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Search results 5901 to 6000 out of 7122 for App

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Hits by Strain

Type Details Score
Publication
18367332 | J:136646
First Author: Dehvari N
Year: 2008
Journal: Neurosci Lett
Title: Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism.
Volume: 436
Issue: 1
Pages: 77-80
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Publication
18436531 | J:138182
First Author: Shen C
Year: 2008
Journal: J Biol Chem
Title: Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase.
Volume: 283
Issue: 25
Pages: 17721-30
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Publication
18669616 | J:139936
First Author: Paulson JB
Year: 2008
Journal: Am J Pathol
Title: Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease.
Volume: 173
Issue: 3
Pages: 762-72
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Publication
18784309 | J:141259
First Author: Nicolakakis N
Year: 2008
Journal: J Neurosci
Title: Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist.
Volume: 28
Issue: 37
Pages: 9287-96
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Publication
19232329 | J:148200
 
First Author: Zhang Q
Year: 2009
Journal: Brain Res
Title: Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism.
Volume: 1264
Pages: 111-8
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Publication
19049493 | J:148977
First Author: Cuesta A
Year: 2009
Journal: Biochem J
Title: The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP).
Volume: 418
Issue: 3
Pages: 643-50
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Publication
19410642 | J:151188
First Author: Castillo CA
Year: 2009
Journal: Exp Gerontol
Title: Age-related expression of adenosine receptors in brain from the senescence-accelerated mouse.
Volume: 44
Issue: 6-7
Pages: 453-61
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Publication
19889971 | J:154760
First Author: Dunys J
Year: 2009
Journal: J Cell Sci
Title: p53-dependent control of transactivation of the Pen2 promoter by presenilins.
Volume: 122
Issue: Pt 21
Pages: 4003-8
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Publication
19625658 | J:154874
First Author: Huttunen HJ
Year: 2009
Journal: FASEB J
Title: Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway.
Volume: 23
Issue: 11
Pages: 3819-28
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Publication
20025930 | J:156882
First Author: Hashimoto T
Year: 2010
Journal: Neurosci Lett
Title: Age-dependent increase in lysosome-associated membrane protein 1 and early-onset behavioral deficits in APPSL transgenic mouse model of Alzheimer's disease.
Volume: 469
Issue: 2
Pages: 273-7
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Publication
21613482 | J:173328
First Author: Winton MJ
Year: 2011
Journal: J Neurosci
Title: Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
Volume: 31
Issue: 21
Pages: 7691-9
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Publication
21534960 | J:175582
First Author: Minami SS
Year: 2011
Journal: J Neurochem
Title: Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent-resistant membranes.
Volume: 118
Issue: 5
Pages: 879-90
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Publication
21989385 | J:180080
First Author: Schmidt V
Year: 2012
Journal: EMBO J
Title: Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
Volume: 31
Issue: 1
Pages: 187-200
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Publication
22279231 | J:180578
First Author: Fjorback AW
Year: 2012
Journal: J Neurosci
Title: Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.
Volume: 32
Issue: 4
Pages: 1467-80
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Publication
22192143 | J:184338
First Author: Fragkouli A
Year: 2012
Journal: J Neurochem
Title: Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9.
Volume: 121
Issue: 2
Pages: 239-51
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Publication
22178988 | J:184401
 
