KASH5 (also known as CCDC155) is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton []. KASH5 interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localisation [].
This is the central coiled-coil region of the protein KASH5 (also known as CCDC155). KASH5 may be involved in meiotic chromosome dynamics and homologue pairing []. The domain also appears to be present in a number of other proteins.
This entry represents the EF-hand-like domain found in protein KASH5. KASH5 is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton []. It interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localisation []. Proteins containing this domain also include lrmp from Zebra fish. It is a maternally expressed membrane and cytoskeletal linker protein, which is essential for attachment of the centrosome to the male pronucleus [].
SUN domain-containing protein 1 is a nuclear inner membrane protein and a component of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [].SUN1 contains a conserved Sad1p/UNC-84 (SUN)-domain at its C terminus that can associate with Klarsicht/ANC-1/Syne homology (KASH)-domain proteins []. The structure of the LINC complex has been solved []. In mammals, SUN1 is widely expressed and can bind to all four Nesprins (KASH-domain containing proteins) []. Sun1 and KASH5 are essential factors which mediate meiotic resumption and spindle formation [].
