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Search results 201 to 300 out of 483 for Dot1l

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EG1393; Specimen G0472
Detected: false
Specimen Num: 1
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Publication
32879489 | J:296748
First Author: Bian Y
Year: 2020
Journal: Nature
Title: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
Volume: 585
Issue: 7824
Pages: 277-282
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Publication
36436817 | J:344511
 
First Author: Jo SY
Year: 2023
Journal: Bone
Title: In vivo intra-articular contrast enhanced μCT imaging of mouse knee cartilage.
Volume: 167
Pages: 116632
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Publication
19956800 | J:155375
First Author: Mueller D
Year: 2009
Journal: PLoS Biol
Title: Misguided transcriptional elongation causes mixed lineage leukemia.
Volume: 7
Issue: 11
Pages: e1000249
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Publication
35143761 | J:348631
First Author: Yang M
Year: 2022
Journal: Cell Stem Cell
Title: Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Volume: 29
Issue: 3
Pages: 400-418.e13
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Publication
23077601 | J:192211
First Author: Zhou Q
Year: 2012
Journal: PLoS One
Title: Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats.
Volume: 7
Issue: 10
Pages: e47360
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Publication
19491102 | J:153184
First Author: Zhang D
Year: 2009
Journal: J Biol Chem
Title: Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct.
Volume: 284
Issue: 31
Pages: 20917-26
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Publication
24813610 | J:214397
First Author: Alpatov R
Year: 2014
Journal: Cell
Title: A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response.
Volume: 157
Issue: 4
Pages: 869-81
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Publication
24026182 | J:202992
First Author: Zhang X
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.
Volume: 305
Issue: 10
Pages: F1436-44
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Publication
20427473 | J:160934
First Author: Reisenauer MR
Year: 2010
Journal: Am J Physiol Renal Physiol
Title: Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.
Volume: 299
Issue: 1
Pages: F63-76
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Publication
28981838 | J:243553
First Author: Fisher CL
Year: 2017
Journal: Nucleic Acids Res
Title: An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.
Volume: 45
Issue: 21
Pages: e174
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Publication
32553114 | J:292114
   
First Author: Pereira M
Year: 2020
Journal: Elife
Title: A trans-eQTL network regulates osteoclast multinucleation and bone mass.
Volume: 9
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Publication
31748268 | J:282322
First Author: Ko HR
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control.
Volume: 116
Issue: 49
Pages: 24852-24860
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Publication
24105743 | J:202816
First Author: Wajapeyee N
Year: 2013
Journal: Genes Dev
Title: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.
Volume: 27
Issue: 20
Pages: 2221-6
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Publication
34368113 | J:313616
 
First Author: Zhang F
Year: 2021
Journal: Front Cell Dev Biol
Title: Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.
Volume: 9
Pages: 642931
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Publication
18022353 | J:126799
First Author: Allis CD
Year: 2007
Journal: Cell
Title: New nomenclature for chromatin-modifying enzymes.
Volume: 131
Issue: 4
Pages: 633-6
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Allele
Dot1l<Gt(RRR032)Byg> | MGI:3784999
Name: DOT1 like histone lysine methyltransferase; gene trap RRR032, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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HT Experiment
GSE221994 | DOT1L deletion impairs the development of cortical Parvalbumin-expressing interneurons
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Gene
361285 | Mllt10
Type: gene
Organism: rat
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Gene
487096 | MLLT10
Type: gene
Organism: dog, domestic
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Gene
450343 | MLLT10
Type: gene
Organism: chimpanzee
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Gene
519864 | MLLT10
Type: gene
Organism: cattle
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Gene
492342 | mllt10
Type: gene
Organism: zebrafish
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Gene
100036598 | mllt10
Type: gene
Organism: frog, western clawed
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Gene
108719864 | mllt10.S
Type: gene
Organism: frog, African clawed
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Gene
494767 | mllt10.L
Type: gene
Organism: frog, African clawed
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Publication
34037658 | J:307937
 
