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Search results 101 to 200 out of 287 for Acd

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Hits by Pathway

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7266397
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
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•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7266397
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266397
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266397
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266397
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684616
Stage: TS16
Assay Id: MGI:7266406
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7266406
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7266406
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:7266406
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7266406
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:7266406
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7266406
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7266406
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7266406
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636716
Stage: TS16
Assay Id: MGI:7266414
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737320
Stage: TS20
Assay Id: MGI:7266414
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:7266414
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737324
Stage: TS24
Assay Id: MGI:7266414
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:7266414
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:7266414
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266414
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266414
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266414
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1640519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5817706
Age: embryonic day 11.5
Image: 1B
Specimen Label: 1B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5817706
Age: embryonic day 11.5
Image: 1C
Specimen Label: 1C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1674819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5817706
Age: embryonic day 11.5
Image: 1B
Specimen Label: 1B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5817706
Age: embryonic day 11.5
Image: 1C
Specimen Label: 1C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Pattern: Uniform
Stage: TS15
Assay Id: MGI:5817706
Age: embryonic day 9.5
Image: 1A
Specimen Label: 1A
Detected: true
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3185819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5817706
Age: embryonic day 11.5
Image: 1B
Note: Expression is in the craniofacial region.
Specimen Label: 1B
Detected: true
Specimen Num: 2
•
•
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•
•
GXD Expression
GXD Expression
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5817706
Age: embryonic day 11.5
Image: 1C
Note: Expression is in the craniofacial region.
Specimen Label: 1C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1616419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5817706
Age: embryonic day 11.5
Image: 1B
Specimen Label: 1B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817703
Assay Type: RNA in situ
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5817706
Age: embryonic day 11.5
Image: 1C
Specimen Label: 1C
Detected: true
Specimen Num: 3
•
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Publication
19648609 | J:159057
First Author: Wan M
Year: 2009
Journal: J Biol Chem
Title: OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation.
Volume: 284
Issue: 39
Pages: 26725-31
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Publication
20493811 | J:160600
First Author: Tejera AM
Year: 2010
Journal: Dev Cell
Title: TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice.
Volume: 18
Issue: 5
Pages: 775-89
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Publication
8855285 | J:35791
First Author: Perlick HA
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Mammalian orthologues of a yeast regulator of nonsense transcript stability.
Volume: 93
Issue: 20
Pages: 10928-32
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Publication
31895940 | J:283371
First Author: Lovejoy CA
Year: 2020
Journal: PLoS Biol
Title: ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity.
Volume: 18
Issue: 1
Pages: e3000594
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Publication
17632522 | J:159142
First Author: Hockemeyer D
Year: 2007
Journal: Nat Struct Mol Biol
Title: Telomere protection by mammalian Pot1 requires interaction with Tpp1.
Volume: 14
Issue: 8
Pages: 754-61
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Publication
26778124 | J:233038
First Author: Kibe T
Year: 2016
Journal: Mol Cell
Title: TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres.
Volume: 61
Issue: 2
Pages: 236-46
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Publication
27559927 | J:254623
First Author: Ahmad T
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.
Volume: 56
Issue: 1
Pages: 38-49
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Publication
19995905 | J:160503
First Author: Kibe T
Year: 2010
Journal: Mol Cell Biol
Title: Telomere protection by TPP1 is mediated by POT1a and POT1b.
Volume: 30
Issue: 4
Pages: 1059-66
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Publication
15383534 | J:319993
First Author: Liu D
Year: 2004
Journal: J Biol Chem
Title: Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
Volume: 279
Issue: 49
Pages: 51338-42
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Publication
24469404 | J:213522
First Author: Frescas D
Year: 2014
Journal: Mol Cell Biol
Title: TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.
Volume: 34
Issue: 7
Pages: 1349-62
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Publication
22099311 | J:178606
First Author: Takai KK
Year: 2011
Journal: Mol Cell
Title: Telomere protection by TPP1/POT1 requires tethering to TIN2.
Volume: 44
Issue: 4
Pages: 647-59
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Publication
25344324 | J:217428
First Author: Zimmermann M
Year: 2014
Journal: Genes Dev
Title: TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.
Volume: 28
Issue: 22
Pages: 2477-91
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Publication
17053789 | J:115639
First Author: He H
Year: 2006
Journal: EMBO J
Title: POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination.
Volume: 25
Issue: 21
Pages: 5180-90
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Publication
28437249 | J:314659
First Author: Wagner KD
Year: 2017
Journal: Aging (Albany NY)
Title: The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.
Volume: 9
Issue: 4
Pages: 1219-1232
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Publication
23685356 | J:199000
First Author: Kappei D
Year: 2013
Journal: EMBO J
Title: HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Volume: 32
Issue: 12
Pages: 1681-701
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Publication
- | J:30359
       
First Author: Sundberg JP (ed.)
Year: 1994
Title: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Gene
733156 | acd.L
Type: gene
Organism: frog, African clawed
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Gene
108720072 | acd.S
Type: gene
Organism: frog, African clawed
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Publication
10478576 | -
First Author: Agius MA
Year: 1999
Journal: Acta Neurol Scand
Title: High prevalence of anti-alpha-crystallin antibodies in multiple sclerosis: correlation with severity and activity of disease.
