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Search results 201 to 300 out of 336 for Als2

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Type Details Score
Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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UniProt Feature
UniProt Feature
Begin: 1
Description: ALS2 C-terminal-like protein
Type: chain
End: 952
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Publication
16473597 | -
 
First Author: Hadano S
Year: 2005
Journal: Methods Enzymol
Title: Purification and functional analyses of ALS2 and its homologue.
Volume: 403
Pages: 310-21
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Protein
Q60I26
Organism: Mus musculus/domesticus
Length: 952  
Fragment?: false
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Protein
A0A0R4J1X4
Organism: Mus musculus/domesticus
Length: 952  
Fragment?: false
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Publication
14668431 | J:265400
First Author: Yamanaka K
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease.
Volume: 100
Issue: 26
Pages: 16041-6
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Protein
Q60I26-3
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
Q60I26-2
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
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Protein
A0A0G2JEP6
Organism: Mus musculus/domesticus
Length: 39  
Fragment?: true
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Gene
100318899 | als2b
Type: gene
Organism: zebrafish
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Gene
557014 | als2a
Type: gene
Organism: zebrafish
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Allele
Als2cl<+> | MGI:3055145
   
Name: ALS2 C-terminal like; wild type
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Publication
27406959 | J:43556
First Author: Wright RM
Year: 1997
Journal: Redox Rep
Title: Molecular cloning, refined chromosomal mapping and structural analysis of the human gene encoding aldehyde oxidase (AOX1), a candidate for the ALS2 gene.
Volume: 3
Issue: 3
Pages: 135-44
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Allele
Als2cl<em1(IMPC)J> | MGI:6117095
Name: ALS2 C-terminal like; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein Coding Gene
MGP_CAROLIEiJ_G0032747 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035275 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2447532 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035861 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034353 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035014 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035120 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035881 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034474 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015614 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033895 | -
Type: protein_coding_gene
Organism: Mus spretus
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Strain
MGI:6117096 | C57BL/6NJ-Als2cl<em1(IMPC)J>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Als2cl<tm1e(KOMP)Wtsi> | MGI:4364663
Name: ALS2 C-terminal like; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Als2cl<tm1a(KOMP)Wtsi> | MGI:4362593
Name: ALS2 C-terminal like; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Als2cl<em1Gpt> | MGI:7309753
Name: ALS2 C-terminal like; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Als2cl/Als2cl
Background: C57BL/6NJ-Als2cl/Mmjax
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060194 | amyotrophic lateral sclerosis type 2
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Publication
12140191 | J:78124
First Author: Mitchem KL
Year: 2002
Journal: Hum Mol Genet
Title: Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6.
Volume: 11
Issue: 16
Pages: 1887-98
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Allele
Als2cl<Gt(IST13851B5)Tigm> | MGI:5190031
 
Name: ALS2 C-terminal like; gene trap IST13851B5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Als2cl<Gt(IST12509D1)Tigm> | MGI:4072578
 
Name: ALS2 C-terminal like; gene trap IST12509D1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Als2cl<Gt(IST12842H5)Tigm> | MGI:5155240
 
Name: ALS2 C-terminal like; gene trap IST12842H5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Als2cl<Gt(IST13596B9)Tigm> | MGI:5181364
 
Name: ALS2 C-terminal like; gene trap IST13596B9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:6766967 | C57BL/6JGpt-Als2cl<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Als2cl<Gt(IST15016C12)Tigm> | MGI:5281538
 
