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Search results 101 to 164 out of 164 for Nek8

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5475297
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2778228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5475530
Age: postnatal day 7
Note: Expressed in the luminal cilia. Expressed in 26% medullary dubules, 26% in cortical tubules. Decreased expression, compared with heterozygous control.
Specimen Label: jck/jck cystic
Detected: true
Specimen Num: 3
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Publication
- | J:73571
   
First Author: Liu S
Year: 2001
Journal: GenBank Submission
Title: Mus musculus NIMA-related kinase 8 (Nek8) mRNA, complete cds
Pages: AF407579
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Publication
20921623 | J:166941
First Author: Viau A
Year: 2010
Journal: J Clin Invest
Title: Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.
Volume: 120
Issue: 11
Pages: 4065-76
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Publication
27053712 | J:236705
First Author: Husson H
Year: 2016
Journal: Hum Mol Genet
Title: Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
Volume: 25
Issue: 11
Pages: 2245-2255
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Publication
24166835 | J:309681
First Author: Liu S
Year: 2014
Journal: J Bone Miner Res
Title: Role of TGF-β in a mouse model of high turnover renal osteodystrophy.
Volume: 29
Issue: 5
Pages: 1141-57
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Publication
20937855 | J:165518
First Author: Hellman NE
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch.
Volume: 107
Issue: 43
Pages: 18499-504
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Publication
25934702 | J:225446
First Author: Lee EJ
Year: 2015
Journal: FASEB J
Title: Soluble receptor for advanced glycation end products inhibits disease progression in autosomal dominant polycystic kidney disease by down-regulating cell proliferation.
Volume: 29
Issue: 8
Pages: 3506-14
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Publication
31915367 | J:297134
First Author: Zhang JQJ
Year: 2020
Journal: Lab Invest
Title: Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease.
Volume: 100
Issue: 5
Pages: 696-711
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Publication
20562878 | J:162080
First Author: Natoli TA
Year: 2010
Journal: Nat Med
Title: Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models.
Volume: 16
Issue: 7
Pages: 788-92
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Publication
36523654 | J:337557
 
First Author: Swenson-Fields KI
Year: 2022
Journal: Front Mol Biosci
Title: Caspase-1 and the inflammasome promote polycystic kidney disease progression.
Volume: 9
Pages: 971219
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Publication
28826940 | J:256270
First Author: Monirujjaman M
Year: 2017
Journal: Biochim Biophys Acta
Title: Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Volume: 1862
Issue: 12
Pages: 1562-1574
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Publication
20554900 | J:162084
First Author: Ahmadie R
Year: 2010
Journal: J Nutr
Title: A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload.
Volume: 140
Issue: 8
Pages: 1438-44
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Publication
24700869 | J:213263
First Author: Tran PV
Year: 2014
Journal: J Am Soc Nephrol
Title: Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models.
Volume: 25
Issue: 10
Pages: 2201-12
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Publication
14600027 | J:87130
First Author: Guay-Woodford LM
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: Murine models of polycystic kidney disease: molecular and therapeutic insights.
Volume: 285
Issue: 6
Pages: F1034-49
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Publication
21565611 | J:173396
First Author: Sang L
Year: 2011
Journal: Cell
Title: Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Volume: 145
Issue: 4
Pages: 513-28
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Publication
25807483 | J:222159
First Author: Li Y
Year: 2015
Journal: Nature
Title: Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Volume: 521
Issue: 7553
Pages: 520-4
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Publication
- | J:175213
     
First Author: Lo C
Year: 2011
Journal: MGI Direct Data Submission (B2B/CvDC)
Title: Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC)
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:72245
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase Nek8
Type: chain
End: 698
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Protein
Q91ZR4
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
E9Q258
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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GXD Expression
GXD Expression
 
Probe: MGI:3526694
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2840726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:5475489
Age: embryonic day 18.5
Note: Expressed in the developing and maturing collecting ducts expressing Nek8 in their cilia.
Specimen Label: 2b
Detected: true
Specimen Num: 1
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DO Term
DOID:0111120 | nephronophthisis 9
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Protein Domain
IPR044120 | STKc_Nek8
Type: Domain
Description: Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. Nek8 human mutations have been shown to cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway []. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control [].This entry represents the catalytic domain of Nek8.
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Allele
l11Jus74 | MGI:4999624
 
Name: lethal, Chr 11, Justice 74
Allele Type: Chemically induced (ENU)
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Allele
Nek8<m1Btlr> | MGI:6268750
Name: NIMA (never in mitosis gene a)-related expressed kinase 8; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6268751 | C57BL/6J-Nek8<m1Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Genotype
Genotype
Symbol: l11Jus74/l11Jus74
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nek8/Nek8
Background: C57BL/6J-Nek8
Zygosity: hm
Has Mutant Allele: true
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Publication
16280549 | -
First Author: Quarmby LM
Year: 2005
Journal: J Cell Sci
Title: Caught Nek-ing: cilia and centrioles.
Volume: 118
Issue: Pt 22
Pages: 5161-9
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Publication
29401581 | J:273819
First Author: Nikonova AS
Year: 2018
Journal: FASEB J
Title: Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).
Volume: 32
Issue: 5
Pages: 2735-2746
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Publication
21917142 | J:176116
First Author: Fairfield H
Year: 2011
Journal: Genome Biol
Title: Mutation discovery in mice by whole exome sequencing.
Volume: 12
Issue: 9
Pages: R86
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Publication
12955145 | J:85113
First Author: Kile BT
Year: 2003
Journal: Nature
Title: Functional genetic analysis of mouse chromosome 11.
Volume: 425
Issue: 6953
Pages: 81-6
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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