Ubiquitously expressed transcript protein UXT is involved in gene transcription regulation. It acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). It is an AR N terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation []. It is a protein which interacts with the N terminus of the Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21. DSCR1 interacts with calcineurin and is overexpressed in Down's syndrome patients. UXT, which is encoded in human Xp11, is a 157-amino acid protein present in both cytosol and nucleus of the cells []. The members of this family are related to prefoldin, which is part of a molecular chaperone system that promotes the correct folding of nascent polypeptide chains. Prefoldin interacts with the nascent chain to stabilise it prior to its folding within the central cavity of a chaperonin. Prefoldin is a hexamer consisting of two types of subunits, alpha and beta. Archaeal prefoldin contains one type of alpha and one type of beta subunit [], while eukaryotic prefoldin contains two different but related alpha subunits and four related beta subunits [].
