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Search results 101 to 200 out of 220 for Mcm6

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Type Details Score
Publication
15286659 | J:116246
First Author: Lee C
Year: 2004
Journal: Nature
Title: Structural basis for inhibition of the replication licensing factor Cdt1 by geminin.
Volume: 430
Issue: 7002
Pages: 913-7
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Publication
15917436 | J:99444
First Author: You Z
Year: 2005
Journal: Nucleic Acids Res
Title: DNA binding and helicase actions of mouse MCM4/6/7 helicase.
Volume: 33
Issue: 9
Pages: 3033-47
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Publication
17554680 | J:123067
First Author: Swiech L
Year: 2007
Journal: Int J Dev Biol
Title: Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle.
Volume: 51
Issue: 4
Pages: 283-95
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Publication
18606811 | J:142022
First Author: You Z
Year: 2008
Journal: J Biol Chem
Title: Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
Volume: 283
Issue: 36
Pages: 24469-77
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Publication
20838603 | J:165667
First Author: Chuang CH
Year: 2010
Journal: PLoS Genet
Title: Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.
Volume: 6
Issue: 9
Pages: e1001110
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Publication
20724472 | J:167101
First Author: Frank CL
Year: 2010
Journal: J Biol Chem
Title: Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.
Volume: 285
Issue: 43
Pages: 33324-37
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Publication
30787433 | J:274368
First Author: McNairn AJ
Year: 2019
Journal: Nature
Title: Female-biased embryonic death from inflammation induced by genomic instability.
Volume: 567
Issue: 7746
Pages: 105-108
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Publication
21220507 | J:167844
First Author: Kuipers MA
Year: 2011
Journal: J Cell Biol
Title: Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload.
Volume: 192
Issue: 1
Pages: 29-41
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Publication
22474384 | J:320137
First Author: Kang YH
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.
Volume: 109
Issue: 16
Pages: 6042-7
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Publication
9636156 | J:48267
First Author: Furumura M
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Characterization of genes modulated during pheomelanogenesis using differential display.
Volume: 95
Issue: 13
Pages: 7374-8
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Publication
23622063 | J:197897
First Author: Mi D
Year: 2013
Journal: Neuron
Title: Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb.
Volume: 78
Issue: 2
Pages: 269-84
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Publication
19433082 | J:152869
First Author: Lee EY
Year: 2009
Journal: Dev Biol
Title: E2F4 cooperates with pRB in the development of extra-embryonic tissues.
Volume: 332
Issue: 1
Pages: 104-15
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Publication
22516201 | J:183999
First Author: Ouseph MM
Year: 2012
Journal: Dev Cell
Title: Atypical E2F repressors and activators coordinate placental development.
Volume: 22
Issue: 4
Pages: 849-62
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Publication
25956904 | J:222249
First Author: Tu HC
Year: 2015
Journal: Genes Dev
Title: LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.
Volume: 29
Issue: 10
Pages: 1074-86
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Publication
11555636 | J:71817
First Author: Sutherland HG
Year: 2001
Journal: Hum Mol Genet
Title: Large-scale identification of mammalian proteins localized to nuclear sub-compartments.
Volume: 10
Issue: 18
Pages: 1995-2011
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Publication
- | J:47259
     
