Type |
Details |
Score |
Publication |
First Author: |
Yang Y |
Year: |
2023 |
Journal: |
Mol Psychiatry |
Title: |
Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology. |
Volume: |
28 |
Issue: |
12 |
Pages: |
5359-5374 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spangenberg E |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. |
Volume: |
10 |
Issue: |
1 |
Pages: |
3758 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai CZ |
Year: |
2022 |
Journal: |
Theranostics |
Title: |
Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models. |
Volume: |
12 |
Issue: |
4 |
Pages: |
1738-1755 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiang J |
Year: |
2023 |
Journal: |
Cell |
Title: |
Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies. |
Volume: |
186 |
Issue: |
16 |
Pages: |
3350-3367.e19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pietri M |
Year: |
2013 |
Journal: |
Nat Med |
Title: |
PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases. |
Volume: |
19 |
Issue: |
9 |
Pages: |
1124-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen P |
Year: |
2022 |
Journal: |
Microsc Res Tech |
Title: |
An easy brain thick-section-clearing protocol to observe antigens in the brains of neurological disease mouse models by conventional epifluorescence and confocal laser scanning microscopy. |
Volume: |
85 |
Issue: |
4 |
Pages: |
1618-1626 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu H |
Year: |
2022 |
Journal: |
MedComm (2020) |
Title: |
Integrated analyses of brain and platelet omics reveal their common altered and driven molecules in Alzheimer's disease. |
Volume: |
3 |
Issue: |
4 |
Pages: |
e180 |
|
•
•
•
•
•
|
Publication |
First Author: |
Crapser JD |
Year: |
2020 |
Journal: |
EBioMedicine |
Title: |
Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain. |
Volume: |
58 |
|
Pages: |
102919 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu D |
Year: |
2023 |
Journal: |
Mol Neurodegener |
Title: |
Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation. |
Volume: |
18 |
Issue: |
1 |
Pages: |
23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Russo ML |
Year: |
2021 |
Journal: |
Neurobiol Aging |
Title: |
Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons. |
Volume: |
106 |
|
Pages: |
207-222 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weigel TK |
Year: |
2023 |
Journal: |
Front Aging Neurosci |
Title: |
Altered circadian behavior and light sensing in mouse models of Alzheimer's disease. |
Volume: |
15 |
|
Pages: |
1218193 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo Y |
Year: |
2024 |
Journal: |
EMBO Mol Med |
Title: |
Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice. |
Volume: |
16 |
Issue: |
11 |
Pages: |
2856-2881 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daini E |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice. |
Volume: |
13 |
|
Pages: |
1082036 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roddick KM |
Year: |
2016 |
Journal: |
Chem Senses |
Title: |
Sex and Genotype Differences in Odor Detection in the 3×Tg-AD and 5XFAD Mouse Models of Alzheimer's Disease at 6 Months of Age. |
Volume: |
41 |
Issue: |
5 |
Pages: |
433-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park JS |
Year: |
2021 |
Journal: |
Acta Neuropathol Commun |
Title: |
Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease. |
Volume: |
9 |
Issue: |
1 |
Pages: |
78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiang J |
Year: |
2024 |
Journal: |
STAR Protoc |
Title: |
Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo. |
Volume: |
5 |
Issue: |
1 |
Pages: |
102788 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zenaro E |
Year: |
2015 |
Journal: |
Nat Med |
Title: |
Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin. |
Volume: |
21 |
Issue: |
8 |
Pages: |
880-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen C |
Year: |
2020 |
Journal: |
Sci Adv |
Title: |
Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model. |
Volume: |
6 |
Issue: |
31 |
Pages: |
eaba0466 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanna PP |
Year: |
2023 |
Journal: |
eNeuro |
Title: |
A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer's Disease. |
Volume: |
10 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Creighton SD |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests. |
Volume: |
9 |
Issue: |
1 |
Pages: |
57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan P |
Year: |
2016 |
Journal: |
Neuron |
Title: |
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. |
Volume: |
90 |
Issue: |
4 |
Pages: |
724-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barnham KJ |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. |
Volume: |
278 |
Issue: |
19 |
Pages: |
17401-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zirah S |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging. |
Volume: |
281 |
Issue: |
4 |
Pages: |
2151-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen GF |
Year: |
2017 |
Journal: |
Acta Pharmacol Sin |
Title: |
Amyloid beta: structure, biology and structure-based therapeutic development. |
Volume: |
38 |
Issue: |
9 |
Pages: |
1205-1235 |
|
•
•
•
•
•
|
Publication |
First Author: |
Breijyeh Z |
Year: |
2020 |
Journal: |
