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Search results 201 to 292 out of 292 for Arhgef12

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5000551
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541111
Age: embryonic day 15.5
Image: GUDMAP:5019
Specimen Label: GUDMAP:5019
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:5000551
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541111
Age: embryonic day 15.5
Image: GUDMAP:5018
Specimen Label: GUDMAP:5018
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886834
Specimen Label: UC Davis_1886834
Detected: true
Specimen Num: 35
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886907
Specimen Label: UC Davis_1886907
Detected: true
Specimen Num: 99
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886908
Specimen Label: UC Davis_1886908
Detected: true
Specimen Num: 100
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886831
Specimen Label: UC Davis_1886831
Detected: true
Specimen Num: 32
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886900
Specimen Label: UC Davis_1886900
Detected: true
Specimen Num: 93
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886901
Specimen Label: UC Davis_1886901
Detected: true
Specimen Num: 94
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6401334
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3544127
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6401410
Age: postnatal day 1
Note: Expression is in the muscle layers of the ileum.
Specimen Label: 3d
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
   
Probe: MGI:6401334
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3544128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6401410
Age: postnatal adult
Specimen Label: 3e
Detected: true
Specimen Num: 11
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•
GXD Expression
GXD Expression
 
Probe: MGI:5000551
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541111
Age: embryonic day 15.5
Image: GUDMAP:5018
Specimen Label: GUDMAP:5018
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5000551
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541111
Age: embryonic day 15.5
Image: GUDMAP:5019
Specimen Label: GUDMAP:5019
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886857
Specimen Label: UC Davis_1886857
Detected: true
Specimen Num: 54
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886858
Specimen Label: UC Davis_1886858
Detected: true
Specimen Num: 55
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5000551
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541111
Age: embryonic day 15.5
Image: GUDMAP:5018
Specimen Label: GUDMAP:5018
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886853
Specimen Label: UC Davis_1886853
Detected: true
Specimen Num: 50
•
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886854
Specimen Label: UC Davis_1886854
Detected: true
Specimen Num: 51
•
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886928
Specimen Label: UC Davis_1886928
Detected: true
Specimen Num: 116
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886929
Specimen Label: UC Davis_1886929
Detected: true
Specimen Num: 117
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886930
Specimen Label: UC Davis_1886930
Detected: true
Specimen Num: 118
•
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886797
Specimen Label: UC Davis_1886797
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886798
Specimen Label: UC Davis_1886798
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886863
Specimen Label: UC Davis_1886863
Detected: true
Specimen Num: 60
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691879
Age: postnatal adult
Image: UC Davis_1886864
Specimen Label: UC Davis_1886864
Detected: true
Specimen Num: 61
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Publication
24106280 | J:204980
First Author: Artamonov MV
Year: 2013
Journal: J Biol Chem
Title: Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
Volume: 288
Issue: 47
Pages: 34030-40
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Publication
19811534 | J:263480
First Author: Katsumata O
Year: 2009
Journal: Eur J Neurosci
Title: IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina.
Volume: 30
Issue: 8
Pages: 1509-16
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Publication
21572419 | J:175274
First Author: Guilluy C
Year: 2011
Journal: Nat Cell Biol
Title: The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.
Volume: 13
Issue: 6
Pages: 722-7
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Publication
20702813 | J:179547
First Author: Medlin MD
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation.
Volume: 30
Issue: 9
Pages: 1779-86
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Publication
28465324 | J:247642
First Author: Bodmann EL
Year: 2017
Journal: FASEB J
Title: Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia-associated RhoGEF.
Volume: 31
Issue: 8
Pages: 3663-3676
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Publication
14513355 | J:85854
First Author: Becknell B
Year: 2003
Journal: Cell Tissue Res
Title: Characterization of leukemia-associated Rho guanine nucleotide exchange factor (LARG) expression during murine development.
Volume: 314
Issue: 3
Pages: 361-6
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Publication
18084302 | J:141641
First Author: Wirth A
Year: 2008
Journal: Nat Med
Title: G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension.
Volume: 14
Issue: 1
Pages: 64-8
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Publication
19265163 | J:145913
First Author: Shi Y
Year: 2009
Journal: J Immunol
Title: The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis.
Volume: 182
Issue: 6
Pages: 3837-45
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Publication
15755723 | J:99931
First Author: Yamada T
Year: 2005
Journal: J Biol Chem
Title: Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs).
Volume: 280
Issue: 19
Pages: 19358-63
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Publication
18164504 | J:131067
First Author: Sakagami H
Year: 2008
Journal: Neurosci Res
Title: IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses.
Volume: 60
Issue: 2
Pages: 199-212
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Publication
25857352 | J:222734
 
