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Search results 101 to 190 out of 190 for Sun2

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0.027s
Type Details Score
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1685328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468030
Specimen Label: MRC Harwell_1468030
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468031
Specimen Label: MRC Harwell_1468031
Detected: true
Specimen Num: 9
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468031
Specimen Label: MRC Harwell_1468031
Detected: true
Specimen Num: 9
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Female
Emaps: EMAPS:3278228
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468032
Specimen Label: MRC Harwell_1468032
Detected: false
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468032
Specimen Label: MRC Harwell_1468032
Detected: true
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3271628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468032
Specimen Label: MRC Harwell_1468032
Detected: true
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3283428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468033
Specimen Label: MRC Harwell_1468033
Detected: true
Specimen Num: 11
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468034
Specimen Label: MRC Harwell_1468034
Detected: true
Specimen Num: 12
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468035
Specimen Label: MRC Harwell_1468035
Detected: true
Specimen Num: 13
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468035
Specimen Label: MRC Harwell_1468035
Detected: true
Specimen Num: 13
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468035
Specimen Label: MRC Harwell_1468035
Detected: true
Specimen Num: 13
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1754928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468035
Specimen Label: MRC Harwell_1468035
Detected: true
Specimen Num: 13
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1842628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468036
Specimen Label: MRC Harwell_1468036
Detected: true
Specimen Num: 14
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1920928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468037
Specimen Label: MRC Harwell_1468037
Detected: true
Specimen Num: 15
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1925228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468038
Specimen Label: MRC Harwell_1468038
Detected: true
Specimen Num: 16
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468039
Specimen Label: MRC Harwell_1468039
Detected: true
Specimen Num: 17
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468039
Specimen Label: MRC Harwell_1468039
Detected: true
Specimen Num: 17
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468039
Specimen Label: MRC Harwell_1468039
Detected: true
Specimen Num: 17
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468016
Specimen Label: MRC Harwell_1468016
Detected: true
Specimen Num: 18
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3667028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468017
Specimen Label: MRC Harwell_1468017
Detected: true
Specimen Num: 19
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468017
Specimen Label: MRC Harwell_1468017
Detected: true
Specimen Num: 19
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468018
Specimen Label: MRC Harwell_1468018
Detected: true
Specimen Num: 20
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468019
Specimen Label: MRC Harwell_1468019
Detected: true
Specimen Num: 21
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:2694228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468020
Specimen Label: MRC Harwell_1468020
Detected: true
Specimen Num: 22
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468021
Specimen Label: MRC Harwell_1468021
Detected: true
Specimen Num: 23
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1720228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692642
Age: postnatal adult
Image: MRC Harwell_1468022
Specimen Label: MRC Harwell_1468022
Detected: true
Specimen Num: 24
GXD Expression
Probe: MGI:7331384
Assay Type: Immunohistochemistry
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7331403
Age: postnatal day 17
Image: 2b WT
Note: Expression in inner nuclear membrane.
Specimen Label: 2b WT
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7331384
Assay Type: Immunohistochemistry
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7331403
Age: postnatal day 17
Image: 2b KO
Note: Authors report nuclear envelope deformations charcterized by pronounced invaginations and projections protruding into sarcomeres.
Specimen Label: 2b KO
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:7580395
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7580402
Age: embryonic day 15.5
Image: S3 Figure 1B WT
Note: Expression is at the nuclear envelope in all cellular layers.
Specimen Label: S3 Figure 1B WT
Detected: true
Specimen Num: 1
Publication
First Author: Yu J
Year: 2011
Journal: Hum Mol Genet
Title: KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
Volume: 20
Issue: 6
Pages: 1061-73
Publication
First Author: Luxton GW
Year: 2010
Journal: Science
Title: Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.
Volume: 329
Issue: 5994
Pages: 956-9
Publication
First Author: Jiao S
Year: 2023
Journal: Nat Commun
Title: SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness.
Volume: 14
Issue: 1
Pages: 6416
Publication
First Author: Kozono T
Year: 2018
Journal: J Biochem
Title: Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins.
Volume: 164
Issue: 4
Pages: 303-311
Publication
First Author: Horn HF
Year: 2013
Journal: J Clin Invest
Title: The LINC complex is essential for hearing.
Volume: 123
Issue: 2
Pages: 740-50
Publication
First Author: Gimpel P
Year: 2017
Journal: Curr Biol
Title: Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
Volume: 27
Issue: 19
Pages: 2999-3009.e9
Publication    
First Author: Carley E
Year: 2021
Journal: Elife
Title: The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation.
Volume: 10
Publication  
First Author: Thiam HR
Year: 2016
Journal: Nat Commun
Title: Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.
Volume: 7
Pages: 10997
Publication
First Author: Stroud MJ
Year: 2017
Journal: J Cell Biol
Title: Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.
Volume: 216
Issue: 7
Pages: 1915-1924
Publication
First Author: Dominguez Gonzalez B
Year: 2018
Journal: Hum Mol Genet
Title: Excess LINC complexes impair brain morphogenesis in a mouse model of recessive TOR1A disease.
Volume: 27
Issue: 12
Pages: 2154-2170
Publication
First Author: Ramirez-Martinez A
Year: 2021
Journal: Nat Commun
Title: The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization.
Volume: 12
Issue: 1
Pages: 690
Publication
First Author: Ross JA
Year: 2023
Journal: Cardiovasc Res
Title: Lem2 is essential for cardiac development by maintaining nuclear integrity.
Volume: 119
Issue: 11
Pages: 2074-2088
Publication
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
Publication
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Allele
Name: transgene insertion KP55, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: mutant stock, transgenic
Publication
First Author: Zhou Z
Year: 2012
Journal: J Biol Chem
Title: Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.
Volume: 287
Issue: 8
Pages: 5317-26
Protein Domain
Type: Domain
Description: LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). The formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. SUN2 possesses two coiled-coil domains (CC1 and CC2). These coiled-coil domains are also believed to act as rigid spacers to delineate the distance between the ONM and INM of the NE. Furthermore, the two coiled-coil domains of SUN2 have been indicated to be able to directly modulate SUN domain activity and regulate the subsequent interactions between the SUN and KASH domains. CC2 forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component. Structure-based sequence analysis demonstrated that several Gly residues are located in the flexible linker regions between the three helices which would ideally provide the breaks/turns in CC2 for three-helix bundle formation. The last helix alpha3 of CC2 (that is immediately connected to the SUN domain) has been shown to be an essential segment for promoting SUN domain trimerization in the SUN-KASH complex structure [, ].
Publication
First Author: Hieda M
Year: 2021
Journal: Sci Rep
Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
Volume: 11
Issue: 1
Pages: 5358
Publication
First Author: Puckelwartz MJ
Year: 2009
Journal: Hum Mol Genet
Title: Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice.
Volume: 18
Issue: 4
Pages: 607-20
Publication      
First Author: Mu X
Year: 2020
Journal: Aging Cell
Title: Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome.
Publication
First Author: Folker ES
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.
Volume: 108
Issue: 1
Pages: 131-6
Publication
First Author: Zhou C
Year: 2017
Journal: Hum Mol Genet
Title: Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.
Volume: 26
Issue: 12
Pages: 2258-2276
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data