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Search results 801 to 900 out of 996 for Ace2

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Hits by Pathway

Hits by Strain

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Type Details Score
Strain
MGI:6877065 | C57BL/6J-Gt(ROSA)26Sor<em25(KRT18-ACE2)Mvw>/MvwJ
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6763024 | C57BL/6J-Ace2<em1Guru>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Ace2<em2.1(ACE2)Synbl> | MGI:7261383
Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 2.1, Synbal
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Allele
Ace2<em1(ACE2)Synbl> | MGI:7261373
Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Synbal
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Protein
Q8R0I0
Organism: Mus musculus/domesticus
Length: 805  
Fragment?: false
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Protein
Q9D836
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
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Protein
F6X479
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: true
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Protein
Q3UXR1
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: true
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Protein
C7ECU2
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: true
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Protein
Q3URC9
Organism: Mus musculus/domesticus
Length: 805  
Fragment?: false
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Strain
MGI:6865656 | NOD.Cg-Prkdc<scid> Il2rg<tm1Wjl> Ace2<tm1(ACE2)Dwnt>/J
Attribute String: congenic, mutant strain, targeted mutation, spontaneous mutation
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Publication
17108019 | J:117824
First Author: Tseng CT
Year: 2007
Journal: J Virol
Title: Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor.
Volume: 81
Issue: 3
Pages: 1162-73
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Strain
MGI:6865648 | B6.Cg-Tg(FCGRT)32Dcr Fcgrt<tm1Dcr> Ace2<em4Lutzy>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, transgenic, targeted mutation
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Strain
MGI:7261384 | C(Cg)-Ace2<em2.1(ACE2)Synbl>/J
Attribute String: endonuclease-mediated mutation, mutant strain
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Strain
MGI:7261376 | C57BL/6J-Ace2<em1(ACE2)Synbl>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Domain
IPR044366 | Spike_S1_RBD_SARS-CoV-2
Type: Domain
Description: The CoV Spike (S) protein is an envelope glycoprotein that plays the most important role in viral attachment, fusion, and entry into host cells, and serves as a major target for the development of neutralizing antibodies, inhibitors of viral entry, and vaccines. It is synthesised as a precursor protein that is cleaved into an N-terminal S1 subunit (~700 amino acids) and a C-terminal S2 subunit (~600 amino acids) that mediates attachment and membrane fusion, respectively. Three S1/S2 heterodimers assemble to form a trimer spike protruding from the viral envelope. The S1 subunit contains a receptor-binding domain (RBD), while the S2 subunit contains a hydrophobic fusion peptide and two heptad repeat regions. S1 contains two structurally independent domains, the N-terminal domain (NTD) and the C-terminal domain (C-domain). Depending on the virus, either the NTD or the C-domain can serve as the receptor-binding domain (RBD). Most CoVs, including SARS-CoV-2, SARS-CoV, and MERS-CoV use the C-domain to bind their receptors. However, CoV such as mouse hepatitis virus (MHV) uses the NTD to bind its receptor, mouse carcinoembryonic antigen related cell adhesion molecule 1a (mCEACAM1a). The S1 NTD contributes to the Spike trimer interface [, , , , ].This entry represents the RBD domain of Spike protein S1 subunit from SARS-CoV-2, which binds the extracellular peptidase domain of angiotensin-converting enzyme 2 (ACE2). It has been shown that the receptor binding induces the dissociation of the S1 with ACE2, prompting the S2 to transit from a metastable pre-fusion to a more-stable post-fusion state that is essential for membrane fusion [, , , ]. Recent structures revealed that only a single RBD is necessary for ACE2 binding and it is not yet clear if protrusion of the RBD from the S protein trimer is necessary for binding to ACE2 or the interconversion of the RBD between closed and open states represents an intrinsic property of the S protein []. During the pandemic, many amino acid substitutions have been reported in the S1 segment, being D614G the most commonly observed amino acid change from the reference sequence. Although it was estimated to be slightly destabilizing, it was hypothesized that it increases virus infectivity by increasing the total amount of S protein incorporated into virions. The most prevalent RBD substitution in the RBD is the T478I, located in a portion of a loop that contacts ACE2. However, most substitutions in the interface with ACE2 appear to be neutral or destabilizing, with none improving binding affinity [].SARS-CoV-2 RBD has a core formed by a twisted five-stranded antiparallel β-sheet (β1-7) with short helices and loops connecting them. Between the β4 and β7 strands in the core, there is an extended insertion, the receptor-binding motif (RBM), containing the short β5 and β6 strands, α4 and α5 helices and loops, which contains most of the contacting residues for binding to ACE2. There are nine cysteine residues in the RBD, eight of which form four pairs of disulfide bonds. Among these four pairs, three are in the core which help to stabilise the β-sheet structure, while the remaining pair connects the loops in the distal end of the RBM [].
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Publication
18026570 | -
First Author: Fraga-Silva RA
Year: 2008
Journal: Mol Med
Title: The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets.
Volume: 14
Issue: 1-2
Pages: 28-35
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Publication
8513325 | -
First Author: Ward K
Year: 1993
Journal: Nat Genet
Title: A molecular variant of angiotensinogen associated with preeclampsia.
Volume: 4
Issue: 1
Pages: 59-61
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Publication
10969042 | -
First Author: Donoghue M
Year: 2000
Journal: Circ Res
Title: A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.
Volume: 87
Issue: 5
Pages: E1-9
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Publication
2476171 | -
First Author: Ehlers MR
Year: 1989
Journal: Biochemistry
Title: Angiotensin-converting enzyme: new concepts concerning its biological role.
Volume: 28
Issue: 13
Pages: 5311-8
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Publication
15010016 | -
First Author: Fuchs S
Year: 2004
Journal: Curr Hypertens Rep
Title: Newly recognized physiologic and pathophysiologic actions of the angiotensin-converting enzyme.
Volume: 6
Issue: 2
Pages: 124-8
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Publication
1132082 | -
First Author: Goodfriend TL
Year: 1975
Journal: Circ Res
Title: Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.
Volume: 36
Issue: 6 Suppl 1
Pages: 38-48
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Publication
23 | -
First Author: Flohr H
Year: 1975
Journal: Arzneimittelforschung
Title: Effect of etafenone on total and regional myocardial blood flow.
Volume: 25
Issue: 9
Pages: 1400-3
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Publication
9 | -
First Author: Marniemi J
Year: 1975
Journal: Biochem Pharmacol
Title: Radiochemical assay of glutathione S-epoxide transferase and its enhancement by phenobarbital in rat liver in vivo.
Volume: 24
Issue: 17
Pages: 1569-72
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Publication
467805 | -
First Author: Agardh CD
Year: 1979
Journal: Diabetes
Title: The effect of pronounced hypoglycemia on monoamine metabolism in rat brain.
Volume: 28
Issue: 9
Pages: 804-9
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Publication
4675 | -
First Author: Lewis J
Year: 1976
Journal: J Stud Alcohol
Title: Washington report.
Volume: 37
Issue: 3
Pages: 409-14
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Protein Domain
IPR000227 | Angiotensinogen
Type: Family
Description: Angiotensinogen is a component of the renin-angiotensin system (RAS), a hormone system that regulates blood pressure and fluid balance. It is also known as the renin substrate, and is a non-inhibitory member of the serpin family of proteinase inhibitors (MEROPS inhibitor family I4, clan ID, MEROPS identifier I04.953).Angiotensinogen is catalytically cleaved by renin to produce angiotensin I in response to lowered blood pressure. Angiotensin converting enzyme (ACE), subsequently removes a dipeptide to produce angiotensin II, the physiologically active peptide, which functions in the regulation of volume and mineral balance of body fluids [, ]. Angiotensin I and angiotensin II can be further processed to generate angiotensin III, which stimulates aldosterone release [], and angiotensin IV. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 []and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4 [, ].Angiotensinogen is synthesised in the liver and secreted in plasma [, , , ]. Angiotensinogen appears to be associated with a predisposition to essential hypertension; it is also associated with pregnancy-induced hypertension (pih) (preeclampsia), a heterogeneous disorder that complicates 5-7% of all pregnancies and remains a leading cause of maternal, foetal and neonatal morbidity and mortality [].The entry represents the full precursor sequence of angiotensinogen.
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Protein Domain
IPR033834 | Angiotensinogen_serpin_dom
Type: Domain
Description: Angiotensinogen is a component of the renin-angiotensin system (RAS), a hormone system that regulates blood pressure and fluid balance. It is also known as the renin substrate, and is a non-inhibitory member of the serpin family of proteinase inhibitors (MEROPS inhibitor family I4, clan ID, MEROPS identifier I04.953).Angiotensinogen is catalytically cleaved by renin to produce angiotensin I in response to lowered blood pressure. Angiotensin converting enzyme (ACE), subsequently removes a dipeptide to produce angiotensin II, the physiologically active peptide, which functions in the regulation of volume and mineral balance of body fluids [, ]. Angiotensin I and angiotensin II can be further processed to generate angiotensin III, which stimulates aldosterone release [], and angiotensin IV. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 []and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4 [, ].Angiotensinogen is synthesised in the liver and secreted in plasma [, , , ]. Angiotensinogen appears to be associated with a predisposition to essential hypertension; it is also associated with pregnancy-induced hypertension (pih) (preeclampsia), a heterogeneous disorder that complicates 5-7% of all pregnancies and remains a leading cause of maternal, foetal and neonatal morbidity and mortality [].This entry represents the serpin domain of angiotensinogen.
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Publication
18424768 | J:259115
First Author: Kowalczuk S
Year: 2008
Journal: FASEB J
Title: A protein complex in the brush-border membrane explains a Hartnup disorder allele.
Volume: 22
Issue: 8
Pages: 2880-7
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Publication
26240152 | J:257334
First Author: Fairweather SJ
Year: 2015
Journal: J Biol Chem
Title: Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
Volume: 290
Issue: 40
Pages: 24308-25
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Publication
17167413 | J:117490
First Author: Danilczyk U
Year: 2006
Journal: Nature
Title: Essential role for collectrin in renal amino acid transport.
Volume: 444
Issue: 7122
Pages: 1088-91
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Publication
32553273 | J:290258
     
