Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3506249 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280927 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3507775 |
Age: |
postnatal newborn |
Image: |
2 |
Note: |
The tissue was olfactory epithelium and/or bulb. |
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506249 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267921 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3507775 |
Age: |
embryonic day 13.5 |
Image: |
1 |
|
Specimen Label: |
1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506249 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267927 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3507775 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506249 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539272 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5564 |
|
Specimen Label: |
GUDMAP:5564 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506249 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3507775 |
Age: |
embryonic day 13.5 |
Image: |
1 |
|
Specimen Label: |
1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506249 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3507775 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506249 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539272 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5564 |
|
Specimen Label: |
GUDMAP:5564 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Souslova V |
Year: |
1997 |
Journal: |
Gene |
Title: |
Structure and chromosomal mapping of the mouse P2X3 gene. |
Volume: |
195 |
Issue: |
1 |
Pages: |
101-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Avvakumov N |
Year: |
2011 |
Journal: |
Mol Cell |
Title: |
Histone chaperones: modulators of chromatin marks. |
Volume: |
41 |
Issue: |
5 |
Pages: |
502-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vethantham V |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation. |
Volume: |
32 |
Issue: |
6 |
Pages: |
1044-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pilon AL |
Year: |
1993 |
Journal: |
Mamm Genome |
Title: |
Localization of the murine Hmg1 gene, encoding an HMG-box protein, to mouse chromosome 2. |
Volume: |
4 |
Issue: |
10 |
Pages: |
612-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Silver A |
Year: |
1999 |
Journal: |
Genes Chromosomes Cancer |
Title: |
Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumor suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11-12. |
Volume: |
24 |
Issue: |
2 |
Pages: |
95-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huppi K |
Year: |
1993 |
Journal: |
Immunogenetics |
Title: |
Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11. |
Volume: |
37 |
Issue: |
4 |
Pages: |
288-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vied CM |
Year: |
2014 |
Journal: |
Front Neurosci |
Title: |
A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development. |
Volume: |
8 |
|
Pages: |
257 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagai K |
Year: |
2001 |
Journal: |
Gene |
Title: |
Molecular evolution of Sry and Sox gene. |
Volume: |
270 |
Issue: |
1-2 |
Pages: |
161-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elsen GE |
Year: |
2018 |
Journal: |
Front Neurosci |
Title: |
The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1. |
Volume: |
12 |
|
Pages: |
571 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung YC |
Year: |
2011 |
Journal: |
Gene Expr Patterns |
Title: |
Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. |
Volume: |
11 |
Issue: |
1-2 |
Pages: |
84-92 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
623
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
633
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
Year: |
2023 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wiese CB |
Year: |
2012 |
Journal: |
Front Neurosci |
Title: |
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. |
Volume: |
6 |
|
Pages: |
130 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
713
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
2 |
Description: |
FACT complex subunit SSRP1 |
Type: |
chain |
End: |
708 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This is the dimerization domain found in structure-specific recognition protein SSRP1 (POB3 in yeast) and related proteins, which are components of the FACT complex - a general chromatin factor that acts to reorganise nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair [, , , ]. During transcription elongation the FACT complex acts as a histone chaperone that both destabilises and restores nucleosomal structure [, ].This domain has a Pleckstrin homology fold, made of 6 β-strands. |
|
•
•
•
•
•
|
Publication |
First Author: |
Mason PB |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo. |
Volume: |
23 |
Issue: |
22 |
Pages: |
8323-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schlesinger MB |
Year: |
2000 |
Journal: |
Genetics |
Title: |
POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae. |
Volume: |
155 |
Issue: |
4 |
Pages: |
1593-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Orphanides G |
Year: |
1998 |
Journal: |
Cell |
Title: |
FACT, a factor that facilitates transcript elongation through nucleosomes. |
Volume: |
92 |
Issue: |
1 |
Pages: |
105-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang W |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Crystal Structure of Human SSRP1 Middle Domain Reveals a Role in DNA Binding. |
Volume: |
5 |
|
Pages: |
18688 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsunaka Y |
Year: |
2016 |
Journal: |
Genes Dev |
Title: |
Integrated molecular mechanism directing nucleosome reorganization by human FACT. |
Volume: |
30 |
Issue: |
6 |
Pages: |
673-86 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelley DE |
Year: |
1999 |
Journal: |
Chromosoma |
Title: |
CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. |
Volume: |
108 |
Issue: |
1 |
Pages: |
10-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lolis AA |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes. |
Volume: |
288 |
Issue: |
11 |
Pages: |
7676-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belotserkovskaya R |
Year: |
2003 |
Journal: |
Science |
Title: |
FACT facilitates transcription-dependent nucleosome alteration. |
Volume: |
301 |
Issue: |
5636 |
Pages: |
1090-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2020 |
Journal: |
Nature |
Title: |
FACT caught in the act of manipulating the nucleosome. |
Volume: |
577 |
Issue: |
7790 |
Pages: |
426-431 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hondele M |
Year: |
2013 |
Journal: |
Nature |
Title: |
Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. |
Volume: |
499 |
Issue: |
7456 |
Pages: |
111-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singer RA |
Year: |
2004 |
Journal: |
Biochem Cell Biol |
Title: |
The FACT chromatin modulator: genetic and structure/function relationships. |
Volume: |
82 |
Issue: |
4 |
Pages: |
419-27 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is found at the N terminus of yeast POB3 and its metazoan homologue SSRP1 [, ]. POB3/SSRP1 is a subunit of the heterodimeric FACT complex involved in transcriptional initiation [, , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Bruhn SL |
Year: |
1993 |
Journal: |
Nucleic Acids Res |
Title: |
Isolation and characterization of cDNA clones encoding the Drosophila homolog of the HMG-box SSRP family that recognizes specific DNA structures. |