Molecules |
Title: |
Comprehensive Review on Alzheimer's Disease: Causes and Treatment. |
Volume: |
25 |
Issue: |
24 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
208
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang C |
Year: |
2012 |
Journal: |
Brain Res |
Title: |
MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2. |
Volume: |
1455 |
|
Pages: |
103-13 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
506
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
633
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
624
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Thy1-APPArc)M8Cagr/? |
Background: |
involves: C57BL/6 * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(NEFL-APP)#Nalb/? |
Background: |
involves: C57BL/6 * C3H |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuda S |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. |
Volume: |
28 |
Issue: |
35 |
Pages: |
8668-76 |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 2348, Yong K Kim |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1480, Yong K Kim |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Ldlr/Ldlr<+> |
Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(PRNP-APPSweInd)19959Dwst/? |
Background: |
involves: 129S6/SvEvTac * FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Prnp-ITM2B*)6Jckr/? Tg(Thy1-APP)3Somm/? |
Background: |
B6.Cg-Tg(Prnp-ITM2B*)6Jckr Tg(Thy1-APP)3Somm |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Prnp-ITM2B*)7Jckr/? Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? |
Background: |
C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Thy1-APPDutch)#Jckr/? Tg(Thy1-PSEN1*G384A)45Jckr/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Abcc1/Abcc1 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? |
Background: |
FVB.Cg-Abcc1 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hdac6/Hdac6 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? |
Background: |
involves: C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
App/App |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Shukla AK |
Year: |
2019 |
Journal: |
Glia |
Title: |
CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. |
Volume: |
67 |
Issue: |
5 |
Pages: |
844-856 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rossjohn J |
Year: |
1999 |
Journal: |
Nat Struct Biol |
Title: |
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. |
Volume: |
6 |
Issue: |
4 |
Pages: |
327-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kroker KS |
Year: |
2014 |
Journal: |
Neurobiol Aging |
Title: |
PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition. |
Volume: |
35 |
Issue: |
9 |
Pages: |
2072-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Navarro-Dorado J |
Year: |
2016 |
Journal: |
Front Neurosci |
Title: |
Vascular Dysfunction in a Transgenic Model of Alzheimer's Disease: Effects of CB1R and CB2R Cannabinoid Agonists. |
Volume: |
10 |
|
Pages: |
422 |
|
•
•
•
•
•
|
Publication |
First Author: |
Comerota MM |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Near infrared light decreases synaptic vulnerability to amyloid beta oligomers. |
Volume: |
7 |
Issue: |
1 |
Pages: |
15012 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wen GY |
Year: |
2002 |
Journal: |
Brain Res |
Title: |
Presence of hydroxysteroid dehydrogenase type 10 in amyloid plaques (APs) of Hsiao's APP-Sw transgenic mouse brains, but absence in APs of Alzheimer's disease brains. |
Volume: |
954 |
Issue: |
1 |
Pages: |
115-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukumoto H |
Year: |
2004 |
Journal: |
Am J Pathol |
Title: |
Beta-secretase activity increases with aging in human, monkey, and mouse brain. |
Volume: |
164 |
Issue: |
2 |
Pages: |
719-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas RS |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology. |
Volume: |
415 |
Issue: |
4 |
Pages: |
656-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baldassarro VA |
Year: |
2017 |
Journal: |
Dis Model Mech |
Title: |
Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes. |
Volume: |
10 |
Issue: |
5 |
Pages: |
671-678 |
|
•
•
•
•
•
|
Publication |
First Author: |
d'Uscio LV |
Year: |
2012 |
Journal: |
Cardiovasc Res |
Title: |
Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein. |
Volume: |
96 |
Issue: |
3 |
Pages: |
504-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katzav A |
Year: |
2011 |
Journal: |
Neurobiol Aging |
Title: |
Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background. |
Volume: |
32 |
Issue: |
2 |
Pages: |
272-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2014 |
Journal: |
Neurobiol Aging |
Title: |
Enhanced defense against mitochondrial hydrogen peroxide attenuates age-associated cognition decline. |
Volume: |
35 |
Issue: |
11 |
Pages: |
2552-2561 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hook VY |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein. |
Volume: |
283 |
Issue: |
12 |
Pages: |
7745-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Apelt J |
Year: |
2004 |
Journal: |
Int J Dev Neurosci |
Title: |
Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology. |
Volume: |
22 |
Issue: |
7 |
Pages: |
475-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pirici D |
Year: |