Name: ALS2 C-terminal like; gene trap IST15016C12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Publication
17219777 | J:144656
First Author: Cho KI
Year: 2006
Journal: Comp Med
Title: The circling mouse (C57BL/6J-cir) has a 40-kilobase genomic deletion that includes the transmembrane inner ear (tmie) gene.
Volume: 56
Issue: 6
Pages: 476-81
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Allele
Als2<tm1Jei> | MGI:3612978
Name: alsin Rho guanine nucleotide exchange factor; targeted mutation 1, Joh-E Ikeda
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Als2<tm1Cai> | MGI:3522476
Name: alsin Rho guanine nucleotide exchange factor; targeted mutation 1, Huaibin Cai
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Als2/Als2
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Allele
Als2<tm1Garo> | MGI:3807480
Name: alsin Rho guanine nucleotide exchange factor; targeted mutation 1, Guy A Rouleau
Allele Type: Targeted
Attribute String: Modified isoform(s)
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Strain
MGI:4429435 | B6;129X1-Als2<tm1Cai>/Mmmh
Attribute String: mutant stock, targeted mutation
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Allele
Tg(Als2-EGFP)IP127Gsat | MGI:4846847
Name: transgene insertion IP127, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Als2/Als2
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:5003864 | STOCK Tg(Als2-EGFP)IP127Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Als2/Als2
Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Als2/Als2<+>
Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Zygosity: ht
Has Mutant Allele: true
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Publication
27256596 | J:239907
 
First Author: Fulcoli FG
Year: 2016
Journal: Nat Commun
Title: Rebalancing gene haploinsufficiency in vivo by targeting chromatin.
Volume: 7
Pages: 11688
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Protein Domain
IPR003123 | VPS9
Type: Domain
Description: Rab proteins form a family of signal-transducing GTPases that cycle betweenactive GTP-bound and inactive GDP-bound forms. The Rab5 GTPase is an essentialregulator of endocytosis and endosome biogenesis. Rab5 is activated by GDP-GTPexchange factors (GEFs) that contain a VPS9 domain and generate the Rab5-GTPcomplex []. The VPS9 domain catalyzes nucleotide exchange on Rab5 or theyeast homologue VPS21. The domain has a length of ~140 residues and forms thecentral part of the yeast VPS9 (vacuolar protein sorting-associated) protein,which acts as a GEF for VPS21. Some domains which canoccur in combinationwith the VPS9 domain are CUE, A20-type zinc finger, Ras-associating (RA), SH2,RCC1, DH, PH, rasGAP, MORN and ankyrin repeat.Structurally, the VPS9 domain adopts a layered fold of six alpha helices. Conserved residues from the fourth and sixth helices and theloops N-terminal to these helices form the surface that interacts with Rab5and Rab21 [].Some proteins known to contain a VPS9 domain:Fungal Vacuolar Protein Sorting-associated protein VPS9, a guaninenucleotide exchange factor for the Rab-like GTPase VPS21. VPS9 is neededfor the transport of proteins from biosynthetic and endocytic pathways intothe vacuole.Mammalian Rab5 GDP/GTP exchange factor or Rabex-5 (Rababtin-5 associatedexchange factor for Rab5), catalyzes nucleotide exchange on RAB5A. Rabex-5promotes endocytic membrane fusion and is involved in membrane traffickingof recycling endosomes.Mammalian Ras and Rab interactor 1 (RIN1), 2 (RIN2) and 3 (RIN3).Mammalian alsin or Amyotrophic Lateral Sclerosis protein 2 (ALS2).Different juvenile-onset forms of neurodegenerative diseases (ALS2, JPLS,IAHSP) are caused by mutations in the ALS2 gene, which result in truncatedalsin lacking the C-terminal part of the VPS9 domain.Fruit fly protein sprint, which is a RIN homologue.Caenorhabditis elegans RME-6 protein, which is conserved among metazoans.
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Protein
A0A0U1RPT7
Organism: Mus musculus/domesticus
Length: 388  
Fragment?: false
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Protein
A0A0R4J2C4
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Publication
15339665 | -
First Author: Delprato A
Year: 2004
Journal: Cell
Title: Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5.
Volume: 118
Issue: 5
Pages: 607-17
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Publication
16330212 | -
First Author: Carney DS
Year: 2006
Journal: Trends Cell Biol
Title: Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons.
Volume: 16
Issue: 1
Pages: 27-35
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Publication
15449545 | J:92574
First Author: Okazaki N
Year: 2004
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 11
Issue: 2
Pages: 127-35
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Protein
Q8C190
Organism: Mus musculus/domesticus
Length: 649  
Fragment?: false
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Protein
Q8VDI6
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
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Protein
A0A140LIA6
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A286YCR5
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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