First Author: Hassan AO
Year: 2020
Journal: Cell
Title: A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.
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Publication
33330862 | J:300213
     
First Author: Spalinger MR
Year: 2020
Journal: bioRxiv
Title: Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells.
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Publication
34237283 | J:335899
First Author: Jennewein MF
Year: 2021
Journal: Cell Rep
Title: Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects.
Volume: 36
Issue: 2
Pages: 109353
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Publication
34957381 | J:335920
First Author: Iwanaga N
Year: 2022
Journal: iScience
Title: ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV-2.
Volume: 25
Issue: 1
Pages: 103670
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Publication
34919799 | J:335935
First Author: Joyce MG
Year: 2021
Journal: Cell Rep
Title: SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity.
Volume: 37
Issue: 12
Pages: 110143
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Publication
35134331 | J:335932
First Author: Stolp B
Year: 2022
Journal: Cell Rep
Title: SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models.
Volume: 38
Issue: 7
Pages: 110387
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Publication
37491352 | J:338561
First Author: Robertson SJ
Year: 2023
Journal: Nat Commun
Title: Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.
Volume: 14
Issue: 1
Pages: 4481
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Publication
36508467 | J:333745
First Author: Parray HA
Year: 2022
Journal: PLoS Pathog
Title: A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern.
Volume: 18
Issue: 12
Pages: e1010994
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Publication
35986481 | J:335980
First Author: Appelberg S
Year: 2022
Journal: EMBO Mol Med
Title: A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cells.
Volume: 14
Issue: 10
Pages: e15821
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Publication
36580912 | J:332438
First Author: Wu CT
Year: 2023
Journal: Cell
Title: SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming.
Volume: 186
Issue: 1
Pages: 112-130.e20
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Publication
33433624 | J:302314
 
