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Search results 2501 to 2600 out of 7122 for App

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Type Details Score
Publication
First Author: Yang Y
Year: 2023
Journal: Mol Psychiatry
Title: Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology.
Volume: 28
Issue: 12
Pages: 5359-5374
Publication
First Author: Spangenberg E
Year: 2019
Journal: Nat Commun
Title: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Volume: 10
Issue: 1
Pages: 3758
Publication
First Author: Cai CZ
Year: 2022
Journal: Theranostics
Title: Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.
Volume: 12
Issue: 4
Pages: 1738-1755
Publication
First Author: Xiang J
Year: 2023
Journal: Cell
Title: Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies.
Volume: 186
Issue: 16
Pages: 3350-3367.e19
Publication
First Author: Pietri M
Year: 2013
Journal: Nat Med
Title: PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
Volume: 19
Issue: 9
Pages: 1124-31
Publication
First Author: Nguyen P
Year: 2022
Journal: Microsc Res Tech
Title: An easy brain thick-section-clearing protocol to observe antigens in the brains of neurological disease mouse models by conventional epifluorescence and confocal laser scanning microscopy.
Volume: 85
Issue: 4
Pages: 1618-1626
Publication
First Author: Yu H
Year: 2022
Journal: MedComm (2020)
Title: Integrated analyses of brain and platelet omics reveal their common altered and driven molecules in Alzheimer's disease.
Volume: 3
Issue: 4
Pages: e180
Publication  
First Author: Crapser JD
Year: 2020
Journal: EBioMedicine
Title: Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain.
Volume: 58
Pages: 102919
Publication
First Author: Wu D
Year: 2023
Journal: Mol Neurodegener
Title: Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation.
Volume: 18
Issue: 1
Pages: 23
Publication  
First Author: Russo ML
Year: 2021
Journal: Neurobiol Aging
Title: Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons.
Volume: 106
Pages: 207-222
Publication  
First Author: Weigel TK
Year: 2023
Journal: Front Aging Neurosci
Title: Altered circadian behavior and light sensing in mouse models of Alzheimer's disease.
Volume: 15
Pages: 1218193
Publication
First Author: Guo Y
Year: 2024
Journal: EMBO Mol Med
Title: Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice.
Volume: 16
Issue: 11
Pages: 2856-2881
Publication  
First Author: Daini E
Year: 2022
Journal: Front Immunol
Title: Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice.
Volume: 13
Pages: 1082036
Publication
First Author: Roddick KM
Year: 2016
Journal: Chem Senses
Title: Sex and Genotype Differences in Odor Detection in the 3×Tg-AD and 5XFAD Mouse Models of Alzheimer's Disease at 6 Months of Age.
Volume: 41
Issue: 5
Pages: 433-40
Publication
First Author: Park JS
Year: 2021
Journal: Acta Neuropathol Commun
Title: Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 78
Publication
First Author: Xiang J
Year: 2024
Journal: STAR Protoc
Title: Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo.
Volume: 5
Issue: 1
Pages: 102788
Publication
First Author: Zenaro E
Year: 2015
Journal: Nat Med
Title: Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.
Volume: 21
Issue: 8
Pages: 880-6
Publication
First Author: Chen C
Year: 2020
Journal: Sci Adv
Title: Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model.
Volume: 6
Issue: 31
Pages: eaba0466
Publication  
First Author: Sanna PP
Year: 2023
Journal: eNeuro
Title: A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer's Disease.
Volume: 10
Issue: 7
Publication
First Author: Creighton SD
Year: 2019
Journal: Sci Rep
Title: Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests.
Volume: 9
Issue: 1
Pages: 57
Publication
First Author: Yuan P
Year: 2016
Journal: Neuron
Title: TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
Volume: 90
Issue: 4
Pages: 724-39
Publication
First Author: Barnham KJ
Year: 2003
Journal: J Biol Chem
Title: Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
Volume: 278
Issue: 19
Pages: 17401-7
Publication
First Author: Zirah S
Year: 2006
Journal: J Biol Chem
Title: Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.
