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Search results 201 to 273 out of 273 for Chek2

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Type Details Score
Publication
28123024 | J:239152
First Author: Enriquez-Rios V
Year: 2017
Journal: J Neurosci
Title: DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.
Volume: 37
Issue: 4
Pages: 893-905
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Publication
24009519 | J:223048
First Author: Pirouz M
Year: 2013
Journal: PLoS Genet
Title: A critical function of Mad2l2 in primordial germ cell development of mice.
Volume: 9
Issue: 8
Pages: e1003712
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Publication
22360967 | J:184928
First Author: Miles DC
Year: 2012
Journal: Dev Biol
Title: The proto-oncogene Ret is required for male foetal germ cell survival.
Volume: 365
Issue: 1
Pages: 101-9
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Publication
29718910 | J:263685
First Author: Kitami K
Year: 2018
Journal: PLoS Genet
Title: BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development.
Volume: 14
Issue: 5
Pages: e1007340
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Publication
27358050 | J:240786
 
First Author: Lee DH
Year: 2016
Journal: Nat Commun
Title: LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.
Volume: 7
Pages: 11961
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Publication
22522401 | J:191367
First Author: Lee Y
Year: 2012
Journal: Nat Neurosci
Title: Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.
Volume: 15
Issue: 6
Pages: 819-26
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Publication
26158450 | J:224364
 
First Author: Marjanović M
Year: 2015
Journal: Nat Commun
Title: CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.
Volume: 6
Pages: 7676
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Publication
26023099 | J:224084
First Author: Elliott EN
Year: 2015
Journal: Development
Title: Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.
Volume: 142
Issue: 12
Pages: 2163-72
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Publication
22266795 | J:181920
First Author: Lee Y
Year: 2012
Journal: EMBO J
Title: ATR maintains select progenitors during nervous system development.
Volume: 31
Issue: 5
Pages: 1177-89
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Publication
22212482 | J:316150
First Author: Li R
Year: 2012
Journal: Cell Res
Title: A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.
Volume: 22
Issue: 5
Pages: 859-72
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Publication
25043184 | J:266021
First Author: Foronda M
Year: 2014
Journal: Cell Rep
Title: Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.
Volume: 8
Issue: 2
Pages: 487-500
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Publication
33798452 | J:314103
First Author: Ulmke PA
Year: 2021
Journal: Stem Cell Reports
Title: Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.
Volume: 16
Issue: 4
Pages: 968-984
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Publication
34746147 | J:314268
 
First Author: Akagawa R
Year: 2021
Journal: Front Cell Dev Biol
Title: Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.
Volume: 9
Pages: 753175
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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UniProt Feature
UniProt Feature
Begin: 341
Description: Phosphoserine; by CHEK2
Type: modified residue
End: 341
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UniProt Feature
UniProt Feature
Begin: 971
Description: Phosphoserine; by CHEK2
Type: modified residue
End: 971
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UniProt Feature
UniProt Feature
Begin: 247
Description: Phosphoserine; by CHEK2
Type: modified residue
End: 247
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UniProt Feature
UniProt Feature
Begin: 374
Description: Phosphoserine; by CHEK2
Type: modified residue
End: 374
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UniProt Feature
UniProt Feature
Begin: 221
Description: Phosphoserine; by CHEK2
Type: modified residue
End: 221
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UniProt Feature
UniProt Feature
Begin: 367
Description: Phosphoserine; by CHEK1 and CHEK2
Type: modified residue
End: 367
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UniProt Feature
UniProt Feature
Begin: 123
Description: Phosphoserine; by CHEK1 and CHEK2
Type: modified residue
End: 123
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UniProt Feature
UniProt Feature
Begin: 271
Description: Phosphoserine; by CHEK1 and CHEK2
Type: modified residue
End: 271
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UniProt Feature
UniProt Feature
Begin: 284
Description: Phosphoserine; by CHEK1 and CHEK2
Type: modified residue
End: 284
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Allele
Chek2<em2Smoc> | MGI:7288963
Name: checkpoint kinase 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0111504 | Li-Fraumeni syndrome 2
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GXD Expression
GXD Expression
 
Probe: MGI:5315099
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-23
Strength: Present
Sex: Male
Emaps: EMAPS:1797527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6436306
Age: postnatal day 1
Note: Significant decrease of primordial germ cells, compared with the wild-type. Chek2 deficiency did not rescue germ cell depletion.
Specimen Label: not shown XG/XG;Chk2-/- M
Detected: true
Specimen Num: 13
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Allele
Chek2<em1Smoc> | MGI:7288962
Name: checkpoint kinase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
25619829 | -
First Author: Wang N
Year: 2015
Journal: Oncogene
Title: A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk.
Volume: 34
Issue: 40
Pages: 5198-205
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GXD Expression
GXD Expression
 
Probe: MGI:5315099
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-23
Strength: Present
Sex: Female
Emaps: EMAPS:1796527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6436306
Age: postnatal day 1
Note: Significant decrease of primordial germ cells, compared with the wild-type. Chek2 deficiency did not rescue germ cell depletion, Although there was an increased number of germ cells, compared with the single mutants.
Specimen Label: not shown XG/XG;Chk2-/- F
Detected: true
Specimen Num: 14
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Strain
MGI:6770655 | C57BL/6J-Chek2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Brca1<tm3Cxd> | MGI:3513253
Name: breast cancer 1, early onset; targeted mutation 3, Chu-Xia Deng
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Brca1/Brca1
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Publication
36543128 | J:334171
First Author: Osma-Garcia IC
Year: 2022
Journal: Cell Rep
Title: The splicing regulators TIA1 and TIAL1 are required for the expression of the DNA damage repair machinery during B cell lymphopoiesis.
Volume: 41
Issue: 12
Pages: 111869
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Publication
29988075 | J:280257
First Author: Kim SY
Year: 2019
Journal: Cell Death Differ
Title: Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.
Volume: 26
Issue: 3
Pages: 502-515
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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