First Author: Song E
Year: 2021
Journal: J Exp Med
Title: Neuroinvasion of SARS-CoV-2 in human and mouse brain.
Volume: 218
Issue: 3
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Publication
35757773 | J:334874
 
First Author: Hedges JF
Year: 2022
Journal: Front Immunol
Title: An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model.
Volume: 13
Pages: 918881
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Publication
35523172 | J:325089
First Author: Chong Z
Year: 2022
Journal: Cell Rep
Title: Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron.
Volume: 39
Issue: 6
Pages: 110799
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Publication
35839775 | J:331767
First Author: Chen IP
Year: 2022
Journal: Cell Rep
Title: Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.
Volume: 40
Issue: 3
Pages: 111088
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Publication
32798445 | J:294058
First Author: Case JB
Year: 2020
Journal: Cell Host Microbe
Title: Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice.
Volume: 28
Issue: 3
Pages: 465-474.e4
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Publication
33257679 | J:300960
First Author: Oladunni FS
Year: 2020
Journal: Nat Commun
Title: Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Volume: 11
Issue: 1
Pages: 6122
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Publication
34338634 | J:336015
   
First Author: Ye G
Year: 2021
Journal: Elife
Title: The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates.
Volume: 10
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Publication
35090597 | J:335933
First Author: Konrath KM
Year: 2022
Journal: Cell Rep
Title: Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection.
Volume: 38
Issue: 5
Pages: 110318
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Publication
34273271 | J:335929
First Author: Bertoglio F
Year: 2021
Journal: Cell Rep
Title: A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations.
Volume: 36
Issue: 4
Pages: 109433
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Publication
36155667 | J:330016
First Author: Bishop CR
Year: 2022
Journal: PLoS Pathog
Title: Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression.
Volume: 18
Issue: 9
Pages: e1010867
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Publication
35587469 | J:335948
First Author: Belouzard S
Year: 2022
Journal: PLoS Pathog
Title: Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice.
Volume: 18
Issue: 5
Pages: e1010498
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Publication
- | J:321906
     
First Author: Bishop CR
Year: 2022
Journal: bioRxiv
Title: Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression.
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Publication
35677392 | J:335951
First Author: Ding S
Year: 2022
Journal: iScience
Title: VE607 stabilizes SARS-CoV-2 Spike in the "RBD-up" conformation and inhibits viral entry.
Volume: 25
Issue: 7
Pages: 104528
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Publication
33811809 | J:335894
First Author: Mills RJ
Year: 2021
Journal: Cell
Title: BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Volume: 184
Issue: 8
Pages: 2167-2182.e22
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Publication
36494335 | J:335987
First Author: Biering SB
Year: 2022
Journal: Nat Commun
Title: SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling.
Volume: 13
Issue: 1
Pages: 7630
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Publication
33441437 | J:303898
First Author: Joag V
Year: 2021
Journal: J Immunol
Title: Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses.
Volume: 206
Issue: 5
Pages: 931-935
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Publication
36514310 | J:335990
First Author: Chen Y
Year: 2023
Journal: iScience
Title: Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.
Volume: 26
Issue: 1
Pages: 105783
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Publication
37015225 | J:337324
First Author: Abdelfattah AS
Year: 2023
Journal: Neuron
Title: Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator.
Volume: 111
Issue: 10
Pages: 1547-1563.e9
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Publication
35879412 | J:331758
First Author: Biering SB
Year: 2022
Journal: Nat Genet
Title: Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.
Volume: 54
Issue: 8
Pages: 1078-1089
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Publication
32643603 | J:291881
First Author: Sun J
Year: 2020
Journal: Cell
Title: Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment.
Volume: 182
Issue: 3
Pages: 734-743.e5
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Publication
32511326 | J:291432
     