Volume: 281
Issue: 4
Pages: 2151-61
Publication
First Author: Chen GF
Year: 2017
Journal: Acta Pharmacol Sin
Title: Amyloid beta: structure, biology and structure-based therapeutic development.
Volume: 38
Issue: 9
Pages: 1205-1235
Publication  
First Author: Breijyeh Z
Year: 2020
Journal: Molecules
Title: Comprehensive Review on Alzheimer's Disease: Causes and Treatment.
Volume: 25
Issue: 24
Protein
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: true
Publication  
First Author: Liang C
Year: 2012
Journal: Brain Res
Title: MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2.
Volume: 1455
Pages: 103-13
Protein
Organism: Mus musculus/domesticus
Length: 506  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 633  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 624  
Fragment?: true
Genotype
Symbol: Tg(Thy1-APPArc)M8Cagr/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(NEFL-APP)#Nalb/?
Background: involves: C57BL/6 * C3H
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Matsuda S
Year: 2008
Journal: J Neurosci
Title: BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.
Volume: 28
Issue: 35
Pages: 8668-76
Transgene
Type: transgene
Organism: mouse, laboratory
Transgene
Type: transgene
Organism: mouse, laboratory
Transgene
Type: transgene
Organism: mouse, laboratory
Transgene
Type: transgene
Organism: mouse, laboratory
Allele
Name: transgene insertion 2348, Yong K Kim
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 1480, Yong K Kim
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Apoe/Apoe Ldlr/Ldlr<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(PRNP-APPSweInd)19959Dwst/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-ITM2B*)6Jckr/? Tg(Thy1-APP)3Somm/?
Background: B6.Cg-Tg(Prnp-ITM2B*)6Jckr Tg(Thy1-APP)3Somm
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-ITM2B*)7Jckr/? Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Thy1-APPDutch)#Jckr/? Tg(Thy1-PSEN1*G384A)45Jckr/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Abcc1/Abcc1 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: FVB.Cg-Abcc1 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Hdac6/Hdac6 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: App/App
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Shukla AK
Year: 2019
Journal: Glia
Title: CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease.
Volume: 67
Issue: 5
Pages: 844-856
Publication
First Author: Rossjohn J
Year: 1999
Journal: Nat Struct Biol
Title: Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Volume: 6
Issue: 4
Pages: 327-31
Publication
First Author: Kroker KS
Year: 2014
Journal: Neurobiol Aging
Title: PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition.
Volume: 35
Issue: 9
Pages: 2072-8
Publication  
First Author: Navarro-Dorado J
Year: 2016
Journal: Front Neurosci
Title: Vascular Dysfunction in a Transgenic Model of Alzheimer's Disease: Effects of CB1R and CB2R Cannabinoid Agonists.
Volume: 10
Pages: 422
Publication
First Author: Comerota MM
Year: 2017
Journal: Sci Rep
Title: Near infrared light decreases synaptic vulnerability to amyloid beta oligomers.
Volume: 7
Issue: 1
Pages: 15012
Publication
First Author: Wen GY
Year: 2002
Journal: Brain Res
Title: Presence of hydroxysteroid dehydrogenase type 10 in amyloid plaques (APs) of Hsiao's APP-Sw transgenic mouse brains, but absence in APs of Alzheimer's disease brains.
Volume: 954
Issue: 1
Pages: 115-22
Publication
First Author: Fukumoto H
Year: 2004
Journal: Am J Pathol
Title: Beta-secretase activity increases with aging in human, monkey, and mouse brain.
Volume: 164
Issue: 2
Pages: 719-25
Publication
First Author: Thomas RS
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology.
Volume: 415
Issue: 4
Pages: 656-61
Publication
First Author: Baldassarro VA
Year: 2017
Journal: Dis Model Mech
Title: Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes.
