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Search results 2601 to 2700 out of 3582 for Tlr4

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Coding Gene
MGI:1929612 | Ikbke
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929658 | Tbk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918898 | Optn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859212 | Irf7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109324 | Fadd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1197009 | Birc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1197007 | Birc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q62210
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: false
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Protein
O08863
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
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Protein
Q9R0T8
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q61160
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
P70434
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
Q8K3K8
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
Q9WUN2
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
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Publication
30332431 | J:266821
First Author: Dong D
Year: 2018
Journal: PLoS One
Title: GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
Volume: 13
Issue: 10
Pages: e0205303
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Publication
23238562 | J:193330
First Author: Gandhi A
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice.
Volume: 266
Issue: 3
Pages: 430-8
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Publication
16301656 | J:122157
First Author: Jeyaseelan S
Year: 2005
Journal: J Immunol
Title: Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli.
Volume: 175
Issue: 11
Pages: 7484-95
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Publication
18039275 | J:169888
First Author: Togbe D
Year: 2007
Journal: Int J Exp Pathol
Title: Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury.
Volume: 88
Issue: 6
Pages: 387-91
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Publication
11526399 | J:72250
First Author: Horng T
Year: 2001
Journal: Nat Immunol
Title: TIRAP: an adapter molecule in the Toll signaling pathway.
Volume: 2
Issue: 9
Pages: 835-41
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Publication
17322885 | J:169893
First Author: Khor CC
Year: 2007
Journal: Nat Genet
Title: A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
Volume: 39
Issue: 4
Pages: 523-8
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Strain
MGI:6472853 | NOD.Cg-Tlr4<lps-del> Prkdc<scid> Il2rg<tm1Wjl>/SzJ
Attribute String: mutant strain, congenic, spontaneous mutation, targeted mutation
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Allele
Tlr4<Lps-d+> | MGI:4943781
 
Name: toll-like receptor 4; lipopolysaccharide response wild-type revertant
Allele Type: Spontaneous
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Strain
MGI:5911248 | B6.Cg-Tg(LY96)7020Haj Tg(TLR4)5271Haj/J
Attribute String: congenic, mutant strain, transgenic
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Publication
28714953 | J:258038
First Author: Shen S
Year: 2017
Journal: Nat Neurosci
Title: Gut microbiota is critical for the induction of chemotherapy-induced pain.
Volume: 20
Issue: 9
Pages: 1213-1216
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Protein
H3BKI0
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Publication
27769858 | -
First Author: Deshar R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4.
Volume: 480
Issue: 2
Pages: 280-287
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Publication
19423080 | -
First Author: Hadjighassem MR
Year: 2009
Journal: Biol Psychiatry
Title: Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.
Volume: 66
Issue: 3
Pages: 214-22
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Publication
18490904 | -
First Author: Meylan E
Year: 2008
Journal: Nat Immunol
Title: IRAK2 takes its place in TLR signaling.
Volume: 9
Issue: 6
Pages: 581-2
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Publication
23166766 | -
First Author: Gosu V
Year: 2012
Journal: PLoS One
Title: Molecular evolution and structural features of IRAK family members.
Volume: 7
Issue: 11
Pages: e49771
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Protein Domain
IPR042151 | Death_IRAK2
Type: Domain
Description: This entry represents the death domain found in interleukin-1 receptor-associated kinase-like 2 (IRAK2) []. IRAK2 is an essential component of several signaling pathways, including NF-kappaB and the IL-1 signaling pathways. It is an inactive kinase that participates in septic shock mediated by TLR4 and TLR9 []. It plays a redundant role with IRAK1 in early NF-kB and MAPK responses, and remains present at later stages whereas IRAK1 disappears [, ].Interleukin-1 receptor-associated kinases (IRAKs) are essential components of innate immunity and inflammation in mammals and other vertebrates []. They are involved in signal transduction pathways involving IL-1 and IL-18 receptors, Toll-like receptors, nuclear factor-kappaB (NF-kB), and mitogen-activated protein kinases (MAPKs). IRAKs contain an N-terminal death domain (DD) and a C-terminal kinase domain [, , , ].Death domains (DDs) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Protein Domain
IPR039725 | CC2D1A/B
Type: Family
Description: This entry includes coiled-coil and C2 domain-containing protein 1A/B (CC2D1A/B, also known as Freud-1/2). CC2D1A is involved in many pathways, including nuclear factor kappaB, PDK1/Akt, cAMP/PKA, Notch and bone morphogenetic protein []. It is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. CC2D1B binds to the 5-HT1A DRE and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons [].CC2D1A and CC2D1B have also been shown to interact with the CHMP4 family of proteins, the major subunit of the ESCRT-III complex. They may regulate degradation and signaling of EGFR and TLR4 [].CC2D1A and CC2D1B share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The CC2D1A C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The CC2D1B C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions []. Mutations in the CC2D1A gene has been linked to nonsyndromic mental retardation [, ].
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Protein Coding Gene
MGI:1341909 | Ly96
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98217 | S100b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914853 | Dusp6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346862 | Mapk9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346868 | Map2k3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346869 | Map2k4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919216 | Nkiras2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919599 | Dusp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95574 | Fos
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920336 | Rps6ka5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108212 | Ripk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916971 | Nkiras1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2445060 | Lrrc14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1298366 | Atf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:893592 | Ager
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2147032 | Ticam1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346878 | Map3k8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1928898 | Usp14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1930715 | Ube2d2a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88318 | Cd14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3040056 | Ticam2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109349 | Atf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918731 | Alpk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2182965 | Tifa
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913355 | Ube2d3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96646 | Jun
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2386643 | Tnip2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346863 | Mapk10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96113 | Hmgb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341839 | Nod1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2429603 | Irak2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1344364 | Usp18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2182465 | Vrk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859179 | Irf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346871 | Map2k7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2442191 | Dusp4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2136825 | N4bp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2429397 | Nod2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3612191 | Nlrc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2429611 | Nlrx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2387100 | Dusp7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2143163 | Mapkapk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9CXB8
Organism: Mus musculus/domesticus
Length: 1231  
Fragment?: false
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Protein
Q9D7X3
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
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Protein
Q62151
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: false
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Protein
Q3UMW7
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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Protein
P05627
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
Q9WTU6
Organism: Mus musculus/domesticus
Length: 423  
Fragment?: false
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Protein
Q61831
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
Q8CE90
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Protein
Q8BFV3
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q3TL44
Organism: Mus musculus/domesticus
Length: 975  
Fragment?: false
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Protein
Q8C050
Organism: Mus musculus/domesticus
Length: 863  
Fragment?: false
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Protein
C3VPR6
Organism: Mus musculus/domesticus
Length: 1915  
Fragment?: false
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Protein
P63158
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
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Protein
Q8BHB0
Organism: Mus musculus/domesticus
Length: 953  
Fragment?: false
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Protein
P01101
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
Q91Z46
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q9DBB1
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
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Protein
Q9JHF9
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Protein
P81269
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
Q8K3Z0
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
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Protein
P10810
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
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Protein
Q9CR56
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
P70671
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
O09110
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Protein
P47809
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q8VC16
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Protein
Q8CEC5
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom