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Search results 3901 to 4000 out of 7122 for App

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Type Details Score
Publication
First Author: Yassine N
Year: 2013
Journal: Neurobiol Aging
Title: Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice.
Volume: 34
Issue: 3
Pages: 716-30
Publication
First Author: Pignataro A
Year: 2019
Journal: Biol Psychiatry
Title: Activity-Induced Amyloid-β Oligomers Drive Compensatory Synaptic Rearrangements in Brain Circuits Controlling Memory of Presymptomatic Alzheimer's Disease Mice.
Volume: 86
Issue: 3
Pages: 185-195
Publication
First Author: Chu J
Year: 2013
Journal: Neurobiol Aging
Title: 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.
Volume: 34
Issue: 6
Pages: 1549-54
Publication
First Author: Kiyota T
Year: 2009
Journal: PLoS One
Title: CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction.
Volume: 4
Issue: 7
Pages: e6197
Publication  
First Author: Xu W
Year: 2015
Journal: Exp Neurol
Title: Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease.
Volume: 264
Pages: 82-91
Publication
First Author: Jacobsen JS
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.
Volume: 103
Issue: 13
Pages: 5161-6
Publication
First Author: Jahrling JB
Year: 2014
Journal: J Neurosci
Title: PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement.
Volume: 34
Issue: 11
Pages: 4054-63
Publication
First Author: Ciccone R
Year: 2019
Journal: Sci Rep
Title: Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer's Disease Mouse Model.
Volume: 9
Issue: 1
Pages: 13592
Publication  
First Author: Kishimoto Y
Year: 2013
Journal: Brain Res
Title: Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease.
Volume: 1491
Pages: 117-26
Publication
First Author: Wang X
Year: 2018
Journal: Biol Psychiatry
Title: A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease.
Volume: 83
Issue: 5
Pages: 395-405
Publication
First Author: Wearne SL
Year: 2005
Journal: Neuroscience
Title: New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales.
Volume: 136
Issue: 3
Pages: 661-80
Publication
First Author: Biron KE
Year: 2011
Journal: PLoS One
Title: Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease.
Volume: 6
Issue: 8
Pages: e23789
Publication
First Author: Tomidokoro Y
Year: 2001
Journal: J Pathol
Title: Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau.
Volume: 194
Issue: 4
Pages: 500-6
Publication  
First Author: Kishimoto Y
Year: 2013
Journal: Neurosci Lett
Title: Presenilin 2 mutation accelerates the onset of impairment in trace eyeblink conditioning in a mouse model of Alzheimer's disease overexpressing human mutant amyloid precursor protein.
Volume: 538
Pages: 15-9
Publication
First Author: Wesson DW
Year: 2010
Journal: J Neurosci
Title: Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model.
Volume: 30
Issue: 2
Pages: 505-14
Publication  
First Author: Watanabe T
Year: 2013
Journal: Neurosci Lett
Title: Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden.
Volume: 536
Pages: 74-9
Publication
First Author: Medeiros R
Year: 2013
Journal: Am J Pathol
Title: Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.
Volume: 182
Issue: 5
Pages: 1780-9
Publication
First Author: Quinn J
Year: 2005
Journal: Brain Res
Title: Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials.
Volume: 1037
Issue: 1-2
Pages: 209-13
Publication
First Author: Pappolla MA
Year: 1998
Journal: Am J Pathol
Title: Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.
Volume: 152
Issue: 4
Pages: 871-7
Allele
Name: transgene insertion 6, David Westaway
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Jee SW
Year: 2005
Journal: Int J Mol Med
Title: cDNA microarray-based analysis of differentially expressed genes in transgenic brains expressing NSE-controlled APPsw.
Volume: 16
Issue: 4
Pages: 547-52
Allele
Name: amyloid beta precursor protein; targeted mutation 1, Christoph Kohler
Allele Type: Targeted
Attribute String: Humanized sequence
Allele
Name: transgene insertion 7, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Quon D
Year: 1991
Journal: Nature
Title: Formation of beta-amyloid protein deposits in brains of transgenic mice.
Volume: 352
Issue: 6332
Pages: 239-41
Allele
Name: transgene insertion 25, Sanjay W Pimplikar
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Colin L Masters
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Genoway
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: deletion, Chr 16, Yann Herault 3
Allele Type: Targeted
Attribute String: Null/knockout
Allele  
Name: duplication, Chr 16, Yann Herault 2
Allele Type: Targeted
Allele
Name: transgene insertion, Akira Kakizuka
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: amyloid beta precursor protein; endonuclease-mediated mutation 1, MODEL-AD Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: congenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Tg(APP)6209Kha/?
Background: (DBA/2 X FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSWE)2576Kha/?
Background: FVB.Cg-Tg(APPSWE)2576Kha
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSWE)2576Kha/?
Background: involves: C57BL/6J * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSWE)2576Kha/Tg(APPSWE)2576Kha
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(ACTB-APP)1Colm/?