Volume: 10
Issue: 5
Pages: 671-678
Publication
First Author: d'Uscio LV
Year: 2012
Journal: Cardiovasc Res
Title: Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.
Volume: 96
Issue: 3
Pages: 504-12
Publication
First Author: Katzav A
Year: 2011
Journal: Neurobiol Aging
Title: Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background.
Volume: 32
Issue: 2
Pages: 272-9
Publication
First Author: Chen L
Year: 2014
Journal: Neurobiol Aging
Title: Enhanced defense against mitochondrial hydrogen peroxide attenuates age-associated cognition decline.
Volume: 35
Issue: 11
Pages: 2552-2561
Publication
First Author: Hook VY
Year: 2008
Journal: J Biol Chem
Title: Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
Volume: 283
Issue: 12
Pages: 7745-53
Publication
First Author: Apelt J
Year: 2004
Journal: Int J Dev Neurosci
Title: Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology.
Volume: 22
Issue: 7
Pages: 475-84
Publication
First Author: Pirici D
Year: 2011
Journal: Neurobiol Aging
Title: Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models.
Volume: 32
Issue: 9
Pages: 1579-87
Publication
First Author: Wesson DW
Year: 2011
Journal: Behav Brain Res
Title: Respiratory and sniffing behaviors throughout adulthood and aging in mice.
Volume: 223
Issue: 1
Pages: 99-106
Publication  
First Author: Wesson DW
Year: 2013
Journal: Behav Brain Res
Title: Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model.
Volume: 237
Pages: 96-102
Publication
First Author: Muche A
Year: 2017
Journal: PLoS One
Title: Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells.
Volume: 12
Issue: 6
Pages: e0178127
Publication
First Author: Lim GP
Year: 2005
Journal: J Neurosci
Title: A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.
Volume: 25
Issue: 12
Pages: 3032-40
Publication  
First Author: Kurata T
Year: 2011
Journal: Neuroscience
Title: Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin.
Volume: 197
Pages: 358-68
Publication  
First Author: Tajeddinn W
Year: 2015
Journal: Neurosci Lett
Title: 5-HT1B and other related serotonergic proteins are altered in APPswe mutation.
Volume: 594
Pages: 137-43
Publication  
First Author: Foley KE
Year: 2025
Journal: J Neurosci
Title: Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-Aβ Antibody-Injected Cortex.
Volume: 45
Issue: 5
Publication
First Author: Chen L
Year: 2012
Journal: Neurobiol Aging
Title: Cognitive impairment and increased Aβ levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H(2)O(2).
Volume: 33
Issue: 2
Pages: 432.e15-26
Publication
First Author: Giunta B
Year: 2010
Journal: Neurosci Lett
Title: Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice.
Volume: 471
Issue: 3
Pages: 134-8
Publication
First Author: Gerenu G
Year: 2013
Journal: Biochim Biophys Acta
Title: Early cognitive stimulation compensates for memory and pathological changes in Tg2576 mice.
Volume: 1832
Issue: 6
Pages: 837-47
Publication
First Author: Elesber AA
Year: 2006
Journal: Neurobiol Aging
Title: Bosentan preserves endothelial function in mice overexpressing APP.
Volume: 27
Issue: 3
Pages: 446-50
Publication
First Author: Pedersen WA
Year: 1999
Journal: J Mol Neurosci
Title: Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease.
Volume: 13
Issue: 1-2
Pages: 159-65
Publication
First Author: Bernardo A
Year: 2007
Journal: Neurobiol Aging
Title: Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet.
Volume: 28
Issue: 8
Pages: 1195-205
Publication
First Author: Good MA
Year: 2007
Journal: Behav Neurosci
Title: Impaired "episodic-like" object memory in adult APPswe transgenic mice.
Volume: 121
Issue: 2
Pages: 443-8
Publication
First Author: Spires TL
Year: 2005
Journal: J Neurosci
Title: Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.
Volume: 25
Issue: 31
Pages: 7278-87
Publication
First Author: McMillan LE
Year: 2011
Journal: Neurosci Lett
Title: Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model.