First Author: Mikelis CM
Year: 2015
Journal: Nat Commun
Title: RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.
Volume: 6
Pages: 6725
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Publication
23467409 | J:198274
First Author: Mikelis CM
Year: 2013
Journal: J Biol Chem
Title: PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
Volume: 288
Issue: 17
Pages: 12232-43
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Publication
22019888 | J:178104
First Author: Negishi-Koga T
Year: 2011
Journal: Nat Med
Title: Suppression of bone formation by osteoclastic expression of semaphorin 4D.
Volume: 17
Issue: 11
Pages: 1473-80
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Publication
12123608 | J:200323
First Author: Swiercz JM
Year: 2002
Journal: Neuron
Title: Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.
Volume: 35
Issue: 1
Pages: 51-63
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Publication
12799088 | J:84356
First Author: Yoshizawa M
Year: 2003
Journal: Gene Expr Patterns
Title: Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.
Volume: 3
Issue: 3
Pages: 375-81
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Publication
16618939 | J:109029
First Author: Mulligan MK
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.
Volume: 103
Issue: 16
Pages: 6368-73
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Publication
24469813 | J:206656
First Author: Worzfeld T
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Genetic dissection of plexin signaling in vivo.
Volume: 111
Issue: 6
Pages: 2194-9
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Publication
24448406 | J:207976
 
First Author: Li Q
Year: 2014
Journal: Elife
Title: The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.
Volume: 3
Pages: e01201
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Arhgef12<tm1.1Wet> | MGI:3849180
Name: Rho guanine nucleotide exchange factor 12; targeted mutation 1.1, Nina Wettschureck
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Arhgef12/Arhgef12 Tg(Lck-cre)548Jxm/?
Background: involves: 129 * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
15331592 | -
First Author: Kristelly R
Year: 2004
Journal: J Biol Chem
Title: Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
Volume: 279
Issue: 45
Pages: 47352-62
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Protein Domain
IPR037801 | ARHGEF12_PH
Type: Domain
Description: ARHGEF12 (also called LARG) is a Rho guanine-nucleotide exchange factor that are RhoA-selective and directly activated by the Galpha12/13 family of heterotrimeric G proteins. LARG contains a regulator of G protein signaling (RGS) homology (RH) domain, the catalytic Dbl homology (DH) domain and the pleckstrin homology (PH) domain. The DH and PH domains bind RhoA and catalyze the exchange of GDP for GTP on RhoA. The active site of RhoA adopts two distinct GDP-excluding conformations among the four unique complexes in the asymmetric unit. The LARG PH domain also contains a potential protein-docking site. LARG forms a homotetramer via its DH domains []. This entry represents the PH domain of ARHGEF12. It has an exposed hydrophobic patch that could interface with other domains of LARG or other regulatory proteins [].
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Publication
31704028 | J:326511
First Author: Fossati M
Year: 2019
Journal: Neuron
Title: Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.
Volume: 104
Issue: 6
Pages: 1081-1094.e7
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Publication
35862649 | J:327589
First Author: Madhavan SM
Year: 2022
Journal: Am J Physiol Renal Physiol
Title: Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier.
Volume: 323
Issue: 3
Pages: F272-F287
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Protein
Q8R4H2
Organism: Mus musculus/domesticus
Length: 1543  
Fragment?: false
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Protein
F8VQN6
Organism: Mus musculus/domesticus
Length: 1544  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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