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Search results 401 to 499 out of 499 for Trem2

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Type Details Score
HT Experiment
GSE200842 | Transcriptomic analysis of injured and uninjured knee joints from Trem2 KO mice [bulk RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
36107206 | J:341604
 
First Author: Zhao N
Year: 2022
Journal: J Exp Med
Title: Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia.
Volume: 219
Issue: 12
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HT Experiment
GSE181135 | Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE185510 | Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Allele
Trem2<em3Adiuj> | MGI:5816607
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 3, MODEL-AD Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Publication
37035000 | J:339336
First Author: Iguchi A
Year: 2023
Journal: iScience
Title: INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.
Volume: 26
Issue: 4
Pages: 106375
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Publication
36219197 | J:350035
 
First Author: Jain N
Year: 2023
Journal: J Exp Med
Title: Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading.
Volume: 220
Issue: 1
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HT Experiment
GSE123022 | Deep single-cell RNAseq of postnatal day 7 microglia from wild type and Trem2 knockout brains
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE233601 | BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
18551625 | J:156263
First Author: Frank S
Year: 2008
Journal: Glia
Title: TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice.
Volume: 56
Issue: 13
Pages: 1438-47
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Publication
39431020 | J:359174
First Author: Shojaei M
Year: 2024
Journal: Theranostics
Title: PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies.
Volume: 14
Issue: 16
Pages: 6319-6336
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Publication
33065553 | J:311239
First Author: Wang Y
Year: 2020
Journal: Aging (Albany NY)
Title: TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice.
Volume: 12
Issue: 20
Pages: 20862-20879
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Publication
37865646 | J:342080
First Author: Zhang X
Year: 2023
Journal: Nat Commun
Title: Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease.
Volume: 14
Issue: 1
Pages: 6670
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Publication
31006066 | J:295793
First Author: Boza-Serrano A
Year: 2019
Journal: Acta Neuropathol
Title: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Volume: 138
Issue: 2
Pages: 251-273
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Publication
32514138 | J:298292
First Author: Andreone BJ
Year: 2020
Journal: Nat Neurosci
Title: Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Volume: 23
Issue: 8
Pages: 927-938
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HT Experiment
GSE172499 | INPP5D modulates TREM2 loss-of-function phenotypes in a beta-amyloidosis mouse model
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
26021803 | J:232902
First Author: Phongsisay V
Year: 2015
Journal: Mol Immunol
Title: Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors.
Volume: 66
Issue: 2
Pages: 463-71
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Publication
28197095 | J:276720
 
First Author: Brendel M
Year: 2017
Journal: Front Aging Neurosci
Title: Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis.
Volume: 9
Pages: 8
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Allele
Trem2<em1Adiuj> | MGI:5770794
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, MODEL-AD Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Trem2<em3Smoc> | MGI:7292958
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Trem2<em5Smoc> | MGI:7292960
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Publication
35670898 | J:350957
First Author: Sanjay
Year: 2022
Journal: Mol Neurobiol
Title: Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model.
Volume: 59
Issue: 8
Pages: 5135-5148
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Publication
28612290 | J:311298
First Author: Haure-Mirande JV
Year: 2017
Journal: Acta Neuropathol
Title: Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Volume: 134
Issue: 5
Pages: 769-788
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Strain
MGI:6355304 | C57BL/6JSmoc-Trem2<em3Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Trem2<em4(TREM2)Smoc> | MGI:7292959
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6771235 | C57BL/6JSmoc-Trem2<em5Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Trem2<tm1(Trem2)Smoc> | MGI:7786970
Name: triggering receptor expressed on myeloid cells 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
29611543 | -
First Author: Zhao Y
Year: 2017
Journal: Exp Mol Med
Title: Intracellular trafficking of TREM2 is regulated by presenilin 1.
Volume: 49
Issue: 12
Pages: e405
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Allele
Trem2<em1Smoc> | MGI:7292956
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6355300 | C57BL/6JSmoc-Trem2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6429726 | C57BL/6JSmoc-Trem2<em4(TREM2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Trem2<em1(cre)Jddl> | MGI:7490214
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Jiandie D Lin
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Strain
MGI:7788826 | C57BL/6JSmoc-Trem2<tm1(TREM2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Trem2<em2Smoc> | MGI:7292957
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
27477018 | -
First Author: Yeh FL
Year: 2016
Journal: Neuron
Title: TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.
Volume: 91
Issue: 2
Pages: 328-40
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Allele
Gt(ROSA)26Sor<tm3(tTA,tetO-TREM2,-EGFP)Gbu> | MGI:7541478
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Guojun Bu
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Inserted expressed sequence, No functional change
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CL Term
CL:4033086 | lipid-associated macrophage
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HT Experiment
GSE140399 | Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer's disease [15 months]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE140510 | Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer's disease [7 months]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:6355303 | C57BL/6JSmoc-Trem2<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Trem2<em1Npa> | MGI:7507636
 
