Type |
Details |
Score |
Publication |
First Author: |
Brambilla L |
Year: |
2018 |
Journal: |
Front Neurosci |
Title: |
Dysregulation of Astrocytic HMGB1 Signaling in Amyotrophic Lateral Sclerosis. |
Volume: |
12 |
|
Pages: |
622 |
|
•
•
•
•
•
|
Publication |
First Author: |
Niemi K |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway. |
Volume: |
186 |
Issue: |
11 |
Pages: |
6119-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Niida T |
Year: |
2012 |
Journal: |
Cardiovasc Res |
Title: |
IκBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice. |
Volume: |
93 |
Issue: |
2 |
Pages: |
371-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng Q |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity. |
Volume: |
13 |
|
Pages: |
1042549 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bala S |
Year: |
2016 |
Journal: |
J Hepatol |
Title: |
The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis. |
Volume: |
64 |
Issue: |
6 |
Pages: |
1378-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu J |
Year: |
2020 |
Journal: |
Theranostics |
Title: |
Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. |
Volume: |
10 |
Issue: |
21 |
Pages: |
9702-9720 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giebeler A |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Deficiency of formyl peptide receptor 1 and 2 is associated with increased inflammation and enhanced liver injury after LPS-stimulation. |
Volume: |
9 |
Issue: |
6 |
Pages: |
e100522 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan F |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
CCR2 gene deletion and pharmacologic blockade ameliorate a severe murine experimental autoimmune neuritis model of Guillain-Barré syndrome. |
Volume: |
9 |
Issue: |
3 |
Pages: |
e90463 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cui TX |
Year: |
2020 |
Journal: |
Front Immunol |
Title: |
CCR2 Mediates Chronic LPS-Induced Pulmonary Inflammation and Hypoalveolarization in a Murine Model of Bronchopulmonary Dysplasia. |
Volume: |
11 |
|
Pages: |
579628 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bauer C |
Year: |
2013 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice. |
Volume: |
48 |
Issue: |
6 |
Pages: |
781-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ray A |
Year: |
2004 |
Journal: |
Mol Immunol |
Title: |
Up-regulation of CD80-CD86 and IgA on mouse peritoneal B-1 cells by porin of Shigella dysenteriae is Toll-like receptors 2 and 6 dependent. |
Volume: |
41 |
Issue: |
12 |
Pages: |
1167-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu W |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
AP-1 activated by toll-like receptors regulates expression of IL-23 p19. |
Volume: |
284 |
Issue: |
36 |
Pages: |
24006-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Caricilli AM |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. |
Volume: |
9 |
Issue: |
12 |
Pages: |
e1001212 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muxel SM |
Year: |
2018 |
Journal: |
Front Immunol |
Title: |
Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages. |
Volume: |
9 |
|
Pages: |
2792 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burdelya LG |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist. |
Volume: |
110 |
Issue: |
20 |
Pages: |
E1857-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li P |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Vitamin D deficiency causes defective resistance to Aspergillus fumigatus in mice via aggravated and sustained inflammation. |
Volume: |
9 |
Issue: |
6 |
Pages: |
e99805 |
|
•
•
•
•
•
|
Publication |
First Author: |
van der Geest R |
Year: |
2023 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection. |
Volume: |
325 |
Issue: |
5 |
Pages: |
L604-L616 |
|
•
•
•
•
•
|
Publication |
First Author: |
Slocum C |
Year: |
2014 |
Journal: |
PLoS Pathog |
Title: |
Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. |
Volume: |
10 |
Issue: |
7 |
Pages: |
e1004215 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Y |
Year: |
2017 |
Journal: |
J Leukoc Biol |
Title: |
Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response. |
Volume: |
102 |
Issue: |
3 |
Pages: |
575-587 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hernandez H |
Year: |
2017 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork. |
Volume: |
58 |
Issue: |
3 |
Pages: |
1811-1823 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menden HL |
Year: |
2016 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung. |
Volume: |
55 |
Issue: |
6 |
Pages: |
767-778 |
|
•
•
•
•
•
|
Publication |
First Author: |
Che X |
Year: |
2018 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages. |
Volume: |
315 |
Issue: |
1 |
Pages: |
G128-G139 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kajiwara K |
Year: |
2021 |
Journal: |
BMC Nephrol |
Title: |
Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy. |
Volume: |
22 |
Issue: |
1 |
Pages: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fernández-Calle R |
Year: |
2017 |
Journal: |
J Neuroinflammation |
Title: |
Pleiotrophin regulates microglia-mediated neuroinflammation. |
Volume: |
14 |
Issue: |
1 |
Pages: |
46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pinheiro CR |
Year: |
2018 |
Journal: |
Cytokine |
Title: |
Recognition of Candida albicans by gingival fibroblasts: The role of TLR2, TLR4/CD14, and MyD88. |
Volume: |
106 |
|
Pages: |
67-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Faridar A |
Year: |
2022 |
Journal: |
Acta Neuropathol Commun |
Title: |
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease. |
Volume: |
10 |
Issue: |
1 |
Pages: |
144 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmad I |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
LncRNA MALAT1/microRNA-30b axis regulates macrophage polarization and function. |
Volume: |
14 |
|
Pages: |