Background: involves: C57BL/6 * DBA
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Midthune B
Year: 2012
Journal: Mol Cell Neurosci
Title: Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function.
Volume: 49
Issue: 4
Pages: 448-55
Publication
First Author: Giliberto L
Year: 2009
Journal: PLoS One
Title: Generation and initial characterization of FDD knock in mice.
Volume: 4
Issue: 11
Pages: e7900
Genotype
Symbol: Tg(APP695)3Dbo/? Tg(PSEN1dE9)S9Dbo/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
GO Term
GO Term
Publication
First Author: Rohe M
Year: 2008
Journal: J Biol Chem
Title: Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis.
Volume: 283
Issue: 21
Pages: 14826-34
Publication
First Author: Borchelt DR
Year: 1996
Journal: Neuron
Title: Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Volume: 17
Issue: 5
Pages: 1005-13
Publication
First Author: Colas D
Year: 2008
Journal: Neurobiol Dis
Title: Sleep and EEG features in genetic models of Down syndrome.
Volume: 30
Issue: 1
Pages: 1-7
Publication
First Author: Harris JA
Year: 2010
Journal: Neuron
Title: Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.
Volume: 68
Issue: 3
Pages: 428-41
Publication  
First Author: Tiberi A
Year: 2023
Journal: Front Cell Dev Biol
Title: Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype.
Volume: 11
Pages: 1165125
Publication
First Author: Flanigan TJ
Year: 2014
Journal: Genes Brain Behav
Title: Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.
Volume: 13
Issue: 5
Pages: 488-500
Publication
First Author: Liu CC
Year: 2022
Journal: Nat Neurosci
Title: Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function.
Volume: 25
Issue: 8
Pages: 1020-1033
Publication
First Author: Ringland C
Year: 2021
Journal: BMC Neurosci
Title: MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer's disease.
Volume: 22
Issue: 1
Pages: 39
Publication
First Author: He Y
Year: 2019
Journal: Nat Commun
Title: Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.
Volume: 10
Issue: 1
Pages: 1193
Publication
First Author: Roy ER
Year: 2022
Journal: Immunity
Title: Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques.
Volume: 55
Issue: 5
Pages: 879-894.e6
Publication
First Author: Islam MR
Year: 2021
Journal: Nat Metab
Title: Exercise hormone irisin is a critical regulator of cognitive function.
Volume: 3
Issue: 8
Pages: 1058-1070
Publication
First Author: Chen W
Year: 2020
Journal: J Neurosci
Title: 14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease.
Volume: 40
Issue: 42
Pages: 8188-8203
Publication
First Author: Escoubas CC
Year: 2024
Journal: Cell
Title: Type-I-interferon-responsive microglia shape cortical development and behavior.
Volume: 187
Issue: 8
Pages: 1936-1954.e24
Publication
First Author: Pao PC
Year: 2020
Journal: Nat Commun
Title: HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
Volume: 11
Issue: 1
Pages: 2484
Publication
First Author: Tewari BP
Year: 2024
Journal: Nat Neurosci
Title: Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice.
Volume: 27
Issue: 8
Pages: 1475-1488
Publication      
First Author: Shen YR
Year: 2024
Journal: Cell Stem Cell
Title: Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming.
Publication
First Author: Andrew RJ
Year: 2019
Journal: J Biol Chem
Title: Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.
Volume: 294
Issue: 12
Pages: 4477-4487
Publication  
First Author: Suzuki K
Year: 2020
Journal: Science
Title: A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.
Volume: 369
Issue: 6507
Publication
First Author: Fu AK
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Volume: 113
Issue: 19
Pages: E2705-13
Publication
First Author: Peretti D
Year: 2015
Journal: Nature
Title: RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Volume: 518
Issue: 7538
Pages: 236-9
Publication  
First Author: Marazuela P
Year: 2022
Journal: Int J Mol Sci
Title: Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study.
Volume: 23
Issue: 9
Publication
First Author: Shi Q
Year: 2022
Journal: J Neurosci
Title: Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model.
Volume: 42
Issue: 27
Pages: 5294-5313
Publication
First Author: Liu YJ
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Cspg4(high) microglia contribute to microgliosis during neurodegeneration.
Volume: 120
Issue: 8
Pages: e2210643120
Publication
First Author: Kim DK
Year: 2024
Journal: Sci Adv
Title: Brain hypothyroidism silences the immune response of microglia in Alzheimer's disease animal model.
Volume: 10
Issue: 11
Pages: eadi1863
Publication
First Author: Gowrishankar S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.
Volume: 112
Issue: 28
Pages: E3699-708
Publication
First Author: Zhang L
Year: 2021
Journal: iScience
Title: BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology.
Volume: 24
Issue: 9
Pages: 102942
Publication
First Author: Soula M
Year: 2023
Journal: Nat Neurosci
Title: Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer's disease model mice.
Volume: 26
Issue: 4
Pages: 570-578
Publication
First Author: Caccamo A
Year: 2017
Journal: Nat Neurosci
Title: Necroptosis activation in Alzheimer's disease.