2011 |
Journal: |
Neurobiol Aging |
Title: |
Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models. |
Volume: |
32 |
Issue: |
9 |
Pages: |
1579-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wesson DW |
Year: |
2011 |
Journal: |
Behav Brain Res |
Title: |
Respiratory and sniffing behaviors throughout adulthood and aging in mice. |
Volume: |
223 |
Issue: |
1 |
Pages: |
99-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wesson DW |
Year: |
2013 |
Journal: |
Behav Brain Res |
Title: |
Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model. |
Volume: |
237 |
|
Pages: |
96-102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muche A |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells. |
Volume: |
12 |
Issue: |
6 |
Pages: |
e0178127 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim GP |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. |
Volume: |
25 |
Issue: |
12 |
Pages: |
3032-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurata T |
Year: |
2011 |
Journal: |
Neuroscience |
Title: |
Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin. |
Volume: |
197 |
|
Pages: |
358-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tajeddinn W |
Year: |
2015 |
Journal: |
Neurosci Lett |
Title: |
5-HT1B and other related serotonergic proteins are altered in APPswe mutation. |
Volume: |
594 |
|
Pages: |
137-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foley KE |
Year: |
2025 |
Journal: |
J Neurosci |
Title: |
Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-Aβ Antibody-Injected Cortex. |
Volume: |
45 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2012 |
Journal: |
Neurobiol Aging |
Title: |
Cognitive impairment and increased Aβ levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H(2)O(2). |
Volume: |
33 |
Issue: |
2 |
Pages: |
432.e15-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giunta B |
Year: |
2010 |
Journal: |
Neurosci Lett |
Title: |
Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice. |
Volume: |
471 |
Issue: |
3 |
Pages: |
134-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerenu G |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Early cognitive stimulation compensates for memory and pathological changes in Tg2576 mice. |
Volume: |
1832 |
Issue: |
6 |
Pages: |
837-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elesber AA |
Year: |
2006 |
Journal: |
Neurobiol Aging |
Title: |
Bosentan preserves endothelial function in mice overexpressing APP. |
Volume: |
27 |
Issue: |
3 |
Pages: |
446-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pedersen WA |
Year: |
1999 |
Journal: |
J Mol Neurosci |
Title: |
Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease. |
Volume: |
13 |
Issue: |
1-2 |
Pages: |
159-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bernardo A |
Year: |
2007 |
Journal: |
Neurobiol Aging |
Title: |
Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. |
Volume: |
28 |
Issue: |
8 |
Pages: |
1195-205 |
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•
•
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•
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Publication |
First Author: |
Good MA |
Year: |
2007 |
Journal: |
Behav Neurosci |
Title: |
Impaired "episodic-like" object memory in adult APPswe transgenic mice. |
Volume: |
121 |
Issue: |
2 |
Pages: |
443-8 |
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•
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•
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Publication |
First Author: |
Spires TL |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. |
Volume: |
25 |
Issue: |
31 |
Pages: |
7278-87 |
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•
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Publication |
First Author: |
McMillan LE |
Year: |
2011 |
Journal: |
Neurosci Lett |
Title: |
Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model. |
Volume: |
502 |
Issue: |
3 |
Pages: |
201-8 |
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•
•
•
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Publication |
First Author: |
Yamamoto M |
Year: |
2005 |
Journal: |
Am J Pathol |
Title: |
Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. |
Volume: |
166 |
Issue: |
5 |
Pages: |
1475-85 |
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Publication |
First Author: |
Lachen-Montes M |
Year: |
2019 |
Journal: |
Front Aging Neurosci |
Title: |
Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease. |
Volume: |
11 |
|
Pages: |
141 |
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•
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•
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Publication |
First Author: |
Li X |
Year: |
2013 |
Journal: |
Neurobiol Dis |
Title: |
Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. |
Volume: |
50 |
|
Pages: |
127-34 |
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•
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•
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Publication |
First Author: |
Gil-Bea FJ |
Year: |
2012 |
Journal: |
Neurobiol Dis |
Title: |
Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice. |
Volume: |
48 |
Issue: |
3 |
Pages: |
439-46 |
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•
