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Search results 4101 to 4200 out of 7122 for App

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Type Details Score
Publication
15016076 | J:96742
First Author: Harris-Cerruti C
Year: 2004
Journal: Eur J Neurosci
Title: Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein [correction].
Volume: 19
Issue: 5
Pages: 1174-90
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Publication
24362760 | J:208008
First Author: Khan UA
Year: 2014
Journal: Nat Neurosci
Title: Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.
Volume: 17
Issue: 2
Pages: 304-11
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Publication
12427834 | J:276917
First Author: Lazarov O
Year: 2002
Journal: J Neurosci
Title: Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
Volume: 22
Issue: 22
Pages: 9785-93
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Publication
24337465 | J:221697
First Author: Lonskaya I
Year: 2014
Journal: J Mol Med (Berl)
Title: Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance.
Volume: 92
Issue: 4
Pages: 373-86
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Publication
15859352 | J:96650
First Author: Villar AJ
Year: 2005
Journal: Mamm Genome
Title: Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.
Volume: 16
Issue: 2
Pages: 79-90
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GO Term
GO:1902944 | aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
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Publication
21755005 | J:174945
First Author: Katsouri L
Year: 2011
Journal: PLoS One
Title: Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.
Volume: 6
Issue: 7
Pages: e21880
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Publication
34247441 | J:310745
First Author: Du S
Year: 2021
Journal: Aging Cell
Title: FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology.
Volume: 20
Issue: 8
Pages: e13432
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Publication
38878650 | J:359210
 
First Author: Kong Y
Year: 2024
Journal: J Neurol Sci
Title: In vivo reactive astrocyte imaging using [(18)F]SMBT-1 in tauopathy and familial Alzheimer's disease mouse models: A multi-tracer study.
Volume: 462
Pages: 123079
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Publication
25069841 | J:232466
First Author: Polito VA
Year: 2014
Journal: EMBO Mol Med
Title: Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB.
Volume: 6
Issue: 9
Pages: 1142-60
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Publication
34131105 | J:308032
First Author: Pérez-Sisqués L
Year: 2021
Journal: Cell Death Dis
Title: RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease.
Volume: 12
Issue: 6
Pages: 616
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Publication
39375474 | J:355028
First Author: Patel AA
Year: 2024
Journal: Sci Rep
Title: Ex vivo propagation of synaptically-evoked cortical depolarizations in a mouse model of Alzheimer's disease at 20 Hz, 40 Hz, or 83 Hz.
Volume: 14
Issue: 1
Pages: 23365
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Publication
37642942 | J:347913
 
First Author: Ralvenius WT
Year: 2023
Journal: J Exp Med
Title: A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
Volume: 220
Issue: 11
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Publication
31076275 | J:276144
First Author: Adaikkan C
Year: 2019
Journal: Neuron
Title: Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection.
Volume: 102
Issue: 5
Pages: 929-943.e8
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Publication
36180790 | J:341009
First Author: Colombo G
Year: 2022
Journal: Nat Neurosci
Title: A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes.
Volume: 25
Issue: 10
Pages: 1379-1393
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Publication
37917195 | J:348194
 
First Author: Matrongolo MJ
Year: 2023
Journal: J Clin Invest
Title: Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice.
Volume: 134
Issue: 4
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Publication
28434692 | J:244833
 
First Author: Yin Z
Year: 2017
Journal: Neurobiol Aging
Title: Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease.
Volume: 55
Pages: 115-122
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Publication
33277246 | J:299756
 
First Author: Zhang X
Year: 2020
Journal: Sci Adv
Title: Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Volume: 6
Issue: 49
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Publication
35025109 | J:324342
First Author: Hohsfield LA
Year: 2022
Journal: Glia
Title: MAC2 is a long-lasting marker of peripheral cell infiltrates into the mouse CNS after bone marrow transplantation and coronavirus infection.
Volume: 70
Issue: 5
Pages: 875-891
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Publication
30804789 | J:281381
 
