| Type |
Details |
Score |
| Publication |
| First Author: |
Das AK |
| Year: |
2012 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
AMP-activated protein kinase stimulates myostatin expression in C2C12 cells. |
| Volume: |
427 |
| Issue: |
1 |
| Pages: |
36-40 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Bowser M |
| Year: |
2013 |
| Journal: |
Exp Gerontol |
| Title: |
Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. |
| Volume: |
48 |
| Issue: |
2 |
| Pages: |
290-7 |
|
•
•
•
•
•
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| Publication |
| First Author: |
González-Mariscal I |
| Year: |
2019 |
| Journal: |
FASEB J |
| Title: |
Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. |
| Volume: |
33 |
| Issue: |
5 |
| Pages: |
5850-5863 |
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•
•
•
•
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| Publication |
| First Author: |
Fennen M |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
A myostatin-CCL20-CCR6 axis regulates Th17 cell recruitment to inflamed joints in experimental arthritis. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
14145 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sartori R |
| Year: |
2013 |
| Journal: |
Nat Genet |
| Title: |
BMP signaling controls muscle mass. |
| Volume: |
45 |
| Issue: |
11 |
| Pages: |
1309-18 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Kong X |
| Year: |
2018 |
| Journal: |
Cell Metab |
| Title: |
Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. |
| Volume: |
28 |
| Issue: |
4 |
| Pages: |
631-643.e3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jeong J |
| Year: |
2013 |
| Journal: |
Acta Pharmacol Sin |
| Title: |
Pharmacological inhibition of myostatin/TGF-β receptor/pSmad3 signaling rescues muscle regenerative responses in mouse model of type 1 diabetes. |
| Volume: |
34 |
| Issue: |
8 |
| Pages: |
1052-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang L |
| Year: |
2013 |
| Journal: |
Cell Metab |
| Title: |
Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass. |
| Volume: |
18 |
| Issue: |
3 |
| Pages: |
368-79 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu J |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis. |
| Volume: |
282 |
| Issue: |
35 |
| Pages: |
25852-63 |
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•
•
•
•
•
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| Publication |
| First Author: |
Morissette MR |
| Year: |
2009 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt. |
| Volume: |
297 |
| Issue: |
5 |
| Pages: |
C1124-32 |
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•
•
•
•
•
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| Publication |
| First Author: |
Tando T |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy. |
| Volume: |
291 |
| Issue: |
23 |
| Pages: |
12184-94 |
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•
•
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| Publication |
| First Author: |
Biesemann N |
| Year: |
2015 |
| Journal: |
Cell Tissue Res |
| Title: |
Myostatin induces interstitial fibrosis in the heart via TAK1 and p38. |
| Volume: |
361 |
| Issue: |
3 |
| Pages: |
779-87 |
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•
•
•
•
•
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| Publication |
| First Author: |
Lee SJ |
| Year: |
2001 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Regulation of myostatin activity and muscle growth. |
| Volume: |
98 |
| Issue: |
16 |
| Pages: |
9306-11 |
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•
•
•
•
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| Publication |
| First Author: |
Zhu J |
| Year: |
2011 |
| Journal: |
Am J Pathol |
| Title: |
Follistatin improves skeletal muscle healing after injury and disease through an interaction with muscle regeneration, angiogenesis, and fibrosis. |
| Volume: |
179 |
| Issue: |
2 |
| Pages: |
915-30 |
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•
•
•
•
•
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| Publication |
| First Author: |
Kondás K |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. |
| Volume: |
283 |
| Issue: |
35 |
| Pages: |
23677-84 |
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•
•
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| Publication |
| First Author: |
MacDonald EM |
| Year: |
2014 |
| Journal: |
Dis Model Mech |
| Title: |
Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition. |
| Volume: |
7 |
| Issue: |
4 |
| Pages: |
471-81 |
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•
•
•
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| Publication |
| First Author: |
Marshall A |
| Year: |
2008 |
| Journal: |
Exp Cell Res |
| Title: |
Mighty is a novel promyogenic factor in skeletal myogenesis. |
| Volume: |
314 |
| Issue: |
5 |
| Pages: |
1013-29 |
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•
•
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| Publication |
| First Author: |
Lamar KM |
| Year: |
2016 |
| Journal: |
PLoS Genet |
| Title: |
Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ. |
| Volume: |
12 |
| Issue: |
5 |
| Pages: |
e1006019 |
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•
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| First Author: |
Lee SJ |
| Year: |
2010 |
| Journal: |
Mol Endocrinol |
| Title: |
Regulation of muscle mass by follistatin and activins. |
| Volume: |
24 |
| Issue: |
10 |
| Pages: |
1998-2008 |