Volume: 20
Issue: 9
Pages: 1236-1246
Publication
First Author: Pan RY
Year: 2019
Journal: Sci Adv
Title: Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance.
Volume: 5
Issue: 2
Pages: eaau6328
Publication
First Author: Zhang J
Year: 2021
Journal: Aging Cell
Title: Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease.
Volume: 20
Issue: 6
Pages: e13380
Publication
First Author: Feng W
Year: 2024
Journal: STAR Protoc
Title: Protocol for evaluating mutualistic cooperative behavior in mice using a water-reward task assay.
Volume: 5
Issue: 2
Pages: 103023
Publication
First Author: Cruz Hernández JC
Year: 2019
Journal: Nat Neurosci
Title: Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models.
Volume: 22
Issue: 3
Pages: 413-420
Publication  
First Author: Tan X
Year: 2021
Journal: Behav Brain Res
Title: Isoorientin, a GSK-3β inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice.
Volume: 398
Pages: 112968
Publication
First Author: Jung H
Year: 2022
Journal: Nat Med
Title: Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein.
Volume: 28
Issue: 9
Pages: 1802-1812
Publication
First Author: Lee HY
Year: 2022
Journal: Alzheimers Res Ther
Title: Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models.
Volume: 14
Issue: 1
Pages: 177
Publication
First Author: Yue W
Year: 2015
Journal: Stem Cell Reports
Title: ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models.
Volume: 5
Issue: 5
Pages: 776-790
Publication
First Author: Baruch K
Year: 2015
Journal: EMBO J
Title: Cerebral nitric oxide represses choroid plexus NFκB-dependent gateway activity for leukocyte trafficking.
Volume: 34
Issue: 13
Pages: 1816-28
Publication
First Author: Yun SM
Year: 2013
Journal: Neurobiol Aging
Title: SUMO1 modulates Aβ generation via BACE1 accumulation.
Volume: 34
Issue: 3
Pages: 650-62
Publication
First Author: Ferguson CM
Year: 2024
Journal: Alzheimers Dement
Title: Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease.
Volume: 20
Issue: 4
Pages: 2632-2652
Publication
First Author: Kim S
Year: 2024
Journal: Mol Neurodegener
Title: Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer's disease.
Volume: 19
Issue: 1
Pages: 55
Publication
First Author: Xu C
Year: 2021
Journal: Theranostics
Title: TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG.
Volume: 11
Issue: 19
Pages: 9452-9469
Publication
First Author: Savage JC
Year: 2015
Journal: J Neurosci
Title: Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
Volume: 35
Issue: 16
Pages: 6532-43
Publication  
First Author: Gharpure M
Year: 2024
Journal: Neurobiol Dis
Title: Alterations in Alzheimer's disease microglia transcriptome might be involved in bone pathophysiology.
Volume: 191
Pages: 106404
Publication
First Author: Chen K
Year: 2024
Journal: Alzheimers Dement
Title: Anesthesia-induced hippocampal-cortical hyperactivity and tau hyperphosphorylation impair remote memory retrieval in Alzheimer's disease.
Volume: 20
Issue: 1
Pages: 494-510
Publication
First Author: Aloi MS
Year: 2023
Journal: J Neuroinflammation
Title: Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures.
Volume: 20
Issue: 1
Pages: 60
Publication
First Author: Baruch K
Year: 2016
Journal: Nat Med
Title: PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease.
Volume: 22
Issue: 2
Pages: 135-7
Publication
First Author: Lee CYD
Year: 2018
Journal: Neuron
Title: Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
Volume: 97
Issue: 5
Pages: 1032-1048.e5
Publication  
First Author: Forny Germano L
Year: 2024
Journal: Mol Metab
Title: The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice.
Volume: 89
Pages: 102019
Publication
First Author: Martorell AJ
Year: 2019
Journal: Cell
Title: Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition.
Volume: 177
Issue: 2
Pages: 256-271.e22
Publication  
First Author: Na D
Year: 2023
Journal: Front Neurosci
Title: Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis.
Volume: 17
Pages: 1106570
Publication
First Author: Park S
Year: 2024
Journal: Exp Neurobiol
Title: FAM19A5 Deficiency Mitigates the Aβ Plaque Burden and Improves Cognition in Mouse Models of Alzheimer's Disease.
Volume: 33
Issue: 4
Pages: 193-201
Publication
First Author: Choi I
Year: 2023
Journal: Nat Cell Biol
Title: Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence.
Volume: 25
Issue: 7
Pages: 963-974
Publication  
First Author: Kim Y
Year: 2023
Journal: Int J Mol Sci
Title: Depressive-like Behaviors Induced by mGluR5 Reduction in 6xTg in Mouse Model of Alzheimer's Disease.
Volume: 24
Issue: 16
Publication
First Author: Kimura T
Year: 2016
Journal: Am J Pathol
Title: The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method.
Volume: 186
Issue: 2
Pages: 398-409