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Search results 101 to 200 out of 285 for Spen

0.049s
Type Details Score
GXD Expression  
Probe: MGI:3615782
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617754
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615782
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617754
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507147
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2854023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540094
Age: embryonic day 15.5
Image: GUDMAP:6686
Specimen Label: GUDMAP:6686
Detected: true
Specimen Num: 1
Publication
First Author: Newberry EP
Year: 1999
Journal: Biochemistry
Title: The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter.
Volume: 38
Issue: 33
Pages: 10678-90
Publication
First Author: Surendran K
Year: 2010
Journal: Dev Biol
Title: The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.
Volume: 337
Issue: 2
Pages: 386-95
Publication
First Author: Yuan Z
Year: 2019
Journal: Cell Rep
Title: Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site.
Volume: 26
Issue: 4
Pages: 845-854.e6
Publication
First Author: Sierra OL
Year: 2004
Journal: J Biol Chem
Title: MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element.
Volume: 279
Issue: 31
Pages: 32913-23
Publication
First Author: Sierra OL
Year: 2010
Journal: Mol Endocrinol
Title: Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.
Volume: 24
Issue: 7
Pages: 1478-97
Publication
First Author: Yang X
Year: 2005
Journal: J Biol Chem
Title: Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1.
Volume: 280
Issue: 19
Pages: 18710-6
Publication
First Author: Obata J
Year: 2001
Journal: Genes Cells
Title: p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos.
Volume: 6
Issue: 4
Pages: 345-60
Publication
First Author: Crozet F
Year: 1997
Journal: Genomics
Title: Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.
Volume: 40
Issue: 2
Pages: 332-41
Publication
First Author: Hodkinson PS
Year: 2007
Journal: J Biol Chem
Title: Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.
Volume: 282
Issue: 39
Pages: 28991-9001
Publication
First Author: Miesfeld JB
Year: 2018
Journal: Sci Rep
Title: Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.
Volume: 8
Issue: 1
Pages: 10195
Publication
First Author: Gradus B
Year: 2011
Journal: Dev Biol
Title: miRNAs control tracheal chondrocyte differentiation.
Volume: 360
Issue: 1
Pages: 58-65
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication  
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Protein Domain
Type: Domain
Description: Spen (split end) proteins regulate the expression of key transcriptional effectors in diverse signalling pathways. They are large proteins characterised by N-terminal RNA-binding motifs and a highly conserved C-terminal SPOC (Spen paralog and ortholog C-terminal) domain. The function of the SPOC domain is unknown, but the SPOC domain of the SHARP Spen protein has been implicated in the interaction of SHARP with the SMRT/NcoR corepressor, where SHARP plays an essential role in the repressor complex [].The SPOC domain is folded into a single compact domain consisting of a β-barrel with seven strands framed by six alpha helices. A number of deep grooves and clefts in the surface, plus two nonpolar loops, render the SPOC domain well suited to protein-protein interactions; most of the conserved residues occur on the protein surface rather than in the core. Other proteins containing a SPOC domain include Drosophila Split ends, which promotes sclerite development in the head and restricts it in the thorax, and mouse MINT (homologue of SHARP), which is involved in skeletal and neuronal development via its repression of Msx2.
Gene
Type: gene
Organism: frog, African clawed
Gene
Type: gene
Organism: frog, African clawed
Publication
First Author: Ariyoshi M
Year: 2003
Journal: Genes Dev
Title: A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.
Volume: 17
Issue: 15
Pages: 1909-20
Protein
Organism: Mus musculus/domesticus
Length: 3644  
Fragment?: false
Allele
Name: spen family transcription repressor; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Protein
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
Protein Domain
Type: Domain
Description: Spen (split end) proteins regulate the expression of key transcriptional effectors in diverse signalling pathways. They are large proteins characterised by N-terminal RNA-binding motifs and a highly conserved C-terminal SPOC (Spen paralog and ortholog C-terminal) domain. The function of the SPOC domain is unknown, but the SPOC domain of the SHARP Spen protein has been implicated in the interaction of SHARP with the SMRT/NcoR corepressor, where SHARP plays an essential role in the repressor complex [].The SPOC domain is folded into a single compact domain consisting of a β-barrel with seven strands framed by six alpha helices. A number of deep grooves and clefts in the surface, plus two nonpolar loops, render the SPOC domain well suited to protein-protein interactions; most of the conserved residues occur on the protein surface rather than in the core. Other proteins containing a SPOC domain include Drosophila Split ends, which promotes sclerite development in the head and restricts it in the thorax, and mouse MINT (homologue of SHARP), which is involved in skeletal and neuronal development via its repression of Msx2.
Allele    
Name: spen family transcription repressor; wild type
Allele  
Name: spen family transcription repressor; gene trap S2-10H1, Philippe Soriano
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap YTA456, BayGenomics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST276181, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST337113, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap XC533, BayGenomics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST207190, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST194458, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap YTA404, BayGenomics
Allele Type: Gene trapped
Allele
Name: spen family transcription repressor; targeted mutation 1, Tasuku Honjo
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: spen family transcription repressor; targeted mutation 2.1, Tasuku Honjo
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele  
Name: spen family transcription repressor; gene trap OST341506, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST68650, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST207942, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST216788, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST299468, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap S14-12D1, Philippe Soriano
Allele Type: Gene trapped
Allele
Name: spen family transcription repressor; targeted mutation 2.2, Tasuku Honjo
Allele Type: Targeted
Attribute String: Null/knockout
Allele  
Name: spen family transcription repressor; gene trap OST204867, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST258404, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap CSH913, BayGenomics
Allele Type: Gene trapped
Allele
Name: spen family transcription repressor; targeted mutation 2, Tasuku Honjo
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele  
Name: spen family transcription repressor; gene trap OST68078, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap CSH316, BayGenomics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap CSJ084, BayGenomics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST320421, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST435366, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST86167, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST276283, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: spen family transcription repressor; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele  
Name: spen family transcription repressor; gene trap OST147501, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST201558, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap OST242524, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: spen family transcription repressor; gene trap CSH492, BayGenomics
Allele Type: Gene trapped