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Search results 401 to 500 out of 2034 for Bcr

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Hits by Strain

Type Details Score
Protein Domain
IPR026072 | Lime1
Type: Family
Description: Lime is involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. It couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilisation or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules [, ].
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Protein Domain
IPR004812 | Efflux_drug-R_Bcr/CmlA
Type: Family
Description: The drug resistance transporter Bcr/CflA proteins are predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in Escherichia coli [], Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium [], and CmlA (chloramphenicol resistance) found on the Pseudomonas plasmid R1033 [].
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Protein Domain
IPR044727 | KLHL42_BACK
Type: Domain
Description: This entry represents the BTB and C-terminal Kelch domain found in KLHL42, which is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis [].
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Publication
37165001 | J:335559
First Author: Hiroki H
Year: 2023
Journal: Sci Rep
Title: Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells.
Volume: 13
Issue: 1
Pages: 7588
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Publication
10666183 | J:60817
First Author: Honda H
Year: 2000
Journal: Blood
Title: Acquired loss of p53 induces blastic transformation in p210(bcr/abl)-expressing hematopoietic cells: a transgenic study for blast crisis of human CML.
Volume: 95
Issue: 4
Pages: 1144-50
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Publication
12082638 | J:76680
First Author: Hemmeryckx B
Year: 2002
Journal: Oncogene
Title: BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.
Volume: 21
Issue: 20
Pages: 3225-31
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Publication
15611294 | J:95335
First Author: Yasuda T
Year: 2004
Journal: J Exp Med
Title: Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.
Volume: 200
Issue: 12
Pages: 1681-7
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Publication
15964830 | J:99168
First Author: Cho YJ
Year: 2005
Journal: Mol Cell Biol
Title: Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia.
Volume: 25
Issue: 13
Pages: 5777-85
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Genotype
Genotype
Symbol: Dok1/Dok1 Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rac3/Rac3 Tg(BCR/ABL)623Hkp/?
Background: involves: C57BL/6 * C57BL/6J * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crkl/Crkl Tg(BCR/ABL)623Hkp/?
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
33878293 | J:307147
First Author: Sadras T
Year: 2021
Journal: Mol Cell
Title: Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Volume: 81
Issue: 10
Pages: 2094-2111.e9
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HT Experiment
GSE173769 | Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
19782033 | -
First Author: Chen Y
Year: 2009
Journal: Mol Cell
Title: Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
Volume: 35
Issue: 6
Pages: 841-55
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Publication
29085068 | -
First Author: Mao H
Year: 2017
Journal: Nat Plants
Title: Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility.
Volume: 3
Issue: 11
Pages: 854-858
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Protein Domain
IPR045068 | BACURD1-3
Type: Family
Description: This entry represents a group of BTB/POZ domain-containing proteins, such as BACURD1-3 from humans. They act as the substrate-specific adapters of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of RhoA, leading to its degradation by the proteasome []. This entry also includes EAP3 from Arabidopsis. The BTB/POZ domain of EAP3 displays poor conservation of the residues required for CUL3 binding and is not likely to function as an E3 ligase adaptor [].
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Protein
A0A1W2P6I7
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
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Protein
A0A571BEM4
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Publication
36010887 | J:327859
 
First Author: Gómez C
Year: 2022
Journal: Cancers (Basel)
Title: Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia.
Volume: 14
Issue: 16
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Publication
9490692 | J:46392
First Author: Honda H
Year: 1998
Journal: Blood
Title: Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias.
Volume: 91
Issue: 6
Pages: 2067-75
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Publication
11245441 | J:68514
First Author: Hemmeryckx B
Year: 2001
Journal: Cancer Res
Title: Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.
