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Search results 101 to 200 out of 314 for Ssb

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Type Details Score
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Author
Komakula SSB
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Protein
Q564E6
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein Domain
IPR038621 | Lacto_phage_SSB_sf
Type: Homologous_superfamily
Description: This single-stranded DNA binding protein (SSB) is found in Lactococcus phage. It can stimulate RecA-mediated homologous recombination. Its structure is a variation of the typical oligonucleotide/oligosaccharide binding-fold of single-stranded DNA binding proteins [].
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GXD Expression
GXD Expression
   
Probe: MGI:6386687
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2775623
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505976
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6505817
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2775623
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505986
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5700554
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505979
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3775098
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505980
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6386686
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505981
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6393610
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505982
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6505811
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505983
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6307038
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505984
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6505803
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505985
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6505813
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505987
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5700554
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505979
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3775098
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505980
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6386686
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505981
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6505811
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505983
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6307038
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505984
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6505803
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505985
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6505813
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505987
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6505809
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505977
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6449791
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505978
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5700554
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505979
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3775098
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505980
Age: embryonic day 15.5
Specimen Label: 4A - SSB
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6307038
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505984
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6505803
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6505985
Age: embryonic day 15.5
Specimen Label: 4B - SSB
Detected: true
Specimen Num: 3
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Publication
19719513 | -
First Author: Scaltriti E
Year: 2009
Journal: Mol Microbiol
Title: Structure and function of phage p2 ORF34(p2), a new type of single-stranded DNA binding protein.
Volume: 73
Issue: 6
Pages: 1156-70
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MP Term
MP:0012026 | abnormal S-shaped body morphology
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Publication
10773070 | -
First Author: Gascón I
Year: 2000
Journal: Nucleic Acids Res
Title: Differential functional behavior of viral phi29, Nf and GA-1 SSB proteins.
Volume: 28
Issue: 10
Pages: 2034-42
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Publication
18937104 | -
First Author: Shereda RD
Year: 2008
Journal: Crit Rev Biochem Mol Biol
Title: SSB as an organizer/mobilizer of genome maintenance complexes.
Volume: 43
Issue: 5
Pages: 289-318
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Publication
21784244 | -
First Author: Zhou R
Year: 2011
Journal: Cell
Title: SSB functions as a sliding platform that migrates on DNA via reptation.
Volume: 146
Issue: 2
Pages: 222-32
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Publication
19515845 | -
First Author: Norais CA
Year: 2009
Journal: J Biol Chem
Title: DdrB protein, an alternative Deinococcus radiodurans SSB induced by ionizing radiation.
Volume: 284
Issue: 32
Pages: 21402-11
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Publication
38788899 | J:360266
First Author: Ge X
Year: 2024
Journal: Cell Mol Gastroenterol Hepatol
Title: A Protein Complex of Liver Origin Activates a Pro-inflammatory Program That Drives Hepatic and Intestinal Injury in Alcohol-Associated Liver Disease.
Volume: 18
Issue: 3
Pages: 101362
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Publication
37028770 | J:359907
First Author: Han H
Year: 2023
Journal: Gastroenterology
Title: Macrophage-derived Osteopontin (SPP1) Protects From Nonalcoholic Steatohepatitis.
Volume: 165
Issue: 1
Pages: 201-217
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Publication
38055645 | J:354052
 
