Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks) []. NTRKs are multi-domain, transmembrane proteins - in addition to their cytoplasmic kinase domains, members of the family possess a number of extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand binding induces them to dimerise, resulting in activation of their cytoplasmic tyrosine kinase domains. The activated receptors couple to a variety of intracellular signalling cascades, including the Ras, phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP) kinase, and phospholipase C (PLC)-gamma pathways []. This entry represents NTRK2 (also termed TrkB) is a high-affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin (NT-4). It is broadly expressed in the nervous system, and is also found in some non neural tissues []. The receptor is involved in synaptogenesis and neuronal development []. It plays a crucial role in learning and memory []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
478
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
455
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rico B |
Year: |
2002 |
Journal: |
Nat Neurosci |
Title: |
TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum. |
Volume: |
5 |
Issue: |
3 |
Pages: |
225-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamada K |
Year: |
2003 |
Journal: |
J Pharmacol Sci |
Title: |
Brain-derived neurotrophic factor/TrkB signaling in memory processes. |
Volume: |
91 |
Issue: |
4 |
Pages: |
267-70 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354366 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:4354838 |
Age: |
embryonic day 14.5 |
Image: |
3C & Table S5 - Ntrk2 |
|
Specimen Label: |
3C & Table S5 - Ntrk2 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354366 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:4354838 |
Age: |
embryonic day 14.5 |
Image: |
3C & Table S5 - Ntrk2 |
Note: |
Expression is present in the upper, but not the lower, cortical plate. |
Specimen Label: |
3C & Table S5 - Ntrk2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354366 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4354838 |
Age: |
embryonic day 14.5 |
Image: |
3C & Table S5 - Ntrk2 |
|
Specimen Label: |
3C & Table S5 - Ntrk2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lei L |
Year: |
2007 |
Journal: |
Cell Mol Life Sci |
Title: |
Transcriptional regulation of Trk family neurotrophin receptors. |
Volume: |
64 |
Issue: |
5 |
Pages: |
522-32 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
821
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Bothwell M |
Year: |
1995 |
Journal: |
Annu Rev Neurosci |
Title: |
Functional interactions of neurotrophins and neurotrophin receptors. |
Volume: |
18 |
|
Pages: |
223-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang EJ |
Year: |
2001 |
Journal: |
Annu Rev Neurosci |
Title: |
Neurotrophins: roles in neuronal development and function. |
Volume: |
24 |
|
Pages: |
677-736 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
466
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
489
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
476
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
492
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Dalton JE |
Year: |
2015 |
Journal: |
PLoS Pathog |
Title: |
The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection. |
Volume: |
11 |
Issue: |
2 |
Pages: |
e1004681 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pattwell SS |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. |
Volume: |
11 |
Issue: |
1 |
Pages: |
2977 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kerr B |
Year: |
2009 |
Journal: |
Reproduction |
Title: |
NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary. |
Volume: |
138 |
Issue: |
1 |
Pages: |
131-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumanogoh H |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system. |
Volume: |
39 |
Issue: |
3 |
Pages: |
465-77 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179393 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190979 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Ntrk2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179393 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190979 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Ntrk2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179393 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190979 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Ntrk2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179393 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190979 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Ntrk2 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179393 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190979 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Ntrk2 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179393 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190979 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Ntrk2 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179393 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190979 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Ntrk2 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pattwell SS |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
