Rho guanine nucleotide exchange factor 25 (ARHGEF25, GEFT), also known as p63RhoGEF, is a RhoA-specific guanine nucleotide exchange factor. It is found in vascular smooth muscle (SM) and may play a role in selective targetingof RhoA-mediated regulation of basal blood pressure through agonists that couple through G alpha(q/11) [, ]. It is thought to be involved in muscle regeneration, myogenesis, and adipogenesis regulation by modulating mesenchymal cell fate decisions [].