First Author: Athavale D
Year: 2023
Journal: Hepatol Commun
Title: Overexpression of HMGB1 in hepatocytes accelerates PTEN inactivation-induced liver cancer.
Volume: 7
Issue: 12
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Publication
22106294 | -
First Author: Paytubi S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales.
Volume: 109
Issue: 7
Pages: E398-405
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Protein Domain
IPR033787 | ThermoDBP
Type: Domain
Description: ThermoDBP is a single-stranded DNA-binding protein (SSB) protein of the Thermoproteales. SSB proteins are essential for the genome maintenance of all known cellular organisms. Many SSBs contain an OB fold domain, albeit with low sequence conservation, and OB fold-containing SSB proteins have been detected in all three domains of life. However, the Thermoproteales SSB protein, ThermoDBP, lacks the OB fold and binds specifically to ssDNA with low sequence specificity. Its three-dimensional structure resembles that of the Hut operon positive regulatory protein HutP [].
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Protein Domain
IPR035408 | Phi29_Phage_SSB
Type: Family
Description: DNA replication of phi29 and related phages takes place via a strand displacement mechanism, a process that generates large amounts of single-stranded DNA (ssDNA). Consequently, phage-encoded ssDNA-binding proteins (SSBs) are essential proteins during phage phi29-like DNA replication. Single-stranded DNA-binding proteins (SSBs) destabilize double-stranded DNA (dsDNA) and bind without sequence specificity, but selectively and cooperatively, to single-stranded DNA (ssDNA) conferring a regular structure to it, which is recognized and exploited by a variety of enzymes involved in DNA replication, repair and recombination.Phage phi29 protein p5 is the SSB protein active during phi29 DNA replication. It protects ssDNA against nuclease degradation and greatly stimulates dNTP incorporation during phi29 DNA replication process. Binding of the SSB to ssDNA prevents non-productive binding of the viral DNA polymerase to ssDNA, and allows the release DNA polymerase molecules that are already titrated by the ssDNA. This effect would be of particular importance in phi29-like DNA replication systems, where large amounts of ssDNA are generated and SSB binding to ssDNA could favor efficient re-usage of templates [].This domain is found in phi29-like SSB proteins, homologues are found in .
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Publication
28436431 | J:249553
 
First Author: Higo T
Year: 2017
Journal: Nat Commun
Title: DNA single-strand break-induced DNA damage response causes heart failure.
Volume: 8
Pages: 15104
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Publication
27699246 | J:280608
First Author: Nakatake S
Year: 2016
Journal: JCI Insight
Title: MUTYH promotes oxidative microglial activation and inherited retinal degeneration.
Volume: 1
Issue: 15
Pages: e87781
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Publication
19103807 | J:145999
First Author: Sugimura K
Year: 2008
Journal: J Cell Biol
Title: PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.
Volume: 183
Issue: 7
Pages: 1203-12
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Publication
19154741 | -
First Author: Kuang Z
Year: 2009
Journal: J Mol Biol
Title: SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.
Volume: 386
Issue: 3
Pages: 662-74
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Publication
24813479 | -
First Author: Leung EW
Year: 2014
Journal: Chem Biol Drug Des
Title: 19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2.
Volume: 84
Issue: 5
Pages: 616-25
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Protein Domain
IPR037340 | SSB2_SOCS
Type: Domain
Description: This entry represents the SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins). SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to interact with c-Met, the hepatocyte growth factor receptor [, ]. It also regulates inducible nitric oxide synthase (iNOS) by targeting it for proteasomal degradation []. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
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Publication
2087220 | -
First Author: Meyer RR
Year: 1990
Journal: Microbiol Rev
Title: The single-stranded DNA-binding protein of Escherichia coli.
Volume: 54
Issue: 4
Pages: 342-80
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Publication
8663106 | -
First Author: Liu J
Year: 1996
Journal: J Biol Chem
Title: The ordered assembly of the phiX174-type primosome. III. PriB facilitates complex formation between PriA and DnaT.
Volume: 271
Issue: 26
Pages: 15656-61
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Publication
1856227 | -
First Author: Zavitz KH
Year: 1991
Journal: J Biol Chem
Title: The priB and priC replication proteins of Escherichia coli. Genes, DNA sequence, overexpression, and purification.
Volume: 266
Issue: 21
Pages: 13988-95
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Publication
10640603 | -
First Author: Smeets LC
Year: 2000
Journal: FEMS Immunol Med Microbiol
Title: The dprA gene is required for natural transformation of Helicobacter pylori.
Volume: 27
Issue: 2
Pages: 99-102
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Publication
17803906 | -
First Author: Mortier-Barrière I
Year: 2007
Journal: Cell
Title: A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA.
Volume: 130
Issue: 5
Pages: 824-36
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Publication
23440217 | -
First Author: Mirouze N
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence.
Volume: 110
Issue: 11
Pages: E1035-44
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Protein Domain
IPR000424 | Primosome_PriB/ssb
Type: Family
Description: The Escherichia coli single-strand binding protein [](gene ssb), also known as the helix-destabilising protein, is a protein of 177 amino acids. It binds tightly, as a homotetramer, to single-stranded DNA (ss-DNA) and plays an important role in DNA replication, recombination and repair. Closely related variants of SSB are encoded in the genome of a variety of large self-transmissible plasmids. SSB has also been characterized in bacteria such as Proteus mirabilis or Serratia marcescens. Eukaryotic mitochondrial proteins that bind ss-DNA and are probably involved in mitochondrial DNA replication are structurally and evolutionary related to prokaryotic SSB.Primosomal replication protein N (PriB) is a specialist protein from bacteria that binds single-stranded DNA at the primosome assembly site (PAS). The primosome is a mobile multiprotein replication priming complex which is believe to operate on the lagging-strand template at the E. coli DNA replication fork []. The primosome consists of one monomer of PriC and DnaT, two monomers of PriA, two dimers of PriB and one hexamer of DnaB [].
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Publication
34174253 | J:310910
 
