Synaptonemal complex protein 2 (SYCP2) is a major component of the axial/lateral elements of synaptonemal complexes (SCs), which regulate the arrangement of homologous chromosomes during meiosis. SYCP2 is a primary determinant of axial/lateral elements and is required for the incorporation of SYCP3 into the synaptonemal complex [].
This entry represents a group of plant meiosis-specific proteins, such as AtASY3 from Arabidopsis and PAIR3 from rice. They are coiled-coil domain proteins required for normal meiosis []. PAIR3 is an axial element and part of the synaptonemal complex (SC) that forms between homologous chromosomes during meiosis []. Members of this family are homologues of SYCP2 from vertebrates and fungal Red1/Red10 [].
This entry includes synaptonemal complex protein 2 (SYCP2) and synaptonemal complex protein 2-like (SYCP2L).SYCP2 is one of the major components of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase [].SYCP2L has partial sequence homology to a SYCP2 and is the major component of nucleolar cortical skeleton in Xenopus oocytes []. In humans, SYCP2L promotes primordial oocytes survival, thus being associated with age at natural menopause (ANM) [].
This entry represents coiled-coil domain of ASY3 and PAIR3.This entry represents a group of plant meiosis-specific proteins, such as AtASY3 from Arabidopsis and PAIR3 from rice. They are coiled-coil domain proteins required for normal meiosis []. PAIR3 is an axial element and part of the synaptonemal complex (SC) that forms between homologous chromosomes during meiosis []. Members of this family are homologues of SYCP2 from vertebrates and fungal Red1/Red10 [].
Synaptonemal complex protein 2 (SYCP2) N-terminal region contains two separate subdomains an ARLD (armadillo-repeat-like domain) and an SLD (Spt16M-like domain). The ARLD domain belongs to the armadillo-repeat protein family. Armadillo-repeat units often form a superhelix, which typically provides a platform for many protein partners that transduce Wnt signaling, such as beta-catenin. The ARLD of mouse SYCP2 was found to associate with different protein partners, including CENP J and CENP F. ARLD structure is highly similar to that of the 'required for cell differentiation (RCD-1)' protein [].