First Author: Sajuthi SP
Year: 2020
Journal: bioRxiv
Title: Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium.
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Publication
32332765 | J:292223
First Author: Lei C
Year: 2020
Journal: Nat Commun
Title: Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig.
Volume: 11
Issue: 1
Pages: 2070
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Publication
33436573 | J:300887
First Author: Fougeroux C
Year: 2021
Journal: Nat Commun
Title: Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity.
Volume: 12
Issue: 1
Pages: 324
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Publication
32970990 | J:298611
First Author: Du S
Year: 2020
Journal: Cell
Title: Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
Volume: 183
Issue: 4
Pages: 1013-1023.e13
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Publication
33251489 | J:319699
First Author: Fodoulian L
Year: 2020
Journal: iScience
Title: SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain.
Volume: 23
Issue: 12
Pages: 101839
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Publication
33758862 | J:303203
     
First Author: Zhuang X
Year: 2021
Journal: bioRxiv
Title: The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells.
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Publication
34815389 | J:315174
First Author: Yamaguchi T
Year: 2021
Journal: Nat Commun
Title: ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury.
Volume: 12
Issue: 1
Pages: 6791
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Publication
34921308 | J:326341
First Author: Sefik E
Year: 2022
Journal: Nat Biotechnol
Title: A humanized mouse model of chronic COVID-19.
Volume: 40
Issue: 6
Pages: 906-920
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Publication
34545347 | J:341699
First Author: Zhuang X
Year: 2021
Journal: iScience
Title: The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells.
Volume: 24
Issue: 10
Pages: 103144
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Publication
- | J:311920
     
First Author: Almanza G
Year: 2021
Journal: bioRxiv
Title: Structure-selected RBM immunogens prime polyclonal memory response that neutralize SARS-CoV-2 variants of concern.
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Publication
- | J:321890
     
First Author: Du W
Year: 2022
Journal: bioRxiv
Title: An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants.
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Protein
P09470
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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Protein
D0G895
Organism: Mus musculus/domesticus
Length: 737  
Fragment?: false
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Protein
Q3U3Q7
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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Protein
F6QCP8
Organism: Mus musculus/domesticus
Length: 1016  
Fragment?: true
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Protein
Q7TSV8
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
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Protein
Q8K233
Organism: Mus musculus/domesticus
Length: 1015  
Fragment?: true
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Protein
Q5XK22
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: true
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Protein
Q61265
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
Q3TU20
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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Publication
9629165 | -
 
