Type |
Details |
Score |
Publication |
First Author: |
Xie W |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice. |
Volume: |
18 |
Issue: |
24 |
Pages: |
3593-607 |
|
•
•
•
•
•
|
Publication |
First Author: |
Atanasoski S |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury. |
Volume: |
26 |
Issue: |
7 |
Pages: |
2124-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huck L |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression. |
Volume: |
107 |
Issue: |
35 |
Pages: |
15559-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirai M |
Year: |
2017 |
Journal: |
J Clin Invest |
Title: |
Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. |
Volume: |
127 |
Issue: |
2 |
Pages: |
569-582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim K |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary. |
Volume: |
405 |
Issue: |
2 |
Pages: |
319-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2019 |
Journal: |
Cells |
Title: |
ERBB2 Regulates MED24 during Cancer Progression in Mice with Pten and Smad4 Deletion in the Pulmonary Epithelium. |
Volume: |
8 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chaturvedi R |
Year: |
2014 |
Journal: |
Gastroenterology |
Title: |
Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. |
Volume: |
146 |
Issue: |
7 |
Pages: |
1739-51.e14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Britsch S |
Year: |
1998 |
Journal: |
Genes Dev |
Title: |
The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. |
Volume: |
12 |
Issue: |
12 |
Pages: |
1825-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meyers N |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Differential impact of the ERBB receptors EGFR and ERBB2 on the initiation of precursor lesions of pancreatic ductal adenocarcinoma. |
Volume: |
10 |
Issue: |
1 |
Pages: |
5241 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xi C |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis. |
Volume: |
287 |
Issue: |
42 |
Pages: |
35646-35657 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moscoso LM |
Year: |
1995 |
Journal: |
Dev Biol |
Title: |
Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. |
Volume: |
172 |
Issue: |
1 |
Pages: |
158-69 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190223 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Erbb2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190223 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Erbb2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190223 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Erbb2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190223 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Erbb2 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190223 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Erbb2 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190223 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Erbb2 |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190223 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Erbb2 |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dillon RL |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. |
Volume: |
27 |
Issue: |
24 |
Pages: |
8648-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim H |
Year: |
1997 |
Journal: |
Endocrinology |
Title: |
Differential expression of the erbB2 gene in the periimplantation mouse uterus: potential mediator of signaling by epidermal growth factor-like growth factors. |
Volume: |
138 |
Issue: |
3 |
Pages: |
1328-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ordonez LD |
Year: |
2021 |
Journal: |
Dis Model Mech |
Title: |
Reproductive history determines Erbb2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model. |
Volume: |
14 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Basak P |
Year: |
2018 |
Journal: |
Genes Chromosomes Cancer |
Title: |
In vivo evidence supporting a metastasis suppressor role for Stard13 (Dlc2) in ErbB2 (Neu) oncogene induced mouse mammary tumors. |
Volume: |
57 |
Issue: |
4 |
Pages: |
182-191 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2018 |
Journal: |
Eur J Neurosci |
Title: |
ERBB2 signaling drives supporting cell proliferation in vitro and apparent supernumerary hair cell formation in vivo in the neonatal mouse cochlea. |
Volume: |
48 |
Issue: |
10 |
Pages: |
3299-3316 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang YZ |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. |
Volume: |
276 |
Issue: |
22 |
Pages: |
19318-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cooley MA |
Year: |
2012 |
Journal: |
Dev Dyn |
Title: |
Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. |
Volume: |
241 |
Issue: |
2 |
Pages: |
303-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shawer H |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure. |
Volume: |
15 |
Issue: |
6 |
Pages: |
e0233007 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Publication |
First Author: |
Borg JP |
Year: |
2000 |
Journal: |
Nat Cell Biol |
Title: |
ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. |
Volume: |
2 |
Issue: |
7 |
Pages: |
407-14 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
519
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Rachmin I |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Erbin is a negative modulator of cardiac hypertrophy. |
Volume: |
111 |
Issue: |
16 |
Pages: |
5902-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang C |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Erbin is required for myelination in regenerated axons after injury. |
Volume: |
32 |
Issue: |
43 |
Pages: |
15169-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sørensen LL |
Year: |
2016 |
Journal: |
Comp Med |
Title: |
Echocardiographic Characterization of a Murine Model of Hypertrophic Obstructive Cardiomyopathy Induced by Cardiac-specific Overexpression of Epidermal Growth Factor Receptor 2. |
Volume: |
66 |
Issue: |
4 |
Pages: |
268-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schade B |
Year: |
2013 |
Journal: |
Cancer Res |
Title: |