First Author: Ano Y
Year: 2019
Journal: Front Pharmacol
Title: Iso-α-Acids, Bitter Components in Beer, Suppress Inflammatory Responses and Attenuate Neural Hyperactivation in the Hippocampus.
Volume: 10
Pages: 81
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Publication
37759260 | J:348213
First Author: Wright AL
Year: 2023
Journal: Mol Neurodegener
Title: The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.
Volume: 18
Issue: 1
Pages: 65
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Publication
39087029 | J:358640
 
First Author: Antila S
Year: 2024
Journal: Nat Cardiovasc Res
Title: Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer's disease-related amyloid pathology.
Volume: 3
Pages: 474-491
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Publication
35142046 | J:350174
First Author: Claes C
Year: 2022
Journal: Alzheimers Dement
Title: The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model.
Volume: 18
Issue: 10
Pages: 1765-1778
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Publication
34476545 | J:357713
First Author: Truong PH
Year: 2021
Journal: Cell Mol Life Sci
Title: Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.
Volume: 78
Issue: 19-20
Pages: 6605-6630
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Publication
24684630 | J:214689
First Author: Kuwabara Y
Year: 2014
Journal: J Neurochem
Title: Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice.
Volume: 130
Issue: 3
Pages: 432-43
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Publication
19838177 | J:154603
First Author: Grathwohl SA
Year: 2009
Journal: Nat Neurosci
Title: Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Volume: 12
Issue: 11
Pages: 1361-3
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Publication
10591213 | -
First Author: Yan R
Year: 1999
Journal: Nature
Title: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Volume: 402
Issue: 6761
Pages: 533-7
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Publication
11439082 | J:70579
First Author: Mbikay M
Year: 2001
Journal: Biochem J
Title: Neuroendocrine secretory protein 7B2: structure, expression and functions.
Volume: 357
Issue: Pt 2
Pages: 329-42
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Protein
P12961
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Publication
12482604 | -
First Author: Kurisaki T
Year: 2002
Journal: FEBS Lett
Title: Meltrin beta mini, a new ADAM19 isoform lacking metalloprotease and disintegrin domains, induces morphological changes in neuronal cells.
Volume: 532
Issue: 3
Pages: 419-22
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Protein
A0A0U1RQ78
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Protein
A0A0U1RQ68
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Protein
Q9Z316
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
A0A0U1RPS9
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
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Protein
Q3TT51
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Publication
10506829 | -
 