First Author: Leon KE
Year: 2021
Journal: J Cell Biol
Title: DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A.
Volume: 220
Issue: 8
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HT Experiment
GSE217931 | DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE95832 | Assesment of DOT1L direct targets via RNAseq at E14.5 of mouse cortex
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE142188 | Transcriptome of murine lumbar spinal cord at E12.5 in control and DOT1L cKO through Wnt1cre2 (B6.Cg-E2f1Tg(Wnt1-cre)2Sor/J, Jackson Laboratory #022501)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Dot1l<em1Smoc> | MGI:7289387
Name: DOT1 like histone lysine methyltransferase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Whitcomb SJ (2012)
Description: Histone Monoubiquitylation Position Determines Specificity and Direction of Enzymatic Crosstalk with Histone Methyltransferases Dot1L and PRC2.
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Interaction Experiment
Castano Betancourt MC (2012)
Description: Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.
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Strain
MGI:6770705 | C57BL/6-Dot1l<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
22619169 | -
First Author: Whitcomb SJ
Year: 2012
Journal: J Biol Chem
Title: Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.
Volume: 287
Issue: 28
Pages: 23718-25
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Allele
Dot1l<tm1.1Tche> | MGI:4459468
Name: DOT1 like histone lysine methyltransferase; targeted mutation 1.1, Taiping Chen
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
22566624 | -
First Author: Castaño Betancourt MC
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.
Volume: 109
Issue: 21
Pages: 8218-23
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Genotype
Genotype
Symbol: Dot1l/Dot1l
Background: either: (involves: C57BL/6) or (involves: 129/Sv * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE95833 | Assesment of Foxg1 targets via RNAseq at E13.5 of mouse cortex
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE184191 | Genome-wide mRNA expression analyses revealed dysregulation of genes important for cardiomyocyte function in XMlc2-Cre;Dot1L mutants and controls
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-40090 | Mouse whole kidney, Dot1lAC vs. Dot1lf/f mice
Series Id: GSE40090
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Genotype
Genotype
Symbol: Dot1l/Dot1l Tg(Myhca-cre)1Abel/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Publication
32398749 | J:292157
First Author: Itskovich SS
Year: 2020
Journal: Nat Commun
Title: MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.
Volume: 11
Issue: 1
Pages: 2369
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Publication
18977325 | J:140628
First Author: Krivtsov AV
Year: 2008
Journal: Cancer Cell
Title: H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Volume: 14
Issue: 5
Pages: 355-68
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Publication
30356100 | J:267817
First Author: Liu Y
Year: 2018
Journal: Nat Commun
Title: Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth.
Volume: 9
Issue: 1
Pages: 4429
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Publication
26214134 | J:227286
First Author: Soria-Valles C
Year: 2015
Journal: Nat Cell Biol
Title: NF-κB activation impairs somatic cell reprogramming in ageing.
Volume: 17
Issue: 8
Pages: 1004-13
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Publication
29777171 | J:263721
First Author: Skucha A
Year: 2018
Journal: Nat Commun
Title: MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Volume: 9
Issue: 1
Pages: 1983
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Publication
31433981 | J:288447
First Author: Kara N
Year: 2019
Journal: Cell Rep
Title: The miR-216a-Dot1l Regulatory Axis Is Necessary and Sufficient for Müller Glia Reprogramming during Retina Regeneration.
Volume: 28
Issue: 8
Pages: 2037-2047.e4
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Publication
28931923 | J:256374
First Author: Ogoh H
Year: 2017
Journal: Sci Rep
Title: Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development.
Volume: 7
Issue: 1
Pages: 11922
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Protein Coding Gene
MGI:1329038 | Mllt10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0023204 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025373 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025319 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025346 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025106 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1329038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024570 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025085 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025217 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025180 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025211 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024319 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024640 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024660 | -
Type: protein_coding_gene
Organism: Mus pahari
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom