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Search results 2501 to 2600 out of 3582 for Tlr4

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Type Details Score
Publication
31263109 | J:294406
First Author: Ye Z
Year: 2019
Journal: Cell Death Dis
Title: The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway.
Volume: 10
Issue: 7
Pages: 507
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Publication
21125645 | J:167222
First Author: Gorina R
Year: 2011
Journal: Glia
Title: Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways.
Volume: 59
Issue: 2
Pages: 242-55
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Publication
25367751 | J:222315
First Author: Desbien AL
Year: 2015
Journal: Eur J Immunol
Title: Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ.
Volume: 45
Issue: 2
Pages: 407-17
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Publication
27794001 | J:303440
First Author: Desbien AL
Year: 2016
Journal: J Immunol
Title: IL-18 and Subcapsular Lymph Node Macrophages are Essential for Enhanced B Cell Responses with TLR4 Agonist Adjuvants.
Volume: 197
Issue: 11
Pages: 4351-4359
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Publication
35862709 | J:353634
First Author: Alexander-Floyd J
Year: 2022
Journal: Infect Immun
Title: Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation.
Volume: 90
Issue: 8
Pages: e0020822
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Publication
26021803 | J:232902
First Author: Phongsisay V
Year: 2015
Journal: Mol Immunol
Title: Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors.
Volume: 66
Issue: 2
Pages: 463-71
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Publication
21098233 | J:168005
First Author: Faria MS
Year: 2011
Journal: J Immunol
Title: Leishmania inhibitor of serine peptidase 2 prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages.
Volume: 186
Issue: 1
Pages: 411-22
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Publication
23734265 | J:202116
First Author: Zhou YH
Year: 2013
Journal: PLoS One
Title: TLR4 ligand/H₂O₂ enhances TGF-β1 signaling to induce metastatic potential of non-invasive breast cancer cells by activating non-Smad pathways.
Volume: 8
Issue: 5
Pages: e65906
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Publication
32005665 | J:286546
First Author: Murugina NE
Year: 2020
Journal: J Biol Chem
Title: Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia.
Volume: 295
Issue: 10
Pages: 3099-3114
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Publication
22447954 | J:191163
First Author: Goldklang M
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice.
Volume: 302
Issue: 11
Pages: L1200-8
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Publication
28724396 | J:274510
First Author: Lee JH
Year: 2017
Journal: Arthritis Res Ther
Title: Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis.
Volume: 19
Issue: 1
Pages: 163
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GO Term
GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway
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GO Term
GO:0034144 | negative regulation of toll-like receptor 4 signaling pathway
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GO Term
GO:0034143 | regulation of toll-like receptor 4 signaling pathway
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Publication
38134862 | J:355703
 
First Author: Zhang Z
Year: 2024
Journal: Phytomedicine
Title: Arjunolic acid protects the intestinal epithelial barrier, ameliorating Crohn's disease-like colitis by restoring gut microbiota composition and inactivating TLR4 signalling.
Volume: 123
Pages: 155223
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Protein
Q9DAU1
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
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Protein
Q9DAU1-2
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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Allele
Tlr4<Lps-d> | MGI:1857718
 
Name: toll-like receptor 4; defective lipopolysaccharide response
Allele Type: Spontaneous
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Publication
19946272 | J:158464
First Author: Sheedy FJ
Year: 2010
Journal: Nat Immunol
Title: Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.
Volume: 11
Issue: 2
Pages: 141-7
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Publication
31076532 | J:275614
First Author: Kwon JO
Year: 2019
Journal: J Immunol
Title: Haptoglobin Acts as a TLR4 Ligand to Suppress Osteoclastogenesis via the TLR4-IFN-β Axis.
Volume: 202
Issue: 12
Pages: 3359-3369
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Publication
30552382 | J:317677
First Author: Zeng X
Year: 2020
Journal: Cell Mol Immunol
Title: Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages.
Volume: 17
Issue: 2
Pages: 153-162
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Publication
20716763 | J:259459
First Author: Mieulet V
Year: 2010
Journal: Sci Signal
Title: TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.
Volume: 3
Issue: 135
Pages: ra61
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Publication
16365431 | J:126269
First Author: Sekine Y
Year: 2006
Journal: J Immunol
Title: Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
Volume: 176
Issue: 1
Pages: 380-9
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Publication
32210720 | J:303144
First Author: Rajamanickam V
Year: 2020
Journal: Int J Biol Sci
Title: Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasis.
Volume: 16
Issue: 8
Pages: 1288-1302
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Publication
36172386 | J:336030
 