First Author: Isaac RE
Year: 1998
Journal: Ann N Y Acad Sci
Title: Toward a role for angiotensin-converting enzyme in insects.
Volume: 839
Pages: 288-92
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Publication
1851160 | -
First Author: Wei L
Year: 1991
Journal: J Biol Chem
Title: The two homologous domains of human angiotensin I-converting enzyme are both catalytically active.
Volume: 266
Issue: 14
Pages: 9002-8
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Publication
12633854 | -
First Author: Kim HM
Year: 2003
Journal: FEBS Lett
Title: Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril.
Volume: 538
Issue: 1-3
Pages: 65-70
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Publication
17439247 | -
First Author: Corradi HR
Year: 2007
Journal: Biochemistry
Title: The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.
Volume: 46
Issue: 18
Pages: 5473-8
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Publication
18457420 | -
First Author: Watermeyer JM
Year: 2008
Journal: Biochemistry
Title: Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme.
Volume: 47
Issue: 22
Pages: 5942-50
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Protein Domain
IPR001548 | Peptidase_M2
Type: Family
Description: This group of metallopeptidases belong to the MEROPS peptidase family M2 (clan MA(E)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA. The catalytic residues and zinc ligands have been identified, the zinc ion being ligated to two His residues within the motif HEXXH, showing that the enzyme belongs to the glu-zincin sub-group of metalloproteases [].Peptidyl-dipeptidase A (angiotensin-converting enzyme or ACE, ) is a mammalian enzyme responsible for cleavage of dipeptides from the C-termini of proteins, notably converting decapeptide angiotensin I to the octapeptide angiotensin II []. The enzyme exists in two differentially transcribed forms, the most common of which is from lung endothelium; this contains two homologous domains that have arisen by gene duplication []. The testis-specific form contains only the C-terminal domain, arising from a duplicated promoter region present in intron 12 of the gene []. Both enzymatic forms are membrane proteins that are anchored by means of a C-terminal transmembrane domain. Both domains of the endothelial enzyme are active, but have differing kinetic constants [, ]. ACE is well-known as a key part of the renin-angiotensin system that regulates blood pressure and ACE inhibitors are important for the treatment of hypertension [, ].An ACE homologue, ACE2 (MEROPS identifier M02.006), has been identified in humans that differs from ACE; it preferentially removes carboxy-terminal hydrophobic or basic amino acids and appears to be important in cardiac function [, ]. ACE3 is a non-peptidase homologue included in this entry which lacks Glu378 in the HEXXH motif.A number of insect enzymes have been shown to be similar to peptidyl-dipeptidase A, these containing a single catalytic domain [, ].
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Publication
26868298 | J:283999
First Author: Zumla A
Year: 2016
Journal: Nat Rev Drug Discov
Title: Coronaviruses - drug discovery and therapeutic options.
Volume: 15
Issue: 5
Pages: 327-47
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Publication
37307197 | J:338419
First Author: Castanheira FVS
Year: 2023
Journal: Blood Adv
Title: Intravital imaging of three different microvascular beds in SARS-CoV-2-infected mice.
Volume: 7
Issue: 15
Pages: 4170-4181
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Publication
32075877 | -
First Author: Wrapp D
Year: 2020
Journal: Science
Title: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Volume: 367
Issue: 6483
Pages: 1260-1263
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Publication
32132184 | -
First Author: Yan R
Year: 2020
Journal: Science
Title: Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.
Volume: 367
Issue: 6485
Pages: 1444-1448
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Publication
26184451 | J:284000
 
First Author: Gretebeck LM
Year: 2015
Journal: Curr Opin Virol
Title: Animal models for SARS and MERS coronaviruses.
Volume: 13
Pages: 123-9
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Strain
MGI:7261379 | C57BL/6J-Tmprss2<em1(TMPRSS2)Synbl> Ace2<em1(ACE2)Synbl>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7261387 | C(Cg)-Tmprss2<em2.1(TMPRSS2)Synbl> Ace2<em2.1(ACE2)Synbl>/J
Attribute String: endonuclease-mediated mutation, mutant strain
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Publication
32225175 | -
First Author: Shang J
Year: 2020
Journal: Nature
Title: Structural basis of receptor recognition by SARS-CoV-2.
Volume: 581
Issue: 7807
Pages: 221-224
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Publication
28371822 | J:261072
First Author: Sato T
Year: 2017
Journal: Cardiovasc Res
Title: ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.
Volume: 113
Issue: 7
Pages: 760-769
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Publication
37310920 | J:341033
First Author: Strine MS
Year: 2023
Journal: PLoS Biol
Title: DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
Volume: 21
Issue: 6
Pages: e3002097
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Publication
24814023 | J:212910
 
First Author: Zheng J
Year: 2014
Journal: Neuroscience
Title: Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction.
Volume: 273
Pages: 39-51
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Publication
22921883 | J:286379
First Author: Guimarães GG
Year: 2012
Journal: Peptides
Title: Exercise induces renin-angiotensin system unbalance and high collagen expression in the heart of Mas-deficient mice.
Volume: 38
Issue: 1
Pages: 54-61
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Publication
31189595 | J:277411
First Author: Wang W
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.
Volume: 116
Issue: 26
Pages: 13006-13015
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