First Author: Jolivalt CG
Year: 2012
Journal: Neuroscience
Title: Similar pattern of peripheral neuropathy in mouse models of type 1 diabetes and Alzheimer's disease.
Volume: 202
Pages: 405-12
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Publication
22505025 | J:184696
First Author: Chávez-Gutiérrez L
Year: 2012
Journal: EMBO J
Title: The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.
Volume: 31
Issue: 10
Pages: 2261-74
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Publication
22586122 | J:184754
First Author: Zhang X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.
Volume: 109
Issue: 22
Pages: 8534-9
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Publication
23238734 | J:192014
First Author: Page RM
Year: 2012
Journal: J Neurosci
Title: Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments.
Volume: 32
Issue: 50
Pages: 18204-14
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Publication
23197725 | J:193050
First Author: Chabrier MA
Year: 2012
Journal: J Neurosci
Title: Soluble aβ promotes wild-type tau pathology in vivo.
Volume: 32
Issue: 48
Pages: 17345-50
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Publication
23658180 | J:198432
First Author: Li W
Year: 2013
Journal: J Neurosci
Title: Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer's disease mouse model.
Volume: 33
Issue: 19
Pages: 8423-41
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Publication
22771797 | J:201292
First Author: Teranishi Y
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
Volume: 424
Issue: 3
Pages: 476-81
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Publication
23926111 | J:205970
First Author: Wang H
Year: 2013
Journal: J Biol Chem
Title: COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.
Volume: 288
Issue: 37
Pages: 26668-77
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Publication
23872114 | J:210772
First Author: Chua LM
Year: 2013
Journal: Biochem Biophys Res Commun
Title: The Kunitz-protease inhibitor domain in amyloid precursor protein reduces cellular mitochondrial enzymes expression and function.
Volume: 437
Issue: 4
Pages: 642-7
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Publication
24440055 | J:212059
 
First Author: Chabrier MA
Year: 2014
Journal: Neurobiol Dis
Title: Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
Volume: 64
Pages: 107-17
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Publication
23624141 | J:214201
 
First Author: Kitaoka K
Year: 2013
Journal: Neuropharmacology
Title: The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice.
Volume: 72
Pages: 58-65
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Publication
24808180 | J:216030
First Author: Karaca I
Year: 2014
Journal: J Biol Chem
Title: Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein.
Volume: 289
Issue: 24
Pages: 16761-72
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Publication
25939386 | J:224097
First Author: Wang Y
Year: 2015
Journal: Mol Cell Biol
Title: Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.
Volume: 35
Issue: 14
Pages: 2368-84
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Publication
26896628 | J:231974
First Author: Ueda N
Year: 2016
Journal: J Neurochem
Title: Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.
Volume: 137
Issue: 4
Pages: 647-58
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Publication
26911678 | J:233018
First Author: Lu J
Year: 2016
Journal: Hum Mol Genet
Title: Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.
Volume: 25
Issue: 9
Pages: 1714-27
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Publication
27179390 | J:234017
First Author: Kimura N
Year: 2016
Journal: Am J Pathol
Title: Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency: Concomitant Disruption of Retrograde Trafficking Is Required for Alteration in β-Amyloid Precursor Protein Metabolism.
Volume: 186
Issue: 7
Pages: 1952-66
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Publication
27266404 | J:234994
First Author: Schriemer D
Year: 2016
Journal: Dev Biol
Title: Regulators of gene expression in Enteric Neural Crest Cells are putative Hirschsprung disease genes.
Volume: 416
Issue: 1
Pages: 255-265
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Publication
27407168 | J:245146
First Author: Toh WH
Year: 2016
Journal: Biochem J
Title: Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions.
Volume: 473
Issue: 14
Pages: 1977-93
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Publication
30003470 | J:265350
     
First Author: Zeng F
Year: 2018
Journal: Transgenic Res
Title: Constitutive expression of antimicrobial peptide PR-39 in transgenic mice significantly enhances resistance to bacterial infection and promotes growth.
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Publication
29277556 | J:270250
 
First Author: Burak K
Year: 2018
Journal: Neurobiol Dis
Title: MicroRNA-16 targets mRNA involved in neurite extension and branching in hippocampal neurons during presymptomatic prion disease.
Volume: 112
Pages: 1-13
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Publication
30347266 | J:270310
 
