|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 285 out of 285 for Spen

<< First    < Previous  |  Next >    Last >>
0.032s
Type Details Score
Allele  
Name: spen family transcription repressor; gene trap OST297071, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap XE537, BayGenomics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST239471, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST57794, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST277439, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap RST255, BayGenomics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST436362, Lexicon Genetics
Allele Type: Gene trapped
Protein
Organism: Mus musculus/domesticus
Length: 3621  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3553  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1015  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 936  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1184  
Fragment?: true
Publication
First Author: Mercher T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.
Volume: 98
Issue: 10
Pages: 5776-9
Allele  
Name: spen family transcription repressor; gene trap IST10455A9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap IST13234H11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele
Name: spen family transcription repressor; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele  
Name: spen family transcription repressor; gene trap AH0674, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap IST14515B11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: targeted mutation, mutant strain, congenic
Strain
Attribute String: mutant stock, targeted mutation
Allele  
Name: spen family transcription repressor; gene trap 463G4, Centre for Modeling Human Disease
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap IST14662F5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap AX0190, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Strain
Attribute String: targeted mutation, mutant strain, congenic
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele  
Name: spen family transcription repressor; gene trap P126B04, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap 184C10, Centre for Modeling Human Disease
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap D040C10, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap D135A06, German Gene Trap Consortium
Allele Type: Gene trapped
Allele
Name: spen family transcription repressor; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele  
Name: spen family transcription repressor; gene trap P137A08, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap XP0367, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap P137A09, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap AV0692, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap D038E04, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap P148A10, German Gene Trap Consortium
Allele Type: Gene trapped
Allele
Name: spen family transcription repressor; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele  
Name: spen family transcription repressor; gene trap IST13584E9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap IST14455D1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap EUCE0158c09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele
Name: spen family transcription repressor; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele  
Name: spen family transcription repressor; gene trap IST14617H12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap IST14517B12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Genotype
Symbol: Spen/Spen
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Spen/Spen
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Spen/Spen
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 643  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3643  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3620  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 962  
Fragment?: false
Genotype
Symbol: Spen/Spen Tg(Nes-cre)1Kag/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Spen/Spen Tg(Camk2a-cre)10Kmik/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 2256  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2025  
Fragment?: false
Publication
First Author: Uranishi H
Year: 2009
Journal: J Biol Chem
Title: The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
Volume: 284
Issue: 38
Pages: 26106-16
Strain
Attribute String: mutant strain, congenic, targeted mutation
Genotype
Symbol: Cd19/Cd19<+> Spen/Spen
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cd19/Cd19<+> Rbpj/Rbpj Spen/Spen
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Oswald F
Year: 2002
Journal: EMBO J
Title: SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.
Volume: 21
Issue: 20
Pages: 5417-26
Publication
First Author: Shi Y
Year: 2001
Journal: Genes Dev
Title: Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
Volume: 15
Issue: 9
Pages: 1140-51
Protein Domain
Type: Homologous_superfamily
Description: This superfamily represents the Spen Paralogue and Orthologue C-terminal (SPOC) domain and its structural homologues. This domain has a closed β-barrel fold of complex topology. Proteins that carry a SPOC-like domain include:Spen proteins, such as SHARP (SMRT/HDAC1-associated repressor protein), which carry a SPOC domain at the C-terminal and an RNA-binding motif in the N-terminal; Spen proteins regulate the expression of key transcriptional effectors in diverse signalling pathways, the SHARP protein being a component of transcriptional repression complexes in both nuclear receptor and Notch/RBP-Jkappa signalling pathways [].The middle domains of Ku70 and Ku80 (which includes the C-terminal α-helical arm and the DNA encircling insertion); the Ku heterodimer, which is composed of Ku70 and Ku80 subunits, contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway [].
