Histone-lysine N-methyltransferase EHMT1, () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT1 also methylates 'Lys-27' of histone H3 (H3K27me), but weakly []. EHMT1 also dimethylates other proteins, including 'Lys-373' of p53 []. EHMT1 forms a heterodimer with EHMT2 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT1 contains eight ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues [].
Histone-lysine N-methyltransferase EHMT1, () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT1 also methylates 'Lys-27' of histone H3 (H3K27me), but weakly []. EHMT1 also dimethylates other proteins, including 'Lys-373' of p53 []. EHMT1 forms a heterodimer with EHMT2 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT1 contains eight ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues [].
Histone-lysine N-methyltransferase EHMT2 () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT2 also monomethylates 'Lys-56' of histone H3 (H3K56me1) during the G1 phase of the cell cycle [], and methylates 'Lys-27' of histone H3 (H3K27me) []. EHMT2 also dimethylates other proteins [], including 'Lys-373' of p53 []. EHMT2 forms a heterdimer with EHMT1 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT2 contains seven ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues [].