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Novartis Pharma AG
Allele Type: Endonuclease-mediated
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Strain
MGI:7780133 | B6.Cg-Gt(ROSA)26Sor<tm3(tTA,tetO-TREM2,-EGFP)Gbu>/NzhaoJ
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Gt(ROSA)26Sor<tm4(tTA,tetO-TREM2*R47H,-EGFP)Gbu> | MGI:7541481
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Guojun Bu
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Inserted expressed sequence, Reporter
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Strain
MGI:6491423 | C57BL/6J-Trem2<em3Bwef>/J
Attribute String: endonuclease-mediated mutation, mutant strain, coisogenic
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Allele
Trem2<em3Npa> | MGI:7509136
 
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 3, Novartis Pharma AG
Allele Type: Endonuclease-mediated
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Strain
MGI:7780135 | B6.Cg-Gt(ROSA)26Sor<tm4(tTA,tetO-TREM2*R47H,-EGFP)Gbu>/NzhaoJ
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Trem2<tm1(TREM2*R47H)Aduci> | MGI:7327131
Name: triggering receptor expressed on myeloid cells 2; targeted mutation 1, Frank LaFerla
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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HT Experiment
GSE204769 | Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination [Trem2KO]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE190012 | Single nucleus analysis of brain tissues from DAP12 loss-of-function (Kdelta75) mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(TREM2)1Xwy | MGI:6194033
Name: transgene insertion 1, X William Yang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7327132 | C57BL/6J-Trem2<tm2(TREM2*R47H)Aduci>
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Trem2<em2(TREM2*R47H)Aduci> | MGI:7327122
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 2, Frank LaFerla
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6194058 | FVB/NJ-Tg(TREM2)1Xwy/J
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:7327123 | C57BL/6-Trem2<em2(TREM2*R47H)Aduci>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7485950 | C57BL/6J-Trem2<em2(TREM2*R47H)Aduci>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Trem2/Trem2<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE181903 | AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states in via Akt hyperactivation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
21110946 | J:167452
First Author: Fujimoto S
Year: 2011
Journal: Biochem Biophys Res Commun
Title: In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice.
Volume: 404
Issue: 1
Pages: 223-7
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Publication
38360943 | J:348826
First Author: Reinisch I
Year: 2024
Journal: Nat Commun
Title: Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.
Volume: 15
Issue: 1
Pages: 1391
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Publication
32199103 | J:298380
First Author: Zhao N
Year: 2020
Journal: Neuron
Title: Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.
Volume: 106
Issue: 5
Pages: 727-742.e6
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Publication
39095344 | J:361203
First Author: Leung SK
Year: 2024
Journal: Nat Commun
Title: Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology.
Volume: 15
Issue: 1
Pages: 6458
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Publication
36658241 | J:337692
First Author: Zhou Y
Year: 2023
Journal: Nat Immunol
Title: Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia.
Volume: 24
Issue: 3
Pages: 545-557
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Publication
33314529 | J:331908
First Author: Audrain M
Year: 2021
Journal: Alzheimers Dement
Title: Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Volume: 17
Issue: 2
Pages: 149-163
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Publication
32941599 | J:299276
 
First Author: Liu T
Year: 2020
Journal: J Exp Med
Title: Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.
Volume: 217
Issue: 12
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Publication
36635496 | J:348189
First Author: van Lengerich B
Year: 2023
Journal: Nat Neurosci
Title: A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Volume: 26
Issue: 3
Pages: 416-429
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Publication
32362324 | J:358575
First Author: Seidman JS
Year: 2020
Journal: Immunity
Title: Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.
Volume: 52
Issue: 6
Pages: 1057-1074.e7
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Publication
25620700 | J:222897
First Author: Matarin M
Year: 2015
Journal: Cell Rep
Title: A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.
Volume: 10
Issue: 4
Pages: 633-44
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HT Experiment
GSE141509 | A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
35477277 | J:354450
First Author: Endo-Umeda K
Year: 2022
Journal: Arterioscler Thromb Vasc Biol
Title: Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis.
Volume: 42
Issue: 6
Pages: 719-731
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Publication
32816243 | J:311336
First Author: Ochi S
Year: 2020
Journal: Mol Neurobiol
Title: Identifying Blood Transcriptome Biomarkers of Alzheimer's Disease Using Transgenic Mice.
Volume: 57
Issue: 12
Pages: 4941-4951
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Publication
35348636 | J:360156
First Author: Greve HJ
Year: 2023
Journal: Brain
Title: The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment.
Volume: 146
Issue: 3
Pages: 991-1005
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Publication
25593125 | J:220893
First Author: Li X
Year: 2015
Journal: FASEB J
Title: Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia.
Volume: 29
Issue: 5
Pages: 1754-62
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Publication
33782087 | J:305076
 