Volume: 100
Issue: 3
Pages: 139-47
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Publication
17568699 | J:123341
First Author: Ousman SS
Year: 2007
Journal: Nature
Title: Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.
Volume: 448
Issue: 7152
Pages: 474-9
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Publication
9731540 | -
First Author: Vicart P
Year: 1998
Journal: Nat Genet
Title: A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy.
Volume: 20
Issue: 1
Pages: 92-5
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Publication
11200685 | -
First Author: Celet B
Year: 2000
Journal: J Neurol
Title: Anti-alpha B-crystallin immunoreactivity in inflammatory nervous system diseases.
Volume: 247
Issue: 12
Pages: 935-9
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Publication
12869022 | -
First Author: Gelderman MP
Year: 2003
Journal: Clin Exp Immunol
Title: A novel inflammatory eye disease induced by lymphocytes from knockout mice sensitized against the deleted ocular antigen.
Volume: 133
Issue: 2
Pages: 177-81
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Protein Domain
IPR037882 | ACD_alphaB-crystallin
Type: Domain
Description: This entry represents the alpha-crystallin domain (ACD) found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa).sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits [, ]. They are characterised by the presence of an alpha-crystallin domain [].Alpha crystallin, an abundant protein in the mammalian lens, is a large (700kDa) heteropolymer composed of HspB4 and HspB5, generally in a molar ratio of HspB4:HspB5 of 3:1. HspB5 shows increased synthesis in response to stress. HspB5 is also expressed constitutively in other tissues including brain, heart, and type I and type IIa skeletal muscle fibres, and in several cancers including gliomas, renal cell carcinomas, basal-like and metaplastic breast carcinomas, and head and neck cancer. Its functions include effects on the apoptotic pathway and on metastasis. Phosphorylation of HspB5 reduces its oligomerization and anti-apoptotic activities. HspB5 is protective in demyelinating disease such as multiple sclerosis (MS), being a negative regulator of inflammation []. In early active MS lesions it is the most abundant gene transcript and an autoantigen, the immune response against it would disrupt its function and worsen inflammation anddemyelination. Given as therapy for ongoing demyelinating disease it may counteract this effect []. It is an autoantigen in the pathogenesis of various other inflammatory disorders including Lens-associated uveitis (LAU), and Behcet's disease [, ]. Mutations in HspB5 have been associated with diseases including dominant cataract and desmin-related myopathy [].
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Publication
10593960 | J:58927
First Author: Krief S
Year: 1999
Journal: J Biol Chem
Title: Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues.
Volume: 274
Issue: 51
Pages: 36592-600
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Publication
15122254 | J:311225
First Author: Evgrafov OV
Year: 2004
Journal: Nat Genet
Title: Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Volume: 36
Issue: 6
Pages: 602-6
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Publication
29037376 | -
 
First Author: Singh MK
Year: 2017
Journal: J Therm Biol
Title: The small heat shock protein Hsp27: Present understanding and future prospects.
Volume: 69
Pages: 149-154
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Publication
9325325 | -
First Author: Piotrowicz RS
Year: 1997
Journal: J Biol Chem
Title: Basolateral membrane-associated 27-kDa heat shock protein and microfilament polymerization.
Volume: 272
Issue: 41
Pages: 25920-7
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Publication
20010861 | -
First Author: Bektas M
Year: 2010
Journal: J Invest Dermatol
Title: What's in a name?: Heat shock protein 27 and keratinocyte differentiation.
Volume: 130
Issue: 1
Pages: 10-2
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Publication
15706088 | -
First Author: Arrigo AP
Year: 2005
Journal: Antioxid Redox Signal
Title: Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels.
Volume: 7
Issue: 3-4
Pages: 414-22
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Publication
17375066 | -
First Author: Perrin V
Year: 2007
Journal: Mol Ther
Title: Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease.
Volume: 15
Issue: 5
Pages: 903-11
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Publication
18573886 | -
First Author: Sinsimer KS
Year: 2008
Journal: Mol Cell Biol
Title: Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay.
Volume: 28
Issue: 17
Pages: 5223-37
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Publication
19411251 | -
First Author: Hayes D
Year: 2009
Journal: J Biol Chem
Title: Phosphorylation dependence of hsp27 multimeric size and molecular chaperone function.
Volume: 284
Issue: 28
Pages: 18801-7
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Publication
18007587 | -
First Author: Sur R
Year: 2008
Journal: J Invest Dermatol
Title: Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating NF-kappaB signaling.
Volume: 128
Issue: 5
Pages: 1116-22
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Publication
17467701 | -
First Author: Arrigo AP
Year: 2007
Journal: FEBS Lett
Title: Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.
Volume: 581
Issue: 19
Pages: 3665-74
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Publication
17761354 | -
First Author: Doran P
Year: 2007
Journal: Eur J Cell Biol
Title: Aging skeletal muscle shows a drastic increase in the small heat shock proteins alphaB-crystallin/HspB5 and cvHsp/HspB7.