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of SHARP (also known as Msx2-interacting protein, or SPEN homologue).SHARP is an estrogen-inducible transcriptional repressor that interacts directly with the nuclear receptor corepressor SMRT, histone deacetylases (HDACs) and components of the NuRD complex. SHARP recruits HDAC activity and binds to the steroid receptor RNA coactivator SRA through four conserved N-terminal RNA recognition motifs (RRMs), further suppressing SRA-potentiated steroid receptor transcription activity []. Thus, SHARP has the capacity to modulate both liganded and nonliganded nuclear receptors. SHARP also has been identified as a component of transcriptional repression complexes in Notch/RBP-Jkappa signaling pathways []. In addition to the N-terminal RRMs, SHARP possesses a C-terminal SPOC domain (Spen paralog and ortholog C-terminal domain), which is highly conserved among Spen proteins [].
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of SHARP (also known as Msx2-interacting protein, or SPEN homologue).SHARP is an estrogen-inducible transcriptional repressor that interacts directly with the nuclear receptor corepressor SMRT, histone deacetylases (HDACs) and components of the NuRD complex. SHARP recruits HDAC activity and binds to the steroid receptor RNA coactivator SRA through four conserved N-terminal RNA recognition motifs (RRMs), further suppressing SRA-potentiated steroid receptor transcription activity []. Thus, SHARP has the capacity to modulate both liganded and nonliganded nuclear receptors. SHARP also has been identified as a component of transcriptional repression complexes in Notch/RBP-Jkappa signaling pathways []. In addition to the N-terminal RRMs, SHARP possesses a C-terminal SPOC domain (Spen paralog and ortholog C-terminal domain), which is highly conserved among Spen proteins [].
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 3 (RRM3) of SHARP (also known as Msx2-interacting protein, or SPEN homologue).SHARP is an estrogen-inducible transcriptional repressor that interacts directly with the nuclear receptor corepressor SMRT, histone deacetylases (HDACs) and components of the NuRD complex. SHARP recruits HDAC activity and binds to the steroid receptor RNA coactivator SRA through four conserved N-terminal RNA recognition motifs (RRMs), further suppressing SRA-potentiated steroid receptor transcription activity []. Thus, SHARP has the capacity to modulate both liganded and nonliganded nuclear receptors. SHARP also has been identified as a component of transcriptional repression complexes in Notch/RBP-Jkappa signaling pathways []. In addition to the N-terminal RRMs, SHARP possesses a C-terminal SPOC domain (Spen paralog and ortholog C-terminal domain), which is highly conserved among Spen proteins [].
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 4 (RRM4) of SHARP (also known as Msx2-interacting protein, or SPEN homologue).SHARP is an estrogen-inducible transcriptional repressor that interacts directly with the nuclear receptor corepressor SMRT, histone deacetylases (HDACs) and components of the NuRD complex. SHARP recruits HDAC activity and binds to the steroid receptor RNA coactivator SRA through four conserved N-terminal RNA recognition motifs (RRMs), further suppressing SRA-potentiated steroid receptor transcription activity []. Thus, SHARP has the capacity to modulate both liganded and nonliganded nuclear receptors. SHARP also has been identified as a component of transcriptional repression complexes in Notch/RBP-Jkappa signaling pathways []. In addition to the N-terminal RRMs, SHARP possesses a C-terminal SPOC domain (Spen paralog and ortholog C-terminal domain), which is highly conserved among Spen proteins [].
Publication
First Author: Markaki Y
Year: 2021
Journal: Cell
Title: Xist nucleates local protein gradients to propagate silencing across the X chromosome.
Volume: 184
Issue: 25
Pages: 6174-6192.e32
Publication
First Author: Lindtner S
Year: 2006
Journal: J Biol Chem
Title: RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.
Volume: 281
Issue: 48
Pages: 36915-28
Publication
First Author: Zolotukhin AS
Year: 2009
Journal: Nucleic Acids Res
Title: Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA.
