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Search results 1101 to 1147 out of 1147 for Notch3

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Type

Details

Score

Protein Domain

IPR046369 | MAML1-3

Type:

Family

Description:

This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.

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Protein Domain

IPR019082 | Mastermind-like_N

Type:

Domain

Description:

This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.

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Protein Coding Gene

MGI:95294 | Egfr

Type:	protein_coding_gene
Organism:	mouse, laboratory

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Protein

Q01279

Organism:	Mus musculus/domesticus
Length:	1210
Fragment?:	false

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Publication

33875602 | J:325198

First Author:	Dabertrand F
Year:	2021
Journal:	Proc Natl Acad Sci U S A
Title:	PIP₂ corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity.
Volume:	118
Issue:	17

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Publication

35202003 | J:323882

First Author:	Oka F
Year:	2022
Journal:	J Clin Invest
Title:	CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis.
Volume:	132
Issue:	8

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Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor Notch3/Notch3<+>
Background:	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Zygosity:	cn
Has Mutant Allele:	true

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Publication

30226866 | J:266199

First Author:	Huang S
Year:	2018
Journal:	PLoS Biol
Title:	Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.
Volume:	16
Issue:	9
Pages:	e2005233

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Publication

21118965 | J:166963

First Author:	Sullivan JP
Year:	2010
Journal:	Cancer Res
Title:	Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Volume:	70
Issue:	23
Pages:	9937-48

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Publication

21743488 | J:181067

First Author:	Pradeep CR
Year:	2012
Journal:	Oncogene
Title:	Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.
Volume:	31
Issue:	7
Pages:	907-17

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Publication

37318881 | J:339975

First Author:	Sugiura K
Year:	2023
Journal:	JCI Insight
Title:	LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3.
Volume:	8
Issue:	14

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Publication

23530123 | J:198219

First Author:	Van de Walle I
Year:	2013
Journal:	J Exp Med
Title:	Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
Volume:	210
Issue:	4
Pages:	683-97

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Publication

21994468 | J:205398

First Author:	Osanyingbemi-Obidi J
Year:	2011
Journal:	Mol Cancer Res
Title:	Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo.
Volume:	9
Issue:	12
Pages:	1746-54

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Publication

28266128 | J:271834

First Author:	Wang S
Year:	2017
Journal:	J Cell Mol Med
Title:	Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.
Volume:	21
Issue:	9
Pages:	1967-1978

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Publication

27613846 | J:274430

First Author:	Wang S
Year:	2016
Journal:	Oncotarget
Title:	Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling.
Volume:	7
Issue:	37
Pages:	58848-58861

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Publication

23630352 | J:204776

First Author:	Gopisetty A
Year:	2013
Journal:	J Immunol
Title:	OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells.
Volume:	190
Issue:	11
Pages:	5516-25

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Publication

31796853 | J:297963

First Author:	Klose R
Year:	2019
Journal:	Sci Rep
Title:	Loss of the serine protease HTRA1 impairs smooth muscle cells maturation.
Volume:	9
Issue:	1
Pages:	18224

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Publication

26868537 | J:263576

First Author:	Zeng H
Year:	2016
Journal:	Sci Rep
Title:	LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways.
Volume:	6

Pages:	20931

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Publication

28752390 | J:263753

First Author:	Cuervo H
Year:	2017
Journal:	Angiogenesis
Title:	PDGFRβ-P2A-CreER^T2 mice: a genetic tool to target pericytes in angiogenesis.
Volume:	20
Issue:	4
Pages:	655-662

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Publication

30502484 | J:282276

First Author:	Papadakos KS
Year:	2019
Journal:	Matrix Biol
Title:	Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.
Volume:	81

Pages:	107-121

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Publication

31704879 | J:282061

First Author:	Kumar P
Year:	2019
Journal:	J Immunol
Title:	OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling.
Volume:	203
Issue:	12
Pages:	3225-3236

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Publication

36645109 | J:338757

First Author:	Li X
Year:	2023
Journal:	FASEB J
Title:	Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
Volume:	37
Issue:	2
Pages:	e22743

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Publication

19688092 | J:152461

First Author:	Dudley DD
Year:	2009
Journal:	PLoS One
Title:	Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.
Volume:	4
Issue:	8
Pages:	e6678

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Publication

20804727 | J:165587

First Author:	Bargo S
Year:	2010
Journal:	Biochem Biophys Res Commun
Title:	Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Volume:	400
Issue:	4
Pages:	606-12

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Publication

29206900 | J:261096

First Author:	Zhang C
Year:	2018
Journal:	Cardiovasc Res
Title:	Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation.
Volume:	114
Issue:	3
Pages:	443-455

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Protein Domain

IPR022331 | Notch_3

Type:

Family

Description:

