This entry represents a group of E3 ubiquitin-protein ligases, including UBR1, UBR2 and UBR3. They are part of the N-end rule pathway []. They recognize and bind to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation [, ].The UBR1 protein was shown to bind specifically to proteins bearing N-terminalresidues that are destabilising according to the N-end rule, but not tootherwise identical proteins bearing stabilising N-terminal residues []. UBR1 contains an N-terminal conserved region (the UBR-type zinc finger) which is also found in various proteins implicated in N-degron recognition [].