First Author: Goodwin N
Year: 1998
Journal: MGI Direct Data Submission
Title: An embryonic stem cell bank for producing deletion complexes in mice
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Publication
26876175 | J:301859
First Author: Poché RA
Year: 2016
Journal: Cell Rep
Title: RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina.
Volume: 14
Issue: 7
Pages: 1684-1697
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Publication
22001906 | J:178114
First Author: Pei L
Year: 2011
Journal: Nat Med
Title: Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.
Volume: 17
Issue: 11
Pages: 1466-72
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Publication
9811942 | J:50869
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
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Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Gene
564982 | mcm6l
Type: gene
Organism: zebrafish
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Publication
36185598 | J:329453
First Author: Wang Y
Year: 2022
Journal: Theranostics
Title: MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.
Volume: 12
Issue: 15
Pages: 6509-6526
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UniProt Feature
UniProt Feature
Begin: 1
Description: DNA replication licensing factor MCM6
Type: chain
End: 821
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Publication
20202939 | -
First Author: Wei Z
Year: 2010
Journal: J Biol Chem
Title: Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.
Volume: 285
Issue: 17
Pages: 12469-73
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Protein Domain
IPR041024 | Mcm6_C
Type: Domain
Description: The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments []. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD [].
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Publication
9305914 | -
First Author: Ishimi Y
Year: 1997
Journal: J Biol Chem
Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
Volume: 272
Issue: 39
Pages: 24508-13
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Publication
9366552 | -
First Author: Adachi Y
Year: 1997
Journal: Genes Cells
Title: A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.
Volume: 2
Issue: 7
Pages: 467-79
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Publication
9658174 | -
First Author: Sherman DA
Year: 1998
Journal: Mol Biol Cell
Title: Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.
Volume: 9
Issue: 7
Pages: 1833-45
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Publication
10588642 | -
First Author: Pasion SG
Year: 1999
Journal: Mol Biol Cell
Title: Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
Volume: 10
Issue: 12
Pages: 4043-57
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Protein
A0A0A0MQF4
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Publication
9383050 | -
First Author: Forsburg SL
Year: 1997
Journal: Genetics
Title: Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.
Volume: 147
Issue: 3
Pages: 1025-41
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Protein Domain
IPR018525 | MCM_CS
Type: Conserved_site
Description: MCM proteins are DNA-dependent ATPases required for the initiation ofeukaryotic DNA replication [, , ]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins [].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.The "MCM motif"contains Walker-A and Walker-B type nucleotide binding motifs. The diagnostic sequence defining the MCMs is IDEFDKM. Only Mcm2 (aka Cdc19 or Nda1) has been subjected to mutational analysis in this region, and most mutations abolish its activity []. The presence of a putative ATP-binding domain implies that these proteins may be involved in an ATP-consuming step in the initiation of DNA replication in eukaryotes.The MCM proteins bind together in a large complex [].Within this complex, individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. This core complex in human MCMs has been associated with helicase activity in vitro[], leading to the suggestion that the MCM proteins are the eukaryotic replicative helicase.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].The signature pattern used in this entry represents a perfectly conserved region that is a special version of the B motif found in ATP-binding proteins.
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Protein Domain
IPR031327 | MCM
Type: Family
Description: MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [, , ]. In eukaryotes there is a family of eight proteins, MCM2 to MCM9. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins []. These proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex []in which individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. Mcm2-7 complex is the replicative helicase involved in replication initiation and elongation [], whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].
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Protein
Q8C5L1
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: true
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Publication
17525332 | -
First Author: Matsuoka S
Year: 2007
Journal: Science
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Volume: 316
Issue: 5828
Pages: 1160-6
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Protein
E9Q956
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
H9KV11
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
H7BXC1
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Publication
22771115 | -
First Author: Nishimura K
Year: 2012
Journal: Mol Cell
Title: Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
Volume: 47
Issue: 4
Pages: 511-22
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Publication
30743181 | -
 
First Author: Griffin WC
Year: 2019
Journal: DNA Repair (Amst)
Title: The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.
Volume: 76
Pages: 1-10
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Protein
Q8C2I9
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
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Publication
1454522 | -
First Author: Coxon A
Year: 1992
Journal: Nucleic Acids Res
Title: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.
Volume: 20
Issue: 21
Pages: 5571-7
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Publication
8332451 | -
First Author: Koonin EV
Year: 1993
Journal: Nucleic Acids Res
Title: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
Volume: 21
Issue: 11
Pages: 2541-7
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Publication
8265339 | -
First Author: Hu B
Year: 1993
Journal: Nucleic Acids Res
Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.
Volume: 21
Issue: 23
Pages: 5289-93
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Publication
14731643 | -
First Author: Tye BK
Year: 1994
Journal: Trends Cell Biol
Title: The MCM2-3-5 proteins: are they replication licensing factors?
Volume: 4
Issue: 5
Pages: 160-6
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Protein
Q61881
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
P97310
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
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Protein
P49718
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P49717
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
P25206
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q3U4T8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
Q3V122
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
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Protein
Q921D5
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UJN1
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q3UA65
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UK39
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
•
•
•
•
•
Protein
Q8BQ03
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
•
•
•
•
•
Protein
Q3UZH2
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
•
•
•
•
•
Protein
Q9D077
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
Q3ULD6
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
•
•
•
•
•
Protein
Q5DTS8
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: true
•
•
•
•
•
Protein
Q542F4
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
Q3UDI8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
•
•
•
•
•
Protein
Q3UI57
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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