First Author: Loh JT
Year: 2022
Journal: Front Immunol
Title: Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein.
Volume: 13
Pages: 996637
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Publication
17277160 | J:143973
First Author: Zhang TY
Year: 2007
Journal: J Immunol
Title: Glucocorticoid conditioning of myeloid progenitors enhances TLR4 signaling via negative regulation of the phosphatidylinositol 3-kinase-Akt pathway.
Volume: 178
Issue: 4
Pages: 2517-26
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Publication
26195767 | J:226061
First Author: De S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal.
Volume: 112
Issue: 31
Pages: 9680-5
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Publication
28839246 | J:256335
First Author: Kong X
Year: 2017
Journal: Sci Rep
Title: Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling.
Volume: 7
Issue: 1
Pages: 9292
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Publication
35714682 | J:326136
 
First Author: Liu J
Year: 2022
Journal: Biochem Pharmacol
Title: Z-Guggulsterone attenuates cognitive defects and decreases neuroinflammation in APPswe/PS1dE9 mice through inhibiting the TLR4 signaling pathway.
Volume: 202
Pages: 115149
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Publication
20802145 | J:164217
First Author: Lysakova-Devine T
Year: 2010
Journal: J Immunol
Title: Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
Volume: 185
Issue: 7
Pages: 4261-71
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Publication
36361652 | J:331258
 
First Author: Chen Q
Year: 2022
Journal: Int J Mol Sci
Title: Ginsenoside Compound K Ameliorates Development of Diabetic Kidney Disease through Inhibiting TLR4 Activation Induced by Microbially Produced Imidazole Propionate.
Volume: 23
Issue: 21
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Publication
31994900 | J:285472
First Author: McKenzie AI
Year: 2020
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Pharmacological inhibition of TLR4 ameliorates muscle and liver ceramide content after disuse in previously physically active mice.
Volume: 318
Issue: 3
Pages: R503-R511
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DO Term
DOID:0110022 | age related macular degeneration 10
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Publication
21098741 | J:168587
First Author: Mukhopadhyay S
Year: 2011
Journal: Blood
Title: SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.
Volume: 117
Issue: 4
Pages: 1319-28
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Publication
17070884 | J:343105
First Author: Hahm B
Year: 2007
Journal: Virology
Title: Measles virus-dendritic cell interaction via SLAM inhibits innate immunity: selective signaling through TLR4 but not other TLRs mediates suppression of IL-12 synthesis.
Volume: 358
Issue: 2
Pages: 251-7
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Publication
32795896 | J:345180
 