Volume: 61
Issue: 4
Pages: 1398-405
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Publication
19818708 | -
First Author: Zhuang M
Year: 2009
Journal: Mol Cell
Title: Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Volume: 36
Issue: 1
Pages: 39-50
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Publication
16524876 | -
First Author: Kwon JE
Year: 2006
Journal: J Biol Chem
Title: BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
Volume: 281
Issue: 18
Pages: 12664-72
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Publication
23999291 | -
First Author: van Geersdaele LK
Year: 2013
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP.
Volume: 69
Issue: Pt 9
Pages: 1677-84
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Publication
23349464 | -
First Author: Canning P
Year: 2013
Journal: J Biol Chem
Title: Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
Volume: 288
Issue: 11
Pages: 7803-14
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Publication
23838290 | -
First Author: Takahashi D
Year: 2013
Journal: Biochem Biophys Res Commun
Title: KLHL2 interacts with and ubiquitinates WNK kinases.
Volume: 437
Issue: 3
Pages: 457-62
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Publication
15715669 | -
First Author: Jiang S
Year: 2005
Journal: J Neurochem
Title: Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven.
Volume: 92
Issue: 5
Pages: 1191-203
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Publication
10397770 | J:47397
First Author: Soltysik-Espanola M
Year: 1999
Journal: Mol Biol Cell
Title: Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain.
Volume: 10
Issue: 7
Pages: 2361-75
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Protein Domain
IPR044072 | KLHL2_BTB/POZ
Type: Domain
Description: KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganisation of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors [, ]. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation [, ]. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.This entry represents the BTB/POZ domain, which is a common protein-protein interaction motif of about 100 amino acids.
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Protein Domain
IPR034089 | SPOP_C
Type: Domain
Description: This entry represents the C-terminal BACK (BTB and C-terminal Kelch) domain of speckle-type POZ protein (SPOP, also known as HIB homologue 1 or Roadkill homologue 1). This domain contains a pair of α-helices which seem to be conserved among Cul3 adaptors [].SPOP is an adaptor protein that forms a complex with Cul3, cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, and is involved in ubiquitination of BMI1, H2AFY, and the death-associated protein 6 (DAXX) []. The C-terminal BACK domain of SPOP, may be involved in oligomer formation and in recruiting Cul3 (together with the adjacent BTB domain), whereas the N-terminal MATH domain recruits substrates [, ].
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Publication
30315705 | J:269485
First Author: Sahputra R
Year: 2018
Journal: Eur J Immunol
Title: Evaluating the IgMi mouse as a novel tool to study B-cell biology.
Volume: 48
Issue: 12
Pages: 2068-2071
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Protein
H3BKT3
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Protein
A0A1W2P6J3
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
H3BKV6
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Protein Coding Gene
MGI:1095404 | Mfng
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19620627 | J:151545
First Author: Trageser D
Year: 2009
Journal: J Exp Med
Title: Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.
Volume: 206
Issue: 8
Pages: 1739-53
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Publication
20393504 | J:160846
First Author: Virely C
Year: 2010
Journal: Leukemia
Title: Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia.
Volume: 24
Issue: 6
Pages: 1200-4
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Publication
21960247 | J:188889
First Author: Waldron T
Year: 2012
Journal: Leukemia
Title: c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells.
Volume: 26
Issue: 4
Pages: 644-53
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Publication
12623846 | J:84626
First Author: Inokuchi K
Year: 2003
Journal: Blood
Title: Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis.
Volume: 102
Issue: 1
Pages: 320-3
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Publication
24747972 | J:216528
First Author: Sato T
Year: 2014
Journal: Oncogene
Title: Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Volume: 33
Issue: 42
Pages: 5028-38
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Genotype
Genotype
Symbol: Ikzf1/Ikzf1<+> Tg(BCR/ABL)623Hkp/?
Background: involves: 129S2/SvPas * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
25875604 | J:307462
First Author: Onyilagha C
Year: 2015
Journal: PLoS Negl Trop Dis
Title: The B cell adaptor molecule Bam32 is critically important for optimal antibody response and resistance to Trypanosoma congolense infection in mice.
