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Search results 301 to 400 out of 747 for Trio

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Type Details Score
Allele  
Name: TRIO and F-actin binding protein; gene trap 363F1, Centre for Modeling Human Disease
Allele Type: Gene trapped
Allele
Name: TRIO and F-actin binding protein; targeted mutation 1, Thomas B Friedman
Allele Type: Targeted
Attribute String: Modified isoform(s), Null/knockout, Reporter
Genotype
Symbol: Triobp/Triobp
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Triobp/Triobp
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Triobp/Triobp
Background: C57BL/6NJ-Triobp/Mmjax
Zygosity: hm
Has Mutant Allele: true
DO Term
Publication
First Author: Debant A
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.
Volume: 93
Issue: 11
Pages: 5466-71
Publication
First Author: Zheng M
Year: 2004
Journal: Am J Pathol
Title: TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.
Volume: 165
Issue: 1
Pages: 63-9
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Genotype
Symbol: Triobp/Triobp
Background: C57BL/6-Triobp
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Shahin H
Year: 2006
Journal: Am J Hum Genet
Title: Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss.
Volume: 78
Issue: 1
Pages: 144-52
Publication
First Author: Riazuddin S
Year: 2006
Journal: Am J Hum Genet
Title: Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness.
Volume: 78
Issue: 1
Pages: 137-43
Allele
Name: partner and localizer of BRCA2; targeted mutation 1.1, Bing Xia
Allele Type: Targeted
Attribute String: Conditional ready
Publication
First Author: Du TT
Year: 2019
Journal: Nat Commun
Title: LMO7 deficiency reveals the significance of the cuticular plate for hearing function.
Volume: 10
Issue: 1
Pages: 1117
Publication
First Author: Mahdi AH
Year: 2018
Journal: Cancer Res
Title: Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1-PALB2 Interaction.
Volume: 78
Issue: 14
Pages: 3969-3981
Publication
First Author: Zechner R
Year: 2014
Journal: Cell Metab
Title: Hormone-sensitive lipase deficiency in humans.
Volume: 20
Issue: 2
Pages: 199-201
Publication
First Author: Lelli A
Year: 2016
Journal: J Cell Biol
Title: Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.
Volume: 212
Issue: 2
Pages: 231-44
Publication
First Author: Akturk A
Year: 2022
Journal: Sci Adv
Title: RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.
Volume: 8
Issue: 42
Pages: eabq2826
Publication
First Author: Simhadri S
Year: 2014
Journal: J Biol Chem
Title: Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.
Volume: 289
Issue: 35
Pages: 24617-29
Publication
First Author: Su X
Year: 2018
Journal: Cell Death Dis
Title: Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.
Volume: 9
Issue: 3
Pages: 302
Publication
First Author: Southard-Smith EM
Year: 1999
Journal: Mamm Genome
Title: Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human.
Volume: 10
Issue: 7
Pages: 744-9
Protein Domain
Type: Family
Description: This entry represents a three-gene system broadly conserved among the Actinobacteria which includes MSMEG_4193 and homologues. Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.
Publication
First Author: Duncan JS
Year: 2013
Journal: PLoS One
Title: Continued expression of GATA3 is necessary for cochlear neurosensory development.
Volume: 8
Issue: 4
Pages: e62046
Protein
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
Publication
First Author: Alam MR
Year: 1997
Journal: J Biol Chem
Title: Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme.
Volume: 272
Issue: 19
Pages: 12667-75
Publication
First Author: Penzes P
Year: 2001
Journal: J Neurosci
Title: Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology.
Volume: 21
Issue: 21
Pages: 8426-34
Publication
First Author: Youn H
Year: 2007
Journal: J Alzheimers Dis
Title: Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus.
Volume: 12
Issue: 3
Pages: 271-81
Publication  
First Author: Mandela P
Year: 2012
Journal: Neural Plast
Title: Kalirin, a key player in synapse formation, is implicated in human diseases.
Volume: 2012
Pages: 728161
Publication      
First Author: Dufurrena Q
Year: 2018
Journal: J Mol Endocrinol
Title: Kalirin/Trio Rho GDP/GTP exchange factors regulate proinsulin and insulin secretion.
Publication
First Author: Ferraro F
Year: 2007
Journal: Mol Biol Cell
Title: Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation.
Volume: 18
Issue: 12
Pages: 4813-25
Publication
First Author: Skowronek K
Year: 2003
Journal: Acta Crystallogr D Biol Crystallogr
Title: Crystallization and initial crystal characterization of the N-terminal DH/PH domain of Trio.
