Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 []. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorylation by AKT leads to loss of its association with Myc []. This interaction affects Myc-dependent apoptosis and transformation [, , ]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [].
This entry includes CDCA7 and CDA7L.Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 []. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorylation by AKT leads to loss of its association with Myc []. This interaction affects Myc-dependent apoptosis and transformation [, , ]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [].Cell division cycle-associated 7-like protein (CDCA7L/JPO2/R1) is closely related to CDCA7/JPO1; and like CDCA7, it plays a role in transcriptional regulation and interacts with c-Myc []. JPO2 overexpression induces metastasis in medulloblastoma []. JPO2 can interact directly and dynamically with chromatin, the dynamics of JPO2 chromatin binding being decelerated upon interaction with LEDGF/p75, which binds and tethers JPO2 to chromatin [, ].JPO2 inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter []. JPO2 and MAOA act upstream of cyclin D1 and E2F1, and are involved in apoptotic signalling pathways [].
