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Search results 401 to 500 out of 669 for Tsc2

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Type Details Score
Publication
12783884 | J:85181
First Author: Yang ZZ
Year: 2003
Journal: J Biol Chem
Title: Protein kinase B alpha/Akt1 regulates placental development and fetal growth.
Volume: 278
Issue: 34
Pages: 32124-31
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Publication
21383064 | J:172815
First Author: Wolff NC
Year: 2011
Journal: Mol Cell Biol
Title: Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
Volume: 31
Issue: 9
Pages: 1870-84
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Publication
21795849 | J:314079
First Author: Jung CH
Year: 2011
Journal: Autophagy
Title: ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.
Volume: 7
Issue: 10
Pages: 1212-21
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Publication
28763796 | J:260078
 
First Author: Lee PY
Year: 2017
Journal: Sci Immunol
Title: The metabolic regulator mTORC1 controls terminal myeloid differentiation.
Volume: 2
Issue: 11
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Publication
27593484 | J:333623
First Author: Yang T
Year: 2016
Journal: Cell Mol Immunol
Title: TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway.
Volume: 13
Issue: 5
Pages: 640-50
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Publication
25175012 | J:274167
 
First Author: Zhu L
Year: 2014
Journal: Nat Commun
Title: TSC1 controls macrophage polarization to prevent inflammatory disease.
Volume: 5
Pages: 4696
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Publication
21896734 | J:176586
First Author: Banerjee S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.
Volume: 108
Issue: 38
Pages: 15996-6001
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Publication
27080031 | J:266755
 
First Author: Petrinovic MM
Year: 2016
Journal: Sci Rep
Title: A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains.
Volume: 6
Pages: 24523
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Publication
30237867 | J:308760
 
First Author: Brown EA
Year: 2018
Journal: Mol Autism
Title: Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models.
Volume: 9
Pages: 48
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Publication
23228442 | J:196914
First Author: Yang J
Year: 2013
Journal: Eur J Cancer
Title: Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
Volume: 49
Issue: 6
Pages: 1479-90
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Publication
21746920 | J:174534
First Author: Parkhitko A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.
Volume: 108
Issue: 30
Pages: 12455-60
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Publication
24931163 | J:221262
First Author: Dodd KM
Year: 2015
Journal: Oncogene
Title: mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.
Volume: 34
Issue: 17
Pages: 2239-50
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Publication
22916036 | J:188124
First Author: Tanwar PS
Year: 2012
Journal: PLoS Genet
Title: Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
Volume: 8
Issue: 8
Pages: e1002906
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Publication
31527310 | J:293727
First Author: Asrani K
Year: 2019
Journal: J Clin Invest
Title: mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.
Volume: 129
Issue: 12
Pages: 5584-5599
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Publication
23142078 | J:193986
First Author: Kim SG
Year: 2013
Journal: Mol Cell
Title: Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
Volume: 49
Issue: 1
Pages: 172-85
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Publication
28013293 | J:241435
First Author: Jin F
Year: 2017
Journal: Hum Mol Genet
Title: Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex.
Volume: 26
Issue: 2
Pages: 407-419
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23274085 | J:195093
First Author: Bae SH
Year: 2013
Journal: Cell Metab
Title: Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Volume: 17
Issue: 1
Pages: 73-84
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18344980 | J:133950
First Author: Lim KH
Year: 2008
Journal: Nature
Title: Tumour maintenance is mediated by eNOS.
Volume: 452
Issue: 7187
Pages: 646-9
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18373617 | J:137320
First Author: Kiebish MA
Year: 2008
Journal: J Neurochem
Title: Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria.
Volume: 106
Issue: 1
Pages: 299-312
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Publication
23315073 | J:193238
First Author: Katholnig K
Year: 2013
Journal: J Immunol
Title: p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin.
Volume: 190
Issue: 4
Pages: 1519-27
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32807950 | J:334054
First Author: Babetto E
Year: 2020
Journal: Nat Neurosci
Title: A glycolytic shift in Schwann cells supports injured axons.
Volume: 23
Issue: 10
Pages: 1215-1228
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Publication
21436046 | J:171212
First Author: Williams T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.
Volume: 108
Issue: 14
Pages: 5849-54
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Publication
35645731 | J:325114
 
