This entry represents Ecd (ecdysoneless) family. Drosophila ecd mutants display reduced steroid titers during larval development []. Mammalian Ecd (also known as SGT1 and hEcd in humans) has been shown to stimulate cell proliferation by interacting with the Retinoblastoma (Rb) proteins []. Ecd proteins may be involved in pre-mRNA splicing []. Overexpression of Ecd has been linked to cancer progression [, ].
This is the extracellular domain (ECD) found in FtsX, a homologue of the transmembrane PG-hydrolase regulator. The FtsX extracellular domain binds the PG peptidase Rv2190c/RipC N-terminal segment, causing a conformational change that activates the enzyme ileading to PG hydrolysis in Mycobacterium tuberculosis. Structural analysis of FtsX ECD reveals fold containing two lobes connected by a flexible hinge. Mutations in the hydrophobic cleft between the lobes showed reduction in RipC binding in vitro and inhibition of FtsX function in Mycobacterium smegmatis [].