Oncogenic role of a developmentally regulated NTRK2 splice variant. |
Volume: |
8 |
Issue: |
40 |
Pages: |
eabo6789 |
|
•
•
•
•
•
|
Publication |
First Author: |
Irintchev A |
Year: |
2005 |
Journal: |
Eur J Neurosci |
Title: |
Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single-frame motion analysis in mice. |
Volume: |
22 |
Issue: |
4 |
Pages: |
802-8 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
829 |
Description: |
Phosphotyrosine; by NTRK2 |
Type: |
modified residue |
End: |
829 |
|
•
•
•
•
•
|
Publication |
First Author: |
An JJ |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1729 |
|
•
•
•
•
•
|
Publication |
First Author: |
Casarotto PC |
Year: |
2021 |
Journal: |
Cell |
Title: |
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. |
Volume: |
184 |
Issue: |
5 |
Pages: |
1299-1313.e19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chakravarthy S |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus. |
Volume: |
103 |
Issue: |
4 |
Pages: |
1071-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saiepour MH |
Year: |
2015 |
Journal: |
Cereb Cortex |
Title: |
Competition and Homeostasis of Excitatory and Inhibitory Connectivity in the Adult Mouse Visual Cortex. |
Volume: |
25 |
Issue: |
10 |
Pages: |
3713-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baydyuk M |
Year: |
2011 |
Journal: |
Exp Neurol |
Title: |
Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration. |
Volume: |
228 |
Issue: |
1 |
Pages: |
118-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lucas EK |
Year: |
2014 |
Journal: |
Behav Brain Res |
Title: |
Mice lacking TrkB in parvalbumin-positive cells exhibit sexually dimorphic behavioral phenotypes. |
Volume: |
274 |
|
Pages: |
219-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao GY |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding. |
Volume: |
116 |
Issue: |
8 |
Pages: |
3256-3261 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boyd JG |
Year: |
2001 |
Journal: |
J Neurobiol |
Title: |
The neurotrophin receptors, trkB and p75, differentially regulate motor axonal regeneration. |
Volume: |
49 |
Issue: |
4 |
Pages: |
314-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomassoni-Ardori F |
Year: |
2019 |
Journal: |
Elife |
Title: |
Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels. |
Volume: |
8 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Southwell DG |
Year: |
2012 |
Journal: |
Nature |
Title: |
Intrinsically determined cell death of developing cortical interneurons. |
Volume: |
491 |
Issue: |
7422 |
Pages: |
109-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dragunas G |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
Cholinergic neuroplasticity in asthma driven by TrkB signaling. |
Volume: |
34 |
Issue: |
6 |
Pages: |
7703-7717 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng K |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus. |
Volume: |
108 |
Issue: |
41 |
Pages: |
17201-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu B |
Year: |
2000 |
Journal: |
J Neurosci |
Title: |
The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB. |
Volume: |
20 |
Issue: |
18 |
Pages: |
6888-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu B |
Year: |
2000 |
Journal: |
Neuron |
Title: |
Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. |
Volume: |
26 |
Issue: |
1 |
Pages: |
233-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dorfman MD |
Year: |
2014 |
Journal: |
Endocrinology |
Title: |
Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure. |
Volume: |
155 |
Issue: |
8 |
Pages: |
3098-111 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horiguchi S |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Downregulation of msh-like 2 (msx2) and neurotrophic tyrosine kinase receptor type 2 (ntrk2) in the developmental gut of KIT mutant mice. |
Volume: |
396 |
Issue: |
3 |
Pages: |
774-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue K |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons. |
Volume: |
282 |
Issue: |
33 |
Pages: |
24175-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wagner N |
Year: |
2005 |
Journal: |
Genes Dev |
Title: |
Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. |
Volume: |
19 |
Issue: |
21 |
Pages: |
2631-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu B |
Year: |
2003 |
Journal: |
Nat Neurosci |
Title: |
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. |
Volume: |
6 |
Issue: |
7 |
Pages: |
736-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye Q |
Year: |
2022 |
Journal: |
Development |
Title: |
Understanding the development of oral epithelial organs through single cell transcriptomic analysis. |
Volume: |
149 |
Issue: |
16 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
An JJ |
Year: |
2015 |
Journal: |
Cell Metab |
Title: |
Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure. |
Volume: |
22 |
Issue: |
1 |
Pages: |
175-88 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Klein R |
Year: |
1990 |
Journal: |
Cell |
Title: |
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. |
Volume: |
61 |
Issue: |
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