Volume: 86
Issue: 10
Pages: 629-40
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Publication
21045566 | -
First Author: Vos MJ
Year: 2011
Journal: Autophagy
Title: Small heat shock proteins, protein degradation and protein aggregation diseases.
Volume: 7
Issue: 1
Pages: 101-3
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Publication
21461572 | -
First Author: Yang Z
Year: 2011
Journal: Mol Med Rep
Title: Molecular characterization of rat cvHsp/HspB7 in vitro and its dynamic molecular architecture.
Volume: 4
Issue: 1
Pages: 105-11
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Publication
29078393 | J:256653
First Author: Wu T
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: HSPB7 is indispensable for heart development by modulating actin filament assembly.
Volume: 114
Issue: 45
Pages: 11956-11961
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Publication
1356969 | -
First Author: Allen SP
Year: 1992
Journal: J Bacteriol
Title: Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli.
Volume: 174
Issue: 21
Pages: 6938-47
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Publication
15665332 | -
First Author: Matuszewska M
Year: 2005
Journal: J Biol Chem
Title: The small heat shock protein IbpA of Escherichia coli cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state.
Volume: 280
Issue: 13
Pages: 12292-8
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Publication
17995456 | -
First Author: Jiao W
Year: 2008
Journal: Biochem J
Title: The dramatically increased chaperone activity of small heat-shock protein IbpB is retained for an extended period of time after the stress condition is removed.
Volume: 410
Issue: 1
Pages: 63-70
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Publication
20158612 | -
First Author: Bissonnette SA
Year: 2010
Journal: Mol Microbiol
Title: The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease.
Volume: 75
Issue: 6
Pages: 1539-49
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Publication
9864316 | -
First Author: Münchbach M
Year: 1999
Journal: J Bacteriol
Title: Multiple small heat shock proteins in rhizobia.
Volume: 181
Issue: 1
Pages: 83-90
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Protein Domain
IPR037876 | ACD_HspB1
Type: Domain
Description: This entry represents the alpha crystallin domain (ACD) found in mammalian Hsp27 (also denoted HspB1 in human).Small heat shock proteins (sHsps) are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits [, ]. They are characterised by the presence of an alpha crystallin domain (ACD) [].Hsp27 shows enhanced synthesis in response to stress. It is a molecular chaperone which interacts with a large number of different proteins. It is found in many types of human cells including breast, uterus, cervix, platelets and cancer cells. Hsp27 has diverse cellular functions including chaperoning, regulation of actin polymerization, keratinocyte differentiation, regulation of inflammatory pathways in keratinocytes, and protection from oxidative stress through modulating glutathione levels [, , , ]. It is also a subunit of AUF1-containing protein complexes []. Hsp27 has been linked to several transduction pathways regulating cellular functions including differentiation, cell growth, development, and apoptosis []. Its activity can be regulated by phosphorylation. Its unphosphorylated state is a high molecular weight aggregated form (100-800kDa) composed of up to 24 subunits, which forms as a result of multiple interactions within the ACD, and is required for chaperone function and resistance to oxidative stress. Upon phosphorylation these large aggregates rapidly disassociate to smaller oligomers and chaperone activity is modified [].High constitutive levels of Hsp27 have been detected in various cancer cells, in particular those of carcinoma origin []. Over-expression of Hsp27 has a protective effect against various diseases-processes, including Huntington's disease []. Mutations in Hsp27 have been associated with a form of distal hereditary motor neuropathy type II and Charcot-Marie-Tooth disease type 2 [].
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Protein Domain
IPR037885 | ACD_HspB7
Type: Domain
Description: This entry represents the alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp).Small Hsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits []. HspB7 is a 25kDa protein, preferentially expressed in heart and skeletal muscle []. It is essential for fetal heart development by modulating actin filament assembly []. It binds the cytoskeleton protein alpha-filamin (also known as actin-binding protein 280) []. The expression of HspB7 is increased during rat muscle aging []. As the human gene encoding HspB7 is mapped to chromosome 1p36.23-p34.3 it is a positional candidate for several dystrophies and myopathies [].
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Protein Domain
IPR037913 | ACD_IbpA/B
Type: Domain
Description: This is the alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. This domain is also found in class A small heat shock proteins from Bradyrhizobium, which consists of proteins that show similarity to E. coli IbpA and IbpB [].IbpA and IbpB are 16kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. They all contain a conserved alpha-crystallin domain flanked by variable N- and C-terminal tails []. IbpA and IbpB are produced during high-level production of various heterologous proteins, specifically human prorenin, renin and bovine insulin-like growth factor 2 (bIGF-2), and are strongly associated with inclusion bodies containing these heterologous proteins []. IbpA and IbpB work as an integrated system to stabilize thermally aggregated proteins in a disaggregation competent state []. The chaperone activity of IbpB is also significantly elevated as the temperature increases from normal to heat shock. The high temperature results in the disassociation of 2-3-MDa IbpB oligomers into smaller approximately 600kDa structures. This elevated activity seen under heat shock conditions is retained for an extended period of time after the temperature is returned to normal []. IbpA also forms multimers [].
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