1214810 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
661
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
661
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeyaseelan S |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa. |
Volume: |
177 |
Issue: |
1 |
Pages: |
538-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakata Y |
Year: |
2007 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. |
Volume: |
292 |
Issue: |
1 |
Pages: |
H503-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Evans S |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Ischemia reperfusion injury provokes adverse left ventricular remodeling in dysferlin-deficient hearts through a pathway that involves TIRAP dependent signaling. |
Volume: |
10 |
Issue: |
1 |
Pages: |
14129 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmad R |
Year: |
2008 |
Journal: |
Blood |
Title: |
Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1. |
Volume: |
112 |
Issue: |
6 |
Pages: |
2360-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto M |
Year: |
2004 |
Journal: |
Mol Immunol |
Title: |
TIR domain-containing adaptors define the specificity of TLR signaling. |
Volume: |
40 |
Issue: |
12 |
Pages: |
861-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Semaan N |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. |
Volume: |
180 |
Issue: |
5 |
Pages: |
3485-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rip J |
Year: |
2019 |
Journal: |
Front Immunol |
Title: |
Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease. |
Volume: |
10 |
|
Pages: |
95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herrero-Cervera A |
Year: |
2019 |
Journal: |
Diabetologia |
Title: |
Genetic inactivation of the LIGHT (TNFSF14) cytokine in mice restores glucose homeostasis and diminishes hepatic steatosis. |
Volume: |
62 |
Issue: |
11 |
Pages: |
2143-2157 |
|
•
•
•
•
•
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Publication |
First Author: |
Steinberg N |
Year: |
2023 |
Journal: |
J Neuroinflammation |
Title: |
Naïve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1. |
Volume: |
20 |
Issue: |
1 |
Pages: |
276 |
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•
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•
•
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Publication |
First Author: |
Caldeira C |
Year: |
2017 |
Journal: |
Front Aging Neurosci |
Title: |
Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation. |
Volume: |
9 |
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Pages: |
277 |
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•
•
•
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Publication |
First Author: |
Huang C |
Year: |
2019 |
Journal: |
Front Immunol |
Title: |
Porcine Beta-Defensin 2 Provides Protection Against Bacterial Infection by a Direct Bactericidal Activity and Alleviates Inflammation via Interference With the TLR4/NF-κB Pathway. |
Volume: |
10 |
|
Pages: |
1673 |
|
•
•
•
•
•
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Publication |
First Author: |
Kim E |
Year: |
2020 |
Journal: |
EBioMedicine |
Title: |
Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. |
Volume: |
55 |
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Pages: |
102743 |
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•
•
•
•
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Publication |
First Author: |
Li D |
Year: |
2020 |
Journal: |
J Neuroinflammation |
Title: |
NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice. |
Volume: |
17 |
Issue: |
1 |
Pages: |
126 |
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•
•
•
•
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Publication |
First Author: |
Holers VM |
Year: |
2020 |
Journal: |
Front Immunol |
Title: |
Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D. |
Volume: |
11 |
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Pages: |
201 |
|
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•
•
•
•
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Publication |
First Author: |
Du M |
Year: |
2017 |
Journal: |
Mol Vis |
Title: |
Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4. |
Volume: |
23 |
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Pages: |
185-197 |
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•
•
•
•
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Publication |
First Author: |
Aryee KE |
Year: |
2020 |
Journal: |
Proceedings of the American Association for Cancer Research Annual Meeting 2019 |
Title: |
Abstract 1522: Novel NOD-scid IL2rgnull (NSG)mice for preclinical evaluation of TLR agonists in cancer immunotherapy |
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•
•
•
•
•
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Publication |
First Author: |
Imanishi T |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression. |
Volume: |
32 |
Issue: |
3 |
Pages: |
107911 |
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•
•
•
•
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Publication |
First Author: |
Fitzgerald KA |
Year: |
2001 |
Journal: |
Nature |
Title: |
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. |
Volume: |
413 |
Issue: |
6851 |
Pages: |
78-83 |
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•
•
•
•
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Publication |
First Author: |
Bonham KS |
Year: |
2014 |
Journal: |
Cell |
Title: |
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. |
Volume: |
156 |
Issue: |
4 |
Pages: |
705-16 |
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•
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Publication |
First Author: |
Hoebe K |
Year: |
2005 |
Journal: |
Nature |
Title: |
CD36 is a sensor of diacylglycerides. |
Volume: |
433 |
Issue: |
7025 |
Pages: |
523-7 |
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•
