Interferon-stimulated 20kDa exonuclease-like 2 (ISG20L2) is a 3' to 5' exoribonuclease involved in the processing of the 12 S precursor rRNA during ribosome biogenesis. Its N-terminal half promotes nucleolar localization and its C-terminal half contains an exonuclease domain responsible for the exoribonuclease activity. The exonuclease domain belongs to the DEDDh group of the DEDD superfamily [].