CNOT8 is a subunit of the CCR4-NOT core complex that contains CCRN4L, CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4 and CNOT8. The CCR4-NOT complex functions as general transcription regulation complex [].
This entry includes subunits CNOT7 and CNOT8 of the CCR4-NOT complex required for RNA degradation. Both CNO7 and CNOT8 are 3'-5' poly(A) exoribonucleases removing the poly-A tail and have somewhat redundant activities []. This entry also includes CNOT7/8 yeast homologue, Pop2, which is a nuclease subunit of the yeast Ccr4-Not complex [, ].
CCR4-NOT transcription complex subunit 7 (CNOT7) is a catalytic component of the CCR4-NOT complex, a major cellular mRNA deadenylase and a key step in mRNA degradation. CNOT7 and CNOT8 have overlapping activities as 3'-5' poly(A) exoribonucleases removing the poly(A) tail [].
