Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cat, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
hamster, Chinese |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents HMGB1 (also known as HMG-1). It has been implicated as an important mediator of many chronic inflammatory diseases, including asthma [, ]. During infection or injury, activated immune cells and damaged cells release HMGB1 into the extracellular space, where HMGB1 functions as a proinflammatory mediator []. Intracellular HMGB1 also has a role during inflammation. Cytosolic HMGB1 regulates apoptosis by protecting the autophagy proteins beclin 1 and ATG5 from calpain-mediated cleavage during inflammation, therefore controlling the switch between the proautophagic and proapoptotic function []. Nuclear HMGB1 is engaged in many DNA activity-associated events.The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2015 |
Journal: |
J Clin Invest |
Title: |
Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. |
Volume: |
125 |
Issue: |
3 |
Pages: |
1098-110 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3826511 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603922 |
Pattern: |
Widespread |
Stage: |
TS22 |
Assay Id: |
MGI:3826662 |
Age: |
embryonic day 14.5 |
Image: |
2 Hmgb1 |
Note: |
There was broad staining throughout the embryo. |
Specimen Label: |
2 Hmgb1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andersson U |
Year: |
2002 |
Journal: |
J Leukoc Biol |
Title: |
HMGB1 as a DNA-binding cytokine. |
Volume: |
72 |
Issue: |
6 |
Pages: |
1084-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu B |
Year: |
2013 |
Journal: |
Protein Cell |
Title: |
Regulation of HMGB1 release by inflammasomes. |
Volume: |
4 |
Issue: |
3 |
Pages: |
163-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang Y |
Year: |
2015 |
Journal: |
Mol Cell Biochem |
Title: |
HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2. |
Volume: |
405 |
Issue: |
1-2 |
Pages: |
63-71 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
55
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
211
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
208
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
González-Romero R |
Year: |
2015 |
Journal: |
Mol Biol Evol |
Title: |
Evolution of high mobility group nucleosome-binding proteins and its implications for vertebrate chromatin specialization. |
Volume: |
32 |
Issue: |
1 |
Pages: |
121-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang D |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
Endogenous HMGB1 regulates autophagy. |
Volume: |
190 |
Issue: |
5 |
Pages: |
881-92 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839153 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-11-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
Pattern: |
Single cells |
Stage: |
TS27 |
Assay Id: |
MGI:4839209 |
Age: |
postnatal day 0 |
Image: |
2A - Hmgb1 |
Note: |
Expression is present in oligodendrocytes and oligoendrocyte progenitors. |
Specimen Label: |
2A - Hmgb1 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Banerjee S |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Intracellular HMGB1 negatively regulates efferocytosis. |
Volume: |
187 |
Issue: |
9 |
Pages: |
4686-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu H |
Year: |
2010 |
Journal: |
J Am Soc Nephrol |
Title: |
HMGB1 contributes to kidney ischemia reperfusion injury. |
Volume: |
21 |
Issue: |
11 |
Pages: |
1878-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang H |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
HMGB1 released from nociceptors mediates inflammation. |
Volume: |
118 |
Issue: |
33 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Volchuk A |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Indirect regulation of HMGB1 release by gasdermin D. |
Volume: |
11 |
Issue: |
1 |
Pages: |
4561 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rovere-Querini P |
Year: |
2004 |
Journal: |
EMBO Rep |
Title: |
HMGB1 is an endogenous immune adjuvant released by necrotic cells. |
Volume: |
5 |
Issue: |
8 |
Pages: |
825-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Campana L |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Leukocyte HMGB1 is required for vessel remodeling in regenerating muscles. |
Volume: |
192 |
Issue: |
11 |
Pages: |
5257-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miao J |
Year: |
2020 |
Journal: |
Exp Cell Res |
Title: |
Nuclear HMGB1 promotes the phagocytic ability of macrophages. |
Volume: |
393 |
Issue: |
1 |
Pages: |
112037 |
|
•
•
•
•
•
|
Publication |
First Author: |
Prasad R |
Year: |
2007 |
Journal: |
Mol Cell |
Title: |
HMGB1 is a cofactor in mammalian base excision repair. |
Volume: |
27 |
Issue: |
5 |
Pages: |
829-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen X |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
8319 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vogel S |
Year: |
2015 |
Journal: |
J Clin Invest |
Title: |
Platelet-derived HMGB1 is a critical mediator of thrombosis. |
Volume: |
125 |
Issue: |
12 |
Pages: |
4638-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su Z |
Year: |
2011 |
Journal: |
Eur J Immunol |
Title: |
HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. |
Volume: |
41 |
Issue: |
12 |
Pages: |
3586-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh B |
Year: |
2016 |
Journal: |
Eur J Immunol |
Title: |
HMGB1 facilitates hypoxia-induced vWF upregulation through TLR2-MYD88-SP1 pathway. |
Volume: |
46 |
Issue: |
10 |
Pages: |
2388-2400 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ekanayaka SA |
Year: |
2016 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Glycyrrhizin Reduces HMGB1 and Bacterial Load in Pseudomonas aeruginosa Keratitis. |
Volume: |
57 |
Issue: |
13 |
Pages: |
5799-5809 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mei L |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p. |