Volume: 59
Issue: Pt 7
Pages: 1273-5
Protein Domain
Type: Family
Description: This entry includes a group of RhoGEFs, including Kalirin and TRIO from mammals. Kalirin and TRIO are encoded by separate genes in mammals and by a single one in invertebrates. Kalirin and TRIO share the same complex multidomain structure and display several splice variants. They are implicated in secretory granule (SG) maturation and exocytosis [, ]. The longest Kalirin and TRIO proteins have a Sec14 domain, a stretch of spectrin repeats, a RhoGEF(DH)/PH cassette (also called GEF1), an SH3 domain, a second RhoGEF(DH)/PH cassette (also called GEF2), a second SH3 domain, Ig/FNIII domains, and a kinase domain. The first RhoGEF(DH)/PH cassette catalyzes exchange on Rac1 and RhoG while the second RhoGEF(DH)/PH cassette is specific for RhoA. Kalirin and TRIO are closely related to p63RhoGEF and have PH domains of similar function. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner [, ].Triple functional domain protein (TRIO) contains a protein kinase domain and two guanine nucleotide exchange factor (GEF) domains []. These functional domains suggest that it may play a role in signalling pathways controlling cell proliferation []. TRIO may form a complex with LAR transmembrane protein tyrosine phosphatase (PT-Pase), which localises to the ends of focal adhesions and plays an important part in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration []. Its expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer [].Kalirin () promotes the exchange of GDP by GTP and stimulates the activity of specific Rho GTPases []. There are several Kalirin isoforms in humans and mice. Each Kalirin isoform is composed of a unique collection of domains and may have different functions []. In rat, isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth, while isoform 6 is required for dendritic spine formation []. In humans, the major isoform of Kalirin in the adult brain is Kalirin-7, which plays a critical role in spine formation/synaptic plasticity. Kalirin-7 has been linked to neuropsychiatric and neurological diseases such as Alzheimer's, Huntingtin's, ischemic stroke, schizophrenia, depression, and cocaine addiction [, , ].
Protein
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
Publication
First Author: Edwards M
Year: 2013
Journal: Mol Biol Cell
Title: Physiological role of the interaction between CARMIL1 and capping protein.
Volume: 24
Issue: 19
Pages: 3047-55
Protein Domain
Type: Family
Description: This entry represents leucine-rich repeat-containing protein 16A (LRRC16A). In humans it is also known as CARMIL1, which belongs to the CARMIL (capping protein, Arp2/3 and Myosin-I linker) family. CARMIL family members are potential regulators of actin capping proteins, which control the polymerisation of actin filaments by capping their barbed ends [, ]. CARMIL1 is essential for cell migration and may control lamellipodial actin assembly via effects on Trio and Rac1 [, ].
Publication
First Author: Deinhardt K
Year: 2011
Journal: Sci Signal
Title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.
Volume: 4
Issue: 202
Pages: ra82
Publication
First Author: Mori Y
Year: 2014
Journal: Biomed Res
Title: S100A1 and S100B are dispensable for endochondral ossification during skeletal development.
Volume: 35
Issue: 4
Pages: 243-50
Publication
First Author: Biben C
Year: 2023
Journal: Nat Commun
Title: In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis.
Volume: 14
Issue: 1
Pages: 41
Publication
First Author: Jeon Y
Year: 2011
Journal: Cell
Title: YY1 tethers Xist RNA to the inactive X nucleation center.
Volume: 146
Issue: 1
Pages: 119-33
Publication
First Author: Steven R
Year: 1998
Journal: Cell
Title: UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.
Volume: 92
Issue: 6
Pages: 785-95
Publication      
First Author: Yap P
Year: 2023
Journal: Eur J Hum Genet
Title: Biallelic ATP2B1 variants as a likely cause of a novel neurodevelopmental malformation syndrome with primary hypoparathyroidism.
Publication
First Author: Lee HK
Year: 2020
Journal: Commun Biol
Title: Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos.
Volume: 3
Issue: 1
Pages: 19
Publication
First Author: Colomer V
Year: 1997
Journal: Hum Mol Genet
Title: Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.
Volume: 6
Issue: 9
Pages: 1519-25
Publication
First Author: Hutchins AP
Year: 2013
Journal: Stem Cells
Title: Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells.
Volume: 31
Issue: 2
Pages: 269-81
Publication
First Author: Ikeda T
Year: 2004
Journal: Arthritis Rheum
Title: The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage.
Volume: 50
Issue: 11
Pages: 3561-73
Publication
First Author: Liu CF
Year: 2015
Journal: Nucleic Acids Res
Title: The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.
Volume: 43
Issue: 17
Pages: 8183-203
Publication
First Author: Smith JD
Year: 2014
Journal: Am J Hum Genet
Title: Exome sequencing identifies a recurrent de novo ZSWIM6 mutation associated with acromelic frontonasal dysostosis.
Volume: 95
Issue: 2
Pages: 235-40
Publication
First Author: Kimple AJ
Year: 2009
Journal: J Biol Chem
Title: Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
Volume: 284
Issue: 29
Pages: 19402-11
Publication
First Author: Sonoshita M
Year: 2015
Journal: Cancer Discov
Title: Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO.