First Author: Nuzzo D
Year: 2019
Journal: Neurobiol Dis
Title: Glucagon-like peptide-2 reduces the obesity-associated inflammation in the brain.
Volume: 121
Pages: 296-304
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Publication
31138646 | J:280821
First Author: Furusawa K
Year: 2019
Journal: J Biol Chem
Title: CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
Volume: 294
Issue: 28
Pages: 10886-10899
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Publication
17431643 | J:285094
First Author: Shin RW
Year: 2007
Journal: Acta Neuropathol
Title: Amyloid precursor protein cytoplasmic domain with phospho-Thr668 accumulates in Alzheimer's disease and its transgenic models: a role to mediate interaction of Abeta and tau.
Volume: 113
Issue: 6
Pages: 627-36
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Publication
14692698 | J:289395
First Author: Jankowsky JL
Year: 2003
Journal: J Neuropathol Exp Neurol
Title: Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
Volume: 62
Issue: 12
Pages: 1220-7
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Publication
32111743 | J:300635
First Author: Wu H
Year: 2020
Journal: J Biol Chem
Title: A kinesin adapter directly mediates dendritic mRNA localization during neural development in mice.
Volume: 295
Issue: 19
Pages: 6605-6628
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Publication
31407125 | J:292296
First Author: Jang S
Year: 2019
Journal: Transgenic Res
Title: Serum amyloid A1 is involved in amyloid plaque aggregation and memory decline in amyloid beta abundant condition.
Volume: 28
Issue: 5-6
Pages: 499-508
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Publication
31908000 | J:296932
First Author: Rudan Njavro J
Year: 2020
Journal: FASEB J
Title: Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
Volume: 34
Issue: 2
Pages: 2465-2482
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Publication
30733594 | J:311353
First Author: Li JG
Year: 2020
Journal: Mol Psychiatry
Title: Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Volume: 25
Issue: 10
Pages: 2630-2640
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Publication
32184288 | J:329641
 
First Author: Jung S
Year: 2020
Journal: Sci Signal
Title: SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions.
Volume: 13
Issue: 623
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Publication
34385305 | J:309543
 
First Author: Wang H
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol.
Volume: 118
Issue: 33
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Publication
34537327 | J:318654
 
First Author: Ochiai T
Year: 2021
Journal: Neurobiol Dis
Title: Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.
Volume: 159
Pages: 105510
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Publication
26477779 | J:318332
 
First Author: Colacurcio DJ
Year: 2015
Journal: Neurosci Lett
Title: Caspase-dependent degradation of MDMx/MDM4 cell cycle regulatory protein in amyloid β-induced neuronal damage.
Volume: 609
Pages: 182-8
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Publication
26160914 | J:318357
First Author: Tong Y
Year: 2015
Journal: Hum Mol Genet
Title: Phospholipid transfer protein (PLTP) deficiency accelerates memory dysfunction through altering amyloid precursor protein (APP) processing in a mouse model of Alzheimer's disease.
Volume: 24
Issue: 19
Pages: 5388-403
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Publication
28943410 | J:318463
 
First Author: Gowert NS
Year: 2017
Journal: Cell Signal
Title: Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.
Volume: 40
Pages: 210-221
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Publication
34875506 | J:319797
 
First Author: Novy MJ
Year: 2022
Journal: Neurobiol Aging
Title: Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice.
Volume: 110
Pages: 73-76
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Publication
35714682 | J:326136
 
First Author: Liu J
Year: 2022
Journal: Biochem Pharmacol
Title: Z-Guggulsterone attenuates cognitive defects and decreases neuroinflammation in APPswe/PS1dE9 mice through inhibiting the TLR4 signaling pathway.
Volume: 202
Pages: 115149
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Publication
36466614 | J:332047
 
