DZIP3 is a RNA-binding ubiquitin-protein ligase that targets H2AK119 (lysine 119 of histone H2A) [, ]. It interacts with CARM1 (coactivator-associated arginine methyltransferase 1) through its RING domain and may act as a coactivator of ERalpha target gene expression [].
Histone-arginine methyltransferase CARM1 (also known as coactivator-associated arginine methyltransferase 1) methylates arginine residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability []. CARM1 is recruited by several transcription factors and plays a critical role in gene expression as a positive regulator. This entry represents the N-terminal domain of CARM1. Structurally this domain adopts a PH domain-like fold, a common structural scaffold found in a broad range proteins with diverse activities, which is frequently found to regulate protein-protein interactions [].
This entry represents the DZIP3-like HEPN nuclease domain. It has been found fused to TPR, Zn-ribbon, RING, Ankyrin, CARD, NACHT ATPase, DEATH and LRR in various animal lineages [].DZIP3 is a RNA-binding ubiquitin-protein ligase that targets H2AK119 (lysine 119 of histone H2A) [, ]. It interacts with CARM1 (coactivator-associated arginine methyltransferase 1) through its RING domain and may act as a coactivator of ERalpha target gene expression [].