First Author: Qi H
Year: 2020
Journal: Int Immunopharmacol
Title: MicroRNA-16 directly binds to DEC2 and inactivates the TLR4 signaling pathway to inhibit lupus nephritis-induced kidney tissue hyperplasia and mesangial cell proliferation.
Volume: 88
Pages: 106859
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Publication
16424218 | J:126417
First Author: Tsatsanis C
Year: 2006
Journal: J Immunol
Title: Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1.
Volume: 176
Issue: 3
Pages: 1869-77
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GO Term
GO:0035667 | TRIF-dependent toll-like receptor 4 signaling pathway
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Publication
21602844 | -
First Author: Seit-Nebi A
Year: 2012
Journal: Cell Mol Immunol
Title: MLK4 has negative effect on TLR4 signaling.
Volume: 9
Issue: 1
Pages: 27-33
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Pathway
R-MMU-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex
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Publication
25388285 | J:219651
First Author: Kadayakkara DK
Year: 2015
Journal: Cancer Res
Title: Paradoxical decrease in the capture and lymph node delivery of cancer vaccine antigen induced by a TLR4 agonist as visualized by dual-mode imaging.
Volume: 75
Issue: 1
Pages: 51-61
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Publication
28584078 | J:247815
First Author: Bala S
Year: 2017
Journal: J Leukoc Biol
Title: Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease.
Volume: 102
Issue: 2
Pages: 487-498
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GO Term
GO:0035665 | TIRAP-dependent toll-like receptor 4 signaling pathway
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UniProt Feature
UniProt Feature
Begin: 3741
Description: In bg; macrophages and dendritic cells show impaired pro-inflammatory cytokine production in response to stimulation of TLR3 and TLR4 receptors; shows impaired inflammatory responses to lipopolysaccharides; following bacteria infections, shows defective phagosomal maturation.
Type: sequence variant
End: 3788
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Allele
Tlr4<em2(TLR4)Smoc> | MGI:7292809
Name: toll-like receptor 4; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
25825441 | -
First Author: Huai W
Year: 2015
Journal: J Immunol
Title: Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM.
Volume: 194
Issue: 9
Pages: 4458-65
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Publication
12471095 | J:341401
First Author: Yamamoto M
Year: 2002
Journal: J Immunol
Title: Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
Volume: 169
Issue: 12
Pages: 6668-72
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Strain
MGI:6429670 | C57BL/6JSmoc-Tlr4<em2(TLR4)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tlr4<em3Smoc> | MGI:7292810
Name: toll-like receptor 4; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Tlr4<em2Cya> | MGI:7657335
Name: toll-like receptor 4; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
20643919 | -
First Author: Wang D
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane.
Volume: 107
Issue: 31
Pages: 13806-11
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Publication
17449723 | -
First Author: Sheedy FJ
Year: 2007
Journal: J Leukoc Biol
Title: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling.
Volume: 82
Issue: 2
Pages: 196-203
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Publication
23677465 | -
First Author: Aerbajinai W
Year: 2013
Journal: J Immunol
Title: Glia maturation factor-γ negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages.
Volume: 190
Issue: 12
Pages: 6093-103
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Publication
12539043 | -
First Author: Oshiumi H
Year: 2003
Journal: Nat Immunol
Title: TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
Volume: 4
Issue: 2
Pages: 161-7
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Protein Domain
IPR041281 | LRR_11
Type: Repeat
Description: This entry represents one repeat unit found in CD180 from mammals. CD180 may cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells [].
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Protein Domain
IPR017278 | TICAM1
Type: Family
Description: TIR domain-containing adapter molecule 1 (TICAM1) is involved in innate immunity against invading pathogens. It is an adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis [, ].
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HT Experiment
GSE123889 | Endothelial Sash1 is required for alveolar surfactant production through nitric oxide signaling
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tlr4<lps-del> | MGI:1860755
Name: toll-like receptor 4; defective lipopolysaccharide response, deletion
Allele Type: Spontaneous
Attribute String: Null/knockout
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Allele
Tlr4<em1Smoc> | MGI:7292808
Name: toll-like receptor 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6355262 | C57BL/6JSmoc-Tlr4<em3Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7657558 | C57BL/6N-Tlr4<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
28609714 | -
 