First Author: Muller L
Year: 1999
Journal: Prog Nucleic Acid Res Mol Biol
Title: The cell biology of the prohormone convertases PC1 and PC2.
Volume: 63
Pages: 69-108
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Publication
10701998 | J:59052
First Author: Seidah NG
Year: 1999
Journal: Brain Res
Title: Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
Volume: 848
Issue: 1-2
Pages: 45-62
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Publication
7913882 | -
First Author: Braks JA
Year: 1994
Journal: Cell
Title: 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway.
Volume: 78
Issue: 2
Pages: 263-73
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Publication
23172224 | -
First Author: Helwig M
Year: 2013
Journal: J Biol Chem
Title: The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.
Volume: 288
Issue: 2
Pages: 1114-24
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Publication
2881207 | -
First Author: Kang J
Year: 1987
Journal: Nature
Title: The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
Volume: 325
Issue: 6106
Pages: 733-6
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Publication
6375662 | -
First Author: Glenner GG
Year: 1984
Journal: Biochem Biophys Res Commun
Title: Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
Volume: 120
Issue: 3
Pages: 885-90
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Publication
10656250 | -
First Author: Hussain I
Year: 1999
Journal: Mol Cell Neurosci
Title: Identification of a novel aspartic protease (Asp 2) as beta-secretase.
Volume: 14
Issue: 6
Pages: 419-27
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Publication
12391600 | -
First Author: Citron M
Year: 2002
Journal: J Neurosci Res
Title: Beta-secretase as a target for the treatment of Alzheimer's disease.
Volume: 70
Issue: 3
Pages: 373-9
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Publication
17167098 | J:115573
First Author: Ho A
Year: 2006
Journal: J Neurosci
Title: Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
Volume: 26
Issue: 50
Pages: 13089-101
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Publication
17352738 | J:127103
First Author: Yokozeki T
Year: 2007
Journal: Genes Cells
Title: Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells.
Volume: 12
Issue: 3
Pages: 329-43
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Publication
12006600 | -
First Author: Kang T
Year: 2002
Journal: J Biol Chem
Title: Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites.
Volume: 277
Issue: 28
Pages: 25583-91
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Publication
25825872 | -
First Author: Kleino I
Year: 2015
Journal: PLoS One
Title: Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.
Volume: 10
Issue: 3
Pages: e0121301
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Publication
19601835 | -
First Author: Qi B
Year: 2009
Journal: Curr Pharm Des
Title: ADAM19/adamalysin 19 structure, function, and role as a putative target in tumors and inflammatory diseases.
Volume: 15
Issue: 20
Pages: 2336-48
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Publication
19727588 | -
First Author: Zhao M
Year: 2009
Journal: Sci China C Life Sci
Title: Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells.
Volume: 52
Issue: 8
Pages: 710-8
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Protein Domain
IPR036176 | E2_sf
Type: Homologous_superfamily
Description: The E2 domain is the largest of the conserved domains in the amyloidogenic glycoproteins. The structure of E2 consists of two coiled-coil sub-structures connected through a continuous helix, and bears an unexpected resemblance to the spectrin family of protein structures. E2 can reversibly dimerise in solution, and the dimerisation occurs along the longest dimension of the molecule in an antiparallel orientation, which enables the N-terminal substructure of one monomer to pack against the C-terminal substructure of a second monomer. The high degree of conservation of residues at the putative dimer interface suggests that the E2 dimer observed in the crystal could be physiologically relevant. Heparin sulphate proteoglycans, the putative ligands for the precursor present in extracellular matrix, bind to E2 at a conserved and positively charged site near the dimer interface []. The E2 domain is also known as CAPPD (for central APP domain) [].
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Protein Domain
IPR007945 | Secretogranin_V
Type: Family
Description: Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors []. Protein 7B2 (secretogranin V) functions as a molecular chaperone for PC2, preventing its premature activation in the regulated secretory pathway []. 7B2 represents a potent inhibitor of PC2, and it is also required for the activation of PC2, which is synthesised as a zymogen. Protein 7B2 has an N-terminalactivation domain and a C-terminal (CT) inhibitory domain (MEROPS inhibitor family I21), separated by a furin cleavage site []. 7B2 is synthesised as a precursor protein that is cleaved into the N-terminal fragment and the C-terminal peptide [].7B2 has been linked to neurodegenerative diseases. It may act as an anti-aggregation chaperone []. However, in an APP model mouse 7B2 knockout has been shown to reduce rather than enhance plaque burden [].
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Protein Domain
IPR030529 | Apba2
Type: Family
Description: Amyloid beta A4 precursor protein-binding family A member 2, also known as Mint2, X11beta, or X11L, is a neuronal adaptor protein that binds to the intracellular domain of the amyloid precursor protein (APP) []. It belongs to the X11/Mint family of adaptor proteins []. It has been shown to modulate processing of APP and accumulation of Abeta (hallmark pathologies of Alzheimer's disease), making it a potential therapeutic target for Alzheimer's disease [, ]. X11beta, as X11alpha, is a important regulator of presynaptic neurotransmitter release [].The X11/Mint family members are multidomain proteins typically composed of a conserved PTB domain and two C-terminal PDZ domains. They are adaptor proteins that possess several functions, such as trafficking and transport, synaptic function and regulation of ion channel []. Two of the family members,X11alpha and X11beta, are expressed primarily in neurones [].
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Protein Domain
IPR033596 | ADAM19
Type: Family
Description: ADAM19 peptidase (also known as meltrin beta; MEROPS identifier M12.214) is located in the Golgi. It sheds the ectodomain of NRG1beta1 from the Golgi membranes []and also sheds other proteins, such as heparin-binding epidermal growth factor, tumour necrosis factor and the amyloid precursor protein (APP) []. Because the peptides released from APP do not form amyloid deposits, ADAM19 may have a protective role in Alzheimer's disease []. ADAM19 is a multidomain protein with a propeptide, a metallopeptidase, a disintegrin, and a cysteine-rich domain, followed by a transmembrane region and a cytoplasmic tail. The propeptide is removed by furin []. The cytoplasmic tail interacts with the SH3 domain of Tks5(I) []. The ADAM19 gene is expressed in muscle and nerve cells during embryonic development and a short isoform is found in dorsal root ganglia []. The gene is also over-expressed in several human cancers and cancer cell lines including astrocytomas and glioblastomas []and in the placenta, where ADAM19 may reduce cell invasion [].
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Publication
26778963 | J:310589
 