First Author: Saito K
Year: 2021
Journal: Immunol Lett
Title: McH-lpr/lpr-RA1 mice: A novel spontaneous mouse model of autoimmune sialadenitis.
Volume: 237
Pages: 3-10
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Publication
23362348 | J:194051
First Author: Heliot C
Year: 2013
Journal: Development
Title: HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.
Volume: 140
Issue: 4
Pages: 873-85
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Publication
38795454 | J:350264
 
First Author: Yano-Sakamoto K
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development.
Volume: 722
Pages: 150155
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Publication
20034479 | J:158786
 
First Author: Michelsen KA
Year: 2010
Journal: Brain Res
Title: Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease.
Volume: 1316
Pages: 139-44
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Publication
15964819 | J:99226
First Author: Masters SL
Year: 2005
Journal: Mol Cell Biol
Title: Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia.
Volume: 25
Issue: 13
Pages: 5639-47
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Publication
20139420 | J:173441
First Author: Griese JJ
Year: 2010
Journal: Nucleic Acids Res
Title: Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins.
Volume: 38
Issue: 10
Pages: 3454-65
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Publication
8293499 | J:21788
First Author: Ozawa K
Year: 1993
Journal: Cell Struct Funct
Title: Mapping of the 70 kDa, 34 kDa, and 11 kDa subunit genes of the human multimeric single-stranded DNA binding protein (hSSB/RPA) to chromosome bands 17p13, 1p35-p36.1, and 7p21-p22.
Volume: 18
Issue: 4
Pages: 221-30
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Publication
7845061 | J:20851
First Author: He P
Year: 1994
Journal: Mech Ageing Dev
Title: Dietary butylated hydroxytoluene counteracts with paraquat to reduce the rate of hepatic DNA single strand breaks in senescence-accelerated mice.
Volume: 76
Issue: 1
Pages: 43-8
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Publication
19208635 | J:173039
First Author: Wang S
Year: 2009
Journal: Nucleic Acids Res
Title: JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks.
Volume: 37
Issue: 6
Pages: 1936-50
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Publication
39123453 | J:353289
 