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Publication |
First Author: |
Jiang Z |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. |
Volume: |
103 |
Issue: |
29 |
Pages: |
10961-6 |
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•
•
•
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Publication |
First Author: |
Siednienko J |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like. |
Volume: |
40 |
Issue: |
11 |
Pages: |
3150-60 |
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•
•
•
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Publication |
First Author: |
Cole LE |
Year: |
2010 |
Journal: |
J Leukoc Biol |
Title: |
Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling. |
Volume: |
87 |
Issue: |
2 |
Pages: |
275-81 |
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•
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Publication |
First Author: |
Fremond CM |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. |
Volume: |
179 |
Issue: |
2 |
Pages: |
1178-89 |
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•
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•
•
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Publication |
First Author: |
Hajishengallis G |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae. |
Volume: |
182 |
Issue: |
11 |
Pages: |
6690-6 |
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•
•
•
•
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Publication |
First Author: |
Santos-Sierra S |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. |
Volume: |
28 |
Issue: |
14 |
Pages: |
2018-27 |
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•
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Publication |
First Author: |
Inoue A |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression. |
Volume: |
6 |
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Pages: |
38684 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
734
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
156
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
305
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Feinstein E |
Year: |
1995 |
Journal: |
Trends Biochem Sci |
Title: |
The death domain: a module shared by proteins with diverse cellular functions. |
Volume: |
20 |
Issue: |
9 |
Pages: |
342-4 |
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•
•
•
•
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Publication |
First Author: |
Troutman TD |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. |
Volume: |
109 |
Issue: |
1 |
Pages: |
273-8 |
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•
•
•
•
|
Publication |
First Author: |
Wei B |
Year: |
2008 |
Journal: |
Eur J Immunol |
Title: |
Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells. |
Volume: |
38 |
Issue: |
12 |
Pages: |
3411-25 |
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•
•
•
•
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Publication |
First Author: |
Dixit E |
Year: |
2010 |
Journal: |
Cell |
Title: |
Peroxisomes are signaling platforms for antiviral innate immunity. |
Volume: |
141 |
Issue: |
4 |
Pages: |
668-81 |
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•
•
•
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Publication |
First Author: |
Gopal A |
Year: |
2022 |
Journal: |
J Exp Med |
Title: |
TIRAP drives myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the endothelial niche in mice. |
Volume: |
219 |
Issue: |
3 |
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•
•
•
•
•
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Publication |
First Author: |
Young GR |
Year: |
2012 |
Journal: |
Nature |
Title: |
Resurrection of endogenous retroviruses in antibody-deficient mice. |
Volume: |
491 |
Issue: |
7426 |
Pages: |
774-8 |
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•
•
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Publication |
First Author: |
Rothenfusser S |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. |
Volume: |
175 |
Issue: |
8 |
Pages: |
5260-8 |
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Publication |
First Author: |
Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas |
Year: |
2023 |
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Title: |
TreeGrafter-generated GO annotations |
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•
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Publication |
First Author: |
Suzuki N |
Year: |
2002 |
Journal: |
Nature |
Title: |
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. |
Volume: |
416 |
Issue: |
6882 |
Pages: |
750-6 |
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Publication |
First Author: |
Weiss G |
Year: |
2012 |
Journal: |
J Immunol |
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J Immunol |
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Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production. |
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Nat Immunol |
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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. |
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Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
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PLoS One |
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Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection. |
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Front Mol Neurosci |
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J Bone Miner Res |
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Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment. |
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PLoS Biol |
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2002 |
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Title: |
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