First Author: Piedrahita D
Year: 2015
Journal: Front Cell Neurosci
Title: β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Volume: 9
Pages: 498
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Publication
28641077 | J:244252
First Author: Qin X
Year: 2017
Journal: Am J Pathol
Title: Inhibition of Early Growth Response 1 in the Hippocampus Alleviates Neuropathology and Improves Cognition in an Alzheimer Model with Plaques and Tangles.
Volume: 187
Issue: 8
Pages: 1828-1847
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Publication
28740171 | J:249725
First Author: Durairajan SSK
Year: 2017
Journal: Sci Rep
Title: A modified formulation of Huanglian-Jie-Du-Tang reduces memory impairments and β-amyloid plaques in a triple transgenic mouse model of Alzheimer's disease.
Volume: 7
Issue: 1
Pages: 6238
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Publication
37171575 | J:351245
First Author: Ricciardi NR
Year: 2023
Journal: Mol Neurobiol
Title: Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer's Disease Models.
Volume: 60
Issue: 8
Pages: 4811-4827
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Publication
30397132 | J:267298
First Author: Janczura KJ
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.
Volume: 115
Issue: 47
Pages: E11148-E11157
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Publication
30411846 | J:273257
First Author: Kim HJ
Year: 2019
Journal: Aging Cell
Title: Carbon monoxide attenuates amyloidogenesis via down-regulation of NF-κB-mediated BACE1 gene expression.
Volume: 18
Issue: 1
Pages: e12864
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Publication
29910725 | J:311224
 
First Author: Huang M
Year: 2018
Journal: Front Aging Neurosci
Title: The Role of Fluoxetine in Activating Wnt/β-Catenin Signaling and Repressing β-Amyloid Production in an Alzheimer Mouse Model.
Volume: 10
Pages: 164
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Publication
29331876 | J:262423
 
First Author: Bignante EA
Year: 2018
Journal: Neurobiol Aging
Title: APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models.
Volume: 64
Pages: 44-57
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Publication
30031227 | J:348501
First Author: Tramutola A
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease.
Volume: 1864
Issue: 10
Pages: 3309-3321
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Publication
33035533 | J:348503
 
First Author: Ju Y
Year: 2020
Journal: Neuropharmacology
Title: 9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model.
Volume: 181
Pages: 108354
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Publication
29073110 | J:255228
First Author: Volmar CH
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.
Volume: 114
Issue: 43
Pages: E9135-E9144
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Publication
32768866 | J:299545
 
First Author: Russo-Savage L
Year: 2020
Journal: Neurobiol Aging
Title: Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer's disease model mouse line.
Volume: 95
Pages: 69-80
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Publication
25092575 | J:218334
 