First Author: Shi Q
Year: 2017
Journal: Mol Immunol
Title: MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.
Volume: 88
Pages: 79-88
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Publication
15509224 | J:95083
First Author: Lehoczky JA
Year: 2004
Journal: Evol Dev
Title: Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication.
Volume: 6
Issue: 6
Pages: 423-30
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Protein Coding Gene
MGI:107676 | Tank
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70347
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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HT Experiment
GSE89966 | Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type Mice and Toll-like Receptor 4 Intestinal Epithelial Conditional Knockout Mice Ileal Transcriptomes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
15169888 | -
First Author: Lang V
Year: 2004
Journal: Mol Cell Biol
Title: ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
Volume: 24
Issue: 12
Pages: 5235-48
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Publication
15670770 | -
First Author: Chan H
Year: 2005
Journal: Biochem Biophys Res Commun
Title: TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40.
Volume: 328
Issue: 1
Pages: 198-205
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Protein Domain
IPR017424 | MAPKKK8
Type: Family
Description: This entry represents mitogen-activated protein kinase kinase kinase 8 (MAP3K8 or COT or TPL2) (), which plays a role in the cell cycle. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway. MAP3K8 is able to activate NF-kappa-B 1 (NFKB1) by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105 []. MAP3K8 forms a ternary complex with NFKB1 and TNIP2 []. MAP3K8 is recruited to the CD40 complex via a mechanism dependent on TRAF-binding sites in CD40 [].
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Strain
MGI:3777649 | C57BL/10ScN
Attribute String: inbred strain
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Strain
MGI:6146258 | C57BL/10ScNCrRbrc
Attribute String: inbred strain
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Strain
MGI:2165217 | C57BL/10ScNJ
Attribute String: inbred strain
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Strain
MGI:3777588 | B6.B10ScN-Tlr4<lps-del>/JthJ
Attribute String: congenic, spontaneous mutation
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Allele
Tg(TLR4)5271Haj | MGI:5911243
Name: transgene insertion 5271, Adeline Hajjar
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6476471 | C57BL/6JSmoc-Tlr4<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Tlr4/Tlr4
Background: C57BL/10ScCr
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tlr4/Tlr4
Background: involves: C57BL/10ScN
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tlr4/Tlr4
Background: C57BL/10ScN
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:2136419 | Sarm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2154952 | Ripk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9QZL0
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
Q6PDS3
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q07174
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
Q80UF7
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
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Protein
Q8CFA1
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Publication
33903225 | J:310487
First Author: Xiang C
Year: 2021
Journal: Mol Cell Biol
Title: RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.
Volume: 41
Issue: 7
Pages: e0052620
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Allele
Tlr4<Lps-2Btlr> | MGI:3842324
 
Name: toll-like receptor 4; defective lipopolysaccharide response 2 Bruce Beutler
Allele Type: Chemically induced (ENU)
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Allele
Tlr4<Lps-8Btlr> | MGI:5789549
Name: toll-like receptor 4; defective lipopolysaccharide response 8 Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:5789773 | C57BL/6J-Tlr4<Lps-8Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Genotype
Genotype
Symbol: Tlr4/Tlr4<+>
Background: C57BL/6J-Tlr4
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tlr4/Tlr4
Background: C57BL/6J-Tlr4
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:108041 | Traf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60803
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Strain
MGI:6148730 | C57BL/10ScCrRbrc
Attribute String: inbred strain
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Strain
MGI:4820999 | C57BL/6J-Tlr4<lps-2Btlr>/Mmucd
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Strain
MGI:3846402 | C57BL/6J-Tlr4<Lps-2Btlr>
Attribute String: coisogenic, chemically induced mutation
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Genotype
Genotype
Symbol: Il12rb2/Il12rb2 Tlr4/Tlr4
Background: C57BL/10ScCr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tlr4/Tlr4<+>
Background: C57BL/6J-Tlr4
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tlr4/?
Background: C57BL/6J-Tlr4
Zygosity: ot
Has Mutant Allele: true
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Publication
- | J:59376
     
First Author: The UK Mouse Genome Centre European Consortium
Year: 2000
Journal: Database Release
Title: European Consortium EST Radiation Hybrid Database
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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