Volume: 502
Issue: 3
Pages: 201-8
Publication
First Author: Yamamoto M
Year: 2005
Journal: Am J Pathol
Title: Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition.
Volume: 166
Issue: 5
Pages: 1475-85
Publication  
First Author: Lachen-Montes M
Year: 2019
Journal: Front Aging Neurosci
Title: Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease.
Volume: 11
Pages: 141
Publication  
First Author: Li X
Year: 2013
Journal: Neurobiol Dis
Title: Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions.
Volume: 50
Pages: 127-34
Publication
First Author: Gil-Bea FJ
Year: 2012
Journal: Neurobiol Dis
Title: Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice.
Volume: 48
Issue: 3
Pages: 439-46
Publication
First Author: He K
Year: 2021
Journal: Aging Cell
Title: Adiponectin alleviated Alzheimer-like pathologies via autophagy-lysosomal activation.
Volume: 20
Issue: 12
Pages: e13514
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Allele
Name: transgene insertion B, William E Van Nostrand
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion, David R Borchelt
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
Genotype
Symbol: Nos2/Nos2 Tg(APPSWE)2576Kha/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Ccr2/Ccr2 Tg(APPSWE)2576Kha/?
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Lrp1/Lrp1 Tg(APP695)3Dbo/? Tg(PSEN1)5Dbo/? Tg(Tagln-cre)1Her/?
Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Wang Y
Year: 2004
Journal: Mol Cell
Title: The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.
Volume: 15
Issue: 3
Pages: 343-53
Publication
First Author: Dulubova I
Year: 2004
Journal: Biochemistry
Title: Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein.
Volume: 43
Issue: 30
Pages: 9583-8
Protein Domain
Type: Domain
Description: This entry represents the cytoplasmic C-terminal domain of calsyntenin (CLSTN) proteins 1, 2 and 3 (also known as alcadein-alpha, beta and gamma). These are postsynaptic Ca2-binding proteins, evolutionarily conserved type I membrane proteins. CLSTN (also known as Alc) forms a tripartite complex with APP (amyloid beta-protein precursor) and X11L (a neuron-specific adaptor protein) in brain; this complex stabilizes both APP and CLSTN proteins metabolically. Deficiencies in the X11L-mediated interaction between CLSTN and APP and/or CTFbeta enhances the production of amyloid beta-protein and have been linked to the development or progression of Alzheimer's disease []. Moreover, CLSTN1 strongly associates with kinesin-1 light chains (KLC1) and acts as a cargo that regulates kinesin-1 function. It may affect the transport of APP-containing vesicles by kinesin-1 []. This domain includes the WD motifs required for KLC1 interaction (although one WD motif is sufficient), and the NP motif [].
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
Publication
First Author: Reddy PH
Year: 2017
Journal: Hum Mol Genet
Title: Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease.
Volume: 26
Issue: 8
Pages: 1483-1496
Publication
First Author: Cheng F
Year: 2011
Journal: J Biol Chem
Title: Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.
Volume: 286
Issue: 31
Pages: 27559-72
Publication
First Author: Dong H
Year: 2008
Journal: Neuroscience
Title: Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice.
Volume: 155
Issue: 1
Pages: 154-63
Publication
First Author: Reddy AP
Year: 2021
Journal: Hum Mol Genet
Title: Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer's disease.
Volume: 30
Issue: 9
Pages: 789-810
Publication
First Author: Münch G
Year: 2003
Journal: J Neurochem
Title: Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology.
Volume: 86
Issue: 2
Pages: 283-9
Publication
First Author: Manczak M
Year: 2006
Journal: Hum Mol Genet
Title: Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression.
Volume: 15
Issue: 9
Pages: 1437-49
Publication
First Author: Kim JY
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Distinct amyloid precursor protein processing machineries of the olfactory system.
Volume: 495
Issue: 1
Pages: 533-538