Volume: |
9 |
Issue: |
1 |
Pages: |
19370 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamkanfi M |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. |
Volume: |
185 |
Issue: |
7 |
Pages: |
4385-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Costello DA |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice. |
Volume: |
31 |
Issue: |
10 |
Pages: |
3871-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tancharoen S |
Year: |
2016 |
Journal: |
Int J Mol Sci |
Title: |
HMGB1 Promotes Intraoral Palatal Wound Healing through RAGE-Dependent Mechanisms. |
Volume: |
17 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Andersson A |
Year: |
2016 |
Journal: |
Nucleic Acids Res |
Title: |
PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation. |
Volume: |
44 |
Issue: |
16 |
Pages: |
7630-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng M |
Year: |
2018 |
Journal: |
Immunity |
Title: |
The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis. |
Volume: |
49 |
Issue: |
4 |
Pages: |
740-753.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Careccia G |
Year: |
2021 |
Journal: |
Sci Transl Med |
Title: |
Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy. |
Volume: |
13 |
Issue: |
596 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lu B |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation. |
Volume: |
111 |
Issue: |
8 |
Pages: |
3068-73 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174909 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190519 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Hmgb1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174909 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190519 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Hmgb1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174909 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190519 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Hmgb1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174909 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190519 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Hmgb1 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174909 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190519 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Hmgb1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174909 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190519 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Hmgb1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174909 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190519 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Hmgb1 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hernandez C |
Year: |
2018 |
Journal: |
J Clin Invest |
Title: |
HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. |
Volume: |
128 |
Issue: |
6 |
Pages: |
2436-2451 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu B |
Year: |
2012 |
Journal: |
Nature |
Title: |
Novel role of PKR in inflammasome activation and HMGB1 release. |
Volume: |
488 |
Issue: |
7413 |
Pages: |
670-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stark K |
Year: |
2016 |
Journal: |
Blood |
Title: |
Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice. |
Volume: |
128 |
Issue: |
20 |
Pages: |
2435-2449 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khambu B |
Year: |
2018 |
Journal: |
J Clin Invest |
Title: |
HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. |
Volume: |
128 |
Issue: |
6 |
Pages: |
2419-2435 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taniguchi N |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. |
Volume: |
27 |
Issue: |
16 |
Pages: |
5650-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bangert A |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Critical role of RAGE and HMGB1 in inflammatory heart disease. |
Volume: |
113 |
Issue: |
2 |
Pages: |
E155-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang YG |
Year: |
2019 |
Journal: |
Autophagy |
Title: |
Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy. |
Volume: |
15 |
Issue: |
11 |
Pages: |
1935-1953 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang W |
Year: |
2008 |
Journal: |
Mol Immunol |
Title: |
The induction of HMGB1 release from RAW 264.7 cells by transfected DNA. |
Volume: |
45 |
Issue: |
7 |
Pages: |
2038-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giavara S |
Year: |
2005 |
Journal: |
Curr Biol |
Title: |
Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability. |
Volume: |
15 |
Issue: |
1 |
Pages: |
68-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang R |
Year: |
2014 |
Journal: |
Gastroenterology |
Title: |
Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. |
Volume: |
146 |
Issue: |
4 |
Pages: |
1097-107 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ivanov S |
Year: |
2007 |
Journal: |
Blood |
Title: |
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. |
Volume: |
110 |
Issue: |
6 |
Pages: |
1970-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boytard L |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages. |
Volume: |
11 |
Issue: |
1 |
Pages: |
4311 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmed C |
Year: |
2024 |
Journal: |
Alzheimers Dement |
Title: |
Peripheral HMGB1 is linked to O(3) pathology of disease-associated astrocytes and amyloid. |
Volume: |
20 |
Issue: |
5 |
Pages: |
3551-3566 |
|
•
•
•
•
•
|
Publication |
First Author: |
Venereau E |
Year: |
2012 |
Journal: |
J Exp Med |
Title: |
Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. |
Volume: |
209 |
Issue: |
9 |
Pages: |
1519-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsung A |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. |
Volume: |
201 |
Issue: |
7 |
Pages: |
1135-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Youn JH |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. |
Volume: |
177 |
Issue: |
11 |
Pages: |