Volume: 37
Issue: 21
Pages: 7151-62
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of RBM15.RNA-binding motif protein 15 (RBM15), also termed one-twenty two protein 1 (OTT1), is a novel mRNA export factor and component of the NXF1 pathway. It binds to NXF1 and serves as receptor for the RNA export element RTE []. It also possesses mRNA export activity and can facilitate the access of DEAD-box protein DBP5 to mRNA at the nuclear pore complex (NPC) []. RBM15 belongs to the Spen (split end) protein family, which contains three N-terminal RNA recognition motifs (RRMs), and a C-terminal SPOC (Spen paralogue and orthologue C-terminal) domain.
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of RBM15.RNA-binding motif protein 15 (RBM15), also termed one-twenty two protein 1 (OTT1), is a novel mRNA export factor and component of the NXF1 pathway. It binds to NXF1 and serves as receptor for the RNA export element RTE []. It also possesses mRNA export activity and can facilitate the access of DEAD-box protein DBP5 to mRNA at the nuclear pore complex (NPC) []. RBM15 belongs to the Spen (split end) protein family, which contains three N-terminal RNA recognition motifs (RRMs), and a C-terminal SPOC (Spen paralogue and orthologue C-terminal) domain.
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 3 (RRM3) of RBM15.RNA-binding motif protein 15 (RBM15), also termed one-twenty two protein 1 (OTT1), is a novel mRNA export factor and component of the NXF1 pathway. It binds to NXF1 and serves as receptor for the RNA export element RTE []. It also possesses mRNA export activity and can facilitate the access of DEAD-box protein DBP5 to mRNA at the nuclear pore complex (NPC) []. RBM15 belongs to the Spen (split end) protein family, which contains three N-terminal RNA recognition motifs (RRMs), and a C-terminal SPOC (Spen paralogue and orthologue C-terminal) domain.
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of RBM15B.RNA binding motif protein 15B (RBM15B, also known as OTT3) is a paralogue of RBM15. Like RBM15, RBM15B has post-transcriptional regulatory activity. It is a nuclear protein sharing with RBM15 the association with the splicing factor compartment and the nuclear envelope as well as the binding to mRNA export factors NXF1 and Aly/REF [].RBM15B belongs to the Spen (split end) protein family, which shares a domain architecture comprising three N-terminal RNA recognition motifs (RRMs) and a C-terminal SPOC (Spen paralog and ortholog C-terminal) domain.
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of RBM15B.RNA binding motif protein 15B (RBM15B, also known as OTT3) is a paralogue of RBM15. Like RBM15, RBM15B has post-transcriptional regulatory activity. It is a nuclear protein sharing with RBM15 the association with the splicing factor compartment and the nuclear envelope as well as the binding to mRNA export factors NXF1 and Aly/REF [].RBM15B belongs to the Spen (split end) protein family, which shares a domain architecture comprising three N-terminal RNA recognition motifs (RRMs) and a C-terminal SPOC (Spen paralog and ortholog C-terminal) domain.
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 3 (RRM3) of RBM15B.RNA binding motif protein 15B (RBM15B, also known as OTT3) is a paralogue of RBM15. Like RBM15, RBM15B has post-transcriptional regulatory activity. It is a nuclear protein sharing with RBM15 the association with the splicing factor compartment and the nuclear envelope as well as the binding to mRNA export factors NXF1 and Aly/REF [].RBM15B belongs to the Spen (split end) protein family, which shares a domain architecture comprising three N-terminal RNA recognition motifs (RRMs) and a C-terminal SPOC (Spen paralog and ortholog C-terminal) domain.
Publication
First Author: Raffel GD
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Ott1(Rbm15) has pleiotropic roles in hematopoietic development.
Volume: 104
Issue: 14
Pages: 6001-6
Publication
First Author: Raffel GD
Year: 2009
Journal: Mol Cell Biol
Title: Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen.
Volume: 29
Issue: 2
Pages: 333-41
Protein
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: true
HT Experiment
Series Id: GSE12628
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
Publication
First Author: Walker JR
Year: 2001
Journal: Nature
Title: Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.
Volume: 412
Issue: 6847
Pages: 607-14
Protein
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false