Volume: |
21 |
Issue: |
7 |
Pages: |
1643-6 |
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•
•
•
•
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Publication |
First Author: |
Bruhn SL |
Year: |
1992 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. |
Volume: |
89 |
Issue: |
6 |
Pages: |
2307-11 |
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•
•
•
•
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Publication |
First Author: |
Hsu T |
Year: |
1993 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A Drosophila single-strand DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus. |
Volume: |
90 |
Issue: |
14 |
Pages: |
6488-92 |
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•
•
•
•
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Publication |
First Author: |
Huang S |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. |
Volume: |
102 |
Issue: |
38 |
Pages: |
13410-5 |
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•
•
•
•
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Publication |
First Author: |
Kemble DJ |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT. |
Volume: |
288 |
Issue: |
15 |
Pages: |
10188-94 |
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•
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Protein Domain |
Type: |
Family |
Description: |
FACT (facilitates chromatin transactions) is a general chromatin factor that acts to reorganise nucleosomes. It is a complex that consists of several subunits [, , , ]. This entry represents the FACT complex subunits POB3, which is present in yeast, and the related SSRP1, found in higher eukaryotes. SSRP1 binds specifically to DNA modified with the anti-cancer drug cisplatin. It contains a high mobility group (HMG) box domain () that probably constitutes the structure recognition element for cisplatin-modified DNA, the probable recognition motif being the local duplex unwinding and bending that occurs on formation of intra-strand cross-links [, , ]. |
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Protein Domain |
Type: |
Domain |
Description: |
This is the dimerization domain found in structure-specific recognition protein SSRP1 (POB3 in yeast) and related proteins, which are components of the FACT complex - a general chromatin factor that acts to reorganise nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair [, , , ]. During transcription elongation the FACT complex acts as a histone chaperone that both destabilises and restores nucleosomal structure [, ].This domain has a Pleckstrin homology fold, made of 6 β-strands. |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents a domain found in the middle region of several eukaryotic proteins [, ]. It is present in various FACT (facilitates chromatin transactions) complex subunits, such as Spt16 and either Pob3 (yeast) or the related SSRP1 (higher eukaryotes). FACT is a general chromatin factor that acts to reorganise nucleosomes [, ]. In these proteins, the middle domain shows a double pleckstrin homology (PH) configuration and plays a role in DNA binding [, , ]. This entry represents the second PH domain, which is also found in Rtt106p, a histone chaperone involved in heterochromatin-mediated silencing []. |
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Publication |
First Author: |
Winkler DD |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization. |
Volume: |
286 |
Issue: |
21 |
Pages: |
18369-74 |
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•
•
•
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Publication |
First Author: |
Farnung L |
Year: |
2021 |
Journal: |
Nat Struct Mol Biol |
Title: |
Structural basis of nucleosome transcription mediated by Chd1 and FACT. |
Volume: |
28 |
Issue: |
4 |
Pages: |
382-387 |
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•
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•
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Publication |
First Author: |
Ishov AM |
Year: |
2004 |
Journal: |
J Cell Sci |
Title: |
Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX. |
Volume: |
117 |
Issue: |
Pt 17 |
Pages: |
3807-20 |
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•
•
•
•
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Publication |
First Author: |
Wang QS |
Year: |
2024 |
Journal: |
Int Immunopharmacol |
Title: |
MiR-204/-211 double knockout exacerbates rheumatoid arthritis progression by promoting splenic inflammation. |
Volume: |
140 |
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Pages: |
112850 |
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•
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•
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Publication |
First Author: |
Shimojima T |
Year: |
2003 |
Journal: |
Genes Dev |
Title: |
Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. |
Volume: |
17 |
Issue: |
13 |
Pages: |
1605-16 |
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Publication |
First Author: |
Wittmeyer J |
Year: |
1999 |
Journal: |
Biochemistry |
Title: |
Spt16 and Pob3 of Saccharomyces cerevisiae form an essential, abundant heterodimer that is nuclear, chromatin-associated, and copurifies with DNA polymerase alpha. |
Volume: |
38 |
Issue: |
28 |
Pages: |
8961-71 |
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Publication |
First Author: |
Biswas D |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
The yeast FACT complex has a role in transcriptional initiation. |
Volume: |
25 |
Issue: |
14 |
Pages: |
5812-22 |
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•
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Publication |
First Author: |
Formosa T |
Year: |
2002 |
Journal: |
Genetics |
Title: |
Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. |
Volume: |
162 |
Issue: |
4 |
Pages: |
1557-71 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1047
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1047
|
Fragment?: |
false |
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•
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Publication |
First Author: |
Sweet SM |
Year: |
2009 |
Journal: |
Mol Cell Proteomics |
Title: |
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. |
Volume: |
8 |
Issue: |
5 |
Pages: |
904-12 |
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•
•
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•
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Publication |
First Author: |
Trost M |
Year: |
2009 |
Journal: |
Immunity |
Title: |
The phagosomal proteome in interferon-gamma-activated macrophages. |
Volume: |
30 |
Issue: |
1 |
Pages: |
143-54 |
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Publication |
First Author: |
Park J |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. |
Volume: |
50 |
Issue: |
6 |
Pages: |
919-30 |
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•
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•
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Publication |
First Author: |
Villén J |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Large-scale phosphorylation analysis of mouse liver. |
Volume: |
104 |
Issue: |
5 |
Pages: |
1488-93 |
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•
•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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•
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•
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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