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•
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Publication |
First Author: |
He K |
Year: |
2021 |
Journal: |
Aging Cell |
Title: |
Adiponectin alleviated Alzheimer-like pathologies via autophagy-lysosomal activation. |
Volume: |
20 |
Issue: |
12 |
Pages: |
e13514 |
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•
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HT Experiment |
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Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Allele |
Name: |
transgene insertion B, William E Van Nostrand |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Allele |
Name: |
transgene insertion, David R Borchelt |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Inserted expressed sequence |
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Genotype |
Symbol: |
Nos2/Nos2 Tg(APPSWE)2576Kha/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Genotype |
Symbol: |
Ccr2/Ccr2 Tg(APPSWE)2576Kha/? |
Background: |
involves: 129S4/SvJae * C57BL/6 * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Genotype |
Symbol: |
Lrp1/Lrp1 Tg(APP695)3Dbo/? Tg(PSEN1)5Dbo/? Tg(Tagln-cre)1Her/? |
Background: |
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
•
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Publication |
First Author: |
Wang Y |
Year: |
2004 |
Journal: |
Mol Cell |
Title: |
The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. |
Volume: |
15 |
Issue: |
3 |
Pages: |
343-53 |
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•
•
•
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Publication |
First Author: |
Dulubova I |
Year: |
2004 |
Journal: |
Biochemistry |
Title: |
Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein. |
Volume: |
43 |
Issue: |
30 |
Pages: |
9583-8 |
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•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the cytoplasmic C-terminal domain of calsyntenin (CLSTN) proteins 1, 2 and 3 (also known as alcadein-alpha, beta and gamma). These are postsynaptic Ca2-binding proteins, evolutionarily conserved type I membrane proteins. CLSTN (also known as Alc) forms a tripartite complex with APP (amyloid beta-protein precursor) and X11L (a neuron-specific adaptor protein) in brain; this complex stabilizes both APP and CLSTN proteins metabolically. Deficiencies in the X11L-mediated interaction between CLSTN and APP and/or CTFbeta enhances the production of amyloid beta-protein and have been linked to the development or progression of Alzheimer's disease []. Moreover, CLSTN1 strongly associates with kinesin-1 light chains (KLC1) and acts as a cargo that regulates kinesin-1 function. It may affect the transport of APP-containing vesicles by kinesin-1 []. This domain includes the WD motifs required for KLC1 interaction (although one WD motif is sufficient), and the NP motif []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
315
 |
Fragment?: |
false |
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•
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•
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Publication |
First Author: |
Reddy PH |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease. |
Volume: |
26 |
Issue: |
8 |
Pages: |
1483-1496 |
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•
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•
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Publication |
First Author: |
Cheng F |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. |
Volume: |
286 |
Issue: |
31 |
Pages: |
27559-72 |
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•
•
•
•
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Publication |
First Author: |
Dong H |
Year: |
2008 |
Journal: |
Neuroscience |
Title: |
Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice. |
Volume: |
155 |
Issue: |
1 |
Pages: |
154-63 |
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•
•
•
•
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Publication |
First Author: |
Reddy AP |
Year: |
2021 |
Journal: |
Hum Mol Genet |
Title: |
Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer's disease. |
Volume: |
30 |
Issue: |
9 |
Pages: |
789-810 |
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•
•
•
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Publication |
First Author: |
Münch G |
Year: |
2003 |
Journal: |
J Neurochem |
Title: |
Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology. |
Volume: |
86 |
Issue: |
2 |
Pages: |
283-9 |
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•
•
•
•
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Publication |
First Author: |
Manczak M |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. |
Volume: |
15 |
Issue: |
9 |
Pages: |
1437-49 |
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•
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•
•
•
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Publication |
First Author: |
Kim JY |
Year: |
2018 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Distinct amyloid precursor protein processing machineries of the olfactory system. |
Volume: |
495 |
Issue: |
1 |
Pages: |
533-538 |
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