Volume: 5
Issue: 2
Pages: 198-211
Publication  
First Author: Balaram P
Year: 2019
Journal: Neuroscience
Title: Synergistic Transcriptional Changes in AMPA and GABAA Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss.
Volume: 407
Pages: 108-119
Publication
First Author: Patel R
Year: 2013
Journal: J Clin Invest
Title: Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.
Volume: 123
Issue: 3
Pages: 1157-75
Publication
First Author: Gao L
Year: 2013
Journal: J Cell Sci
Title: TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.
Volume: 126
Issue: Pt 24
Pages: 5704-13
Publication  
First Author: Azzu V
Year: 2021
Journal: Mol Metab
Title: Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression.
Volume: 48
Pages: 101210
Publication
First Author: Rinchik EM
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene.
Volume: 92
Issue: 14
Pages: 6394-8
Publication
First Author: Yang X
Year: 2013
Journal: J Biol Chem
Title: SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic development in mice.
Volume: 288
Issue: 28
Pages: 20111-20
Publication
First Author: Han Y
Year: 2008
Journal: Mol Cell Biol
Title: L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer.
Volume: 28
Issue: 16
Pages: 4999-5013
Publication  
First Author: Lee WJ
Year: 2017
Journal: Biomed Res Int
Title: An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos.
Volume: 2017
Pages: 8932583
Publication
First Author: Chen CA
Year: 2020
Journal: Hum Mol Genet
Title: Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder.
Volume: 29
Issue: 3
Pages: 459-470
Publication
First Author: Song J
Year: 2012
Journal: Nature
Title: Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision.
Volume: 489
Issue: 7414
Pages: 150-4
Publication
First Author: Southgate RJ
Year: 2005
Journal: FASEB J
Title: PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.
Volume: 19
Issue: 14
Pages: 2072-4
Publication
First Author: Bieker JJ
Year: 1996
Journal: DNA Cell Biol
Title: Isolation, genomic structure, and expression of human erythroid Krüppel-like factor (EKLF).
Volume: 15
Issue: 5
Pages: 347-52
Publication
First Author: Sato T
Year: 2003
Journal: Genomics
Title: Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior.
Volume: 82
Issue: 2
Pages: 218-29
Publication
First Author: Szénási T
Year: 2013
Journal: Biochim Biophys Acta
Title: Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis.
Volume: 1829
Issue: 10
Pages: 1075-91
Publication
First Author: Seachrist DD
Year: 2019
Journal: Endocrinology
Title: The Activin Social Network: Activin, Inhibin, and Follistatin in Breast Development and Cancer.
Volume: 160
Issue: 5
Pages: 1097-1110
Protein
Organism: Mus musculus/domesticus
Length: 823  
Fragment?: false
Publication
First Author: Yang C
Year: 2005
Journal: Dev Cell
Title: Mammalian CARMIL inhibits actin filament capping by capping protein.
Volume: 9
Issue: 2
Pages: 209-21
Protein
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
Publication
First Author: Liang Y
Year: 2009
Journal: Mol Biol Cell
Title: Distinct roles for CARMIL isoforms in cell migration.
Volume: 20
Issue: 24
Pages: 5290-305
Publication
First Author: Kim T
Year: 2012
Journal: J Biol Chem
Title: Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.
Volume: 287
Issue: 19
Pages: 15251-62
Protein Domain
Type: Homologous_superfamily
Description: The CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules []. The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor.The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and mammalian retinaldehyde- and alpha-tocopherol-binding proteins. The domain may either constitute all of the protein or only part of it [, , , ].The structure of the domain in SEC14 proteins has been determined []. The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and 5 form a parallel beta sheet with strands 1 and 6 being anti-parallel. The structure also identified a hydrophobic binding pocket for lipid binding.
Protein Domain
Type: Domain
Description: The CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules []. The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor.The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and mammalian retinaldehyde- and alpha-tocopherol-binding proteins. The domain may either constitute all of the protein or only part of it [, , , ].The structure of the domain in SEC14 proteins has been determined []. The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and 5 form a parallel beta sheet with strands 1 and 6 being anti-parallel. The structure also identified a hydrophobic binding pocket for lipid binding.
Protein Domain
Type: Family
Description: This narrowly distributed protein family contains an N-terminal radical SAM domain. It occurs in Pseudomonas fluorescens Pf0-1, Ralstonia solanacearum, and numerous species and strains of Burkholderia. Members always occur next to a trio of three mutually homologous genes, all of which contain the domain as the whole of the protein (about 60 amino acids) or as the C-terminal domain. The function is unknown, but the fact that all phylogenetically correlated proteins are mutually homologous with prominent invariant motifs (an invariant tyrosine and a GDL motif) and as small as 60 amino acids suggests that post-translational modification of domain-containing proteins may be its function. This view is supported by closer homology to the PqqE radical SAM protein involved in PQQ biosynthesis from the PqqA precursor peptide than to other characterised radical SAM proteins.
Protein
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false