This entry represents a DNA/RNA binding domain found in the telomere elongation protein EST1 and related sequences, such as the nonsense-mediated mRNA decay pathway proteins SMG5 and SMG7 [, , , ].
This entry includes Est1/Esl1/Esl2/Ebs1 from budding yeasts and Est1A/SMG6/SMG7 from humans. Est1 is a TLC1 RNA-associated factor involved in telomere length regulation [, ]. Ebs1, an Est1 paralogue and human Smg7 orthologue, is involved in translation inhibition and nonsense-mediated decay []. Esl1 and Esl2 are not involved in nonsense-mediated mRNA decay or telomere maintenance pathways, instead, they regulate adaptive gene expression responses of environmental sensing pathways [].