7889-97 |
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Publication |
First Author: |
Zhou H |
Year: |
2018 |
Journal: |
Blood Adv |
Title: |
Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice. |
Volume: |
2 |
Issue: |
6 |
Pages: |
638-648 |
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Publication |
First Author: |
Lee G |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert. |
Volume: |
115 |
Issue: |
19 |
Pages: |
E4463-E4472 |
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Publication |
First Author: |
Sitia G |
Year: |
2007 |
Journal: |
J Leukoc Biol |
Title: |
Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice. |
Volume: |
81 |
Issue: |
1 |
Pages: |
100-7 |
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Publication |
First Author: |
Enokido Y |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain. |
Volume: |
376 |
Issue: |
1 |
Pages: |
128-33 |
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Publication |
First Author: |
Rabadi MM |
Year: |
2012 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Interaction between uric acid and HMGB1 translocation and release from endothelial cells. |
Volume: |
302 |
Issue: |
6 |
Pages: |
F730-41 |
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Publication |
First Author: |
Chen C |
Year: |
2014 |
Journal: |
Stem Cells |
Title: |
Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice. |
Volume: |
32 |
Issue: |
10 |
Pages: |
2679-89 |
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Publication |
First Author: |
Wenzhao L |
Year: |
2019 |
Journal: |
Cell Cycle |
Title: |
Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice. |
Volume: |
18 |
Issue: |
18 |
Pages: |
2268-2280 |
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Publication |
First Author: |
Ayoub M |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance. |
Volume: |
9 |
Issue: |
1 |
Pages: |
6348 |
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Publication |
First Author: |
Vidyanti AN |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion. |
Volume: |
21 |
Issue: |
6 |
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Publication |
First Author: |
Cao S |
Year: |
2018 |
Journal: |
Biomed Res Int |
Title: |
Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis. |
Volume: |
2018 |
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Pages: |
2649585 |
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Publication |
First Author: |
Zhao J |
Year: |
2020 |
Journal: |
Neurotherapeutics |
Title: |
HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window. |
Volume: |
17 |
Issue: |
2 |
Pages: |
710-721 |
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Publication |
First Author: |
Alves JN |
Year: |
2013 |
Journal: |
Arch Biochem Biophys |
Title: |
Critical role for CCR2 and HMGB1 in induction of experimental endotoxic shock. |
Volume: |
537 |
Issue: |
1 |
Pages: |
72-81 |
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Publication |
First Author: |
Tohme S |
Year: |
2017 |
Journal: |
Hepatology |
Title: |
Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction. |
Volume: |
66 |
Issue: |
1 |
Pages: |
182-197 |
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Publication |
First Author: |
Ghaffari S |
Year: |
2021 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2-SR-BI Axis. |
Volume: |
41 |
Issue: |
1 |
Pages: |
200-216 |
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Publication |
First Author: |
Ferrara M |
Year: |
2020 |
Journal: |
Front Immunol |
Title: |
Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions. |
Volume: |
11 |
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Pages: |
1122 |
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Publication |
First Author: |
Kaya Z |
Year: |
2023 |
Journal: |
J Neuroinflammation |
Title: |
Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes. |
Volume: |
20 |
Issue: |
1 |
Pages: |
295 |
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Publication |
First Author: |
Koutsodendris N |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release. |
Volume: |
42 |
Issue: |
10 |
Pages: |
113252 |
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Publication |
First Author: |
Hoste E |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation. |
Volume: |
29 |
Issue: |
9 |
Pages: |
2689-2701.e4 |
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Publication |
First Author: |
Davalos AR |
Year: |
2013 |
Journal: |
J Cell Biol |
Title: |
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. |
Volume: |
201 |
Issue: |
4 |
Pages: |
613-29 |
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Publication |
First Author: |
Moreno JA |
Year: |
2013 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes. |
Volume: |
33 |
Issue: |
3 |
Pages: |
612-20 |
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Publication |
First Author: |
Xu J |
Year: |
2018 |
Journal: |
J Vasc Surg |
Title: |
Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation. |
Volume: |
67 |
Issue: |
3 |
Pages: |
910-921 |
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Publication |
First Author: |
Personnaz J |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor. |
Volume: |
8 |
Issue: |
12 |
Pages: |
eabg9055 |
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Publication |
First Author: |
Yang R |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects. |
Volume: |
40 |
Issue: |
11 |
Pages: |
111330 |
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Publication |
First Author: |
Yanai H |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. |
Volume: |
110 |
Issue: |
51 |
Pages: |
20699-704 |
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Publication |
First Author: |
Mao Y |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease. |
Volume: |
13 |
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Pages: |
944772 |
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