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Search results 101 to 160 out of 160 for Sp110

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Hits by Strain

Type Details Score
Strain
MGI:6347394 | C57BL/6N-Sp110<tm1(KOMP)Vlcg>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:7834990 | C57BL/6JCya-Sp110<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Sp110/Sp110
Background: C57BL/6J-Sp110
Zygosity: hm
Has Mutant Allele: true
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Publication
10913195 | -
First Author: Bloch DB
Year: 2000
Journal: Mol Cell Biol
Title: Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator.
Volume: 20
Issue: 16
Pages: 6138-46
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Publication
16648851 | -
First Author: Roscioli T
Year: 2006
Journal: Nat Genet
Title: Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease.
Volume: 38
Issue: 6
Pages: 620-2
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DO Term
DOID:0112254 | hepatic venoocclusive disease with immunodeficiency
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Protein
Q8C308
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
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Protein
F6V9G0
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
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Protein Domain
IPR043563 | Sp110/Sp140/Sp140L
Type: Family
Description: This entry includes a group of nuclear dot-associated proteins, including Sp110/Sp140/Sp140L from humans. They are proteins with a constituent of nuclear domains, also known as nuclear dots (NDs). Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region) [].Sp110 is a leukocyte-specific component of the nuclear body []. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells []. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers [, ]. Sp110 gene polymorphisms may be associated with susceptibility to tuberculosis in Chinese population []. The function of nuclear protein Sp140 is not known, though it contains several chromatin related modules such as plant homeodomain (PHD), bromodomain (BRD) and SAND domain, which suggests a role in chromatin-mediated regulation of gene expression []. It also harbours a nuclear localisation signal and a dimerisation domain (HSR or CARD domain). The PHD finger of Sp140 presents an atypical fold which does not bind to histone H3 tails but binds to peptidylprolyl isomerase Pin1. Pin1 catalyses the isomerisation of a phospho-Threonine-Proline bond in Sp140-PHD and thus may modulate Sp140 function [].Human Sp140 is an interferon inducible nuclear leukocyte-specific protein that may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection []. It localises to LYSP100-associated nuclear dots and is also a component of the promyelocytic leukemia nuclear body (PML-NBs) [, ]. The Sp140 locus has been identified as a lymphocytic leukemia (CLL) risk locus [].This family also includes protein Sp140-like (SP140L) [].
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Publication
- | J:109762
     
First Author: Mouse Genome Informatics and VEGA Genome Database Project
Year: 2006
Journal: Database Release
Title: Collaboration to Associate VEGA (Vertebrate Genome Annotation) Mouse Gene Models with MGI Markers
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Protein
Q99388
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
E0CXN9
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
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Protein
Q3UTB2
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
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Protein
Q3TQS4
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
Q3TZR7
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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Protein
E9PV05
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
E9Q422
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
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Protein
Q4KKY3
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: false
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Protein
E9Q4Y0
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
Q52KL8
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: false
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Protein
E9Q3M7
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
Q8BNW8
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: true
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Protein
Q8BS13
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q8C9H3
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
Q3UT50
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
Q7TSS9
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Protein
D6RIJ4
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
E0CXL1
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: false
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Protein
Q3UKD8
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
E0CY74
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
Q3KNJ6
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
Q8C9T1
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
Q8C898
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Publication
10212234 | -
First Author: Sternsdorf T
Year: 1999
Journal: J Biol Chem
Title: The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers.
Volume: 274
Issue: 18
Pages: 12555-66
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Publication
24267382 | -
First Author: Zucchelli C
Year: 2014
Journal: FEBS J
Title: Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1.
Volume: 281
Issue: 1
Pages: 216-31
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Publication
20923397 | -
First Author: Yap KL
Year: 2010
Journal: Crit Rev Biochem Mol Biol
Title: Keeping it in the family: diverse histone recognition by conserved structural folds.
Volume: 45
Issue: 6
Pages: 488-505
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Publication
8910577 | -
First Author: Bloch DB
Year: 1996
Journal: J Biol Chem
Title: Identification and characterization of a leukocyte-specific component of the nuclear body.
Volume: 271
Issue: 46
Pages: 29198-204
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Publication
18758461 | -
First Author: Di Bernardo MC
Year: 2008
Journal: Nat Genet
Title: A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
Volume: 40
Issue: 10
Pages: 1204-10
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Publication
8695863 | -
First Author: Dent AL
Year: 1996
Journal: Blood
Title: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.
Volume: 88
Issue: 4
Pages: 1423-6
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Publication
26347895 | -
 
First Author: Saare M
Year: 2015
Journal: J Immunol Res
Title: SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.
Volume: 2015
Pages: 526518
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Protein
O35892
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
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Protein
Q3U876
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
Q6NTA3
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
A0A1B0GX24
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: true
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Protein
A0A1B0GT08
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: true
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Protein
E9QA05
Organism: Mus musculus/domesticus
Length: 494  
Fragment?: false
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Protein
A0A1B0GRR4
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: false
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Protein
Q4FK53
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
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Protein
Q3U5P2
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: true
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Protein
Q922J2
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
F6Q968
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
E9Q441
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
Q3ZB72
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
Q8C405
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
F7DFN7
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: true
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Protein
F6WL90
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
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Protein
Q6NSQ5
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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