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Search results 101 to 122 out of 122 for Sec62

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0.018s
Type Details Score
Allele  
Name: SEC62 homolog, preprotein translocation; gene trap E200G04, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog, preprotein translocation; gene trap W038C03, German Gene Trap Consortium
Allele Type: Gene trapped
Genotype
Symbol: Sec62/Sec62
Background: C57BL/6NJ-Sec62/Mmjax
Zygosity: hm
Has Mutant Allele: true
Protein Domain
Type: Family
Description: Members of the NSCC2 family have been sequenced from various fungal and animal species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.This family of Sec62 proteins is restricted to the Ascomycota.
Publication
First Author: Young BP
Year: 2001
Journal: EMBO J
Title: Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.
Volume: 20
Issue: 1-2
Pages: 262-71
Publication
First Author: Skowronek MH
Year: 1999
Journal: Biol Chem
Title: Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog.
Volume: 380
Issue: 9
Pages: 1133-8
Publication
First Author: Davila S
Year: 2004
Journal: Nat Genet
Title: Mutations in SEC63 cause autosomal dominant polycystic liver disease.
Volume: 36
Issue: 6
Pages: 575-7
Protein Domain
Type: Family
Description: In Saccharomyces cerevisiae, Sec63 is a component of the Sec62/63 complex (includes Sec63p, Sec62p, Sec66p and Sec72p), which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex []. In humans, Sec63 is part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63. It is required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane [, ].Defects in SEC63 are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterised by the presence of multiple liver cysts of biliary epithelial origin [].
Publication
First Author: Lee J
Year: 2007
Journal: Mol Cell Proteomics
Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.
Volume: 6
Issue: 4
Pages: 669-76
Protein
Organism: Mus musculus/domesticus
Length: 516  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
Publication
First Author: Zhou H
Year: 2008
Journal: J Proteome Res
Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
Volume: 7
Issue: 9
Pages: 3957-67
Publication
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
Publication
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
Publication
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
Publication  
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
Publication
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
Publication
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89