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Search results 501 to 510 out of 510 for Stam2

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Type

Details

Score

Protein Domain

IPR035675 | STAM2_SH3

Type:

Domain

Description:

This entry represents the SH3 domain of STAM2 (signal transducing adapter molecule 2). STAM2, a subunit of the ESCRT-0 complex, is an endosomal protein acting as a regulator of receptor signaling and trafficking. It contains an N-terminal VHS domain (Vps-27/Hrs/Stam), UIM (ubiquitin-interacting motif), SH3 (Src homology 3), CC ("coiled coil"), SSM (STAM-specific motif) and C-terminal ITAM (immunoreceptor tyrosine-based activation motif) domain. It may play a regulatory role in the endosomal sorting of ubiquitinated membrane proteins []. STAMs were discovered as proteins that are highly phosphorylated following cytokine and growth factor stimulation []. They function in cytokine signaling and surface receptor degradation, as well as regulate Golgi morphology. They associate with many proteins including Jak2 and Jak3 tyrosine kinases [], Hrs, AMSH, and UBPY. STAM adaptor proteins contain VHS (Vps27, Hrs, STAM homology), ubiquitin interacting (UIM), and SH3 domains [].

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Publication

15640163 | J:97764

First Author:	Kobayashi H
Year:	2005
Journal:	J Biol Chem
Title:	Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2.
Volume:	280
Issue:	11
Pages:	10468-77

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Publication

9407053 | J:44869

First Author:	Asao H
Year:	1997
Journal:	J Biol Chem
Title:	Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.
Volume:	272
Issue:	52
Pages:	32785-91

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Publication

11728436 | -

First Author:	Lohi O
Year:	2001
Journal:	FEBS Lett
Title:	STAM/EAST/Hbp adapter proteins--integrators of signalling pathways.
Volume:	508
Issue:	3
Pages:	287-90

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Publication

10899310 | -

First Author:	Endo K
Year:	2000
Journal:	FEBS Lett
Title:	STAM2, a new member of the STAM family, binding to the Janus kinases.
Volume:	477
Issue:	1-2
Pages:	55-61

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Protein

O88811

Organism:	Mus musculus/domesticus
Length:	523
Fragment?:	false

•

Publication

11042159 | J:68323

First Author:	Carninci P
Year:	2000
Journal:	Genome Res
Title:	Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume:	10
Issue:	10
Pages:	1617-30

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Publication

10349636 | J:80645

First Author:	Carninci P
Year:	1999
Journal:	Methods Enzymol
Title:	High-efficiency full-length cDNA cloning.
Volume:	303

Pages:	19-44

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Publication

11076861 | J:68324

First Author:	Shibata K
Year:	2000
Journal:	Genome Res
Title:	RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume:	10
Issue:	11
Pages:	1757-71

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Publication

16141073 | -

First Author:	Katayama S
Year:	2005
Journal:	Science
Title:	Antisense transcription in the mammalian transcriptome.
Volume:	309
Issue:	5740
Pages:	1564-6

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