First Author: Serra I
Year: 2022
Journal: Front Mol Neurosci
Title: Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum.
Volume: 15
Pages: 831687
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24209762 | J:205532
First Author: Wang S
Year: 2013
Journal: Cell Stem Cell
Title: Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency.
Volume: 13
Issue: 5
Pages: 617-25
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17015619 | J:114498
First Author: Gan B
Year: 2006
Journal: J Cell Biol
Title: Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.
Volume: 175
Issue: 1
Pages: 121-33
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Publication
23275438 | J:315254
First Author: Zurashvili T
Year: 2013
Journal: Mol Cell Biol
Title: Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
Volume: 33
Issue: 5
Pages: 1027-40
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Publication
15249583 | J:91846
First Author: Harrington LS
Year: 2004
Journal: J Cell Biol
Title: The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Volume: 166
Issue: 2
Pages: 213-23
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Publication
8945939 | J:36847
First Author: Soonpaa MH
Year: 1996
Journal: Am J Physiol
Title: Cardiomyocyte DNA synthesis and binucleation during murine development.
Volume: 271
Issue: 5 Pt 2
Pages: H2183-9
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19620286 | J:152599
First Author: Bhaskar PT
Year: 2009
Journal: Mol Cell Biol
Title: mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.
Volume: 29
Issue: 18
Pages: 5136-47
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19398581 | J:149890
First Author: Saiga T
Year: 2009
Journal: Mol Cell Biol
Title: Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Volume: 29
Issue: 13
Pages: 3529-43
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9226367 | J:41656
First Author: Brinkmeier ML
Year: 1997
Journal: Genomics
Title: Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.
Volume: 43
Issue: 1
Pages: 9-14
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Publication
27050589 | J:235088
First Author: de la Torre-Ubieta L
Year: 2016
Journal: Nat Med
Title: Advancing the understanding of autism disease mechanisms through genetics.
Volume: 22
Issue: 4
Pages: 345-61
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Publication
25273085 | J:217495
First Author: Ka M
Year: 2014
Journal: Development
Title: mTOR regulates brain morphogenesis by mediating GSK3 signaling.
Volume: 141
Issue: 21
Pages: 4076-86
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Publication
20665729 | J:164696
First Author: Tan Y
Year: 2010
Journal: Genesis
Title: Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.
Volume: 48
Issue: 9
Pages: 531-9
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Publication
20399730 | J:160624
First Author: Kim S
Year: 2010
Journal: Neuron
Title: The apical complex couples cell fate and cell survival to cerebral cortical development.
Volume: 66
Issue: 1
Pages: 69-84
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Publication
34242585 | J:308686
First Author: Tiu GC
Year: 2021
Journal: Dev Cell
Title: A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.
Volume: 56
Issue: 14
Pages: 2089-2102.e11
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28069738 | J:244710
 
First Author: Yamauchi T
Year: 2017
Journal: Mol Cell Biol
Title: FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Volume: 37
Issue: 8
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21238928 | J:168571
First Author: Zou J
Year: 2011
Journal: Dev Cell
Title: Rheb1 is required for mTORC1 and myelination in postnatal brain development.
Volume: 20
Issue: 1
Pages: 97-108
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Publication
27416896 | J:240829
 
First Author: Jiang M
Year: 2016
Journal: Nat Commun
Title: Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.
Volume: 7
Pages: 12185
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Publication
27582005 | J:235788
First Author: Nagy II
Year: 2016
Journal: BMC Dev Biol
Title: Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.
Volume: 16
Issue: 1
Pages: 30
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28671696 | J:249721
First Author: Li J
Year: 2017
Journal: Nat Neurosci
Title: Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
Volume: 20
Issue: 8
Pages: 1150-1161
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16452087 | J:263376
First Author: Trinidad JC
Year: 2006
Journal: Mol Cell Proteomics
Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Volume: 5
Issue: 5
Pages: 914-22
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29950673 | J:266104
First Author: Choi JH
Year: 2018
Journal: Nat Commun
Title: mTORC1 accelerates retinal development via the immunoproteasome.
Volume: 9
Issue: 1
Pages: 2502
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Publication
25211037 | J:263419
First Author: Distler U
Year: 2014
Journal: Proteomics
Title: In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.
Volume: 14
Issue: 21-22
Pages: 2607-13
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Publication
37494420 | J:344559
First Author: Hughes CHK
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.
Volume: 120
Issue: 32
Pages: e2220849120
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:345476
       
