomic profiles of small cell lung cancer.
Volume: 524
Issue: 7563
Pages: 47-53
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Publication
34593608 | J:345784
First Author: Voigt E
Year: 2021
Journal: Mol Cancer Res
Title: Sox2 Is an Oncogenic Driver of Small-Cell Lung Cancer and Promotes the Classic Neuroendocrine Subtype.
Volume: 19
Issue: 12
Pages: 2015-2025
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Publication
38355807 | J:346650
First Author: Wang J
Year: 2024
Journal: Oncogene
Title: Targeted inhibition of SCF(SKP2) confers anti-tumor activities resulting in a survival benefit in osteosarcoma.
Volume: 43
Issue: 13
Pages: 962-975
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Publication
16403804 | J:106760
First Author: Melcon G
Year: 2006
Journal: Hum Mol Genet
Title: Loss of emerin at the nuclear envelope disrupts the Rb1/E2F and MyoD pathways during muscle regeneration.
Volume: 15
Issue: 4
Pages: 637-51
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Publication
20016601 | J:155800
First Author: Chen D
Year: 2009
Journal: Nature
Title: Division and apoptosis of E2f-deficient retinal progenitors.
Volume: 462
Issue: 7275
Pages: 925-9
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Publication
35840016 | J:329209
 
First Author: Nguyen BT
Year: 2022
Journal: Free Radic Biol Med
Title: Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene.
Volume: 189
Pages: 2-19
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Publication
15659706 | J:105467
First Author: Tan KA
Year: 2005
Journal: Biol Reprod
Title: Androgen regulation of stage-dependent cyclin D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis.
Volume: 72
Issue: 5
Pages: 1151-60
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Publication
2630183 | J:10376
First Author: Valentine M
Year: 1989
Journal: Cytogenet Cell Genet
Title: Closely linked loci on the long arm of chromosome 13 flank a specific 2;13 translocation breakpoint in childhood rhabdomyosarcoma.
Volume: 52
Issue: 3-4
Pages: 128-32
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Publication
15313589 | J:92008
First Author: Rice JM
Year: 2004
Journal: Toxicol Appl Pharmacol
Title: Causation of nervous system tumors in children: insights from traditional and genetically engineered animal models.
Volume: 199
Issue: 2
Pages: 175-91
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Publication
33481853 | J:300806
First Author: Quaglia F
Year: 2021
Journal: PLoS One
Title: Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression.
Volume: 16
Issue: 1
Pages: e0244985
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Genotype
Genotype
Symbol: Rb1/Rb1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129/Sv * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hells/Hells Rb1/Rb1 Rbl1/Rbl1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129 * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129 * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
33218272 | J:313636
First Author: Choong CJ
Year: 2021
Journal: Autophagy
Title: Alternative mitochondrial quality control mediated by extracellular release.
Volume: 17
Issue: 10
Pages: 2962-2974
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Publication
32876528 | J:310981
First Author: González-Rodríguez P
Year: 2021
Journal: Autophagy
Title: The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
Volume: 17
Issue: 5
Pages: 1259-1277
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Publication
10202156 | J:54310
First Author: Aagaard L
Year: 1999
Journal: EMBO J
Title: Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.
Volume: 18
Issue: 7
Pages: 1923-38
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Publication
18004385 | J:127714
First Author: Vaquero A
Year: 2007
Journal: Nature
Title: SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Volume: 450
Issue: 7168
Pages: 440-4
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Publication
11701123 | J:72503
First Author: Peters AH
Year: 2001
Journal: Cell
Title: Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Volume: 107
Issue: 3
Pages: 323-37
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Publication
14690609 | -
First Author: Peters AH
Year: 2003
Journal: Mol Cell
Title: Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.
Volume: 12
Issue: 6
Pages: 1577-89
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Publication
14690610 | -
First Author: Rice JC
Year: 2003
Journal: Mol Cell
Title: Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.
Volume: 12
Issue: 6
Pages: 1591-8
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Publication
14702045 | J:88268
First Author: García-Cao M
Year: 2004
Journal: Nat Genet
Title: Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.
Volume: 36
Issue: 1
Pages: 94-9
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Protein
A2AEB6
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Publication
12039029 | -
First Author: Alvarez-Venegas R
Year: 2002
Journal: Gene
Title: SET-domain proteins of the Su(var)3-9, E(z) and trithorax families.
Volume: 285
Issue: 1-2
Pages: 25-37
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Publication
10848615 | -
First Author: Firestein R
Year: 2000
Journal: Mol Cell Biol
Title: Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.
Volume: 20
Issue: 13
Pages: 4900-9
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Publication
14765126 | J:88283
First Author: Ait-Si-Ali S
Year: 2004
Journal: EMBO J
Title: A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.
Volume: 23
Issue: 3
Pages: 605-15
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Publication
16858404 | J:200435
First Author: Mal AK
Year: 2006
Journal: EMBO J
Title: Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.
Volume: 25
Issue: 14
Pages: 3323-34
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Publication
16449642 | -
First Author: Carbone R
Year: 2006
Journal: Mol Cell Biol
Title: Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.
Volume: 26
Issue: 4
Pages: 1288-96
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Publication
16818776 | J:134992
First Author: Bradley SP
Year: 2006
Journal: J Immunol
Title: The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.
Volume: 177
Issue: 2
Pages: 1179-88
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Protein Domain
IPR011381 | Histone_H3-K9_MeTrfase
Type: Family
Description: Members of this family trimethylate 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. It also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. This enzyme mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats [, , ]. SUV39H1 (the human ortholog) is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation[], regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein [], BMP-induced repression, repression of switch recombination to IgA []and regulation of telomere length [, ]. SUV39H1 is a component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus []. The activity of this enzyme has been mapped to the SET domain and the adjacent cysteine-rich regions []. The SET domain was originally identified in Su(var)3-9, E(z) and Trithorax genes in Drosophila melanogaster (Fruit fly) []. The sequence conservation pattern and structure analysis of the SET domain provides clues regarding the possible active site residues of the domain. There are three conserved sequence motifs in most of the SET domains. The N-terminal motif (I) has characteristic glycines. The central motif (II) has a distinct pattern of polar and charged residues (Asn, His). The C-terminal conserved motif (III) has a characteristic dyad of polar residues. It has been shown that deregulated SUV39H1 interferes at multiple levels with mammalian higher-order chromatin organisation []and these properties depend primarily on the SET domain [, ]. Methyltransferases (EC [intenz:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.
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Publication
17493263 | J:160877
First Author: Herschkowitz JI
Year: 2007
Journal: Genome Biol
Title: Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors.
Volume: 8
Issue: 5
Pages: R76
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Publication
8139568 | J:72121
First Author: Sáenz Robles MT
Year: 1994
Journal: Mol Cell Biol
Title: Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.
Volume: 14
Issue: 4
Pages: 2686-98
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Protein
Q9R0Q4
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
A2AEB3
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: true
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Protein
Q3TME1
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
Q3TXN7
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Protein
A2AEB5
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein
Q3U6G8
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
A2AEB4
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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