First Author: Balzamino BO
Year: 2022
Journal: Front Aging Neurosci
Title: Morphological and biomolecular targets in retina and vitreous from Reelin-deficient mice (Reeler): Potential implications for age-related macular degeneration in Alzheimer's dementia.
Volume: 14
Pages: 1015359
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Protein
Q9QXJ1
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Publication
11518718 | -
First Author: Saxena MT
Year: 2001
Journal: J Biol Chem
Title: Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.
Volume: 276
Issue: 43
Pages: 40268-73
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Protein
Q8R1C9
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
Q9DBR4
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
Q3TIZ5
Organism: Mus musculus/domesticus
Length: 758  
Fragment?: false
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Protein
A0A087WRP1
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: true
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Protein
A0A087WPI2
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
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Protein
E9QPX0
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
Q3U674
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Protein
A0A0R4J2C1
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Protein
E9PWH3
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Protein
A0A087WPS7
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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Protein
A0A087WQH0
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
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Protein
A0A087WNN4
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
F6V8Y6
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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Protein
Q3UR23
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
Q3TDW6
Organism: Mus musculus/domesticus
Length: 736  
Fragment?: false
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Protein
A0A087WR62
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
A0A0R4J2C6
Organism: Mus musculus/domesticus
Length: 708  
Fragment?: false
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Publication
8755489 | J:34323
First Author: Thinakaran G
Year: 1996
Journal: Neuron
Title: Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Volume: 17
Issue: 1
Pages: 181-90
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Publication
10206644 | -
First Author: Wolfe MS
Year: 1999
Journal: Nature
Title: Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Volume: 398
Issue: 6727
Pages: 513-7
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Publication
14504279 | J:86802
First Author: Schulz JG
Year: 2003
Journal: J Biol Chem
Title: Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling.
Volume: 278
Issue: 49
Pages: 48651-7
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Protein Coding Gene
MGI:1916867 | Pitrm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Apoe<tm3(APOE*4)Mae> | MGI:2158398
Name: apolipoprotein E; targeted mutation 3, Nobuyo Maeda
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Cfh<tm1Mbo> | MGI:2384179
Name: complement component factor h; targeted mutation 1, Marina Botto
Allele Type: Targeted
Attribute String: Null/knockout
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Transgene
MGI:2385632 | Tg(APPSWE)2576Kha
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3510602 | Tg(Thy1-APP<SL>)28Lpr
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3590546 | Tg(PRNP-APPSweInd)8Dwst
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3653675 | Tg(tetO-CDK5R1/GFP)337Lht
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3708461 | Tg(tetO-APPSwInd)107Dbo
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:4415605 | Tg(Prnp-ITM2B*)1Ruvi
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(Thy1-APP)3Somm/?
Background: involves: C57BL/6J * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-CDK5R1/GFP)337Lht/?
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nr1h2/Nr1h2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cav1/Cav1
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Trib2/Trib2
Background: involves: C57BL/6 * DBA/1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psap/Psap
Background: involves: 129S/SvEv * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPswe,PSEN1dE9)85Dbo/?
Background: involves: C3H/HeH * C57BL/6JNju
Zygosity: ot
Has Mutant Allele: true
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Protein
F6TV37
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: true
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Protein
Q69ZQ6
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: true
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Protein
Q9CUU5
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Publication
7539437 | J:23276
 
First Author: Blangy A
Year: 1995
Journal: J Cell Sci
Title: CDEBP, a site-specific DNA-binding protein of the 'APP-like' family, is required during the early development of the mouse.
Volume: 108 ( Pt 2)
Pages: 675-83
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Publication
3909945 | J:30521
 
First Author: Clarke L
Year: 1985
Journal: Annu Rev Genet
Title: The structure and function of yeast centromeres.
Volume: 19
Pages: 29-55
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Publication
16645641 | J:132255
First Author: Xu Y
Year: 2007
Journal: Cell Death Differ
Title: Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3beta expression.
Volume: 14
Issue: 1
Pages: 79-91
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Publication
10087507 | J:53789
First Author: Ritzel MW
Year: 1998
Journal: Mol Membr Biol
Title: Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.
Volume: 15
Issue: 4
Pages: 203-11
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Publication
28521611 | J:319832
First Author: Mitroi DN
Year: 2017
Journal: Autophagy
Title: SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.
Volume: 13
Issue: 5
Pages: 885-899
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Publication
12354787 | J:94943
First Author: Hartmann D
Year: 2002
Journal: Hum Mol Genet
Title: The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Volume: 11
Issue: 21
Pages: 2615-24
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Publication
31527120 | J:280628
First Author: Bonds JA
Year: 2019
Journal: J Neurosci
Title: Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors.
Volume: 39
Issue: 43
Pages: 8576-8583
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