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•
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| First Author: |
Varga L |
| Year: |
2003 |
| Journal: |
Genetics |
| Title: |
Mapping modifiers affecting muscularity of the myostatin mutant (Mstn(Cmpt-dl1Abc)) compact mouse. |
| Volume: |
165 |
| Issue: |
1 |
| Pages: |
257-67 |
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•
•
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| First Author: |
Lee SJ |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. |
| Volume: |
109 |
| Issue: |
35 |
| Pages: |
E2353-60 |
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•
•
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| Publication |
| First Author: |
Cassano M |
| Year: |
2008 |
| Journal: |
PLoS One |
| Title: |
Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis. |
| Volume: |
3 |
| Issue: |
9 |
| Pages: |
e3223 |
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•
•
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| Publication |
| First Author: |
Winbanks CE |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin. |
| Volume: |
197 |
| Issue: |
7 |
| Pages: |
997-1008 |
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•
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| Publication |
| First Author: |
Prajapati-DiNubila M |
| Year: |
2019 |
| Journal: |
Elife |
| Title: |
A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. |
| Volume: |
8 |
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•
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| Publication |
| First Author: |
Zhou J |
| Year: |
2009 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression. |
| Volume: |
29 |
| Issue: |
6 |
| Pages: |
921-8 |
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| First Author: |
Proserpio V |
| Year: |
2013 |
| Journal: |
Genes Dev |
| Title: |
The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. |
| Volume: |
27 |
| Issue: |
11 |
| Pages: |
1299-312 |
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| First Author: |
Conlon I |
| Year: |
1999 |
| Journal: |
Cell |
| Title: |
Size control in animal development. |
| Volume: |
96 |
| Issue: |
2 |
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235-44 |
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| First Author: |
Sengle G |
| Year: |
2008 |
| Journal: |
J Mol Biol |
| Title: |
A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. |
| Volume: |
381 |
| Issue: |
4 |
| Pages: |
1025-39 |
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| First Author: |
Kemaladewi DU |
| Year: |
2012 |
| Journal: |
FASEB J |
| Title: |
Cell-type specific regulation of myostatin signaling. |
| Volume: |
26 |
| Issue: |
4 |
| Pages: |
1462-72 |
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| First Author: |
Heydemann A |
| Year: |
2007 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Genetic modifiers of muscular dystrophy: implications for therapy. |
| Volume: |
1772 |
| Issue: |
2 |
| Pages: |
216-28 |
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| First Author: |
Wu HH |
| Year: |
2003 |
| Journal: |
Neuron |
| Title: |
Autoregulation of neurogenesis by GDF11. |
| Volume: |
37 |
| Issue: |
2 |
| Pages: |
197-207 |
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| First Author: |
Li H |
| Year: |
2023 |
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FASEB J |
| Title: |
Increased Ca(2+) signaling through Ca(V) 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties. |
| Volume: |
37 |
| Issue: |
7 |
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e23007 |
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Li ZB |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Myostatin directly regulates skeletal muscle fibrosis. |
| Volume: |
283 |
| Issue: |
28 |
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19371-8 |
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Callis TE |
| Year: |
2009 |
| Journal: |
J Clin Invest |
| Title: |
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. |
| Volume: |
119 |
| Issue: |
9 |
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2772-86 |
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Umansky KB |
| Year: |
2015 |
| Journal: |
PLoS Genet |
| Title: |
Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration. |
| Volume: |
11 |
| Issue: |
8 |
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e1005457 |
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Cortez-Toledo O |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. |
| Volume: |
12 |
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2 |
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e0171268 |
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Arai KY |
| Year: |
2007 |
| Journal: |
Biol Reprod |
| Title: |
Developmental changes in extracellular matrix messenger RNAs in the mouse placenta during the second half of pregnancy: possible factors involved in the regulation of placental extracellular matrix expression. |
| Volume: |
77 |
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6 |
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Funato N |
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2018 |
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Arch Oral Biol |
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Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans. |
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95 |
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Economides AN |