Volume: 9
Issue: 4
Pages: e0003716
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Publication
17371232 | -
First Author: Marshall AJ
Year: 2007
Journal: Biochem Soc Trans
Title: Regulation of B-lymphocyte activation by the PH domain adaptor protein Bam32/DAPP1.
Volume: 35
Issue: Pt 2
Pages: 181-2
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Protein Domain
IPR035877 | STAP1_SH2
Type: Domain
Description: STAP1 is a signal-transducing adaptor protein. It is composed of a Pleckstrin Homology (PH) and SH2 domains along with several tyrosine phosphorylation sites. STAP-1 is an orthologue of BRDG1 (also known as BCR downstream signaling 1). STAP1 protein functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is phosphorylated by Tec and participates in a positive feedback loop, increasing Tec activity []. STAP-1 has been shown to interact with STAT5 []. This entry represents the SH2 domain of STAP1.In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ].
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Protein Domain
IPR035843 | DAPP1_SH2
Type: Domain
Description: DAPP1/Bam32 is an adaptor protein that plays important roles in B cell receptor signalling, T cell receptor signalling and antibody affinity maturation in germinal centres []. It contains a putative myristoylation site at its N terminus, followed by a SH2 domain, and a pleckstrin homology (PH) domain at its C terminus. It translocates to the plasma membrane of B-lymphoma cells upon BCR (B-cell receptor) cross-linking; this translocation is PI3K (phosphoinositide 3-kinase)-dependent and PH domain-mediated []. This entry represents the SH2 domain of DAPP1/Bam32. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , , , , ].
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Allele
Sppl2a<m1Anu> | MGI:5432126
 
Name: signal peptide peptidase like 2A; mutation 1, Australian National University
Allele Type: Chemically induced (ENU)
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Allele
Ell2<tm1.1Cmil> | MGI:5790670
Name: elongation factor for RNA polymerase II 2; targeted mutation 1.1, Christine Milcarek
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Sppl2a/Sppl2a
Background: involves: C57BL/6JAnu
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Card11/Card11<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Protein
P25911
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
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Gene Segment
MGI:4439556 | Ighv5-16
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645977 | Ighv5-12-4
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439873 | Ighv5-9
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439895 | Ighv5-4
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439533 | Ighv5-17
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3643949 | Ighv3-3
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644034 | Ighv3-4
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3648045 | Ighv3-5
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439856 | Ighv3-6
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645298 | Ighv3-8
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3705861 | Ighv13-2
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3646760 | Ighv12-3
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439854 | Ighv6-3
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3704120 | Ighv6-4
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439619 | Ighv6-6
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644477 | Ighv6-7
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3647474 | Ighv8-2
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3646040 | Ighv8-4
Type: gene_segment
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96529 | Igll1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene Segment
MGI:99546 | Iglc1
Type: gene_segment
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99852 | Runx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene Segment
MGI:3642338 | Igkv11-125
Type: gene_segment
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96055 | Ptpn6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99851 | Cbfb
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene Segment
MGI:4439534 | Ighv3-1
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:99886 | Iglc3
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:99547 | Iglc2
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439879 | Igkv2-137
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3647671 | Igkv17-121
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3648380 | Igkv1-133
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3648800 | Igkv1-132
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645551 | Igkv1-131
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439721 | Igkv1-117
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439558 | Igkv1-110
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439722 | Igkv1-122
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644894 | Igkv2-112
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:2685913 | Igkv16-104
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:96513 | Igkv15-103
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:5009884 | Igkv20-101-2
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439828 | Igkv1-88
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:1330840 | Igkv8-21
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3647134 | Ighv6-5
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439734 | Ighv8-13
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644475 | Ighv8-9
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645823 | Ighv8-6
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3643819 | Ighv16-1
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439516 | Ighv5-12
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439815 | Ighv5-6
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645478 | Ighv8-5
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3815333 | Ighv8-8
Type: gene_segment
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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