β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression. |
Volume: |
73 |
Issue: |
14 |
Pages: |
4474-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie W |
Year: |
1998 |
Journal: |
Cell Growth Differ |
Title: |
Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles. |
Volume: |
9 |
Issue: |
4 |
Pages: |
313-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quan L |
Year: |
2012 |
Journal: |
Genes Chromosomes Cancer |
Title: |
Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice. |
Volume: |
51 |
Issue: |
7 |
Pages: |
631-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tao Y |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Role of Erbin in ErbB2-dependent breast tumor growth. |
Volume: |
111 |
Issue: |
42 |
Pages: |
E4429-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2015 |
Journal: |
Mol Cell Biol |
Title: |
Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition. |
Volume: |
35 |
Issue: |
23 |
Pages: |
4069-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng M |
Year: |
2015 |
Journal: |
Cell Death Dis |
Title: |
Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse. |
Volume: |
6 |
|
Pages: |
e1848 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muraoka RS |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. |
Volume: |
22 |
Issue: |
7 |
Pages: |
2204-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrechek ER |
Year: |
2003 |
Journal: |
Cancer Res |
Title: |
Gene expression profiling of neu-induced mammary tumors from transgenic mice reveals genetic and morphological similarities to ErbB2-expressing human breast cancers. |
Volume: |
63 |
Issue: |
16 |
Pages: |
4920-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrechek ER |
Year: |
2005 |
Journal: |
Oncogene |
Title: |
Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth. |
Volume: |
24 |
Issue: |
5 |
Pages: |
932-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simond AM |
Year: |
2022 |
Journal: |
Oncogene |
Title: |
Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer. |
Volume: |
41 |
Issue: |
25 |
Pages: |
3445-3451 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu M |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer. |
Volume: |
65 |
Issue: |
12 |
Pages: |
5325-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ling C |
Year: |
2012 |
Journal: |
Cancer Discov |
Title: |
Loss of the 14-3-3σ tumor suppressor is a critical event in ErbB2-mediated tumor progression. |
Volume: |
2 |
Issue: |
1 |
Pages: |
68-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kiguchi K |
Year: |
2001 |
Journal: |
Cancer Res |
Title: |
Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma. |
Volume: |
61 |
Issue: |
19 |
Pages: |
6971-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tung B |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
β-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model. |
Volume: |
114 |
Issue: |
5 |
Pages: |
E707-E716 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hulit J |
Year: |
2006 |
Journal: |
Cancer Res |
Title: |
p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling. |
Volume: |
66 |
Issue: |
17 |
Pages: |
8529-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hodgson JG |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling. |
Volume: |
65 |
Issue: |
21 |
Pages: |
9695-704 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tao Y |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Erbin regulates NRG1 signaling and myelination. |
Volume: |
106 |
Issue: |
23 |
Pages: |
9477-82 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Rao GN |
Year: |
2000 |
Journal: |
Breast Cancer Res Treat |
Title: |
Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. |
Volume: |
64 |
Issue: |
3 |
Pages: |
287-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang H |
Year: |
2024 |
Journal: |
EBioMedicine |
Title: |
A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice. |
Volume: |
106 |
|
Pages: |
105260 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guy CT |
Year: |
1992 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. |
Volume: |
89 |
Issue: |
22 |
Pages: |
10578-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rovero S |
Year: |
2001 |
Journal: |
Gene Ther |
Title: |
Insertion of the DNA for the 163-171 peptide of IL1beta enables a DNA vaccine encoding p185(neu) to inhibit mammary carcinogenesis in Her-2/neu transgenic BALB/c mice. |
Volume: |
8 |
Issue: |
6 |
Pages: |
447-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muthuswamy SK |
Year: |
1994 |
Journal: |
Mol Cell Biol |
Title: |
Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. |
Volume: |
14 |
Issue: |
1 |
Pages: |
735-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Siegel PM |
Year: |
1994 |
Journal: |
Mol Cell Biol |
Title: |
Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors. |
Volume: |
14 |
Issue: |
11 |
Pages: |
7068-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muller WJ |
Year: |
1998 |
Journal: |
Biochem Soc Symp |
Title: |
Oncogenic activation of Neu/ErbB-2 in a transgenic mouse model for breast cancer. |
Volume: |
63 |
|
Pages: |
149-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou H |
Year: |
2001 |
Journal: |
Oncogene |
Title: |
MMTV promoter hypomethylation is linked to spontaneous and MNU associated c-neu expression and mammary carcinogenesis in MMTV c-neu transgenic mice. |
Volume: |
20 |
Issue: |
42 |
Pages: |
6009-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrechek ER |
Year: |
2000 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. |
Volume: |
97 |
Issue: |
7 |
Pages: |
3444-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Montagna C |
Year: |
2002 |
Journal: |
Oncogene |
Title: |
Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu. |
Volume: |
21 |
Issue: |
6 |
Pages: |
890-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jäger R |
Year: |
2005 |
Journal: |
Breast Cancer Res Treat |
Title: |
Dual role of AP-2gamma in ErbB-2-induced mammary tumorigenesis. |
Volume: |
90 |
Issue: |
3 |
Pages: |
273-80 |
|
•
•
•
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