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Search results 1 to 94 out of 94 for Guf1

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Hits by Strain

Hits by Category

Type Details Score
Gene
60558 | GUF1
Type: gene
Organism: human
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Gene
553030 | guf1
Type: gene
Organism: zebrafish
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Gene
703333 | GUF1
Type: gene
Organism: macaque, rhesus
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Gene
100489624 | guf1
Type: gene
Organism: frog, western clawed
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Gene
422773 | GUF1
Type: gene
Organism: chicken
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Gene
305317 | Guf1
Type: gene
Organism: rat
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Gene
482127 | GUF1
Type: gene
Organism: dog, domestic
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Gene
461197 | GUF1
Type: gene
Organism: chimpanzee
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Gene
522459 | GUF1
Type: gene
Organism: cattle
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Protein Coding Gene
MGI:2140726 | Guf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27065197 | J:333298
First Author: Gao Y
Year: 2016
Journal: Nat Struct Mol Biol
Title: Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis.
Volume: 23
Issue: 5
Pages: 441-9
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Protein Coding Gene
MGP_129S1SvImJ_G0029603 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029519 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030034 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029378 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029406 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028435 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017055 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_CAROLIEiJ_G0027274 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_AJ_G0029571 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029580 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2140726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029418 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029503 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028791 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_SPRETEiJ_G0028269 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
18442968 | -
First Author: Bauerschmitt H
Year: 2008
Journal: J Biol Chem
Title: The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions.
Volume: 283
Issue: 25
Pages: 17139-46
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Protein Domain
IPR027518 | GUFP
Type: Family
Description: Elongation factor 4, also known as ribosomal back-translocase LepA, is present in bacteria and mitochondria, and is required for accurate and efficient protein synthesis under certain stress conditions []. The yeast counterpart of LepA is known as GUF1 []. GUF1 promotes protein synthesis and acts as a fidelity factor of the translation reaction, by catalysing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.This entry represents translation factor GUF1 homologues from plants and cyanobacteria (chloroplastic and from organellar chromatophores).
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Gene
100381110 | guf1.L
Type: gene
Organism: frog, African clawed
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Allele
Guf1<+> | MGI:3613698
 
Name: GUF1 homolog, GTPase; wild type
Allele Type: Not Specified
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Publication
17110332 | -
First Author: Qin Y
Year: 2006
Journal: Cell
Title: The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome.
Volume: 127
Issue: 4
Pages: 721-33
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Allele
Guf1<em1(IMPC)J> | MGI:7450840
Name: GUF1 homolog, GTPase; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Guf1<em1Gpt> | MGI:7462144
Name: GUF1 homolog, GTPase; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:7450842 | C57BL/6NJ-Guf1<em1(IMPC)J>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Guf1<em1Smoc> | MGI:7623922
Name: GUF1 homolog, GTPase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Guf1<tm1e(KOMP)Wtsi> | MGI:4841183
Name: GUF1 homolog, GTPase; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Guf1<Gt(OST297193)Lex> | MGI:4269452
 
Name: GUF1 homolog, GTPase; gene trap OST297193, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Guf1<em4Gpt> | MGI:7300033
Name: GUF1 homolog, GTPase; endonuclease-mediated mutation 4, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Guf1<tm1a(KOMP)Wtsi> | MGI:4841244
Name: GUF1 homolog, GTPase; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Protein
Q8C3X4
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Strain
MGI:7469182 | C57BL/6JGpt-Guf1<em1Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Guf1<tm1.1Nju> | MGI:7439318
Name: GUF1 homolog, GTPase; targeted mutation 1.1, Model Animal Research Center of Nanjing University
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:7624195 | C57BL/6J-Guf1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Guf1<tm1Nju> | MGI:7439317
Name: GUF1 homolog, GTPase; targeted mutation 1, Model Animal Research Center of Nanjing University
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Protein
Q8C3X4-2
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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DO Term
DOID:0080427 | developmental and epileptic encephalopathy 40
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Genotype
Genotype
Symbol: Guf1/Guf1
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Guf1/Guf1 Alpl/Alpl<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR038363 | LepA_C_sf
Type: Homologous_superfamily
Description: The elongation factor 4 (LepA or GUF1 in Saccaromyces) is a GTP-binding membrane protein related to EF-G and EF-Tu. LepA is a noncanonical GTPase that has an unknown function. It is highly conserved and present in bacteria, mitochondria, and chloroplasts []. LepA contains domains that are homologous to EF-G domain I, II, III, V. However, it also contains a C-terminal domain (CTD) that is not homologous to any region in EF-G. This entry represents the unique C-terminal region of LepA []. The CTD of LepA may play a primary role in back translocation by providing additional binding interactions with a back-translocated tRNA [].
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Protein Domain
IPR006297 | EF-4
Type: Family
Description: Elongation factor 4, also known as ribosomal back-translocase LepA, is required for accurate and efficient protein synthesis under certain stress conditions. Its function is not clear. However, it may act as a fidelity factor of the translation reaction, by catalysing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly [, ]. Elongation factor 4 binds to ribosomes in a GTP-dependent manner. The eukaryotic homologue is known as GUF1 and promotes protein synthesis in chloroplasts and mitochondria [].
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Protein Domain
IPR013842 | LepA_CTD
Type: Domain
Description: The elongation factor 4 (LepA or GUF1 in Saccaromyces) is a GTP-binding membrane protein related to EF-G and EF-Tu. LepA is a noncanonical GTPase that has an unknown function. It is highly conserved and present in bacteria, mitochondria, and chloroplasts []. LepA contains domains that are homologous to EF-G domain I, II, III, V. However, it also contains a C-terminal domain (CTD) that is not homologous to any region in EF-G. This entry represents the unique C-terminal region of LepA []. The CTD of LepA may play a primary role in back translocation by providing additional binding interactions with a back-translocated tRNA [].
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Publication
20045415 | -
First Author: Liu H
Year: 2010
Journal: J Mol Biol
Title: Interrupted catalysis: the EF4 (LepA) effect on back-translocation.
Volume: 396
Issue: 4
Pages: 1043-52
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Publication
28320876 | -
 
First Author: Heller JLE
Year: 2017
Journal: Mol Cell Biol
Title: Taking a Step Back from Back-Translocation: an Integrative View of LepA/EF4's Cellular Function.
Volume: 37
Issue: 12
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Protein Domain
IPR035654 | LepA_IV
Type: Domain
Description: Elongation factor 4, also known as ribosomal back-translocase LepA, is required for accurate and efficient protein synthesis under certain stress conditions. Its function is not clear. However, it may act as a fidelity factor of the translation reaction, by catalysing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly [, ]. Elongation factor 4 binds to ribosomes in a GTP-dependent manner. The eukaryotic homologue is known as GUF1 and promotes protein synthesis in chloroplasts and mitochondria [].EF4 has six domains, of which four (I, II, III, and V) are homologous to corresponding domains in EF-G [, , ]. This entry represents domain IV of EF4, homologous to domain V of EF-G.
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Publication
18362332 | -
First Author: Evans RN
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The structure of LepA, the ribosomal back translocase.
Volume: 105
Issue: 12
Pages: 4673-8
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Publication
25104389 | -
First Author: Gagnon MG
Year: 2014
Journal: Science
Title: Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome.
Volume: 345
Issue: 6197
Pages: 684-7
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Protein
G3UWY0
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: true
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Protein
A0A0J9YUM0
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
F6ZM03
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: true
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Protein
Q8C8D6
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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