Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
Allele |
Name: |
RB transcriptional corepressor like 1; targeted mutation 1, Hein te Riele |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 66, Terry van Dyke |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
RB transcriptional corepressor like 1; targeted mutation 1, Tyler Jacks |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Allele |
Name: |
RB transcriptional corepressor like 1; targeted mutation 1, Michael Rudnicki |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 |
Background: |
involves: 129S2/SvPas |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 |
Background: |
involves: 129S2/SvPas * FVB/N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Loedige I |
Year: |
2013 |
Journal: |
Nucleic Acids Res |
Title: |
The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. |
Volume: |
41 |
Issue: |
1 |
Pages: |
518-32 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE9567 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
•
•
•
|
Publication |
First Author: |
Simin K |
Year: |
2004 |
Journal: |
PLoS Biol |
Title: |
pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia. |
Volume: |
2 |
Issue: |
2 |
Pages: |
E22 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Tg(Pcp2-cre)756Mro/? |
Background: |
involves: 129P2/OlaHsd * FVB |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Tg(En2-cre)22Alj/? |
Background: |
involves: 129P2/OlaHsd * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1<+> Tg(En2-cre)22Alj/? |
Background: |
involves: 129P2/OlaHsd * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 |
Background: |
involves: 129S4/SvJae * BALB/cJ * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 |
Background: |
involves: 129S4/SvJae * BALB/cJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 |
Background: |
involves: 129S4/SvJae * BALB/c * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 |
Background: |
involves: 129S4/SvJae * BALB/c |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Rbl2/Rbl2 |
Background: |
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Rocha-Sanchez SM |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells. |
Volume: |
31 |
Issue: |
24 |
Pages: |
8883-93 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1<+> Trp53/Trp53 Tg(En2-cre)22Alj/? |
Background: |
involves: 129P2/OlaHsd * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129 * C57BL/6 * FVB/N * NMRI |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie C |
Year: |
2015 |
Journal: |
Mol Cancer |
Title: |
Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas. |
Volume: |
14 |
|
Pages: |
93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sherr CJ |
Year: |
2002 |
Journal: |
Cancer Cell |
Title: |
The RB and p53 pathways in cancer. |
Volume: |
2 |
Issue: |
2 |
Pages: |
103-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas DM |
Year: |
2001 |
Journal: |
Mol Cell |
Title: |
The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. |
Volume: |
8 |
Issue: |
2 |
Pages: |
303-16 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents the retinoblastoma protein family, including retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also known as RB2 or p130). Members of this family contain a conserved domain named the 'pocket' that interacts with the LXCXE motif found in viral proteins, such as SV40 large T antigen []. Therefore, this family is also called the pocket protein family.In humans, RB is a tumour suppressor linked to several major cancers []. RB forms complexes with E2Fs and represses gene expression by recruiting chromatin remodeling factors, such as histone deacetylases (HDACs) to E2F-responsive promoters [, ]. This interaction regulates genes necessary for DNA replication and cell cycle. Phosphorylation of RB family by CDK and cyclin complexes leads to release of the repressor complex and enables E2F-dependent gene expression []. Apart from E2Fs, RB also interacts with other transcription factors that govern cell differentiation [, ]. RBL1 and RBL2 are the components of the DREAM complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [, ]. |
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•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> Rbl1/Rbl1 |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> Rbl1/Rbl1<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 Rbl2/Rbl2 |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1<+> Rbl2/Rbl2 |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 Rbl2/Rbl2<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f2/E2f2 Rbl1/Rbl1 Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129 * C57BL/6 * FVB/N * NMRI |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f1/E2f1<+> Rbl1/Rbl1 Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129 * C57BL/6 * FVB/N * NMRI |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f1/E2f1 Rbl1/Rbl1 Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129 * C57BL/6 * FVB/N * NMRI |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f3/E2f3 Rbl1/Rbl1 Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129 * C57BL/6 * FVB/N * NMRI |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/? |
Background: |
involves: 129 * C57BL/6 * FVB/N * NMRI * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Tg(Nes-cre)1Atp/? |
Background: |
involves: 129S2/SvPas * 129S4/SvJae * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 |
Background: |
involves: 129S2/SvPas * 129S4/SvJae * BALB/c * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Rbl2/Rbl2 |
Background: |
involves: 129 * 129S2/SvPas * 129S4/SvJae |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbl1/Rbl1<+> Rbl2/Rbl2<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Tg(KRT14-cre)8Brn/? |
Background: |
involves: 129 * 129S2/SvPas * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
187
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Harbour JW |
Year: |
2000 |
Journal: |
Genes Dev |
Title: |
The Rb/E2F pathway: expanding roles and emerging paradigms. |
Volume: |
14 |
Issue: |
19 |
Pages: |
2393-409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murphree AL |
Year: |
1984 |
Journal: |
Science |
Title: |
Retinoblastoma: clues to human oncogenesis. |
Volume: |
223 |
Issue: |
4640 |
Pages: |
1028-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schvartzman JM |
Year: |
2011 |
Journal: |
Cancer Cell |
Title: |
Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. |
Volume: |
19 |
Issue: |
6 |
Pages: |
701-14 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f1/E2f1 E2f3/E2f3 Rbl1/Rbl1 Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129 * C57BL/6 * FVB/N * NMRI |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/? |
Background: |
involves: 129 * C57BL/6N * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
405
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
174
|
Fragment?: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/? |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1 Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/? |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1<+> Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/? |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Rbl1/Rbl1<+> Tg(Chx10-EGFP/cre,-ALPP)2Clc/? |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hells/Hells Rb1/Rb1 Rbl1/Rbl1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/? |
Background: |
involves: 129 * C57BL/6N * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
921
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1135
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
921
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
549
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1135
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1125
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
748
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1092
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Herschkowitz JI |
Year: |
2007 |
Journal: |
Genome Biol |
Title: |
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. |
Volume: |
8 |
Issue: |
5 |
Pages: |
R76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|