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
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24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
21613414 | J:175260
First Author: Buller CL
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: GLUT1 enhances mTOR activity independently of TSC2 and AMPK.
Volume: 301
Issue: 3
Pages: F588-96
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Publication
23818547 | J:202264
First Author: Lu J
Year: 2013
Journal: Blood
Title: Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.
Volume: 122
Issue: 9
Pages: 1610-20
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HT Experiment
E-GEOD-40630 | Divergent dysregulation of gene expression in Fmr1 and Tsc2 knockout mouse models of autism spectrum disorders
Series Id: GSE40630
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
20160076 | J:158578
First Author: Alexander A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Volume: 107
Issue: 9
Pages: 4153-8
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Publication
32781001 | J:301371
 
First Author: Iffland PH 2nd
Year: 2020
Journal: Exp Neurol
Title: Dynamic analysis of 4E-BP1 phosphorylation in neurons with Tsc2 or Depdc5 knockout.
Volume: 334
Pages: 113432
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Publication
23348097 | J:199040
First Author: Wang HL
Year: 2013
Journal: Biochim Biophys Acta
Title: XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons.
Volume: 1832
Issue: 4
Pages: 585-93
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10944454 | J:64047
First Author: Yamashita Y
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model.
Volume: 275
Issue: 1
Pages: 134-40
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9831664 | J:52359
First Author: Imai K
Year: 1998
Journal: Gene
Title: Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.
Volume: 222
Issue: 2
Pages: 287-95
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9580671 | -
First Author: van Slegtenhorst M
Year: 1998
Journal: Hum Mol Genet
Title: Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products.
Volume: 7
Issue: 6
Pages: 1053-7
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Interaction Experiment
Cao Y (2006)
Description: Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.
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Publication
16464865 | -
First Author: Chong-Kopera H
Year: 2006
Journal: J Biol Chem
Title: TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.
Volume: 281
Issue: 13
Pages: 8313-6
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Publication
12869586 | -
First Author: Inoki K
Year: 2003
Journal: Genes Dev
Title: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Volume: 17
Issue: 15
Pages: 1829-34
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Publication
15340059 | -
First Author: Li Y
Year: 2004
Journal: Mol Cell Biol
Title: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Volume: 24
Issue: 18
Pages: 7965-75
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HT Experiment
E-MTAB-1487 | Transcription profiling by array of mice overexpressing a transgenic mutant human TDP-43 (hTDP-43) gene and wild-type mice to study TDP-43 mutations in relation to amyotrophic lateral sclerosis
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
24444419 | -
First Author: Ha JY
Year: 2014
Journal: J Neurochem
Title: Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model.
Volume: 129
Issue: 3
Pages: 527-38
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Publication
8806680 | -
First Author: Wienecke R
Year: 1996
Journal: Oncogene
Title: Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.
Volume: 13
Issue: 5
Pages: 913-23
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Publication
18381890 | -
First Author: Hu J
Year: 2008
Journal: Genes Dev
Title: WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
Volume: 22
Issue: 7
Pages: 866-71
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Allele
Tsc2<tm1Smoc> | MGI:7293014
Name: TSC complex subunit 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
21827857 | J:179850
First Author: Chévere-Torres I
Year: 2012
Journal: Neurobiol Dis
Title: Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin.
Volume: 45
Issue: 1
Pages: 156-64
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DO Term
DOID:0080325 | tuberous sclerosis 2
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Publication
17077083 | -
First Author: Cao Y
Year: 2006
Journal: J Biol Chem
Title: Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.
Volume: 281
Issue: 52
Pages: 40242-51
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Allele
Tg(CMV-Tsc2*)1Arbi | MGI:5049894
Name: transgene insertion 1, Jack Arbiser
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Pkd1)18Mtru | MGI:4437719
Name: transgene insertion 18, Marie Trudel
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5049914 | C57BL/6-Tg(CMV-Tsc2*)1Arbi/KlanJ
Attribute String: transgenic, mutant strain, coisogenic
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Publication
15576369 | J:96943
First Author: Govindarajan B
Year: 2005
Journal: J Biol Chem
Title: Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain.
Volume: 280
Issue: 7
Pages: 5870-4
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