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Proc Natl Acad Sci U S A |
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Conditionals by inversion provide a universal method for the generation of conditional alleles. |
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2017 |
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Hum Mol Genet |
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Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy. |
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Klattig J |
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Sex Dev |
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WT1-mediated gene regulation in early urogenital ridge development. |
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PLoS One |
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Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. |
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Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. |
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J Neurosci |
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Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. |
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JCI Insight |
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Identification and characterization of a supraclavicular brown adipose tissue in mice. |
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TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. |
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•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
376
 |
| Fragment?: |
false |
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•
•
•
•
•
|
| Allele |
| Name: |
myostatin; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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•
•
•
•
•
|
| Allele |
| Name: |
myostatin; targeted mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
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•
•
•
•
•
|
| Allele |
| Name: |
myostatin; compact |
| Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
myostatin; targeted mutation 1, Se-Jin Lee |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Nestor F Gonzales-Cadavid |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mstn/Mstn |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mstn/Mstn<+> |
| Background: |
either: HCI or HCR |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Ckm-Mstn)1Nfg/? |
| Background: |
involves: BALB/c * C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Nestor F Gonzales-Cadavid |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Ckm*-Mstn)1Nfg/? |
| Background: |
involves: BALB/c * C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pydi SP |
| Year: |
2020 |
| Journal: |
Sci Adv |
| Title: |
β-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia. |
| Volume: |
6 |
| Issue: |
23 |
| Pages: |
eaba1733 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McPherron AC |
| Year: |
1999 |
| Journal: |
Nat Genet |
| Title: |
Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. |
| Volume: |
22 |
| Issue: |
3 |
| Pages: |
260-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo T |
| Year: |
2012 |
| Journal: |
Diabetes |
| Title: |
Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy. |
| Volume: |
61 |
| Issue: |
10 |
| Pages: |
2414-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyake M |
| Year: |
2007 |
| Journal: |
Cell Biol Int |
| Title: |
Myostatin and MyoD family expression in skeletal muscle of IGF-1 knockout mice. |
| Volume: |
31 |
| Issue: |
10 |
| Pages: |
1274-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lozier NR |
| Year: |
2018 |
| Journal: |
Front Physiol |
| Title: |
Relative Contributions of Myostatin and the GH/IGF-1 Axis in Body Composition and Muscle Strength. |
| Volume: |
9 |
|
| Pages: |
1418 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee EJ |
| Year: |
2016 |
| Journal: |
FASEB J |
| Title: |
Fibromodulin: a master regulator of myostatin controlling progression of satellite cells through a myogenic program. |
| Volume: |
30 |
| Issue: |
8 |
| Pages: |
2708-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baig MH |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Methylglyoxal and Advanced Glycation End products: Insight of the regulatory machinery affecting the myogenic program and of its modulation by natural compounds. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
5916 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huynh T |
| Year: |
2013 |
| Journal: |
J Pathol |
| Title: |
Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice. |
| Volume: |
231 |
| Issue: |
2 |
| Pages: |
223-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bonomi L |
| Year: |
2012 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity. |
| Volume: |
303 |
| Issue: |
5 |
| Pages: |
E587-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li X |
| Year: |
2022 |
| Journal: |
Front Genet |
| Title: |
MiR-208b Regulates the Conversion of Skeletal Muscle Fiber Types by Inhibiting Mettl8 Expression. |
| Volume: |
13 |
|
| Pages: |
820464 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sonstegard TS |
| Year: |
1998 |
| Journal: |
Anim Genet |
| Title: |
Refinement of bovine chromosome 2 linkage map near the mh locus reveals rearrangements between the bovine and human genomes. |
| Volume: |
29 |
| Issue: |
5 |
| Pages: |
341-7 |
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•
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