First Author: Pensalfini A
Year: 2014
Journal: Neurobiol Dis
Title: Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.
Volume: 71
Pages: 53-61
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Publication
30530690 | J:269161
First Author: Wang H
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer's disease.
Volume: 115
Issue: 52
Pages: E12427-E12434
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Publication
23312564 | J:284611
First Author: Baglietto-Vargas D
Year: 2013
Journal: Biol Psychiatry
Title: Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Volume: 74
Issue: 5
Pages: 357-66
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Publication
35011699 | J:322134
 
First Author: Fernandes A
Year: 2022
Journal: Cells
Title: Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice.
Volume: 11
Issue: 1
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Publication
18566467 | J:141764
First Author: Ning A
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease.
Volume: 49
Issue: 11
Pages: 5136-43
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Publication
12218652 | J:285259
First Author: Xu G
Year: 2002
Journal: Alzheimer Dis Assoc Disord
Title: Abeta deposition does not cause the aggregation of endogenous tau in transgenic mice.
Volume: 16
Issue: 3
Pages: 196-201
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Publication
14637096 | J:86694
First Author: Blanchard V
Year: 2003
Journal: Exp Neurol
Title: Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice.
Volume: 184
Issue: 1
Pages: 247-63
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Publication
19036982 | J:142501
First Author: Dodson SE
Year: 2008
Journal: J Neurosci
Title: Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.
Volume: 28
Issue: 48
Pages: 12877-86
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Publication
33402196 | J:329601
First Author: Pons V
Year: 2021
Journal: Alzheimers Res Ther
Title: Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 8
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Publication
10931940 | -
First Author: Farzan M
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
Volume: 97
Issue: 17
Pages: 9712-7
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Publication
10749877 | -
First Author: Bennett BD
Year: 2000
Journal: J Biol Chem
Title: Expression analysis of BACE2 in brain and peripheral tissues.
Volume: 275
Issue: 27
Pages: 20647-51
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Protein Domain
IPR009121 | BACE2
Type: Family
Description: One of the major neuropathological hallmarks of Alzheimer's disease (AD) is the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of beta-amyloid protein (beta-APP) []. Production of beta-APP requires proteolytic cleavage of the large type-1 transmembrane (TM) protein amyloid precursor protein (APP) []. This process is performed by a variety of enzymes known as secretases. To initiate beta-APP formation, beta-secretase cleaves APP to release a soluble N-terminal fragment (APPsBeta) and a C-terminal fragment that remains membrane bound. This fragment is subsequently cleaved by gamma-secretase to liberate beta-APP.Several independent studies identified a novel TM aspartic protease as the major beta-secretase [, , ]. This protein, termed memapsin 2 or beta-site APP cleaving enzyme 1 (BACE1), shares 64% amino acid sequence similarity with a second enzyme, termed BACE2. Together, BACE1 and BACE2 define a novel family of aspartyl proteases []. Both enzymes share significant sequence similarity with other members of the pepsin family of aspartyl proteases and contain the two characteristic D(T/S)G(T/S) motifs that form the catalytic site. However, by contrast with other aspartyl proteases, BACE1 and BACE2 are type I TM proteins. Each protein comprises a large lumenal domain containing the active centre, a single TM domain and a small cytoplasmic tail.BACE2, also termed Asp1 and memapsin 1, was initially identified though Expressed Sequence Tag (EST) database searching. In vitro enzymaticassays with peptide substrates have demonstrated that BACE2 cleaves beta-secretase substrates in a similar fashion to BACE1 []. The BACE2 mRNA is expressed in the central nervous system and many peripheral tissues, although its expression level in neurons is substantially lower than that of BACE1 [].
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Publication
38747498 | J:351617
First Author: Chen XQ
Year: 2024
Journal: Ann Neurol
Title: γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.
Volume: 96
Issue: 2
Pages: 390-404
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Publication
27023444 | J:253508
First Author: Belichenko PV
Year: 2016
Journal: PLoS One
Title: An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.
Volume: 11
Issue: 3
Pages: e0152471
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Publication
26341908 | J:227512
 