First Author: Fatema K
Year: 2024
Journal: Cancers (Basel)
Title: Arid1a Loss Enhances Disease Progression in a Murine Model of Osteosarcoma.
Volume: 16
Issue: 15
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Publication
1634538 | -
First Author: Kim YT
Year: 1992
Journal: J Biol Chem
Title: Purification and characterization of the bacteriophage T7 gene 2.5 protein. A single-stranded DNA-binding protein.
Volume: 267
Issue: 21
Pages: 15022-31
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Publication
16807232 | -
First Author: Marintcheva B
Year: 2006
Journal: J Biol Chem
Title: Essential residues in the C terminus of the bacteriophage T7 gene 2.5 single-stranded DNA-binding protein.
Volume: 281
Issue: 35
Pages: 25831-40
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Publication
11222583 | -
First Author: Yu M
Year: 2001
Journal: J Bacteriol
Title: T7 single strand DNA binding protein but not T7 helicase is required for DNA double strand break repair.
Volume: 183
Issue: 6
Pages: 1862-9
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Publication
8617248 | -
First Author: Kong D
Year: 1996
Journal: EMBO J
Title: Single-stranded DNA binding protein and DNA helicase of bacteriophage T7 mediate homologous DNA strand exchange.
Volume: 15
Issue: 8
Pages: 2010-9
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Publication
15713673 | -
First Author: Wang D
Year: 2005
Journal: J Biol Chem
Title: The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.
Volume: 280
Issue: 16
Pages: 16393-401
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Publication
25138221 | -
First Author: Yadav T
Year: 2014
Journal: J Biol Chem
Title: Roles of Bacillus subtilis DprA and SsbA in RecA-mediated genetic recombination.
Volume: 289
Issue: 40
Pages: 27640-52
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Protein Domain
IPR016411 | SSB_T7
Type: Family
Description: This group represents single-stranded DNA-binding proteins (SSB, also known as helix-destabilising proteins and gp2.5) from bacteriophage T7. It is expressed in the late stage of lytic development, binding preferentially to single-stranded DNA and is implicated in DNA replication, formation of concatemers, recombination and repair of double-stranded breaks [, , , , ]. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions and mediates homologous DNA strand exchange []. SSB disrupts loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation []. The C-terminal aromatic Phe and the overall acidic charge of this region are critical for its function [].
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Protein Domain
IPR041614 | DprA_WH
Type: Domain
Description: This winged helix domain is found in the DprA protein [].DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation []. In Helicobacter pylori, DprA is required for natural chromosomal and plasmid transformation []. It has now been shown that DprA binds cooperatively to single-stranded DNA (ssDNA) and interacts with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyse the homology-dependent formation of joint molecules. While the Escherichia coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier []. DprA has a role not only in ensuring production of transformants via interaction with RecA, it is also involved in competence shut-off via interaction with ComE [].
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Protein Domain
IPR036036 | SOCS_box-like_dom_sf
Type: Homologous_superfamily
Description: The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family []but was later also found in:the WSB (WD-40-repeat-containing proteins with a SOCS box) family,the SSB (SPRY domain-containing proteins with a SOCS box) family,the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,and ras and ras-like GTPases [].The SOCS box found in these proteins is an about 50 amino acid C-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues []. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [], which binds to the Elongin BC complex [, ]. It has been demonstrated that this association couple bound proteins to the ubiquitination or proteasomal compartments [, ].
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Protein Domain
IPR003488 | DprA
Type: Family
Description: This family of bacterial proteins includes DNA processing protein A (DprA) from Streptococcus pneumoniae and Smf, the Bacillus subtilis orthologue. DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation []. In Helicobacter pylori, DprA is required for natural chromosomal and plasmid transformation []. It has now been shown that DprA binds cooperatively to single-stranded DNA (ssDNA) and interacts with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyse the homology-dependent formation of joint molecules. While the Escherichia coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier []. DprA has a role not only in ensuring production of transformants via interaction with RecA, it is also involved in competence shut-off via interaction with ComE [].
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Protein Domain
IPR001496 | SOCS_box
Type: Domain
Description: The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family []but was later also found in:the WSB (WD-40-repeat-containing proteins with a SOCS box) family,the SSB (SPRY domain-containing proteins with a SOCS box) family,the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,and ras and ras-like GTPases [].The SOCS box found in these proteins is an about 50 amino acid C-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues []. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [], which binds to the Elongin BC complex [, ]. It has been demonstrated that this association couple bound proteins to the ubiquitination or proteasomal compartments [, ].
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Publication
9202125 | J:43735
First Author: Starr R
Year: 1997
Journal: Nature
Title: A family of cytokine-inducible inhibitors of signalling.
Volume: 387
Issue: 6636
Pages: 917-21
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Publication
10051596 | -
First Author: Zhang JG
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Volume: 96
Issue: 5
Pages: 2071-6
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Protein
A0A0A0MQ78
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein
H7BX71
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
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Protein
Q3TPP7
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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