Notch cell surface receptors are large, single-pass type-1 transmembrane proteins found in a diverse range of metazoan species, from human to Caenorhabditis species. The fruit fly, Drosophila melanogaster, possesses only one Notch protein, whereas in C.elegans, two receptors have been found; by contrast, four Notch paralogues (designated N1-4) have been identified in mammals, playing both unique and redundant roles. The hetero-oligomer Notch comprises a large extracellular domain (ECD), containing 10-36 tandem Epidermal Growth Factor (EFG)-like repeats, which are involved in ligand interactions; a negative regulatory region, including three cysteine-rich Lin12-Notch Repeats (LNR); a single trans-membrane domain (TM); a small intracellular domain (ICD), which includes a RAM (RBPjk-association module) domain; six ankyrin repeats (ANK), which are involved in protein-protein interactions; and a PEST domain. Drosophila Notch also contains an OPA domain []. Notch signalling is an evolutionarily conserved pathway involved in a wide variety of developmental processes, including adult homeostasis and stem cell maintenance, cell proliferation and apoptosis []. Notch is activated by a range of ligands -the so-called DSL ligands (Delta/Seratte/LAG-2). Activation is also mediated by a sequence of proteolytic events: ligand binding leads to cleavage of Notch by ADAM proteases []at site 2 (S2) and presenilin-1/g-secretase at sites 3 (S3)and 4 (S4) [].The last cleavage releases the Notch intracellular part of the protein (NICD) from the membrane and, upon release, the NICD translocates to the nucleus where it associates with a CBF1/RBJk/Su(H)/Lag1 (CSL) family of DNA-binding proteins. The subsequent recruitment of a co-activator mastermind like (MAML1) protein []promotes transcriptional activation of Notch target genes: well established Notch targets are the Hes and Hey gene families. Aberrant Notch function and signalling has been associated with a number of human disorders, including Allagile syndrome, spondylocostal dysostosis, aortic valve disease, CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), and T-cell Acute Lympho-blastic Leukemia (T-ALL); it has also been implicated in various human carcinomas [, ]. Notch3 displays a more restrictive distribution than the rest of the Notch subtypes, being expressed predominantly in vascular smooth muscle cells, the central nervous system, certain thymocytes subsets, and in regulatory T cells [].

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Publication

26279302 | J:309335

First Author:	Zhang S
Year:	2016
Journal:	Oncogene
Title:	Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Volume:	35
Issue:	19
Pages:	2485-95

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Publication

35792302 | J:341865

First Author:	Breikaa RM
Year:	2022
Journal:	Vascul Pharmacol
Title:	Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes.
Volume:	145

Pages:	107087

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Publication

24039710 | J:225185

First Author:	Li L
Year:	2013
Journal:	PLoS One
Title:	Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction.
Volume:	8
Issue:	9
Pages:	e71041

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Publication

32325086 | J:314302

First Author:	Kunze B
Year:	2020
Journal:	Gastroenterology
Title:	Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma.
Volume:	159
Issue:	2
Pages:	575-590

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Publication

36107978 | J:329263

First Author:	Alexander GM
Year:	2022
Journal:	PLoS One
Title:	Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease.
Volume:	17
Issue:	9
Pages:	e0274615

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Publication

29162437 | J:277897

First Author:	Andersson ER
Year:	2018
Journal:	Gastroenterology
Title:	Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.
Volume:	154
Issue:	4
Pages:	1080-1095

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Publication

19379690 | -

First Author:	Kopan R
Year:	2009
Journal:	Cell
Title:	The canonical Notch signaling pathway: unfolding the activation mechanism.
Volume:	137
Issue:	2
Pages:	216-33

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Publication

12354787 | J:94943

First Author:	Hartmann D
Year:	2002
Journal:	Hum Mol Genet
Title:	The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Volume:	11
Issue:	21
Pages:	2615-24

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Publication

11101851 | -

First Author:	Wu L
Year:	2000
Journal:	Nat Genet
Title:	MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Volume:	26
Issue:	4
Pages:	484-9

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Publication

12668592 | J:82719

First Author:	Gridley T
Year:	2003
Journal:	Hum Mol Genet
Title:	Notch signaling and inherited disease syndromes.
Volume:	12 Spec No 1

Pages:	R9-13

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Publication

16429119 | -

First Author:	Louvi A
Year:	2006
Journal:	Nat Rev Neurosci
Title:	Notch signalling in vertebrate neural development.
Volume:	7
Issue:	2
Pages:	93-102

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Publication

10206645 | J:54336

First Author:	De Strooper B
Year:	1999
Journal:	Nature
Title:	A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Volume:	398
Issue:	6727
Pages:	518-22

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Protein Coding Gene

MGI:1925544 | Rps27a

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98887 | Uba52

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98888 | Ubb

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98889 | Ubc

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

P62984

Organism:	Mus musculus/domesticus
Length:	128
Fragment?:	false

•

Protein

P0CG50

Organism:	Mus musculus/domesticus
Length:	734
Fragment?:	false

•

Protein

P62983

Organism:	Mus musculus/domesticus
Length:	156
Fragment?:	false

•

Protein

P0CG49

Organism:	Mus musculus/domesticus
Length:	305
Fragment?:	false

•

Publication

10221902 | -

First Author:	Artavanis-Tsakonas S
Year:	1999
Journal:	Science
Title:	Notch signaling: cell fate control and signal integration in development.
Volume:	284
Issue:	5415
Pages:	770-6

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