First Author: Overk CR
Year: 2015
Journal: Neuroscience
Title: Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506.
Volume: 310
Pages: 549-60
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Publication
21383152 | J:170096
First Author: Park L
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta.
Volume: 108
Issue: 12
Pages: 5063-8
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Publication
23382216 | J:194544
First Author: Park L
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Innate immunity receptor CD36 promotes cerebral amyloid angiopathy.
Volume: 110
Issue: 8
Pages: 3089-94
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Allele
Tg(App)1874Kha | MGI:2183639
Name: transgene insertion 1874, Karen Hsiao Ashe
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5763665 | FVB/N-Tg(App)1874Kha
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(APPV717I)1130Kha | MGI:2183645
Name: transgene insertion 1130, Karen Hsiao Ashe
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(APPSWE)2123Kha | MGI:2183650
Name: transgene insertion 2123, Karen Hsiao Ashe
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
34120899 | J:333785
First Author: Stoiljkovic M
Year: 2022
Journal: J Alzheimers Dis
Title: TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice.
Volume: 88
Issue: 3
Pages: 837-847
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Publication
22105352 | J:178937
First Author: Wen L
Year: 2011
Journal: J Cell Biol
Title: VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.
Volume: 195
Issue: 5
Pages: 765-79
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Publication
28141794 | J:258573
First Author: You MH
Year: 2017
Journal: Cell Death Differ
Title: Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.
Volume: 24
Issue: 2
Pages: 238-250
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Allele
Tg(APP)8.9Btla | MGI:2447591
Name: transgene insertion 8.9, Bruce Lamb
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
36357367 | J:341736
First Author: Pan JX
Year: 2022
Journal: Cell Death Dis
Title: Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer's disease.
Volume: 13
Issue: 11
Pages: 952
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Strain
MGI:5004645 | B6.Cg-Tg(Thy1-APP<SL>)28Lpr
Attribute String: congenic, mutant strain, transgenic
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Publication
21115069 | J:174156
First Author: Blanchard J
Year: 2011
Journal: Behav Brain Res
Title: Detection of age-dependent working memory deterioration in APP751SL mice.
Volume: 218
Issue: 1
Pages: 129-37
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Publication
16519965 | J:121174
First Author: Sizova D
Year: 2007
Journal: Neurobiol Aging
Title: Proteomic analysis of brain tissue from an Alzheimer's disease mouse model by two-dimensional difference gel electrophoresis.
Volume: 28
Issue: 3
Pages: 357-70
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Publication
17350733 | J:140918
First Author: Blanchard J
Year: 2008
Journal: Neurobiol Aging
Title: Impairment of spatial memory consolidation in APP(751SL) mice results in cue-guided response.
Volume: 29
Issue: 7
Pages: 1011-21
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Publication
16337798 | J:108027
First Author: El Tannir El Tayara N
Year: 2006
Journal: Neurobiol Dis
Title: Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease.
Volume: 22
Issue: 1
Pages: 199-208
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Publication
17125750 | J:117687
First Author: Damjanac M
Year: 2007
Journal: Brain Res
Title: Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease.
Volume: 1128
Issue: 1
Pages: 40-9
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Publication
19428628 | J:148385
First Author: Blanchard J
Year: 2009
Journal: Behav Brain Res
Title: Characterization of cognition alteration across the course of the disease in APP751SL mice with parallel estimation of cerebral Abeta deposition.
Volume: 201
Issue: 1
Pages: 147-57
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Publication
17588710 | J:145822
First Author: Dhenain M
Year: 2009
Journal: Neurobiol Aging
Title: Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice.
Volume: 30
Issue: 1
Pages: 41-53
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Publication
17566751 | J:134839
First Author: Cacquevel M
Year: 2007
Journal: Neurobiol Dis
Title: Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms.
Volume: 27
Issue: 2
Pages: 164-73
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