First Author: Kemp SB
Year: 2021
Journal: Life Sci Alliance
Title: Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages.
Volume: 4
Issue: 6
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Publication
23962980 | J:259716
First Author: Peng Q
Year: 2013
Journal: Sci Signal
Title: A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages.
Volume: 6
Issue: 289
Pages: ra72
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Publication
26458770 | J:229025
First Author: Varvel NH
Year: 2015
Journal: J Exp Med
Title: Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease.
Volume: 212
Issue: 11
Pages: 1803-9
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Publication
38565291 | J:354305
 
First Author: Liu Y
Year: 2024
Journal: J Neurosci
Title: Imbalance in Glucose Metabolism Regulates the Transition of Microglia from Homeostasis to Disease-Associated Microglia Stage 1.
Volume: 44
Issue: 20
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Publication
25904803 | J:352207
First Author: Savage JC
Year: 2015
Journal: J Neurosci
Title: Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
Volume: 35
Issue: 16
Pages: 6532-43
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Publication
26888450 | J:264934
 
First Author: Graham LC
Year: 2016
Journal: Sci Rep
Title: Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease.
Volume: 6
Pages: 21568
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Publication
33584248 | J:351272
 
First Author: Molina-Martínez P
Year: 2020
Journal: Front Aging Neurosci
Title: Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer's Disease Traits.
Volume: 12
Pages: 622360
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Publication
33817786 | J:353374
First Author: Vasilopoulou F
Year: 2021
Journal: Br J Pharmacol
Title: Disease-modifying treatment with I(2) imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil.
Volume: 178
Issue: 15
Pages: 3017-3033
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Publication
36142627 | J:329866
 
First Author: Choo XY
Year: 2022
Journal: Int J Mol Sci
Title: Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex.
Volume: 23
Issue: 18
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Publication
32413556 | J:331819
 
First Author: Guan YF
Year: 2020
Journal: Brain Behav Immun
Title: Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula.
Volume: 88
Pages: 748-762
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Publication
32917267 | J:307714
First Author: Takalo M
Year: 2020
Journal: Mol Neurodegener
Title: The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.
Volume: 15
Issue: 1
Pages: 52
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Publication
34254352 | J:308279
   
First Author: Maguire E
Year: 2021
Journal: EMBO J
Title: PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522.
Pages: e105603
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Publication
25805889 | J:259514
First Author: Zhang Y
Year: 2015
Journal: Sci Signal
Title: DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis.
Volume: 8
Issue: 369
Pages: ra31
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Publication
32657463 | J:293897
First Author: Scott-Hewitt N
Year: 2020
Journal: EMBO J
Title: Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.
Volume: 39
Issue: 16
Pages: e105380
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Publication
31440125 | J:313078
 
First Author: Yli-Karjanmaa M
Year: 2019
Journal: Front Neurosci
Title: Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice.
Volume: 13
Pages: 781
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Publication
33053435 | J:343047
 
First Author: Cui X
Year: 2021
Journal: Brain Res Bull
Title: Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response.
Volume: 166
Pages: 21-28
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Publication
37085492 | J:357204
First Author: Brase L
Year: 2023
Journal: Nat Commun
Title: Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers.
Volume: 14
Issue: 1
Pages: 2314
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Publication
37609485 | J:356215
 
First Author: Padiadpu J
Year: 2023
Journal: Front Nutr
Title: Early transcriptome changes associated with western diet induced NASH in Ldlr(-/-) mice points to activation of hepatic macrophages and an acute phase response.
Volume: 10
Pages: 1147602
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Publication
38500108 | J:350688
First Author: Jagadeesan N
Year: 2024
Journal: J Transl Med
Title: Modulation of hippocampal protein expression by a brain penetrant biologic TNF-α inhibitor in the 3xTg Alzheimer's disease mice.
Volume: 22
Issue: 1
Pages: 291
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Year: 2021
Journal: J Neuroinflammation
Title: Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease.
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Journal: Neurobiol Dis
Title: Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis.
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35921534 | J:350179
First Author: Zhao P
Year: 2022
Journal: MAbs
Title: Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice.
Volume: 14
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Pages: 2107971
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First Author: Choi H
Year: 2021
Journal: J Neuroinflammation
Title: Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer's disease.
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First Author: Tucker AE
Year: 2022
Journal: Front Behav Neurosci
Title: Chronic Ethanol Causes Persistent Increases in Alzheimer's Tau Pathology in Female 3xTg-AD Mice: A Potential Role for Lysosomal Impairment.
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First Author: Natunen T
Year: 2020
Journal: Mol Neurodegener
Title: Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.
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